2024
Activated sputum eosinophils associated with exacerbations in children on mepolizumab
Wilson G, Knight J, Liu Q, Shelar A, Stewart E, Wang X, Yan X, Sanders J, Visness C, Gill M, Gruchalla R, Liu A, Kattan M, Khurana Hershey G, Togias A, Becker P, Altman M, Busse W, Jackson D, Montgomery R, Chupp G. Activated sputum eosinophils associated with exacerbations in children on mepolizumab. Journal Of Allergy And Clinical Immunology 2024, 154: 297-307.e13. PMID: 38485057, PMCID: PMC11305967, DOI: 10.1016/j.jaci.2024.01.031.Peer-Reviewed Original ResearchAirway eosinophilsSputum eosinophilsPatients treated with mepolizumabPlacebo-controlled clinical trialAnti-IL-5 treatmentEffect of mepolizumabEosinophil subpopulationsSevere eosinophilic asthmaAnti-interleukin-5Expression of CD62LFrequency of exacerbationsEosinophilic asthmaActivation markersSputum samplesUnsupervised cluster analysisMepolizumabTreatment armsReduce exacerbationsCD62LClinical trialsExacerbationMass cytometryEosinophilsExacerbation riskIntracellular markers
2021
Neutrophil Activation: Influence of Antimony Tolerant and Susceptible Clinical Strains of L. (V.) panamensis and Meglumine Antimoniate
Fernández OL, Ramírez G, Díaz-Varela M, Tacchini-Cottier F, Saravia NG. Neutrophil Activation: Influence of Antimony Tolerant and Susceptible Clinical Strains of L. (V.) panamensis and Meglumine Antimoniate. Frontiers In Cellular And Infection Microbiology 2021, 11: 710006. PMID: 34631596, PMCID: PMC8493214, DOI: 10.3389/fcimb.2021.710006.Peer-Reviewed Original ResearchMeglumine antimoniateActivation of neutrophilsClinical strainsActivation markersNET formationExpression of CD62LReactive oxygen speciesMaximal plasma concentrationInnate host responseSusceptible clinical strainsROS productionDrug-sensitive strainsCD66b expressionNeutrophil activationHealthy donorsInflammatory responsePlasma concentrationsTherapeutic effectAntimonial drugsAntimicrobial medicationsDsDNA releaseHost responseNeutrophilsAntileishmanial drugsCD62L
2014
An age-related decline of CD62L and vaccine response
Shin J, Bayry J. An age-related decline of CD62L and vaccine response. Human Vaccines & Immunotherapeutics 2014, 10: 1404-1405. PMID: 24401614, PMCID: PMC4896605, DOI: 10.4161/hv.27665.Peer-Reviewed Original Research
2011
Lymphocyte Surface Molecule Expression on Basal State and After Challenge: Association of Clinical Profile, Inflammation, Hematological and Biochemical Markers in Sickle Cell Anemia Patients
Cerqueira B, Vilas-Boas W, Zanette A, Clarencio J, Salvino M, Cezar R, Andrade D, Reis M, Goncalves M. Lymphocyte Surface Molecule Expression on Basal State and After Challenge: Association of Clinical Profile, Inflammation, Hematological and Biochemical Markers in Sickle Cell Anemia Patients. Blood 2011, 118: 2146. DOI: 10.1182/blood.v118.21.2146.2146.Peer-Reviewed Original ResearchSickle cell anemia patientsSoluble adhesion moleculesSickle cell anemiaSurface molecule expressionSCA patientsControl groupAnemia patientsAdhesion moleculesLymphocyte expressionLPS challengeMedical historyCD18 expressionMolecule expressionSoluble vascular adhesion moleculeBasal statePro-inflammatory interactionsEffector immune responsesVaso-occlusive episodesExpression of CD62LMarkers of inflammationChronic inflammatory stateTNF-alpha valuesVascular adhesion moleculesComplete medical historyExpression of CD11b
2008
Expression Levels of CD11b, CD18, CD32, CD62L (L-Selectin) and CD62P (P-Selectin) and Its Role in Sickle Cell Anemia Inflammatory State
Cerqueira B, Boas W, Seixas M, Damasceno E, Souza C, Reis M, Goncalves M. Expression Levels of CD11b, CD18, CD32, CD62L (L-Selectin) and CD62P (P-Selectin) and Its Role in Sickle Cell Anemia Inflammatory State. Blood 2008, 112: 2504. DOI: 10.1182/blood.v112.11.2504.2504.Peer-Reviewed Original ResearchVaso-occlusive eventsInflammatory stateVascular occlusionSCA patientsRed blood cellsLeukocyte activationHemolytic stateExpression levelsSickle cell complicationsExpression of CD62LHigher CRP levelsSoluble adhesion moleculesChronic inflammatory stateVenous blood samplesNaïve T lymphocytesHigh endothelial venulesFetal hemoglobinActivation stateCD62L expression levelsCell surface antigensLeukocyte cell surface antigensVascular complicationsCD62L expressionCRP levelsEndothelial dysfunction
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