2023
In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease
Zhang J, Wang J, Xu X, You Z, Huang Q, Huang Y, Guo Q, Guan Y, Zhao J, Liu J, Xu W, Deng Y, Xie F, Li B. In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer’s disease. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 977-988. PMID: 36718002, PMCID: PMC10196742, DOI: 10.1177/0271678x231153730.Peer-Reviewed Original ResearchConceptsMiddle frontal gyrusAlzheimer's diseaseSynaptic densityMild cognitive impairmentSynapse lossCognitive impairmentCaudal middle frontal gyrusFunctional connectivityLower synaptic densityMajor pathological changesRight insular cortexStructural connectivity alterationsRight middle frontal gyrusWhite matter tractsSynaptic alterationsBilateral cortexConnectivity alterationsInsular cortexAD groupPathological changesConnectivity dysfunctionCognitive declineCognitive functionFunctional MRIDisease
2017
SA64. Hallucination Severity Predicted by Auditory Cortex Resting State Connectivity in Bipolar and Schizophrenia Network on Intermediate Phenotypes Study
Okuneye V, Meda S, Keshavan M, Sweeney J, Tamminga C, Pearlson G, Gershon E, Keedy S. SA64. Hallucination Severity Predicted by Auditory Cortex Resting State Connectivity in Bipolar and Schizophrenia Network on Intermediate Phenotypes Study. Schizophrenia Bulletin 2017, 43: s136-s136. PMCID: PMC5475960, DOI: 10.1093/schbul/sbx023.063.Peer-Reviewed Original ResearchAuditory cortexHallucination severityState connectivityPsychosis patientsSignificant negative associationIntermediate Phenotypes (B-SNIP) studySchizophrenia NetworkResting-state connectivityAbnormal activation patternsBrodmann area 22Primary auditory cortexSecondary auditory cortexRight orbitofrontal cortexPrevious functional imaging studiesPhenotype studiesClinical rating scalesAuditory processing areasPossible common pathwayFunctional imaging studiesMiddle temporal cortexNegative associationPsychosis subjectsHealthy controlsHealthy subjectsConnectivity dysfunction
2009
Association between symptom severity and internal capsule volume in obsessive-compulsive disorder
de Souza Duran F, Hoexter M, Valente A, Miguel E, Busatto G. Association between symptom severity and internal capsule volume in obsessive-compulsive disorder. Neuroscience Letters 2009, 452: 68-71. PMID: 19150484, DOI: 10.1016/j.neulet.2009.01.007.Peer-Reviewed Original ResearchConceptsWhite matter volumeObsessive-compulsive disorderMagnetic resonance imagingMatter volumeCingulum bundleWhite matter volume deficitsPathophysiology of OCDOCD patientsAsymptomatic control subjectsWhite matter reductionThalamic-cortical circuitWhite matter alterationsVoxel-based morphometryWhite matter tractsRegional white matter volumeSymptom severity ratingsInternal capsuleNeurosurgical treatmentSeverity scoreControl subjectsAnterior limbConnectivity dysfunctionT MRI scannerOCD severity scoresVolume deficits
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