Peripheral Brain-Derived Neurotrophic Factor Levels in Alzheimer’s Disease and Mild Cognitive Impairment: a Comprehensive Systematic Review and Meta-analysis
Kim B, Lee S, Graham P, Angelucci F, Lucia A, Pareja-Galeano H, Leyhe T, Turana Y, Lee I, Yoon J, Shin J. Peripheral Brain-Derived Neurotrophic Factor Levels in Alzheimer’s Disease and Mild Cognitive Impairment: a Comprehensive Systematic Review and Meta-analysis. Molecular Neurobiology 2016, 54: 7297-7311. PMID: 27815832, DOI: 10.1007/s12035-016-0192-9.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorPeripheral blood BDNF levelsBlood BDNF levelsBrain-derived neurotrophic factor levelsBDNF levelsPeripheral BDNF levelsMeta-analysisMild cognitive impairmentMini-Mental State ExaminationSystematic reviewNeurotrophic factor levelsStatistically significant differenceAD patientsCognitive impairmentComprehensive systematic reviewSubgroup analysisHealthy controlsNeurotrophic factorAlzheimer's diseaseTrophic effectsPatientsBlood biomarkersInclusion criteriaMini-Mental State Examination scoreSignificant difference
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