2024
Is there a need for fresh frozen plasma and platelet transfusion in trauma patients receiving submassive transfusion?
Jehan F, Zangbar B, Rafieezadeh A, Shnaydman I, Klein J, Con J, Prabhakaran K. Is there a need for fresh frozen plasma and platelet transfusion in trauma patients receiving submassive transfusion? Trauma Surgery & Acute Care Open 2024, 9: e001310. PMID: 38737815, PMCID: PMC11086383, DOI: 10.1136/tsaco-2023-001310.Peer-Reviewed Original ResearchUnits of PRBCsFresh frozen plasmaPlatelet transfusionsFrozen plasmaMultivariate regression modelTrauma patientsUnits packed red blood cellsLevel III retrospective studyQuality Improvement Program databaseAcute respiratory distress syndromeSafety of fresh frozen plasmaTrauma Quality Improvement Program databaseRate of complicationsRespiratory distress syndromeRate of sepsisAcute kidney injuryMultivariate regression analysisRegression modelsPropensity score matchingDistress syndromeBlood transfusionImproved survivalRetrospective studySurvival improvementAdult patients
2022
Fresh Frozen Plasma and Platelets Is Associated with Better Outcomes Even in Trauma Patients Requiring Submassive Transfusion
Jehan F, Sabegh B, Shnaydman I, Hanna K, Bronstein M, Khan M, Klein J, Con J, Policastro A, Prabhakaran K. Fresh Frozen Plasma and Platelets Is Associated with Better Outcomes Even in Trauma Patients Requiring Submassive Transfusion. Journal Of The American College Of Surgeons 2022, 235: s280-s281. DOI: 10.1097/01.xcs.0000895212.34817.8b.Peer-Reviewed Original Research
2021
Prothrombin complex concentrates in cardiac surgery: where are we?
Santana J, Brovman E. Prothrombin complex concentrates in cardiac surgery: where are we? Current Opinion In Anaesthesiology 2021, 35: 36-41. PMID: 34669612, DOI: 10.1097/aco.0000000000001074.Peer-Reviewed Original ResearchConceptsProthrombin complex concentrateFresh frozen plasmaCardiac surgeryRBC transfusionRed blood cellsRate of RBC transfusionProthrombin complex concentrate administrationReducing RBC transfusionsConcentrations of coagulation factorsOff-label useAssociated with reduced ratesFrozen plasmaSafety profileProthrombin complexSurgeryCoagulation factorsHemostatic agentsTransfusionComplex concentrateBlood cellsMeta-analysisCochrane reviewAdministration timeProthrombinShort acquisition
2020
The Application of ROTEM in a Parturient With Antiphospholipid Syndrome in the Setting of Anticoagulation for Cesarean Delivery: A Case Report.
Fiol AG, Fardelmann KL, McGuire PJ, Merriam AA, Miller A, Alian A. The Application of ROTEM in a Parturient With Antiphospholipid Syndrome in the Setting of Anticoagulation for Cesarean Delivery: A Case Report. A&A Practice 2020, 14: e01182. PMID: 32224689, DOI: 10.1213/xaa.0000000000001182.Peer-Reviewed Case Reports and Technical NotesConceptsAntiphospholipid syndromeHeparin neutralizationDiagnosis of hemolysisElevated liver enzymesSetting of anticoagulationFresh frozen plasmaPartial thromboplastin timeCesarean deliveryLow plateletsTransfusion managementCase reportFrozen plasmaLiver enzymesThromboplastin timeParturientsSyndromeIntrinsic pathwayAnticoagulationROTEMDiagnosisNeutralizationHeparin
2018
Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients
Flaherty D, Kim S, Zerillo J, Park C, Joseph T, Hill B, Lin H, Li J, Hamsher C, Weiner M, DeMaria S. Preoperative QTc Interval is Not Associated With Intraoperative Cardiac Events or Mortality in Liver Transplantation Patients. Journal Of Cardiothoracic And Vascular Anesthesia 2018, 33: 961-966. PMID: 30097315, DOI: 10.1053/j.jvca.2018.06.002.Peer-Reviewed Original ResearchConceptsIntraoperative cardiac eventsLiver transplant recipientsProlonged QTc intervalQTc intervalCardiac eventsTransplant recipientsPostoperative mortalityQTc lengthSeverity of liver diseaseLength of hospital stayQTc interval groupFresh frozen plasmaHospital length of stayLiver transplant patientsBlood component requirementsRetrospective cohort studyIn-Hospital MortalitySingle academic hospitalLength of stayElectronic medical recordsProlonged QTcPlatelet transfusionsPreoperative electrocardiogramFrozen plasmaTransplant patients
2017
Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*
Camazine MN, Karam O, Colvin R, Leteurtre S, Demaret P, Tucci M, Muszynski JA, Stanworth S, Spinella PC. Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*. Pediatric Critical Care Medicine 2017, 18: e215-e223. PMID: 28350560, DOI: 10.1097/pcc.0000000000001149.Peer-Reviewed Original ResearchConceptsSolvent detergent plasmaPlasma 24 hoursICU mortalityIll childrenPlasma transfusionStudy groupHours groupPretransfusion international normalized ratioSolvent/detergent-treated plasmaCritically Ill ChildrenInternational normalized ratioHypothesis-generating dataMultivariable logistic regressionIllness scoresImproved survivalMedian ageAdjusted analysisNormalized ratioPrimary indicationIndependent associationFrozen plasmaObservational studyPlasma useLactate valuesPatients
2016
Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery
Siddon AJ, Tormey CA. Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery. Lab Medicine 2016, 47: e35-e37. PMID: 27378481, PMCID: PMC4985779, DOI: 10.1093/labmed/lmw037.Peer-Reviewed Original ResearchConceptsCongenital factor X deficiencyFactor X deficiencyX deficiencyExcessive bleedingComplex concentrateFour-factor prothrombin complex concentrateFactor prothrombin complex concentrateFirst-line therapyAnterior cervical discectomySetting of traumaProthrombin complex concentrateFresh frozen plasmaRare coagulation disorderMajor neurosurgeryCervical discectomyThromboembolic complicationsSpontaneous hemorrhageCoagulation disordersFrozen plasmaInvasive proceduresOperative casesBleedingWhite menDeficiencyDisordersIs There an Association Between Indication for Intrauterine Balloon Tamponade and Balloon Failure?
Son M, Einerson BD, Schneider P, Fields IC, Grobman WA, Miller ES. Is There an Association Between Indication for Intrauterine Balloon Tamponade and Balloon Failure? American Journal Of Perinatology 2016, 34: 164-168. PMID: 27367285, DOI: 10.1055/s-0036-1585084.Peer-Reviewed Original ResearchConceptsIntrauterine balloon tamponadeFresh frozen plasmaUterine atonyPostpartum hemorrhageBalloon tamponadeRed blood cellsBalloon placementIntensive care unit admissionCare unit admissionUterine artery embolizationUnit admissionICU admissionSite bleedingArtery embolizationCohort studySecondary outcomesBlood lossPrimary outcomeRBC transfusionPotential confoundersFrozen plasmaMedian EBLBleedingTransfusionAtony
2014
The Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital
Gehrie EA, Tormey CA. The Development and Implementation of, and First Years' Experience With, a Massive/Emergency Transfusion Protocol (Damage Control Hematology Protocol) in a Veterans Affairs Hospital. Military Medicine 2014, 179: 1099-1105. PMID: 25269127, DOI: 10.7205/milmed-d-14-00045.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlood BanksBlood Grouping and CrossmatchingBlood Loss, SurgicalBlood TransfusionClinical AuditClinical ProtocolsConnecticutEmergenciesErythrocyte TransfusionFactor VIIaFactor VIIIFibrinogenHematemesisHospitals, VeteransHumansLaboratories, HospitalMalePlasma ExchangePlatelet TransfusionPostoperative HemorrhageRetrospective StudiesUnited StatesUnited States Department of Veterans AffairsConceptsFresh frozen plasmaRecombinant factor VIIaRed blood cellsVeterans Affairs hospitalTransfusion protocolFactor VIIaUnits of RBCsVeterans Affairs Connecticut Healthcare SystemUnits of FFPLarge trauma centersHospital-based blood banksETP patientsMassive transfusionTrauma centerFrozen plasmaSeparate patientsPatientsWest HavenBleeding emergenciesBlood bankBlood cellsYears' experienceHealthcare systemPlateletsHospital
2010
Management of Thrombolysis-Associated Symptomatic Intracerebral Hemorrhage
Goldstein J, Marrero M, Masrur S, Pervez M, Barrocas A, Abdullah A, Oleinik A, Rosand J, Smith E, Dzik W, Schwamm L. Management of Thrombolysis-Associated Symptomatic Intracerebral Hemorrhage. JAMA Neurology 2010, 67: 965-969. PMID: 20697046, PMCID: PMC3690951, DOI: 10.1001/archneurol.2010.175.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageIntra-arterial thrombolysisHospital mortalityIntracerebral hemorrhageHealth Stroke Scale scoreIntravenous tissue plasminogen activatorGuidelines-Stroke databaseStroke Scale scoreAcute ischemic strokeMultivariable logistic regressionFresh frozen plasmaTissue plasminogen activatorMulticenter registryAcute strokeDevastating complicationIschemic strokeIndependent predictorsThrombolytic therapyFrozen plasmaAppropriate treatmentRetrospective analysisPatientsScale scoreCoagulopathyThrombolysis
2008
Warfarin Reversal in Anticoagulant-Associated Intracerebral Hemorrhage
Goldstein J, Rosand J, Schwamm L. Warfarin Reversal in Anticoagulant-Associated Intracerebral Hemorrhage. Neurocritical Care 2008, 9: 277-283. PMID: 18214714, DOI: 10.1007/s12028-008-9049-z.Peer-Reviewed Original ResearchConceptsFresh frozen plasmaIntravenous vitamin KProthrombin complex concentrateIntracerebral hemorrhageVitamin KWarfarin reversalClinical trialsCoagulation factorsCoagulation factor productsHalf of patientsMajority of survivorsDependent coagulation factorsHospital presentationDefinitive therapyTreatment optionsComplex concentrateAdjunct agentFrozen plasmaPermanent disabilityProcoagulant effectTreatment strategiesExpert guidelinesFactor VIIReal-world settingFactor products
1989
Enhancement of neutrophil function for treatment of neonatal infections
KRAUSE P, HERSON V, EISENFELD L, JOHNSON G. Enhancement of neutrophil function for treatment of neonatal infections. The Pediatric Infectious Disease Journal 1989, 8: 382-389. PMID: 2664694, DOI: 10.1097/00006454-198906000-00011.Peer-Reviewed Original ResearchConceptsNewborn infantsRisk of morbidityFresh frozen plasmaMaximum therapeutic benefitHost defense mechanismsNeonatal infectionImportant therapyNeutrophil functionFrozen plasmaPMN functionTherapeutic benefitAdult PMNInfectionFurther studiesInfantsNew antibioticsDefense mechanismsTransfusionMorbidityNeonatesTherapyMortalityAdministrationImpairmentAntibodies
1984
Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma
Hashim S, Kay H, Hammond G, Kopf G, Geha A. Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma. The American Journal Of Surgery 1984, 147: 560-564. PMID: 6711758, DOI: 10.1016/0002-9610(84)90022-9.Peer-Reviewed Original ResearchConceptsNoncardiogenic pulmonary edemaFresh frozen plasmaCardiac outputCardiopulmonary bypassPulmonary edemaFrozen plasmaWedge pressureAnaphylactic reactionsLeft-sided filling pressuresPulmonary artery diastolic pressurePulmonary capillary wedge pressureAdult respiratory distress syndromePositive end-expiratory pressureCapillary wedge pressureLow cardiac outputIntraaortic balloon pumpRespiratory distress syndromeAdministration of catecholaminesEnd-expiratory pressureSatisfactory cardiac outputNormal saline solutionAtrial pressureBalloon pumpDistress syndromeDiastolic pressure
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