2024
Patient-specific, multiscale modelling of neointimal hyperplasia in lower-limb vein grafts using readily available clinical data
Ninno F, Chiastra C, Donadoni F, Dardik A, Strosberg D, Aboian E, Tsui J, Balabani S, Díaz-Zuccarini V. Patient-specific, multiscale modelling of neointimal hyperplasia in lower-limb vein grafts using readily available clinical data. Journal Of Biomechanics 2024, 177: 112428. PMID: 39561605, DOI: 10.1016/j.jbiomech.2024.112428.Peer-Reviewed Original ResearchTime-averaged wall shear stressInflow boundary conditionsBoundary conditionsWall shear stressShear stressMultiscale modelWaveform shapePeripheral arterial diseaseNeointimal hyperplasiaVein graftsClinical dataMechanobiological mechanismsGraft responseMultiscale in silico modelSystolic acceleration time
2021
Full facial retransplantation in a female patient—Technical, immunologic, and clinical considerations
Kauke M, Panayi AC, Safi A, Haug V, Perry B, Kollar B, Nizzi M, Broyles J, Annino DJ, Marty FM, Sinha I, Lian CG, Murphy GF, Chandraker A, Pomahac B. Full facial retransplantation in a female patient—Technical, immunologic, and clinical considerations. American Journal Of Transplantation 2021, 21: 3472-3480. PMID: 34033210, DOI: 10.1111/ajt.16696.Peer-Reviewed Original ResearchConceptsChronic antibody-mediated rejectionPatient underwent retransplantationRecurrent cellular rejectionAntibody-mediated rejectionImmediate postoperative phaseInterposition vein graftAllograft lossCellular rejectionFirst allograftOlder allograftsRejection episodesUnderwent retransplantationSecond transplantationFirst transplantPostoperative outcomesAllotransplant recipientsPostoperative phaseVein graftsHyperacute rejectionFacial nerveOutcomes 6Arterial anastomosisRetransplantationSurgical techniquePsychosocial managementAngiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials
Gaudino M, Hameed I, Robinson NB, Ruan Y, Rahouma M, Naik A, Weidenmann V, Demetres M, Tam D, Hare DL, Girardi LN, Biondi‐Zoccai G, Fremes S. Angiographic Patency of Coronary Artery Bypass Conduits: A Network Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2021, 10: e019206. PMID: 33686866, PMCID: PMC8174193, DOI: 10.1161/jaha.120.019206.Peer-Reviewed Original ResearchConceptsCoronary artery bypass conduitsTouch saphenous veinAngiographic patency ratesRadial arterySaphenous veinPatency ratesGraft occlusionRandomized trialsBypass conduitRight internal thoracic arteryTouch saphenous vein graftsCoronary bypass surgerySaphenous vein graftsGraft occlusion rateInternal thoracic arteryBest conduitNetwork Meta-AnalysisSystematic literature searchGastroepiploic arteryBypass surgeryPrimary outcomeThoracic arteryAngiographic patencyVein graftsOcclusion rate
2020
Association of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Puskas JD, Girardi LN, Hare DL, Taggart DP. Association of Radial Artery Graft vs Saphenous Vein Graft With Long-term Cardiovascular Outcomes Among Patients Undergoing Coronary Artery Bypass Grafting. JAMA 2020, 324: 179-187. PMID: 32662861, PMCID: PMC7361649, DOI: 10.1001/jama.2020.8228.Peer-Reviewed Original ResearchConceptsCoronary artery bypassSaphenous vein graftsComposite of deathRadial artery graftArtery bypassVein graftsRadial arteryMyocardial infarctionArtery graftCardiovascular outcomesClinical outcomesSaphenous veinLong-term cardiovascular outcomesPatient-level pooled analysisCoronary Artery Bypass GraftingArtery Bypass GraftingIndividual participant dataBypass GraftingAdult patientsComposite outcomeSecondary outcomesPrimary outcomeRandomized trialsPooled analysisObservational study
2019
The RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol
Gaudino M, Benedetto U, Fremes S, Ballman K, Biondi-Zoccai G, Sedrakyan A, Nasso G, Raman J, Buxton B, Hayward PA, Moat N, Collins P, Webb C, Peric M, Petrovic I, Yoo KJ, Hameed I, Di Franco A, Moscarelli M, Speziale G, Girardi LN, Hare DL, Taggart DP, Investigators R. The RADial artery International ALliance (RADIAL) extended follow-up study: rationale and study protocol. European Journal Of Cardio-Thoracic Surgery 2019, 56: 1025-1030. PMID: 31535147, DOI: 10.1093/ejcts/ezz247.Peer-Reviewed Original ResearchConceptsPatency ratesSaphenous veinGood mid-term patency ratesMid-term patency ratesCoronary artery bypass surgeryRadial artery graftArtery bypass surgeryEvent-free survivalSaphenous vein graftsLong-term outcomesImproved patency ratesRA armArtery graftPostoperative yearRepeat revascularizationBypass surgeryCardiac eventsVein graftsClinical correlatesStudy protocolObservational studyRole of RASGraftTrialsSurvivalVein Graft Interposition: A Training Model Using Gradually Thawed Cryopreserved Vessels.
Safi AF, Safi S, Tayeh M, Gojowy D, Timmer M, Goldbrunner R, Kauke M. Vein Graft Interposition: A Training Model Using Gradually Thawed Cryopreserved Vessels. Journal Of Craniofacial Surgery 2019, 30: e213-e216. PMID: 30845093, DOI: 10.1097/scs.0000000000005197.Peer-Reviewed Original Research
2018
Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model
Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model. Journal Of Vascular Surgery 2018, 68: 188s-200s.e4. PMID: 30064835, PMCID: PMC6252159, DOI: 10.1016/j.jvs.2018.05.206.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Inflammatory AgentsBlood Vessel Prosthesis ImplantationCarotid Artery, CommonCell ProliferationChemotaxis, LeukocyteDisease Models, AnimalDocosahexaenoic AcidsDrug CarriersFemaleGelsGraft Occlusion, VascularHyperplasiaJugular VeinsNeointimaPoloxamerPolylactic Acid-Polyglycolic Acid CopolymerRabbitsTime FactorsConceptsRabbit vein graft modelLocal perivascular deliveryVein graftsPerivascular deliveryVein graft modelNeointimal hyperplasiaResolvin D1Macrophage infiltrationLipid mediatorsSpecialized proresolving lipid mediatorsGraft modelTotal leukocyte infiltrationMajor wound complicationsProresolving lipid mediatorsVein bypass graftsD-series resolvinsNew Zealand white rabbitsPotential therapeutic roleIpsilateral jugular veinCell proliferationZealand white rabbitsExcessive neointimal hyperplasiaVein graft hyperplasiaPerivascular fashionRvD1 treatment
2017
Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries?
Isaji T, Hashimoto T, Yamamoto K, Santana JM, Yatsula B, Hu H, Bai H, Jianming G, Kudze T, Nishibe T, Dardik A. Improving the Outcome of Vein Grafts: Should Vascular Surgeons Turn Veins into Arteries? Annals Of Vascular Diseases 2017, 10: ra.17-00008. PMID: 29034014, PMCID: PMC5579803, DOI: 10.3400/avd.ra.17-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEndothelial nitric oxide synthaseVein graftsVein graft failureGraft failureEph-B4Endothelial cellsCritical limb ischemiaAutogenous vein graftsNitric oxide synthaseGold standard conduitNovel therapeutic targetMouse vein graftsVein graft wallExcessive neointimal hyperplasiaVein graft adaptationVenous endothelial cellsPREVENT trialArterial environmentGraft outcomeLimb ischemiaAdequate dilationArterial bypassOxide synthaseVascular surgeonsNeointimal hyperplasia
2016
Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase
Wang M, Collins MJ, Foster TR, Bai H, Hashimoto T, Santana JM, Shu C, Dardik A. Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase. Journal Of Vascular Surgery 2016, 65: 179-189. PMID: 26817610, PMCID: PMC4958608, DOI: 10.1016/j.jvs.2015.11.041.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell MovementCells, CulturedEnzyme InhibitorsEphrin-B2GenotypeHumansMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIIPhenotypePhosphorylationReceptor, EphB4Saphenous VeinSignal TransductionTime FactorsVascular RemodelingVena Cava, InferiorConceptsEndothelial nitric oxide synthaseEphrin-B2/FcVein graft adaptationENOS knockout miceNitric oxide synthaseVein graftsGraft adaptationENOS phosphorylationENOS activityEph-B4Oxide synthaseKnockout miceWild-type vein graftsVessel remodelingWestern blotLess wall thickeningArginine methyl ester hydrochlorideMouse vein graftsNitric oxide productionLung endothelial cellsMouse lung endothelial cellsCell migrationLigand ephrin-B2Mechanism of actionMethyl ester hydrochloride
2015
Early and late clinical outcomes after saphenous vein graft treatment with MGuardTM stents vs. drug-eluting stents
da Silva D, da Costa J, de Castro Filho A, Staico R, Costa R, Moreira A, Siqueira D, Chamié D, Centemero M, Maldonado G, Cano M, Tanajura L, Chaves Á, Feres F, Abizaid A, Sousa A, Sousa J. Early and late clinical outcomes after saphenous vein graft treatment with MGuardTM stents vs. drug-eluting stents. Journal Of Transcatheter Interventions 2015, 23: 251-255. DOI: 10.1016/j.rbciev.2017.02.007.Peer-Reviewed Original ResearchSaphenous vein graftsPercutaneous coronary interventionTarget lesion revascularizationClinical outcomesLesion revascularizationClinical outcomes of patientsDES groupRate of target lesion revascularizationOutcomes of patientsCohort of patientsAdverse cardiovascular eventsSVG treatmentSaphenous vein graft lesionsTreated with DESProportion of womenEmbolization of fragmentsTertiary centerRetrospective studyMACE rateAngiographic successCardiovascular eventsLow incidencePeriprocedural infarctionCoronary interventionVein grafts
2014
The “Free” Right Internal Thoracic Artery: A Versatile and Durable Conduit
Assi R, Youssef SJ, Almarzooq Z, Al‐Raweshidy Y, Hashim PW, Geirsson A, Hashim SW. The “Free” Right Internal Thoracic Artery: A Versatile and Durable Conduit. Journal Of Cardiac Surgery 2014, 29: 609-615. PMID: 25040250, DOI: 10.1111/jocs.12396.Peer-Reviewed Original ResearchConceptsRight internal thoracic arteryInternal thoracic arteryThoracic arteryPatency ratesCoronary revascularizationCoronary systemFree graftSitu right internal thoracic arterySurvival ratePredominant targetDistal coronary vesselsSaphenous vein graftsAngiographic patency ratesRight coronary systemSternal nonunionPerioperative complicationsPerioperative mortalityPerioperative outcomesSymptomatic patientsConsecutive patientsDurable conduitVein graftsCoronary angiogramMyocardial infarctionExcellent patencyVein graft adaptation and fistula maturation in the arterial environment
Lu DY, Chen EY, Wong DJ, Yamamoto K, Protack CD, Williams WT, Assi R, Hall MR, Sadaghianloo N, Dardik A. Vein graft adaptation and fistula maturation in the arterial environment. Journal Of Surgical Research 2014, 188: 162-173. PMID: 24582063, PMCID: PMC3972303, DOI: 10.1016/j.jss.2014.01.042.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaVein graftsVein graft adaptationVenous adaptationGraft adaptationArterial environmentCommon surgical procedureAVF maturationDifferent hemodynamic conditionsFistula maturationVenous dilationUnderlying molecular mechanismsIntimal thickeningSurgical proceduresWall thickeningHemodynamic conditions
2012
Neointimal Hyperplasia: Basic Considerations
Model L, Dardik A. Neointimal Hyperplasia: Basic Considerations. 2012, 178-196. DOI: 10.1002/9781118481370.ch10.ChaptersSmooth muscle cell proliferationMuscle cell proliferationNeointimal hyperplasiaIII trialsBypass graft failureCell proliferationVein graft adaptationVein graft restenosisExtracellular matrix depositionGraft failureVein graftsVascular surgeonsVascular surgeryGraft restenosisGraft adaptationNew molecular mechanismHyperplasiaTrialsRestenosisMatrix depositionBody responseArterial environmentMolecular mechanismsDisappointing failuresProliferation
2011
Decellularized tissue-engineered blood vessel as an arterial conduit
Quint C, Kondo Y, Manson RJ, Lawson JH, Dardik A, Niklason LE. Decellularized tissue-engineered blood vessel as an arterial conduit. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 9214-9219. PMID: 21571635, PMCID: PMC3107282, DOI: 10.1073/pnas.1019506108.Peer-Reviewed Original ResearchConceptsTissue-engineered vesselsBiomimetic perfusion systemArterial tissue engineeringTissue-engineered blood vesselsTissue engineering techniquesEndothelial progenitor cellsTissue engineeringRobust extracellular matrixVein graftsBiological vascular graftPorcine carotid arteriesVascular graftsTissue regenerationIntimal hyperplasiaAutologous endothelial progenitor cellsGraft wallProgenitor cellsControl vein graftsSmooth muscle cellsGraft lumenGraft occlusionArterial conduitsImproved patencyCarotid arteryPorcine smooth muscle cells5-Year Follow-Up of Polytetrafluoroethylene-Covered Stents Compared With Bare-Metal Stents in Aortocoronary Saphenous Vein Grafts The Randomized BARRICADE (Barrier Approach to Restenosis: Restrict Intima to Curtail Adverse Events) Trial
Stone GW, Goldberg S, O'Shaughnessy C, Midei M, Siegel RM, Cristea E, Dangas G, Lansky AJ, Mehran R. 5-Year Follow-Up of Polytetrafluoroethylene-Covered Stents Compared With Bare-Metal Stents in Aortocoronary Saphenous Vein Grafts The Randomized BARRICADE (Barrier Approach to Restenosis: Restrict Intima to Curtail Adverse Events) Trial. JACC Cardiovascular Interventions 2011, 4: 300-309. PMID: 21435608, DOI: 10.1016/j.jcin.2010.11.013.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryChi-Square DistributionCoated Materials, BiocompatibleCoronary AngiographyCoronary Artery BypassCoronary RestenosisFemaleGraft Occlusion, VascularHumansKaplan-Meier EstimateMaleMetalsMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPolytetrafluoroethyleneProspective StudiesProsthesis DesignRisk AssessmentRisk FactorsSaphenous VeinStentsThrombosisTime FactorsTreatment OutcomeUnited StatesConceptsSaphenous vein graftsBare metal stentsPercutaneous coronary interventionDiseased saphenous vein graftsHigh-pressure implantationDual antiplatelet therapyTarget vessel failureAntiplatelet therapyMajor secondary end pointEnd pointPrimary end pointSecondary end pointsLong-term prognosisBinary restenosisBMS patientsCoronary interventionVein graftsVessel failureInferior outcomesSaphenous veinDiscrete lesionsPatientsPrior trialsJostentLesions
2010
Umbilical Vein Grafts for Lower Limb Revascularization
Dardik A, Dardik H. Umbilical Vein Grafts for Lower Limb Revascularization. 2010, 189-198. DOI: 10.1007/978-1-84882-718-9_19.Chapters
2009
A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery
Desai P, Kurian D, Thirumavalavan N, Desai S, Ziu P, Grant M, White C, Landis R, Poston R. A Randomized Clinical Trial Investigating the Relationship Between Aprotinin and Hypercoagulabilityin Off-Pump Coronary Surgery. Anesthesia & Analgesia 2009, 109: 1387-1394. PMID: 19843776, PMCID: PMC2789288, DOI: 10.1213/ane.0b013e3181b81068.Peer-Reviewed Original ResearchMeSH KeywordsAprotininBlood CoagulationBlood Coagulation TestsBlood PlateletsCoronary Artery Bypass, Off-PumpDouble-Blind MethodErythrocyte TransfusionFibrinolytic AgentsGraft Occlusion, VascularHumansPeptide FragmentsPlatelet AdhesivenessPlatelet AggregationPlatelet Function TestsPostoperative HemorrhageProspective StudiesProthrombinReceptor, PAR-1ThrombinThrombosisTreatment OutcomeWound HealingConceptsMajor adverse cardiovascular eventsProtease-activated receptor 1Adverse cardiovascular eventsSaphenous vein graftsCardiovascular eventsOPCAB surgeryAprotinin groupCoronary sinusHypercoagulable stateVein graftsThrombin generationAntifibrinolytic propertiesPump coronary artery bypass surgeryOff-pump coronary surgeryCoronary artery bypass surgeryRed blood cell transfusionAprotinin-treated patientsFull-dose regimenArtery bypass surgeryBlood cell transfusionCoronary sinus bloodPAR-1 antagonistsPlatelet-leukocyte conjugatesPAR-1 activationPlatelet-derived microparticles
2007
Prospective, Multicenter Study of Thrombectomy in Patients with Acute Myocardial Infarction: The X‐Tract AMI Registry
YOUNG JJ, COX DA, STUCKEY T, BABB J, TURCO M, LANSKY AJ, MEHRAN R, STONE GW. Prospective, Multicenter Study of Thrombectomy in Patients with Acute Myocardial Infarction: The X‐Tract AMI Registry. Journal Of Interventional Cardiology 2007, 20: 44-50. PMID: 17300402, DOI: 10.1111/j.1540-8183.2007.00223.x.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryCanadaCardiac CatheterizationCoronary ThrombosisCoronary VesselsFemaleGraft Occlusion, VascularHumansMaleMiddle AgedMyocardial InfarctionMyocardial ReperfusionPostoperative ComplicationsProspective StudiesRegistriesSaphenous VeinSeverity of Illness IndexStentsThrombectomyTreatment OutcomeUnited StatesConceptsSaphenous vein graftsAcute myocardial infarctionNative coronary arteriesPrimary angioplastyCoronary arteryAMI registryMulticenter studyMyocardial infarctionGlycoprotein IIb/IIIa inhibitorsMyocardial blush grade 3IIb/IIIa inhibitorsDiseased saphenous vein graftsTIMI 0/1 flowMajor cardiovascular eventsTIMI 3 flowMajority of patientsEpicardial blood flowBare metal stentsCardiovascular eventsThrombectomy systemDistal embolizationMulticenter experienceThromboembolic complicationsVein graftsMyocardial blush
2004
Relation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome
Iakovou I, Dangas G, Mintz GS, Mehran R, Kobayashi Y, Aymong E, Hirose M, Ashby DT, Lansky AJ, Stone GW, Leon MB, Moses JW. Relation of final lumen dimensions in saphenous vein grafts after stent implantation to outcome. The American Journal Of Cardiology 2004, 93: 963-968. PMID: 15081436, DOI: 10.1016/j.amjcard.2003.12.049.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsAggressive stent expansionSVG lesionsStent expansionVein graftsMyocardial infarctionStent implantationHospital non-Q-wave myocardial infarctionLumen dimensionsGroup IINon-Q-wave myocardial infarctionIntravascular ultrasound-guided stentingTarget vessel revascularization rateVessel revascularization rateBaseline patient characteristicsMyocardial infarction rateNative coronary lesionsStent cross-sectional areaTarget vessel revascularizationPercutaneous coronary interventionNative coronary arteriesCross-sectional areaLower restenosis rateRevascularization ratesVessel revascularization830-5 The impact of myocardial blush grade on clinical outcomes of patients treated with saphenous vein grafts and thrombotic native coronary arteries: Analysis from the X-TRACT trial
Tsuchiya Y, Lansky A, Costa R, Mehran R, Negoita M, Cristea E, Marginean H, Corral M, Tarawali M, Babb J, Cox D, Stone G. 830-5 The impact of myocardial blush grade on clinical outcomes of patients treated with saphenous vein grafts and thrombotic native coronary arteries: Analysis from the X-TRACT trial. Journal Of The American College Of Cardiology 2004, 43: a72. DOI: 10.1016/s0735-1097(04)90300-2.Peer-Reviewed Original Research
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