2025
Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients
Droby A, Yoffe-Vasiliev A, Atias D, Fraser K, Mabrouk O, Omer N, Bar-Shira A, Gana-Weisz M, Goldstein O, Artzi M, Ben Bashat D, Alcalay R, Orr-Urtreger A, Shirvan J, Cedarbaum J, Giladi N, Mirelman A, Thaler A. Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients. Npj Parkinson's Disease 2025, 11: 7. PMID: 39753572, PMCID: PMC11698941, DOI: 10.1038/s41531-024-00854-4.Peer-Reviewed Original ResearchStriatal binding ratiosLRRK2-PD patientsFunctional connectivityLeft fronto-occipital fasciculusCerebrospinal fluidGray matter volumeDeep gray matter volumesRegional brain volumesWhole-brain gray matterNeuromelanin MRIFronto-occipital fasciculusLRRK2-PDWhite matterParkinson's diseaseLeft caudateMatter volumeReduced FCParkinson's disease patientsWhole-brainBrain volumeRadiological markersHealthy controlsFractional anisotropyRadiological measurementsPatients
2024
Investigating the association between the GAP-43 concentration with diffusion tensor imaging indices in Alzheimer’s dementia continuum
Ariaei A, Ghorbani A, Habibzadeh E, Moghaddam N, Chegeni Nezhad N, Abdoli A, Mazinanian S, Sadeghi M, Mayeli M. Investigating the association between the GAP-43 concentration with diffusion tensor imaging indices in Alzheimer’s dementia continuum. BMC Neurology 2024, 24: 397. PMID: 39420261, PMCID: PMC11484424, DOI: 10.1186/s12883-024-03904-9.Peer-Reviewed Original ResearchConceptsDiffusion tensor imaging valuesDiffusion tensor imagingLevels of GAP-43Cerebrospinal fluidGAP-43 levelsGAP-43MethodsA total numberMonitoring treatment efficacySuperior fronto-occipital fasciculusGrowth-associated protein 43Diffusion tensor imaging indicesSuperior corona radiateCerebrospinal fluid levelsDementia continuumFronto-occipital fasciculusFollow-upWhite matter microstructural changesTreatment efficacyCorona radiateStructural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
Male A, Goudzwaard E, Nakahara S, Turner J, Calhoun V, Mueller B, Lim K, Bustillo J, Belger A, Voyvodic J, O'Leary D, Mathalon D, Ford J, Potkin S, Preda A, van Erp T. Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity. Psychiatry Research Neuroimaging 2024, 342: 111843. PMID: 38896909, DOI: 10.1016/j.pscychresns.2024.111843.Peer-Reviewed Original ResearchConceptsSymptom severityFractional anisotropyDiffusion tensor imagingNeurocognitive performanceCognitive performanceAssociated with speed of processingLeft inferior fronto-occipital fasciculusWM abnormalitiesAssociated with neurocognitive performancePathophysiology of schizophreniaCognitive performance deficitsInferior fronto-occipital fasciculusSpeed of processingStructural white matter abnormalitiesMean diffusivityAxial diffusivityFronto-occipital fasciculusHealthy controlsRadial diffusivityRegional WM abnormalitiesNegative symptomsPerformance deficitsWhite matterWhite matter abnormalitiesAssociated with speedImmunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia
Li N, Li Y, Yu T, Gou M, Chen W, Wang X, Tong J, Chen S, Tan S, Wang Z, Tian B, Li C, Tan Y. Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia. Schizophrenia Research 2024, 269: 36-47. PMID: 38723519, DOI: 10.1016/j.schres.2024.04.017.Peer-Reviewed Original ResearchCD95+ T cellsTardive dyskinesiaT-cell phenotypeT cell subpopulationsBrain structural abnormalitiesT cellsSchizophrenia patientsFractional anisotropyCD95+Distribution of T cell phenotypesStructural abnormalitiesAssociated with brain structural abnormalitiesMemory T-cell subpopulationsCD8+ T cellsLevels of IFN-gInferior fronto-occipital fasciculusLevels of cytokinesSuperior longitudinal fasciculusFronto-occipital fasciculusChoroid plexus volumeIntracellular levelsWhite matter tractsOrofacial TDPallidum volumesPublished routinesAssociations Between Brain Structural Connectivity and 1‐Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study
Liang M, Chen P, Tang Y, Liang Y, Li S, Hu G, Sun Z, Yu Y, Molassiotis A, Knobf M, Ye Z. Associations Between Brain Structural Connectivity and 1‐Year Demoralization in Breast Cancer: A Longitudinal Diffusion Tensor Imaging Study. Depression And Anxiety 2024, 2024: 5595912. PMID: 40226738, PMCID: PMC11919035, DOI: 10.1155/2024/5595912.Peer-Reviewed Original ResearchInferior fronto-occipital fasciculusBreast cancerIntegrated discrimination improvementDiagnosed breast cancerIncremental predictive valueDiffusion tensor imagingQuantitative anisotropyPredictive valueDiffusion tensor imaging studiesDemoralization Scale-IIFronto-occipital fasciculusWhite matter tractsSelf-reported dataImaging studiesDiscrimination improvementLongitudinal diffusion tensor imaging studyCancerPatientsCorrelational tractographyNeural pathwaysBrain structural connectivityTensor imagingLongitudinal programBreastScale II
2022
Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study
Chiang H, Tseng W, Tseng W, Tung Y, Hsu Y, Chen C, Gau S. Atypical development in white matter microstructures in ADHD: A longitudinal diffusion imaging study. Asian Journal Of Psychiatry 2022, 79: 103358. PMID: 36481569, DOI: 10.1016/j.ajp.2022.103358.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderInferior fronto-occipital fasciculusGeneralized fractional anisotropyAttention performanceWhite matter microstructureDevelopmental trajectoriesComputerized continuous performance testAtypical developmental trajectoriesContinuous Performance TestDiffusion spectrum imagingFrontal aslant tractWhite matter tractsInattention symptomsAtypical developmentADHD symptomsHyperactivity disorderSuperior longitudinal fasciculusPrefrontal cortexFrontostriatal tractsImaging studiesArcuate fasciculusDevelopmental changesFronto-occipital fasciculusNeuroplastic processesDiagnosis interaction
2020
Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior
Grazioplene R, Tseng WL, Cimino K, Kalvin C, Ibrahim K, Pelphrey KA, Sukhodolsky DG. Fixel-Based Diffusion Magnetic Resonance Imaging Reveals Novel Associations Between White Matter Microstructure and Childhood Aggressive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2020, 5: 490-498. PMID: 32144044, PMCID: PMC7214205, DOI: 10.1016/j.bpsc.2019.12.018.Peer-Reviewed Original ResearchConceptsWhite matter densityCorpus callosumFiber densityAggressive behaviorCingulum bundleAbnormal interhemispheric connectivityHealthy control childrenWhite matter abnormalitiesAttention-deficit/hyperactivity disorderMiddle cerebellar peduncleSuperior thalamic radiationMagnetic resonance imagingInferior fronto-occipital fasciculusWhole-brain analysisInferior longitudinal fasciculusFronto-occipital fasciculusPotential neural mechanismsWhite matter microstructureDiffusion magnetic resonance imagingInterhemispheric connectivityCortical pathwaysCerebellar peduncleChild Behavior ChecklistThalamic radiationFiber bundle density
2013
DTI-measured white matter abnormalities in adolescents with Conduct Disorder
Haney-Caron E, Caprihan A, Stevens MC. DTI-measured white matter abnormalities in adolescents with Conduct Disorder. Journal Of Psychiatric Research 2013, 48: 111-120. PMID: 24139595, PMCID: PMC3863548, DOI: 10.1016/j.jpsychires.2013.09.015.Peer-Reviewed Original ResearchConceptsFractional anisotropyAxial diffusivityWhite matter microstructureMicrostructural abnormalitiesLong-range white matter connectionsWhite matter microstructural abnormalitiesWhite matter abnormalitiesDiffusion tensor imaging (DTI) findingsAnatomical connectivity abnormalitiesLower fractional anisotropySuperior corona radiataAbnormal white matter microstructureBrain white matter microstructureDifferent brain regionsWhite matter connectionsTemporal lobe regionsFronto-occipital fasciculusTwo-sample t-testFunctional neuroimaging studiesCD ageCD adolescentsMajor white matterImaging findingsRadial diffusivity measurementsStudy group
2012
White Matter Abnormalities in Pediatric Obsessive-Compulsive Disorder
Gruner P, Vo A, Ikuta T, Mahon K, Peters BD, Malhotra AK, Uluğ AM, Szeszko PR. White Matter Abnormalities in Pediatric Obsessive-Compulsive Disorder. Neuropsychopharmacology 2012, 37: 2730-2739. PMID: 22871914, PMCID: PMC3473339, DOI: 10.1038/npp.2012.138.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderDorsal cingulum bundleFractional anisotropyYale-Brown ObsessiveCingulum bundleGreater fractional anisotropyT GE systemDrug-naïve patientsCourse of illnessNeurobiology of OCDPatients' symptom severityWhite matter abnormalitiesPediatric OCD patientsRight corticospinal tractWhite matter deficitsPediatric obsessive-compulsive disorderInferior fronto-occipital fasciculusLower fractional anisotropyWhite matter tractsChildren's Yale-Brown ObsessiveFronto-occipital fasciculusResponse inhibition functionHigher fractional anisotropyPediatric patientsCorticospinal tract
2011
Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity
Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR. Diffusion Tensor Imaging in Autism Spectrum Disorders: Preliminary Evidence of Abnormal Neural Connectivity. Australian & New Zealand Journal Of Psychiatry 2011, 45: 153-162. PMID: 21128874, PMCID: PMC3123660, DOI: 10.3109/00048674.2010.534069.Peer-Reviewed Original ResearchConceptsInferior fronto-occipital fasciculusFronto-occipital fasciculusLongitudinal fasciculusInferior longitudinal fasciculusSuperior longitudinal fasciculus
2008
Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain
Sepulcre J, Masdeu J, Sastre-Garriga J, Goñi J, Vélez-de-Mendizábal N, Duque B, Pastor M, Bejarano B, Villoslada P. Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. NeuroImage 2008, 42: 1237-1243. PMID: 18585467, DOI: 10.1016/j.neuroimage.2008.05.038.Peer-Reviewed Original ResearchConceptsAnterior temporal stemDeclarative verbal memoryLiving Human BrainVerbal memoryTemporal stemDisrupted white matter pathwaysVerbal memory processesHuman brainFronto-occipital fasciculusWhite matter pathwaysMemory processesLeft hemisphereBrain pathwaysWhite matter regionsWhite matter lesionsAnterior limbThalamic regionsMemory storageMatter regionsMagnetic resonance imagingBrainInternal capsuleWhite matterMemoryMultiple sclerosis patients
1984
Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey
Goldman-Rakic P, Selemon L, Schwartz M. Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey. Neuroscience 1984, 12: 719-743. PMID: 6472617, DOI: 10.1016/0306-4522(84)90166-0.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexPrefrontal cortexParahippocampal gyrusTransitional cortexReciprocal projectionsHippocampal formationHorseradish peroxidase histochemistryFronto-occipital fasciculusPrestriate areasNeurons projectRhinal sulcusAfferent inputPrefrontal projectionsPosterior subdivisionsCaudal partCaudomedial lobuleCytoarchitectonic areasPosterior cingulatePresubiculumCingulum bundleCortical regionsParahippocampal cortexRhesus monkeysCortexHippocampus
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