2018
Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals
Jacobs H, Hedden T, Schultz A, Sepulcre J, Perea R, Amariglio R, Papp K, Rentz D, Sperling R, Johnson K. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience 2018, 21: 424-431. PMID: 29403032, PMCID: PMC5857215, DOI: 10.1038/s41593-018-0070-z.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexMemory declineCingulate cortexHippocampal volumeTau accumulationAssociated with increased mean diffusivityCognitively healthy older individualsBaseline hippocampal volumeAmyloid-positive individualsWhite matter connectivityAmyloid-negative individualsPreclinical Alzheimer's diseaseAmyloid pathologyAnimal models of Alzheimer's diseaseHealthy older individualsTau pathology propagationModel of Alzheimer's diseaseAlzheimer's diseaseTau positron emission tomographyMemory performanceNeural vulnerabilityCingulum bundleOlder individualsPositron emission tomographyMean diffusivity
2016
IC‐P‐185: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding
Jacobs H, Schultz A, Amariglio R, Hedden T, Papp K, Perea R, Rentz D, Sepulcre J, Sperling R, Johnson K. IC‐P‐185: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding. Alzheimer's & Dementia 2016, 12: p135-p135. DOI: 10.1016/j.jalz.2016.06.216.Peer-Reviewed Original ResearchLoss of white matter connectivityWhite matter connectivityHealthy older individualsCognitive declineO3‐08‐03: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding
Jacobs H, Schultz A, Amariglio R, Hedden T, Papp K, Perea R, Rentz D, Sepulcre J, Sperling R, Johnson K. O3‐08‐03: The Effect of Tract‐Specific Loss of White Matter Connectivity on Cognitive Decline in Healthy Older Individuals Depends on Entorhinal T807 Binding. Alzheimer's & Dementia 2016, 12: p304-p305. DOI: 10.1016/j.jalz.2016.06.551.Peer-Reviewed Original ResearchLoss of white matter connectivityWhite matter connectivityHealthy older individualsCognitive declineQuantifying prion disease penetrance using large population control cohorts
Minikel EV, Vallabh SM, Lek M, Estrada K, Samocha KE, Sathirapongsasuti JF, McLean CY, Tung JY, Yu LP, Gambetti P, Blevins J, Zhang S, Cohen Y, Chen W, Yamada M, Hamaguchi T, Sanjo N, Mizusawa H, Nakamura Y, Kitamoto T, Collins SJ, Boyd A, Will RG, Knight R, Ponto C, Zerr I, Kraus TF, Eigenbrod S, Giese A, Calero M, de Pedro-Cuesta J, Haïk S, Laplanche JL, Bouaziz-Amar E, Brandel JP, Capellari S, Parchi P, Poleggi A, Ladogana A, O’Donnell-Luria A, Karczewski KJ, Marshall JL, Boehnke M, Laakso M, Mohlke KL, Kähler A, Chambert K, McCarroll S, Sullivan PF, Hultman CM, Purcell SM, Sklar P, van der Lee SJ, Rozemuller A, Jansen C, Hofman A, Kraaij R, van Rooij JG, Ikram MA, Uitterlinden AG, van Duijn CM, Consortium E, Daly MJ, MacArthur DG. Quantifying prion disease penetrance using large population control cohorts. Science Translational Medicine 2016, 8: 322ra9. PMID: 26791950, PMCID: PMC4774245, DOI: 10.1126/scitranslmed.aad5169.Peer-Reviewed Original ResearchConceptsPrion protein genePopulation control cohortPrion disease casesHealthy older individualsPrion protein expressionControl cohortLifetime riskTherapeutic suppressionDisease casesTruncating variantsDisease-causing genotypesOlder individualsBenign variantsDisease prevalenceProtein expressionDisease penetranceDiseaseMissense variantsPrion diseasesControl exomesDisease susceptibilityImpact of variantsGenetic variantsRiskPenetrance
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