2025
Lats1/2 Are Essential for Developmental Vascular Remodeling and Biomechanical Adaptation to Shear Stress.
Cowdin M, Pramanik T, Mohr-Allen S, Fu Y, Mills A, Spurgin S, Varner V, Davis G, Cleaver O. Lats1/2 Are Essential for Developmental Vascular Remodeling and Biomechanical Adaptation to Shear Stress. Arteriosclerosis Thrombosis And Vascular Biology 2025 PMID: 40501385, DOI: 10.1161/atvbaha.124.322258.Peer-Reviewed Original ResearchShear stressLaminar shear stressCultured endothelial cellsEndothelial cellsResponse to shear stressCell shapeBlood flowShearHemodynamic forcesHippo pathway kinasesHuman pulmonary artery endothelial cellsPrimary human pulmonary artery endothelial cellsPulmonary artery endothelial cellsResponse to blood flowBiomechanical cuesMechanical cuesIn vitroArtery endothelial cellsCytoskeletal rearrangementsPhenotype in vivoMurine endothelial cellsFlowEmbryonic lethalityMRNA expression analysisPathway kinasesInvolvement of long non-coding RNA (lncRNA) MALAT1 in shear stress regulated adipocyte differentiation
Caron J, Ghanbariabdolmaleki M, Marino M, Qiu C, Wang B, Mak M, Wang S. Involvement of long non-coding RNA (lncRNA) MALAT1 in shear stress regulated adipocyte differentiation. Frontiers In Bioengineering And Biotechnology 2025, 13: 1570518. PMID: 40395673, PMCID: PMC12089105, DOI: 10.3389/fbioe.2025.1570518.Peer-Reviewed Original ResearchShear stressMesenchymal stem cellsPhysiologically relevant shear stressRelevant shear stressAdipocyte differentiationDifferentiation of mesenchymal stem cellsInvolvement of long non-coding RNAsShearBiophysical cuesFluid shearLong non-coding RNAsMechanical microenvironmentDownregulation of MALAT1Mechanosensitive roleTargets of lncRNAsRegulates adipocyte differentiationLong noncoding RNAsNon-coding RNAsSilencing MALAT1Mechanical cuesLncRNA MALAT1
2024
Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing
X S, Aitken C, Mehta V, Tardajos-Ayllon B, Serbanovic-Canic J, Zhu J, Miao B, Tzima E, Evans P, Fang Y, Schwartz M. Controversy in mechanotransduction – the role of endothelial cell–cell junctions in fluid shear stress sensing. Journal Of Cell Science 2024, 137: jcs262348. PMID: 39143856, PMCID: PMC11423816, DOI: 10.1242/jcs.262348.Peer-Reviewed Original ResearchShear stress sensingFluid shear stressFluid flowCell-cell contactShear stressCell-cell adhesionStress sensingCell-cell junctionsEndothelial cell-cell junctionsEC alignmentRegulates vascular developmentAdhesion receptorsCell typesEndothelial cellsFlowSingle cellsVascular developmentShearAdhesionContact
2022
Rheology of marine sponges reveals anisotropic mechanics and tuned dynamics
Kraus E, Mellenthin L, Siwiecki S, Song D, Yan J, Janmey P, Sweeney A. Rheology of marine sponges reveals anisotropic mechanics and tuned dynamics. Journal Of The Royal Society Interface 2022, 19: 20220476. PMID: 36259170, PMCID: PMC9579767, DOI: 10.1098/rsif.2022.0476.Peer-Reviewed Original ResearchConceptsErect spongesSponge cellsSiliceous spiculesMarine spongesErect formsNegative normal stressFilter small particlesSponge morphologyMechanical signalsExtracellular matrixNormal stressCompression stiffeningCell proliferationShear softeningUniaxial deformationShear strainMechanical responsePhysiological implicationsAnisotropic elasticityRheological propertiesPhysiological shearSpongeSpeciesAnisotropic mechanismsShear
2020
Developing staggered woven mesh aerator with three variable-micropore layers in recycling water pipeline to enhance CO2 conversion for improving Arthrospira growth
Cheng J, Liu S, Guo W, Song Y, Kumar S, Kubar AA, Su Y, Li Y. Developing staggered woven mesh aerator with three variable-micropore layers in recycling water pipeline to enhance CO2 conversion for improving Arthrospira growth. The Science Of The Total Environment 2020, 760: 143941. PMID: 33341634, DOI: 10.1016/j.scitotenv.2020.143941.Peer-Reviewed Original ResearchConceptsWater pipelinesArthrospira growthHigh-speed cameraLarge-scale raceway pondsCarbonization efficiencyInput COConversion efficiencySmall bubblesAeratorCO2 conversionUniform microporesRaceway pondsBubble picturesImage processing softwareUtilization efficiencyOptimized structureProcessing softwareEfficiencyLayerCOPipelineBiomass measurementsMicroporesShearBubbles
2017
Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flow
Ghim M, Alpresa P, Yang S, Braakman S, Gray S, Sherwin S, van Reeuwijk M, Weinberg P. Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flow. AJP Heart And Circulatory Physiology 2017, 313: h959-h973. PMID: 28754719, PMCID: PMC5792200, DOI: 10.1152/ajpheart.00218.2017.Peer-Reviewed Original ResearchConceptsShear stressDifferent flow profilesType of flowTransverse stressesNumerical simulationsFlow profileFluid mechanical forcesShear profileShear vectorSolute transportTwo-pore theoryStatic conditionsFlowMacromolecule transportMechanical forcesTransportStressMicrovessel wallShearOrbital shakerStress metricsLong axisTracer distributionSimulations
2013
Particle-scale reversibility in athermal particulate media below jamming
Schreck CF, Hoy RS, Shattuck MD, O'Hern CS. Particle-scale reversibility in athermal particulate media below jamming. Physical Review E 2013, 88: 052205. PMID: 24329257, DOI: 10.1103/physreve.88.052205.Peer-Reviewed Original Research
2007
Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium
Duan Y, Du Z, Yan Q, Weinstein A, Weinbaum S, Wang T. Role of fluid shear stress in cytoskeleton reorganization of mouse proximal tubule epithelium. The FASEB Journal 2007, 21: a915-a915. DOI: 10.1096/fasebj.21.6.a915-a.Peer-Reviewed Original ResearchCytoskeleton reorganizationShear stressPeripheral actin networkCell-cell contactModulate cellular functionsTransmit mechanical forcesActin cytoskeletonActin networkCytoskeleton remodelingStress fibersF-actinCellular functionsVinculin expressionCytoskeletonZO-1Collagen substrateE-cadherinParallel plate flow chamberJunction-like structuresFluid shear stressShearFluid shearStrikingly different responsesCellsPT cells
2005
Velocity Profiles in Repulsive Athermal Systems under Shear
Xu N, O'Hern CS, Kondic L. Velocity Profiles in Repulsive Athermal Systems under Shear. Physical Review Letters 2005, 94: 016001. PMID: 15698098, DOI: 10.1103/physrevlett.94.016001.Peer-Reviewed Original ResearchVelocity profilesMean velocity profileNonlinear velocity profilesPlanar shear flowEnhanced velocity fluctuationsVelocity fluctuationsAthermal systemsShear wavesShear flowShearing wallsVelocity uUnderdamped systemUnderdamped dynamicsRandom close packingOverdamped dynamicsPacking fractionSmall dampingSpatial dimensionsCritical valueDynamics simulationsMolecular dynamics simulationsFraction phiDampingShearClose packing
2001
Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images
Sinusas A, Papademetris X, Constable R, Dione D, Slade M, Shi P, Duncan J. Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images. AJP Heart And Circulatory Physiology 2001, 281: h698-h714. PMID: 11454574, DOI: 10.1152/ajpheart.2001.281.2.h698.Peer-Reviewed Original Research
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