2023
Chronic diastolic stretch unmasks conduction defects in an in vitro model of arrhythmogenic cardiomyopathy
Ng R, Gokhan I, Stankey P, Akar F, Campbell S. Chronic diastolic stretch unmasks conduction defects in an in vitro model of arrhythmogenic cardiomyopathy. AJP Heart And Circulatory Physiology 2023, 325: h1373-h1385. PMID: 37830983, PMCID: PMC10977872, DOI: 10.1152/ajpheart.00709.2022.Peer-Reviewed Original ResearchArrhythmogenic cardiomyopathyDiastolic stretchConduction deficitsConduction velocityIntensity of exerciseAction potential parametersDifferent time pointsDisease progressionHigh afterloadContractile functionHemodynamic parametersProgressive disorderUnderlying pathomechanismsArrhythmia vulnerabilityConduction defectsPhysiological shorteningHeart tissueConnexin 43Time pointsERK signalingCardiomyopathyLysosome activityCardiac cycleDesmosomal proteinsExercise
2022
Angiographic Pulse Wave Coherence in the Human Brain
Koch MJ, Duy PQ, Grannan BL, Patel AB, Raymond SB, Agarwalla PK, Kahle KT, Butler WE. Angiographic Pulse Wave Coherence in the Human Brain. Frontiers In Bioengineering And Biotechnology 2022, 10: 873530. PMID: 35592552, PMCID: PMC9110661, DOI: 10.3389/fbioe.2022.873530.Peer-Reviewed Original ResearchCerebral angiogramDiagnostic cerebral angiogramIntact human brainHuman brainRigid craniumPathophysiologic disturbancesArterial anatomyVenous bloodStroke volumeArterial bloodCardiac ratePhysiologic mechanismsHuman patientsNeurological pathologiesEquivalent volumePulse waveBrainAngiogramsCardiac cycleBloodFluoroscopic imagesVolume displacementFirst direct evidencePatientsArtery
2019
Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis
Parajuli N, Lu A, Ta K, Stendahl J, Boutagy N, Alkhalil I, Eberle M, Jeng GS, Zontak M, O'Donnell M, Sinusas AJ, Duncan JS. Flow network tracking for spatiotemporal and periodic point matching: Applied to cardiac motion analysis. Medical Image Analysis 2019, 55: 116-135. PMID: 31055125, PMCID: PMC6939679, DOI: 10.1016/j.media.2019.04.007.Peer-Reviewed Original ResearchConceptsDeformation/strainExcellent tracking accuracyEntire cardiac cycleTracking accuracyCardiac motion analysisAccurate estimationSurface pointsEchocardiographic image sequencesLV motionDisplacementMotion analysisImage sequencesCardiac cyclePoint matchingMotionConsecutive framesEstimationNetwork trackingImportant characteristicsSignificant promiseSchemeGood correlationFlowRelation of Fontan Baffle Stroke Volume to Fontan Failure and Lower Exercise Capacity in Patients With an Atriopulmonary Fontan
Alsaied T, van der Ven JPG, Juggan S, Sleeper LA, Azcue N, Kroft LJ, Powell AJ, Helbing WA, Rathod RH. Relation of Fontan Baffle Stroke Volume to Fontan Failure and Lower Exercise Capacity in Patients With an Atriopulmonary Fontan. The American Journal Of Cardiology 2019, 124: 151-157. PMID: 31027653, DOI: 10.1016/j.amjcard.2019.03.040.Peer-Reviewed Original ResearchConceptsFontan failureAtriopulmonary FontanLower peak VOStroke volumePeak VOExercise capacityMultivariable analysisCardiac magnetic resonance studyHeart failure symptomsLateral tunnel Fontan operationWorse exercise capacityCardiopulmonary exercise testLateral tunnel procedureMedian followFontan operationMost patientsFontan circulationVentricular tachycardiaExercise testFailure symptomsStudy groupFontanPatientsOlder ageCardiac cycle
2016
Single cardiac cycle three-dimensional intracoronary optical coherence tomography.
Kim T, Park H, Jang S, Song J, Cho H, Kim S, Bouma B, Kim J, Oh W. Single cardiac cycle three-dimensional intracoronary optical coherence tomography. Biomedical Optics Express 2016, 7: 4847-4858. PMID: 28018710, PMCID: PMC5175536, DOI: 10.1364/boe.7.004847.Peer-Reviewed Original ResearchOptical coherence tomographyIntracoronary optical coherence tomographyCoherence tomographySingle cardiac cycleMotion artifactsCoronary arterial wallLong coronary segmentsImaging speedCardiac cycleCardiac motion artifactsCoronary arteryProspective electrocardiogramCoronary segmentsClinical utilityArterial wallOCT systemThree-dimensional visualizationElectrocardiogramVolumetric imagingTechnologyTomographySpeed
2013
Mitral Valve Dynamics in Severe Aortic Stenosis before and after Aortic Valve Replacement
Tsang W, Veronesi F, Sugeng L, Weinert L, Takeuchi M, Jeevanandam V, Lang R. Mitral Valve Dynamics in Severe Aortic Stenosis before and after Aortic Valve Replacement. Journal Of The American Society Of Echocardiography 2013, 26: 606-614. PMID: 23602168, DOI: 10.1016/j.echo.2013.03.004.Peer-Reviewed Original ResearchConceptsAortic valve replacementAortic-mitral fibrous continuitySystolic heart failureSevere aortic stenosisFibrous continuityLeft ventricular functionMitral valveAortic stenosisVentricular functionValve replacementHeart failureNormal left ventricular functionThree-dimensional transesophageal echocardiographyNormal valvesSurgical aortic valve replacementProsthetic aortic valveMitral valve functionMA areaProsthetic valve ringPre-AVRCardiac cycleTransesophageal echocardiographyAortic valveValve functionLeft ventricle
2011
Management of Pediatric Cardiac Trauma in the ED
Kamdar G, Santucci K, Emerson B. Management of Pediatric Cardiac Trauma in the ED. Clinical Pediatric Emergency Medicine 2011, 12: 323-332. DOI: 10.1016/j.cpem.2011.09.001.Peer-Reviewed Original ResearchCardiac traumaStructural cardiac damageBlunt chest traumaAggressive resuscitationAortic injuryCardiac tamponadeCardiac contusionChest traumaCardiac enzymesMultisystem injuriesCommotio cordisCardiac damageCardiac injuryClinical syndromeClassic signsHigh indexTraumaInjuryCardiac cycleDiagnosisChildrenContusionTamponadeEchocardiographyComplicationsMitral Annulus Dynamics Early after Valve Repair: Preliminary Observations of the Effect of Resectional Versus Non-Resectional Approaches
Zekry S, Lang R, Sugeng L, McCulloch M, Weinert L, Raman J, Little S, Xu J, Lawrie G, Zoghbi W. Mitral Annulus Dynamics Early after Valve Repair: Preliminary Observations of the Effect of Resectional Versus Non-Resectional Approaches. Journal Of The American Society Of Echocardiography 2011, 24: 1233-1242. PMID: 21956119, DOI: 10.1016/j.echo.2011.08.010.Peer-Reviewed Original ResearchConceptsMitral valve repairValve repairMitral annular areaLeaflet mobilityMitral annulusMitral leaflet mobilityLeaflet resectionMitral regurgitationThree-dimensional transesophageal echocardiographyOrganic mitral regurgitationAnnular areaAnterior-posterior diameterPosterior leaflet mobilityCardiac cycleMitral repairSevere MRAnnular plicationTransesophageal echocardiographyPosterior leafletSurgical approachChordal insertionsPatientsResectionMitralRepair
2010
Pulmonary vein and left atrial changes during the cardiac cycle, pre and post pulmonary vein isolation
Peters D, Goldman A, Goddu B, Kissinger K, Manning W, Hauser T, Taclas J. Pulmonary vein and left atrial changes during the cardiac cycle, pre and post pulmonary vein isolation. Journal Of Cardiovascular Magnetic Resonance 2010, 12: p142. DOI: 10.1186/1532-429x-12-s1-p142.Peer-Reviewed Original Research
2008
Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging
Chen J, Garcia EV, Lerakis S, Henneman MM, Bax JJ, Trimble MA, Borges‐Neto S, Velazquez EJ, Iskandrian AE. Left Ventricular Mechanical Dyssynchrony as Assessed by Phase Analysis of ECG‐Gated SPECT Myocardial Perfusion Imaging. Echocardiography 2008, 25: 1186-1194. PMID: 18986406, DOI: 10.1111/j.1540-8175.2008.00782.x.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyMyocardial perfusion imagingTissue Doppler imagingLV dyssynchronyPerfusion imagingTomography myocardial perfusion imagingSPECT myocardial perfusion imagingElectrocardiography-gated single-photon emissionSevere heart failureVentricular mechanical dyssynchronySingle photon emissionHeart failureMechanical dyssynchronyResynchronization therapyClinical evaluationDyssynchronyLeft ventricleDoppler imagingPatientsRegional wallMechanical contractionPhoton emissionCardiac cycleImportant predictorFourier harmonic functionsSemi-Automatic Detection and Tracking of Mitral and Aortic Annuli from Real-Time 3D Transesophageal Echocardiographic Images
Veronesi F, Corsi C, Mor-Avi V, Sugeng L, Caiani E, Weinert L, Lamberti C, Lang R. Semi-Automatic Detection and Tracking of Mitral and Aortic Annuli from Real-Time 3D Transesophageal Echocardiographic Images. 2008, 33-36. DOI: 10.1109/cic.2008.4748970.Peer-Reviewed Original ResearchLucas–Kanade optical flow techniqueOptical flow techniqueFrame-by-frame detectionTransesophageal echocardiographic imagesValve axisTracking algorithmCardiac cycleFeature tracking algorithmValve geometryAortic annulusAortic valveFrame-by-frameNon-invasive quantitative measurementManual initializationNormal valvesSemi-automatic detectionStudy of functional anatomyEchocardiographic imagesTrackingFlow technique
2007
Coronary magnetic resonance vein imaging: Imaging contrast, sequence, and timing
Nezafat R, Han Y, Peters DC, Herzka DA, Wylie JV, Goddu B, Kissinger KK, Yeon SB, Zimetbaum PJ, Manning WJ. Coronary magnetic resonance vein imaging: Imaging contrast, sequence, and timing. Magnetic Resonance In Medicine 2007, 58: 1196-1206. PMID: 17969081, DOI: 10.1002/mrm.21395.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyCoronary vein anatomyCongestive heart failureCoronary veinVein anatomyCardiovascular MRCoronary sinus leadCoronary venous anatomyTransvenous lead placementInterventional cardiovascular proceduresResynchronization therapyDevice therapyHeart failureVenous anatomyLead placementEpicardial leadsCardiovascular proceduresLeft ventricleCHF subjectsCMR techniquesVivo studiesLateral wallVeinTherapyCardiac cycleQuantification of Mitral Apparatus Dynamics in Functional and Ischemic Mitral Regurgitation Using Real-time 3-Dimensional Echocardiography
Veronesi F, Corsi C, Sugeng L, Caiani E, Weinert L, Mor-Avi V, Cerutti S, Lamberti C, Lang R. Quantification of Mitral Apparatus Dynamics in Functional and Ischemic Mitral Regurgitation Using Real-time 3-Dimensional Echocardiography. Journal Of The American Society Of Echocardiography 2007, 21: 347-354. PMID: 17681731, DOI: 10.1016/j.echo.2007.06.017.Peer-Reviewed Original ResearchConceptsReal-time 3-dimensional echocardiographyMitral regurgitationDCM-MRMitral annulusIschemic mitral regurgitationPapillary muscle displacementWall-motion abnormalitiesSignificant intergroup differencesPapillary muscle positionIschemic cardiomyopathyDilated CardiomyopathyVentricle remodelingMitral apparatusIntergroup differencesEchocardiographyHealthy individualsPatientsMuscle displacementMuscle symmetryMA areaRegurgitationCardiomyopathyMA motionVolumetric measurementsCardiac cycle
2004
Feasibility of real-time 3D echocardiography in weightlessness during parabolic flight.
Caiani E, Sugeng L, Weinert L, Husson S, Bailliart O, Capderou A, Lang R, Vaida P. Feasibility of real-time 3D echocardiography in weightlessness during parabolic flight. Journal Of Gravitational Physiology 2004, 11: p235-6. PMID: 16240526.Peer-Reviewed Original Research
2001
Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images
Sinusas A, Papademetris X, Constable R, Dione D, Slade M, Shi P, Duncan J. Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images. AJP Heart And Circulatory Physiology 2001, 281: h698-h714. PMID: 11454574, DOI: 10.1152/ajpheart.2001.281.2.h698.Peer-Reviewed Original Research
2000
Power Doppler Imaging as a Basis for Automated Endocardial Border Detection During Left Ventricular Contrast Enhancement
Mor‐Avi V, Bednarz J, Weinert L, Sugeng L, Lang R. Power Doppler Imaging as a Basis for Automated Endocardial Border Detection During Left Ventricular Contrast Enhancement. Echocardiography 2000, 17: 529-537. PMID: 11000587, DOI: 10.1046/j.1540-8175.2000.00529.x.Peer-Reviewed Original ResearchConceptsFractional area changePower Doppler imagingHarmonic power Doppler imagingDoppler imagingContrast enhancementLeft ventricular (LV) systolic functionApical four-chamber viewEvaluation of left ventricular (LV) systolic functionPoor endocardial definitionPeak dobutamine infusionSemi-automated border detectionEvaluation of LV functionFour-chamber viewDobutamine stress echocardiographyDobutamine stress testingAutomated endocardial border detectionHarmonic power Doppler modeBorder detectionEndocardial boundaryEndocardial border detectionLV cavity areaContrast-enhanced imagesGray scale imagesPower Doppler modeCardiac cycle
1999
Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging
Shen M, Liu Y, Sinusas A, Fetterman R, Bruni W, Drozhinin O, Zaret B, Wackers F. Quantification of regional myocardial wall thickening on electrocardiogram-gated SPECT imaging. Journal Of Nuclear Cardiology 1999, 6: 583-595. PMID: 10608585, DOI: 10.1016/s1071-3581(99)90095-8.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputer SimulationDiastoleElectrocardiographyHeart VentriclesHumansImage Processing, Computer-AssistedModels, CardiovascularMyocardial InfarctionObserver VariationPhantoms, ImagingPilot ProjectsRadiopharmaceuticalsReproducibility of ResultsSoftwareSystoleTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonVentricular Function, LeftVentricular RemodelingVentriculography, First-PassConceptsPrior myocardial infarctionRegional wall thickeningNormal subjectsMyocardial infarctionWall thickeningNormal wall thickeningPilot studyRegional left ventricular functionLeft ventricular functionAbnormal wall thickeningPercent count increaseECG-gated SPECT imagesSingle photon emissionSPECT imagesCardiac cycleLeft ventricular wallReproducibility of interpretationRegional left ventricular wallPrior infarctionCoronary diseaseVentricular functionValidation studyInfarct areaNormal rangeAnatomic areas
1997
The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus
d'Ancona R, Rahman F, Ozcan T, Copel J, Mari G. The effect of intravascular blood transfusion on the flow velocity waveform of the portal venous system of the anemic fetus. Ultrasound In Obstetrics And Gynecology 1997, 10: 333-337. PMID: 9444047, DOI: 10.1046/j.1469-0705.1997.10050333.x.Peer-Reviewed Original ResearchConceptsFlow velocity waveformsPortal venous systemAnemic fetusesVelocity waveformsPortal hypertensionIntravascular transfusionPortal veinVenous systemNormal fetusesIntravascular blood transfusionNon-pulsatile flowBlood transfusionRhesus alloimmunizationGestational agePulsatile patternTransfusionFetusesPresence of pulsatilityHypertensionIncreased numberCardiac cyclePulsatileVeinAlloimmunizationUtero
1996
Dense nonrigid motion tracking from a sequence of velocity fields
Meyer F, Constable R, Sinusas A, Duncan J. Dense nonrigid motion tracking from a sequence of velocity fields. 2015 IEEE Conference On Computer Vision And Pattern Recognition (CVPR) 1996, 839-844. DOI: 10.1109/cvpr.1996.517169.Peer-Reviewed Original Research
1994
Latency of Skeletal Muscle Contraction after Pulse Train Stimulation: An Important Factor in Correct Timing of Skeletal Muscle Cardiac Assist Devices
Letsou G, Zarif A, Smith A, Hogan J, Lee P, Ariyan S, Baldwin J, Elefteriades J. Latency of Skeletal Muscle Contraction after Pulse Train Stimulation: An Important Factor in Correct Timing of Skeletal Muscle Cardiac Assist Devices. Journal Of Surgical Research 1994, 57: 672-676. PMID: 7996844, DOI: 10.1006/jsre.1994.1199.Peer-Reviewed Original ResearchConceptsPeak tensionSkeletal muscle contractionSkeletal muscleAssist deviceEnd-stage cardiac failureMuscle contractionCanine latissimus dorsi musclePulse train stimulationLatissimus dorsi muscleCanine heart rateContraction/relaxation cycleCardiac assist devicesCardiac augmentationConditioning regimensCardiac failureTrain stimulationHeart rateCardiac assistanceContraction timingOptimal timingMuscleDorsi muscleCardiac cycleContractionCorrect timing
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