2025
Sex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging
Fu J, Xu W, Yu D, Jiang Y, Wang L, Cai H, Xia Q, Shu X, Zheng W. Sex‐Specific Aging Patterns of Gut Microbiota in Urban Chinese Adults: Guild‐Based Analysis and Implications for Healthy Aging. Aging Cell 2025, e70192. PMID: 40757475, DOI: 10.1111/acel.70192.Peer-Reviewed Original ResearchPatterns of gut microbiotaGut microbiotaBray-CurtisRRNA gene sequencesEcological indicatorsGroup of bacteriaMicrobial agingBray-Curtis distanceGene sequencesShanghai MePielou's evennessHealthy lifestyleMicrobial guildsChinese adultsChao1 indexHigher risk of type 2 diabetesHealthy lifestyle behaviorsMicrobiotaRisk of type 2 diabetesWomen's Health StudyUrban Chinese adultsCoherent groupsGuildsHigh riskLifestyle behaviorsHSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMID: 40227422, PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidence
2024
Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China
Rahman M, Breeze C, Shu X, Wong J, Blechter B, Cardenas A, Wang X, Ji B, Hu W, Cai Q, Hosgood H, Yang G, Shi J, Long J, Gao Y, Bell D, Zheng W, Rothman N, Lan Q. Epigenome-wide association study of lung cancer among never smokers in two prospective cohorts in Shanghai, China. Thorax 2024, 79: 735-744. PMID: 38702190, PMCID: PMC11251856, DOI: 10.1136/thorax-2023-220352.Peer-Reviewed Original ResearchAssociated with lung cancerLung cancer casesNever smokersHealth StudyOral rinse samplesCancer casesShanghai Men's Health StudyShanghai Women's Health StudyIncident lung cancer casesEpigenome-wide significance levelLung cancerWomen's Health StudyAetiology of lung cancerFixed-effect meta-analysisMen's Health StudyNested Case-Control StudyCase-control studyBlood DNA methylationSmoking remainsStudy of Lung CancerGrimAge accelerationNever-smoking controlsRinse samplesDNA methylationIllumina MethylationEPIC arrayA nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study
Rahman M, Shu X, Jones D, Hu W, Ji B, Blechter B, Wong J, Cai Q, Yang G, Gao Y, Zheng W, Rothman N, Walker D, Lan Q. A nested case‐control study of untargeted plasma metabolomics and lung cancer among never‐smoking women within the prospective Shanghai Women's Health Study. International Journal Of Cancer 2024, 155: 508-518. PMID: 38651675, PMCID: PMC11284831, DOI: 10.1002/ijc.34929.Peer-Reviewed Original ResearchShanghai Women's Health StudyProspective Shanghai Women's Health StudyNested Case-Control StudyNever-smoking womenLung cancerWomen's Health StudyCase-control studyNever-smokersPlasma metabolomeLung adenocarcinomaRisk factorsPre-diagnostic plasmaHealth StudyLung cancer risk factorsMetabolic featuresCancer risk factorsCancer-free womenAssociated with lung adenocarcinomaFactors of lung cancerLung cancer pathogenesisRisk factors of lung cancerLung cancer casesConditional logistic regression modelsEtiology of lung cancerTraffic-related air pollution
2022
Choice and application of time scale selection for Cox proportional hazards regression model in cohort studies
Li Z, Shen Q, Tuo J, Tang D, Xiao Y, Zhao L, Xiang Y. Choice and application of time scale selection for Cox proportional hazards regression model in cohort studies. Chinese Journal Of Epidemiology 2022, 43: 2002-2007. PMID: 36572476, DOI: 10.3760/cma.j.cn112338-20220720-00644.Peer-Reviewed Original ResearchConceptsCohort study dataCox proportional hazards regression modelsProportional hazards regression modelsHazards regression modelsShanghai Women's Health StudyCox modelRisk of liver cancerWomen's Health StudyRegression modelsStudy dataHealth StudyCentral obesityData analysisCohort studyTime-to-event data analysisCoxOutcome eventsTime scalesLiver cancerTea Consumption and Gut Microbiome in Chinese Men and Women
Wang L, Shu X, Cai H, Yang Y, Xu W, Wu J, Cai Q, Zheng W, Yu D. Tea Consumption and Gut Microbiome in Chinese Men and Women. Current Developments In Nutrition 2022, 6: 1035. DOI: 10.1093/cdn/nzac069.040.Peer-Reviewed Original ResearchTea drinking habitsHealth StudyStool collectionTea drinkingGut microbiomeChinese menDrinking habitsShanghai Men's Health StudyShanghai Women's Health StudySignificant associationPotential sex-specific effectsTea drinking statusWomen's Health StudyBody mass indexDiet quality scoresMen's Health StudyGreen tea drinkingSex-specific effectsGut microbiome diversitySD ageTobacco smokingMass indexHypertension statusAlcohol drinkingMicrobiome diversity
2018
Prospective cohort studies of dietary vitamin B6 intake and risk of cause-specific mortality
Zhao L, Shu X, Li H, Gao J, Han L, Wang J, Fang J, Gao Y, Zheng W, Xiang Y. Prospective cohort studies of dietary vitamin B6 intake and risk of cause-specific mortality. Clinical Nutrition 2018, 38: 1180-1187. PMID: 29764693, PMCID: PMC6551204, DOI: 10.1016/j.clnu.2018.04.016.Peer-Reviewed Original ResearchConceptsCause-specific mortalityRisk of all-causeAssociated with riskProspective cohort studyHazard ratioHealth StudyAll-CauseAssociated with risk of all-causeShanghai Men's Health StudyShanghai Women's Health StudyVitamin B6 intakeRisk of cause-specific mortalityLow vitamin B6 intakeWomen's Health StudyConfidence intervalsMen's Health StudyProspective Chinese cohortCox proportional hazards modelsB6 intakeDietary vitamin B6Dietary vitamin B6 intakeCVD mortalityCHD mortalityStroke mortalityNo significant association
2016
Dietary antioxidant vitamins intake and mortality: A report from two cohort studies of Chinese adults in Shanghai
Zhao L, Shu X, Li H, Zhang W, Gao J, Sun J, Zheng W, Xiang Y. Dietary antioxidant vitamins intake and mortality: A report from two cohort studies of Chinese adults in Shanghai. Journal Of Epidemiology 2016, 27: 89-97. PMID: 28142039, PMCID: PMC5363781, DOI: 10.1016/j.je.2016.10.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntioxidantsAscorbic AcidAsian PeopleCardiovascular DiseasesCarotenoidsCause of DeathChinaCohort StudiesDietDietary SupplementsDose-Response Relationship, DrugFemaleHumansMaleNeoplasmsProportional Hazards ModelsProspective StudiesRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesVitamin EVitaminsConceptsDietary antioxidant vitamin intakeAntioxidant vitamin intakeRisk of mortalityHealth StudyCohort study of middle-agedChinese adultsCohort study of Chinese adultsShanghai Men's Health StudyShanghai Women's Health StudyRisk of cardiovascular disease mortalityStudy of middle-agedCohort studyHazard ratioMiddle-agedWomen's Health StudyCardiovascular disease mortalityConfidence intervalsElderly Chinese adultsMen's Health StudyVitamin intakeCardiovascular diseaseCox proportional hazards regression modelsProportional hazards regression modelsVitamin C intakeHazards regression modelsGreen tea consumption and cause-specific mortality: Results from two prospective cohort studies in China
Zhao L, Li H, Sun J, Yang Y, Ma X, Shu X, Zheng W, Xiang Y. Green tea consumption and cause-specific mortality: Results from two prospective cohort studies in China. Journal Of Epidemiology 2016, 27: 36-41. PMID: 28135196, PMCID: PMC5328738, DOI: 10.1016/j.je.2016.08.004.Peer-Reviewed Original ResearchConceptsShanghai Men's Health StudyRisk of all-causeElderly Chinese adultsGreen tea consumptionAssociated with riskGreen tea intakeHealth StudyTea consumptionChinese adultsAll-CauseAssociated with risk of all-causeShanghai Women's Health StudyTea intakeCardiovascular diseasePopulation-based prospective cohortHazard ratioMiddle-agedWomen's Health StudyCardiovascular disease mortalityCause-specific mortalityConfidence intervalsMen's Health StudyCox proportional hazards regression modelsProspective cohort studyProportional hazards regression modelsDietary selenium intake and mortality in two population-based cohort studies of 133 957 Chinese men and women
Sun J, Shu X, Li H, Zhang W, Gao J, Zhao L, Zheng W, Xiang Y. Dietary selenium intake and mortality in two population-based cohort studies of 133 957 Chinese men and women. Public Health Nutrition 2016, 19: 2991-2998. PMID: 27197889, PMCID: PMC5063694, DOI: 10.1017/s1368980016001130.Peer-Reviewed Original ResearchConceptsShanghai Men's Health StudyHazard ratioHealth StudyCancer mortalityAll-CauseShanghai Women's Health StudyPopulation-based cohort studyAssociated with all-causeWomen's Health StudyEvaluate all-causeAssociated with all-cause mortalityMen's Health StudyCalculate hazard ratiosIn-person interviewsAll-Cause MortalityCox proportional hazards modelsCVD mortalityDietary Se intakeNo significant associationLowest quintileProportional hazards modelIn-personCohort studyAverage follow-upSignificant association
2015
Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health Study
Bassig BA, Friesen MC, Vermeulen R, Shu XO, Purdue MP, Stewart PA, Xiang YB, Chow WH, Zheng T, Ji BT, Yang G, Linet MS, Hu W, Zhang H, Zheng W, Gao YT, Rothman N, Lan Q. Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women’s Health Study. Environmental Health Perspectives 2015, 123: 971-977. PMID: 25748391, PMCID: PMC4590744, DOI: 10.1289/ehp.1408307.Peer-Reviewed Original ResearchConceptsNon-Hodgkin lymphomaShanghai Women's Health StudyWomen's Health StudyBenzene exposureHealth StudyNHL riskOccupational exposurePopulation-based prospective cohortCox proportional hazards modelInconsistent epidemiologic evidenceCancer Working GroupProportional hazards modelOccupational benzene exposureCumulative exposure levelsExposure tertilesUnexposed womenProspective cohortEpidemiologic evidenceHigh riskOccupational historyHazards modelExposure levelsWomenHigh associationExposure metrics
2009
Peripubertal estrogen levels and physical activity affect femur geometry in young adult women
Devlin M, Stetter C, Lin H, Beck T, Legro R, Petit M, Lieberman D, Lloyd T. Peripubertal estrogen levels and physical activity affect femur geometry in young adult women. Osteoporosis International 2009, 21: 609-617. PMID: 19575140, PMCID: PMC3230251, DOI: 10.1007/s00198-009-0999-6.Peer-Reviewed Original ResearchConceptsPhysical activityAdolescent physical activity levelsTertile of physical activityAdolescent physical activityPhysical activity levelsPenn State Young Women's Health StudyWomen's Health StudyYoung womenE2 levelsAssociated with bone strengthDual-energy X-ray absorptiometry scanBone strengthX-ray absorptiometry scanResultsAt ageHealth StudyYoung adult womenHip structural analysisHormone levelsActive subjectsActivity levelsFemoral narrow neckHigher E2 levelsAdult womenMenarcheTiming of puberty
2005
Influence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women
Wise LA, Palmer JR, Spiegelman D, Harlow BL, Stewart EA, Adams-Campbell LL, Rosenberg L. Influence of Body Size and Body Fat Distribution on Risk of Uterine Leiomyomata in U.S. Black Women. Epidemiology 2005, 16: 346-354. PMID: 15824551, PMCID: PMC1847589, DOI: 10.1097/01.ede.0000158742.11877.99.Peer-Reviewed Original ResearchConceptsBody mass indexIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyParous womenUterine leiomyomataHealth StudyWeight gainMultivariate incidence rate ratiosSelf-reported uterine leiomyomataU.S. prospective cohort studiesBlack womenProspective cohort studyBody fat distributionConfidence intervalsU.S. Black womenPremenopausal womenCohort studyPrior diagnosisHip ratioMass indexHip circumferenceFat distributionHealth QuestionnaireLarge cohort
2004
Femoral bone structural geometry adapts to mechanical loading and is influenced by sex steroids: The Penn State Young Women's Health Study
Petit M, Beck T, Lin H, Bentley C, Legro R, Lloyd T. Femoral bone structural geometry adapts to mechanical loading and is influenced by sex steroids: The Penn State Young Women's Health Study. Bone 2004, 35: 750-759. PMID: 15336612, DOI: 10.1016/j.bone.2004.05.008.Peer-Reviewed Original ResearchConceptsPenn State Young Women's Health StudyLean massWomen's Health StudySex steroidsBone structural geometryHip structural analysis programAreal bone mineral densityHealth StudyTotal body lean massProximal femur DXA scansTotal body scanBone mineral densityBone cross-sectional areaAge of menarcheBody lean massCross-sectional areaCortical thicknessDXA scansMineral densityShaft cortical thicknessBone widthAssess predictorsTestosterone levelsYears of longitudinal dataSubperiosteal widthRisk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study
Wise LA, Palmer JR, Harlow BL, Spiegelman D, Stewart EA, Adams-Campbell LL, Rosenberg L. Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study. Human Reproduction 2004, 19: 1746-1754. PMID: 15218005, PMCID: PMC1876785, DOI: 10.1093/humrep/deh309.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosBlack Women's Health StudyWomen's Health StudyUterine leiomyomataHealth StudyCaffeine consumptionCigarette smokingMultivariate incidence rate ratiosSelf-reported uterine leiomyomataDrinks/weekConfidence intervalsUS black womenHeavy coffeePremenopausal womenIncident casesOvarian functionLeiomyomataAlcohol consumptionRate ratioHormone metabolismWomenSmokingRiskBeer consumptionBlack womenLifestyle factors and the development of bone mass and bone strength in young women
Lloyd T, Petit M, Lin H, Beck T. Lifestyle factors and the development of bone mass and bone strength in young women. The Journal Of Pediatrics 2004, 144: 776-782. PMID: 15192626, DOI: 10.1016/j.jpeds.2004.02.047.Peer-Reviewed Original ResearchConceptsOral contraceptive useCalcium intakeContraceptive useBone strengthBone massAssociated with increased BMDDual-energy X-ray absorptiometryPenn State Young Women's Health StudyEnergy X-ray absorptiometryProspective food recordsDevelopment of bone massDaily calcium intakeFemoral neck BMDX-ray absorptiometryAssociated with bone gainBone mineral massBody composition measurementsAdolescents' lifestyle patternsMeasure bone mineral massWomen's Health StudyYears of ageFood recordsBone gainNeck BMDBone bending strength
2002
Modifiable determinants of bone status in young women
Lloyd T, Beck T, Lin H, Tulchinsky M, Eggli D, Oreskovic T, Cavanagh P, Seeman E. Modifiable determinants of bone status in young women. Bone 2002, 30: 416-421. PMID: 11856651, DOI: 10.1016/s8756-3282(01)00675-5.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryBone mineral densityPeak bone mineral densityDaily calcium intakeAerobic capacityCalcium intakeFemoral neckBone structure measuresEstimate aerobic capacityPenn State Young Women's Health StudyWomen's Health StudyBody compositionContribution of exerciseMineral densityLevels of exerciseDual-energy X-ray absorptiometry scan dataAssociated with totalHip bone mineral densityYoung womenFemoral shaftProspective food recordsExercise scoreHealth StudyX-ray absorptiometryCross-sectional areaAdolescent Caucasian mothers have reduced adult hip bone density
Lloyd T, Lin H, Eggli D, Dodson W, Demers L, Legro R. Adolescent Caucasian mothers have reduced adult hip bone density. Fertility And Sterility 2002, 77: 136-140. PMID: 11779603, DOI: 10.1016/s0015-0282(01)02924-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlgorithmsBody CompositionBody Mass IndexBone DensityChildCholesterolCoronary DiseaseEstradiolExerciseFemaleFollicle Stimulating HormoneHumansLuteinizing HormoneMothersPelvic BonesPennsylvaniaPregnancyPregnancy in AdolescenceReference ValuesRisk FactorsSportsTestosteroneTriglyceridesWhite PeopleConceptsHip bone mineral densityBone mineral densityMineral densityRisk of future hip fractureNon-Hispanic white femalesTotal body bone mineral contentCardiovascular disease risk factorsPenn State Young Women's Health StudyBody bone mineral contentWomen's Health StudyDisease risk factorsFull-term pregnancyFuture hip fractureHip bone densityBlood lipid patternBone mineral contentAge of menarcheBody mass indexReproductive hormone patternsHealth StudyHip fractureMass indexBone densityIncreased riskMatched Controls
2000
Oral contraceptive use by teenage women does not affect peak bone mass: a longitudinal study
Lloyd T, Taylor D, Lin H, Matthews A, Eggli D, Legro R. Oral contraceptive use by teenage women does not affect peak bone mass: a longitudinal study. Fertility And Sterility 2000, 74: 734-738. PMID: 11020515, DOI: 10.1016/s0015-0282(00)00719-6.Peer-Reviewed Original ResearchConceptsOral contraceptive pillsPeak bone massOral contraceptive pill usersBone massAcquisition of peak bone massDuration of OCP useTotal body bone measurementsEffects of oral contraceptive pillsPenn State Young Women's Health StudyBody compositionOral contraceptive pill useTotal body boneOral contraceptive useBone measurementsContraceptive pill useBody composition measurementsAge of menarcheWomen's Health StudyOCP useContraceptive pillsPill useTotal bodyContraceptive useTeenage womenAverage duration
1997
Regression calibration method for correcting measurement-error bias in nutritional epidemiology
Spiegelman D, McDermott A, Rosner B. Regression calibration method for correcting measurement-error bias in nutritional epidemiology. American Journal Of Clinical Nutrition 1997, 65: s1179-s1186. PMID: 9094918, DOI: 10.1093/ajcn/65.4.1179s.Peer-Reviewed Original ResearchConceptsHealth StudyDietary intakeMassachusetts Women's Health StudyUltradistal radius bone densityCox proportional hazards modelRadius bone densityNurses' Health StudyWomen's Health StudyIncidence rate ratiosRate ratioProportional hazards modelOdds ratioBone densityBreast cancerHazards modelVitamin ANutritional epidemiologyLogistic regressionGold standardLinear regression modelsEpidemiologyIntakeRegression modelsValidation studyPerson error
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply