2022
How I Learned is How I Teach – Perspectives on How Faculty Surgeons Approach Informed Consent Education
White EM, Esposito AC, Kurbatov V, Wang X, Caty MG, Laurans M, Yoo PS. How I Learned is How I Teach – Perspectives on How Faculty Surgeons Approach Informed Consent Education. Journal Of Surgical Education 2022, 79: e181-e193. PMID: 36253332, DOI: 10.1016/j.jsurg.2022.09.001.Peer-Reviewed Original ResearchConceptsInformed consentDepartment of SurgeryHealth care systemKruskal-Wallis testingTeaching hospitalCritical careGeneral surgeonsClinical practiceSurgeon demographicsCare systemSurgeonsChi-squarePrivate practiceResident competencySignificant heterogeneityPatientsFaculty surgeonsAttendingsConsentClinical facultyDemographicsSpecialtiesExperiences residentsResidentsHigh levelsBDNF blood levels after electroconvulsive therapy in patients with mood disorders: An updated systematic review and meta-analysis
Pelosof R, dos Santos L, Farhat L, Gattaz W, Talib L, Brunoni A. BDNF blood levels after electroconvulsive therapy in patients with mood disorders: An updated systematic review and meta-analysis. The World Journal Of Biological Psychiatry 2022, 24: 24-33. PMID: 35332840, DOI: 10.1080/15622975.2022.2058083.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorBrain-derived neurotrophic factor blood levelsBrain-derived neurotrophic factor levelsElectroconvulsive therapyMeta-analysisSystematic reviewBrain-derived neurotrophic factor changesRandom-effects meta-analysesTreatment of depressionDepression severity scoresElectroconvulsive therapy treatmentsSample sizeBlood levelsEvidence of significant heterogeneityDepressive symptomatologyMood disordersDepressive symptomsMeta-analysesMeta-RegressionGlobal healthNeurotrophic factorSignificant heterogeneitySubgroup analysisClinical trialsSeverity scoreEvaluation of the Content of Ophthalmology Fellowship Program Web sites
Alsaloum P, Alsaloum M, Kim T, Zheng D, Valentim C, Muste J, Goshe J, Singh R. Evaluation of the Content of Ophthalmology Fellowship Program Web sites. Journal Of Academic Ophthalmology 2022, 14: e127-e132. PMID: 37388469, PMCID: PMC9928003, DOI: 10.1055/s-0042-1747673.Peer-Reviewed Original ResearchMAIN OUTCOMEOphthalmology subspecialtiesCross-sectional studyFellowship programsHospital affiliationWellness programsSignificant heterogeneitySubspecialtySurgical statisticsSignificant differencesCurrent fellowsOutcomesProgram demographicsDemographic criteriaProgram Web sitesCase diversityCriteriaAverage numberProgram description
2021
Discovering dominant tumor immune archetypes in a pan-cancer census
Combes A, Samad B, Tsui J, Chew N, Yan P, Reeder G, Kushnoor D, Shen A, Davidson B, Barczak A, Adkisson M, Edwards A, Naser M, Barry K, Courau T, Hammoudi T, Argüello R, Rao A, Olshen A, Consortium T, Spitzer M, Fong L, Nelson A, Kumar R, Lee J, Burra A, Hsu J, Hackett C, Tolentino K, Sjarif J, Johnson P, Shao E, Abrau D, Lupin L, Shaw C, Collins Z, Lea T, Corvera C, Nakakura E, Carnevale J, Alvarado M, Loo K, Chen L, Chow M, Grandis J, Ryan W, El-Sayed I, Jablons D, Woodard G, Meng M, Porten S, Okada H, Tempero M, Ko A, Kirkwood K, Vandenberg S, Guevarra D, Oropeza E, Cyr C, Glenn P, Bolen J, Morton A, Eckalbar W, Cai C, Zhan J, Davis K, Kelley R, Chapman J, Atreya C, Patel A, Daud A, Ha P, Diaz A, Kratz J, Collisson E, Fragiadakis G, Erle D, Boissonnas A, Asthana S, Chan V, Krummel M. Discovering dominant tumor immune archetypes in a pan-cancer census. Cell 2021, 185: 184-203.e19. PMID: 34963056, PMCID: PMC8862608, DOI: 10.1016/j.cell.2021.12.004.Peer-Reviewed Original ResearchConceptsTumor immune microenvironmentIndividual tumorsTumor gene expression patternsCancer immunityImmune microenvironmentImmune compositionImmune systemTumor biologyUnique immuneTissue of originFlow cytometryCancer typesDriver mutationsImmune organizationDominant patternStandardized protocolTumorsSignificant heterogeneityCancerUniversity of CaliforniaTissueGene expression patternsCommon patternTherapyImmuneHuman B cell lineages associated with germinal centers following influenza vaccination are measurably evolving
Hoehn KB, Turner JS, Miller FI, Jiang R, Pybus OG, Ellebedy A, Kleinstein SH. Human B cell lineages associated with germinal centers following influenza vaccination are measurably evolving. ELife 2021, 10: e70873. PMID: 34787567, PMCID: PMC8741214, DOI: 10.7554/elife.70873.Peer-Reviewed Original ResearchConceptsSeasonal influenza vaccinationInfluenza vaccinationB-cell lineageGerminal centersB cell evolutionPoor efficacyB cellsSeasonal influenza virus vaccinationSeasonal influenza virus vaccinesVaccine-induced B cell responsesInfluenza virus vaccinationInfluenza virus vaccinePre-existing immunityB cell responsesMemory B cellsCell lineagesGC B cellsSeasonal vaccinationHIV infectionVirus vaccinationVirus vaccineVaccinationVaccine antigensCell responsesSignificant heterogeneityDevelopment and Implementation of Multidisciplinary Liver Tumor Boards in the Veterans Affairs Health Care System: A 10-Year Experience
Rabiee A, Taddei T, Aytaman A, Rogal SS, Kaplan DE, Morgan TR. Development and Implementation of Multidisciplinary Liver Tumor Boards in the Veterans Affairs Health Care System: A 10-Year Experience. Cancers 2021, 13: 4849. PMID: 34638333, PMCID: PMC8508370, DOI: 10.3390/cancers13194849.Peer-Reviewed Original ResearchVeterans Affairs Health Care SystemMultidisciplinary liver tumor boardHealth care systemTumor boardCare systemIntegrated health care systemSingle care providerMultidisciplinary tumor boardUnnecessary invasive proceduresVirtual tumor boardsHealth care costsActive therapyVA centersPatient outcomesHepatology careHigher oddsCare providersInvasive proceduresCare costsSignificant heterogeneityCareHealthcare deliveryMortalitySignificant barriersVAReach and Adoption of a Geriatric Emergency Department Accreditation Program in the United States
Kennedy M, Lesser A, Israni J, Liu SW, Santangelo I, Tidwell N, Southerland LT, Carpenter CR, Biese K, Ahmad S, Hwang U. Reach and Adoption of a Geriatric Emergency Department Accreditation Program in the United States. Annals Of Emergency Medicine 2021, 79: 367-373. PMID: 34389196, PMCID: PMC10015385, DOI: 10.1016/j.annemergmed.2021.06.013.Peer-Reviewed Original ResearchConceptsGeriatric Emergency DepartmentEmergency departmentCare processesUrinary catheter useUS emergency departmentsHealth care utilizationPatient-oriented outcomesAccreditation programCatheter useCare utilizationEmergency physiciansAmerican CollegeRural designationStudy periodInterquartile rangeSignificant heterogeneityPotential needContinuous dataLow levelsLevel 1Level 2CohortPhysiciansPrevention
2018
Continued Interest and Controversy: Vitamin D in HIV
Hsieh E, Yin MT. Continued Interest and Controversy: Vitamin D in HIV. Current HIV/AIDS Reports 2018, 15: 199-211. PMID: 29713871, PMCID: PMC6003869, DOI: 10.1007/s11904-018-0401-4.BooksConceptsVitD deficiencyVitD supplementationExtra-skeletal outcomesSetting of HIVSubgroup of HIVBone mineral densityRecent FindingsRecent studiesART regimensD deficiencyClinical outcomesPoor outcomeSummaryFurther researchVitamin DChronic diseasesClinical trialsDifferent demographic strataMineral densityClinical roleHIVGreater riskDemographic strataSignificant heterogeneityOutcomesRiskSupplementationThe Impact of the Entry of Biosimilars: Evidence from Europe
Scott Morton F, Stern A, Stern S. The Impact of the Entry of Biosimilars: Evidence from Europe. Review Of Industrial Organization 2018, 53: 173-210. DOI: 10.1007/s11151-018-9630-3.Peer-Reviewed Original ResearchOngoing policy discussionsU.S. drug marketEntry of biosimilarsBiosimilar entryMarket featuresBiosimilar penetrationBiosimilar competitionEuropean marketPolicy discussionsPublic policyOwn surveyPricesMarketDrug marketShareCompetitionPolicySignificant heterogeneityEntryCountriesInstitutionsEuropeGenericsImpactHeterogeneity
2017
Genetic Effects on the Correlation Structure of CVD Risk Factors Exome-Wide Data From a Ghanaian Population
Kodaman N, Sobota RS, Asselbergs FW, Oetjens MT, Moore JH, Brown NJ, Aldrich MC, Williams SM. Genetic Effects on the Correlation Structure of CVD Risk Factors Exome-Wide Data From a Ghanaian Population. Global Heart 2017, 12: 133-140. PMID: 28408189, PMCID: PMC5642993, DOI: 10.1016/j.gheart.2017.01.013.Peer-Reviewed Original ResearchConceptsPlasminogen activator inhibitor-1CVD risk factorsRisk factorsCardiovascular disease risk factorsDisease risk factorsHigh blood pressureActivator inhibitor-1Dissolution of thrombusArterial pressureBlood pressureMyocardial infarctionPlasma concentrationsStudy participantsGhanaian populationInhibitor-1Significant heterogeneityHeterogeneity of correlationAfrican AmericansGenetic variantsGenetic association studiesDirect role
2016
Characterizing treatment pathways at scale using the OHDSI network
Hripcsak G, Ryan P, Duke J, Shah N, Park R, Huser V, Suchard M, Schuemie M, DeFalco F, Perotte A, Banda J, Reich C, Schilling L, Matheny M, Meeker D, Pratt N, Madigan D. Characterizing treatment pathways at scale using the OHDSI network. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 7329-7336. PMID: 27274072, PMCID: PMC4941483, DOI: 10.1073/pnas.1510502113.Peer-Reviewed Original ResearchConceptsAdministrative claims dataTreatment pathwaysClaims dataType 2 diabetes mellitusFirst-line medicationElectronic health record dataClinical trial resultsObservational researchHealth record dataElectronic health recordsDiabetes mellitusHypertension patientsDepression patientsConsistent therapyObservational studyOHDSI networkObservational Health Data SciencesPatientsTrial resultsClinical hypothesisHealth recordsRecord dataSignificant heterogeneityHealth Data SciencesHypertensionCoordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation
Moura L, Crossley N, Zugman A, Pan P, Gadelha A, Del Aquilla M, Picon F, Anés M, Amaro E, de Jesus Mari J, Miguel E, Rohde L, Bressan R, McGuire P, Sato J, Jackowski A. Coordinated brain development: exploring the synchrony between changes in grey and white matter during childhood maturation. Brain Imaging And Behavior 2016, 11: 808-817. PMID: 27169540, DOI: 10.1007/s11682-016-9555-0.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCortical thicknessDiffusion tensor imagingFractional anisotropyWhite matterBrain regionsStructural magnetic resonance imagingGray matter changesWhite matter tractsGray matter regionsCortical thinningMatter changesResonance imagingBrain developmentMatter regionsTensor imagingRespective tractsSignificant heterogeneityTractPrefrontal regionsAge 7Previous studiesBrain architectureAsynchronous maturation
2015
Pacemaker Dependency after Cardiac Surgery: A Systematic Review of Current Evidence
Steyers CM, Khera R, Bhave P. Pacemaker Dependency after Cardiac Surgery: A Systematic Review of Current Evidence. PLOS ONE 2015, 10: e0140340. PMID: 26470027, PMCID: PMC4607414, DOI: 10.1371/journal.pone.0140340.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPermanent pacemaker implantationPacemaker dependencyCardiac surgeryPacemaker implantationRisk factorsSystematic reviewAV conduction diseasePerioperative risk factorsPostoperative conduction disturbancesProcedure-specific variablesWeb of ScienceConduction disturbancesEmbase databasesConduction diseaseAV conductionExclusion criteriaCurrent evidencePredetermined inclusionSurgeryPatientsComprehensive searchSignificant heterogeneityIndividual studiesUniform definitionImplantation
2014
Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals
Khandelwal N, Dale CR, Benkeser DC, Joffe AM, Yanez ND, Treggiari MM. Variation in Tracheal Reintubations Among Patients Undergoing Cardiac Surgery Across Washington State Hospitals. Journal Of Cardiothoracic And Vascular Anesthesia 2014, 29: 551-559. PMID: 25802193, PMCID: PMC4427545, DOI: 10.1053/j.jvca.2014.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAirway ExtubationAirway ManagementCardiac Surgical ProceduresCohort StudiesCoronary Artery BypassCritical CareDatabases, FactualFemaleHealth SurveysHumansIntubation, IntratrachealMaleMiddle AgedRetrospective StudiesRisk FactorsSocioeconomic FactorsTreatment FailureTreatment OutcomeWashingtonConceptsIntensive care unitCardiac surgeryWashington State hospitalsNonfederal hospitalsState HospitalAcute care daysGreater hospital volumeOdds of reintubationCoronary artery bypassRetrospective cohort studyPatient-level characteristicsMultivariate logistic regressionSignificant heterogeneityValvular surgeryArtery bypassCohort studyHospital factorsHospital volumePatient characteristicsTracheal reintubationCare unitProcedure characteristicsHospital characteristicsCare daysReintubation
2013
Toward standard HER2 testing of endometrial serous carcinoma: 4-year experience at a large academic center and recommendations for clinical practice
Buza N, English DP, Santin AD, Hui P. Toward standard HER2 testing of endometrial serous carcinoma: 4-year experience at a large academic center and recommendations for clinical practice. Modern Pathology 2013, 26: 1605-1612. PMID: 23765245, DOI: 10.1038/modpathol.2013.113.Peer-Reviewed Original ResearchConceptsEndometrial serous carcinomaSerous carcinomaHER2 overexpressionEndometrial carcinomaMedical recordsImmunohistochemical scoreHER2 testingProtein expressionHER2 immunohistochemistrySignificant heterogeneityScoring systemMultiple tumor sectionsPure serous carcinomaHER2-positive casesHER2-positive tumorsScoring criteriaEndometrial carcinoma casesFDA criteriaPatients' medical recordsLarge academic centerHER2 FISH resultsHER2 protein overexpressionPromising therapeutic targetOverall concordance rateHER2 immunohistochemical scoresMeta-analysis of LCPUFA Supplementation of Infant Formula and Visual Acuity
Qawasmi A, Landeros-Weisenberger A, Bloch MH. Meta-analysis of LCPUFA Supplementation of Infant Formula and Visual Acuity. 2013, 131: e262-e272. PMID: 23248232, PMCID: PMC3529943, DOI: 10.1542/peds.2012-0517.Peer-Reviewed Original ResearchConceptsInfant visual acuityMonths of ageLCPUFA supplementationVisual acuityInfant formulaTrial methodologic qualitySecondary subgroup analysisVisual acuity developmentVisual resolution acuityPrimary outcomeSubgroup analysisMethodologic qualityUnsupplemented infantsAcuity developmentNineteen studiesCurrent evidenceAcuityResolution acuityBirth statusSecondary analysisPublication biasMean differenceInfantsSupplementationSignificant heterogeneity
2012
4-Liter Split-Dose Polyethylene Glycol Is Superior to Other Bowel Preparations, Based on Systematic Review and Meta-analysis
Enestvedt BK, Tofani C, Laine LA, Tierney A, Fennerty MB. 4-Liter Split-Dose Polyethylene Glycol Is Superior to Other Bowel Preparations, Based on Systematic Review and Meta-analysis. Clinical Gastroenterology And Hepatology 2012, 10: 1225-1231. PMID: 22940741, DOI: 10.1016/j.cgh.2012.08.029.Peer-Reviewed Original ResearchConceptsSplit-dose PEGBowel preparation methodsBowel preparation qualityAdjunct therapyRandomized trialsBowel cleansingBowel preparationOdds ratioPooled estimatesSplit dosePublication biasPreparation qualityDose polyethylene glycolSplit-dose regimensCochrane Central RegisterMajor conference proceedingsSignificant heterogeneitySignificant publication biasLow-volume regimensRandom-effects modelSame preparationAbdominal crampingCentral RegisterPatient demographicsControlled Trials
2008
Oropharyngeal cancer.
Psyrri A, Prezas L, Burtness B. Oropharyngeal cancer. Clinical Advances In Hematology And Oncology 2008, 6: 604-12. PMID: 18820604.Peer-Reviewed Original ResearchConceptsOropharyngeal squamous cell carcinomaMolecular pathogenesisHigh-risk human papillomavirus (HPV) typesSquamous cell carcinomaHuman papillomavirus typesTerms of etiologySquamous histologyClinical presentationCell carcinomaClinical behaviorPapillomavirus typesType 16Significant heterogeneityCarcinomaPathogenesisHPVOropharynxEtiologyTherapyHistologyInfectionEpidemiologyDiagnosis
2003
Na-H Exchange Function in Colonic Epithelial Cells
Binder H, Rajendran V, Geibel J. Na-H Exchange Function in Colonic Epithelial Cells. 2003, 71-90. DOI: 10.1007/978-1-4615-0427-6_5.Peer-Reviewed Original ResearchColonic epithelial cellsShort-chain fatty acidsEpithelial cellsSmall intestinal epithelial cellsAbsorption of carbohydratesIntestinal epithelial cellsSecretion of fluidEpithelial cell functionNeonatal periodCrypt cellsDistal segmentsCell functionSignificant heterogeneityMammalian colonSecretory processColonFatty acidsCl transportMultiple factorsCellsNutrient absorptionExchange functionHormoneSecretion
2000
Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis
Han L, Cole M, Bellavance F, McCusker J, Primeau F. Tracking Cognitive Decline in Alzheimer's Disease Using the Mini-Mental State Examination: A Meta-Analysis. International Psychogeriatrics 2000, 12: 231-247. PMID: 10937543, DOI: 10.1017/s1041610200006359.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationAD patientsAlzheimer's diseaseCognitive declineInclusion criteriaStudy populationMMSE scoresState ExaminationCourse of ADPathological diagnostic criteriaEffect sizeInitial MMSE scoreNumber of assessmentsLongitudinal study designOutcome measuresDiagnostic criteriaPopulation characteristicsFollowing keywordsMeta-analysisPatientsStudy designDiseaseChange scoresRandom effects regression modelsSignificant heterogeneity
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