2021
Chapter 13 Assessment of female sex in preclinical vascular models
Gao M, Gorecka J, Liu J, Dardik A. Chapter 13 Assessment of female sex in preclinical vascular models. 2021, 349-385. DOI: 10.1016/b978-0-12-822959-0.00005-5.ChaptersAneurysm formationSequelae of atherosclerosisArteriovenous fistula maturationPathophysiology of atherosclerosisCause of deathPositive vessel remodelingAtherosclerotic complicationsFistula maturationFemale sexVenous remodelingClinical trialsInflammatory responseSex hormonesCardiovascular diseaseDisease outcomePreclinical studiesAnimal modelsProtective roleAtherosclerosisLipid metabolismVessel remodelingFemale animalsOxidative stressNational InstituteNumber of participants
2016
Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development
Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M. Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development 2016, 143: 4441-4451. PMID: 27789626, PMCID: PMC5201046, DOI: 10.1242/dev.140129.Peer-Reviewed Original ResearchConceptsLymphatic endothelial cellsPlanar cell polarity protein Vangl2Lymphatic vessel remodelingMouse embryonic developmentHuman lymphatic endothelial cellsVangl2 overexpressionVangl2 expressionEmbryonic developmentValve morphogenesisEndothelial cellsVasculature developmentSyndecan-4Lymphatic vasculatureFluid shear stressSDC4Double knockout miceMice resultsHigh expressionVessel remodelingLymphatic vesselsExpressionVangl2RemodelingCellsMorphogenesisEph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase
Wang M, Collins MJ, Foster TR, Bai H, Hashimoto T, Santana JM, Shu C, Dardik A. Eph-B4 mediates vein graft adaptation by regulation of endothelial nitric oxide synthase. Journal Of Vascular Surgery 2016, 65: 179-189. PMID: 26817610, PMCID: PMC4958608, DOI: 10.1016/j.jvs.2015.11.041.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell MovementCells, CulturedEnzyme InhibitorsEphrin-B2GenotypeHumansMice, Inbred C57BLMice, KnockoutNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIIPhenotypePhosphorylationReceptor, EphB4Saphenous VeinSignal TransductionTime FactorsVascular RemodelingVena Cava, InferiorConceptsEndothelial nitric oxide synthaseEphrin-B2/FcVein graft adaptationENOS knockout miceNitric oxide synthaseVein graftsGraft adaptationENOS phosphorylationENOS activityEph-B4Oxide synthaseKnockout miceWild-type vein graftsVessel remodelingWestern blotLess wall thickeningArginine methyl ester hydrochlorideMouse vein graftsNitric oxide productionLung endothelial cellsMouse lung endothelial cellsCell migrationLigand ephrin-B2Mechanism of actionMethyl ester hydrochloride
2009
Volumetric Intravascular Ultrasound Analysis of Paclitaxel-Eluting and Bare Metal Stents in Acute Myocardial Infarction
Maehara A, Mintz GS, Lansky AJ, Witzenbichler B, Guagliumi G, Brodie B, Kellett MA, Parise H, Mehran R, Stone GW. Volumetric Intravascular Ultrasound Analysis of Paclitaxel-Eluting and Bare Metal Stents in Acute Myocardial Infarction. Circulation 2009, 120: 1875-1882. PMID: 19858413, DOI: 10.1161/circulationaha.109.873893.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPaclitaxel-eluting stentsBare metal stentsElevation myocardial infarctionPositive vessel remodelingMyocardial infarctionVolume obstructionStent malappositionMetal stentsAcute Myocardial Infarction trialVessel remodelingVolumetric intravascular ultrasound analysisIntravascular ultrasound substudyMyocardial Infarction trialPrespecified end pointAcute myocardial infarctionBlinded core laboratoryNew aneurysm formationIntravascular ultrasound analysisMedian stent lengthDrug-eluting stentsPaclitaxel-ElutingThrombus protrusionUltrasound substudySymptom onset
2006
Safety of beta radiation exposure to the non-target segment: an intravascular ultrasound dosimetric analysis.
Kaneda H, Honda Y, Morino Y, Fox T, Crocker I, Lansky AJ, Yock PG, Bonan R, Fitzgerald PJ. Safety of beta radiation exposure to the non-target segment: an intravascular ultrasound dosimetric analysis. Journal Of Invasive Cardiology 2006, 18: 309-12. PMID: 16816435.Peer-Reviewed Original ResearchConceptsDosimetric analysisDistal segmentsRadiation exposureDistal reference sitesStent restenosis casesSignificant serial changesGreater radiation exposurePositive vessel remodelingRestenosis casesBeta radiation exposureLumen lossPositive remodelingCoronary arteryPlaque volumeGeographic missPlaque areaDistal vasculatureSerial changesPlaque massPlaque increasePrescribed doseVessel changesMild increaseMinimum doseVessel remodeling
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