2025
The Flagellin‐Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis
Sze C, Zhang K, Lynch M, Guo W, Liu J, Crane B, Li C. The Flagellin‐Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis. Molecular Microbiology 2025 PMID: 40491023, DOI: 10.1111/mmi.15380.Peer-Reviewed Original ResearchFlagellar assemblyRNA-binding protein CsrALevel of translation initiationNon-motile mutantPartner-switching mechanismPost-transcriptional regulatory mechanismsLyme disease spirochete Borrelia burgdorferiGroup of bacteriaLoss-of-function studiesCryo-electron tomographyFlagellar biosynthesisFlagellin proteinTranslation initiationTranscriptional cascadeRegulatory circuitsFlagellar filamentsCytoplasmic poolFliSInternal flagellaCytoplasmic accumulationRegulatory mechanismsCryo-electronFlaBSpirochete Borrelia burgdorferiFliWFlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi
Botting J, Rahman M, Xu H, Yue J, Guo W, Del Mundo J, Hammel M, Motaleb M, Liu J. FlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi. PLOS Pathogens 2025, 21: e1012812. PMID: 39777417, PMCID: PMC11750108, DOI: 10.1371/journal.ppat.1012812.Peer-Reviewed Original ResearchConceptsComplex protein networkPeriplasmic flagellaProtein networkB. burgdorferi mutantFlagellar motorFlat-wave morphologyStator complexLyme disease spirochete Borrelia burgdorferiGroup of bacteriaCryo-electron tomographyCollar proteinFlagellar assemblyHost infectionHuman pathogensFlbBPeriplasmic ringSpirochete Borrelia burgdorferiCollar assemblyMotilityFlagellaBorrelia burgdorferiSpirochetesMolecular modelingCollarMutants
2023
Anti-σ28 Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola
Kurniyati K, Chang Y, Guo W, Liu J, Malkowski M, Li C. Anti-σ28 Factor FlgM Regulates Flagellin Gene Expression and Flagellar Polarity of Treponema denticola. Journal Of Bacteriology 2023, 205: e00463-22. PMID: 36715541, PMCID: PMC9945498, DOI: 10.1128/jb.00463-22.Peer-Reviewed Original ResearchConceptsFlagellin gene expressionPeriplasmic flagellaGene expressionSpirochete Treponema denticolaOral spirochete Treponema denticolaCryo-electron tomography analysisFlagellar gene expressionCore RNA polymeraseGroup of bacteriaFlgM proteinFlagellar genesBipolar flagellaHeterologous expressionDependent promotersFlagellar numberRNA polymeraseFlgMFliAMutational analysisFlagellin geneMolecular mechanismsSpirochete motilityHuman diseasesLines of evidenceEnds of cells
2014
Novel Components of the Flagellar System in Epsilonproteobacteria
Gao B, Lara-Tejero M, Lefebre M, Goodman AL, Galán JE. Novel Components of the Flagellar System in Epsilonproteobacteria. MBio 2014, 5: 10.1128/mbio.01349-14. PMID: 24961693, PMCID: PMC4073491, DOI: 10.1128/mbio.01349-14.Peer-Reviewed Original ResearchConceptsBacterial pathogen Campylobacter jejuniPathogen Campylobacter jejuniFlagellar systemBacterial speciesNovel componentGenetic screenFlagellar structureMost bacteriaMolecular basisHigh-throughput genetic screensFlagellar apparatusComprehensive genetic screenDiverse bacterial speciesCampylobacter jejuniDifferent bacterial speciesGroup of bacteriaBacterial poleBacterial organellesFlagellar machineryTransposon mutagenesisNext-generation sequencingEpsilonproteobacteriaFlagellaRecent studiesSpecies
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