2025
Contemporary understanding of myeloid-derived suppressor cells in the acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) tumor microenvironment
Alhajahjeh A, Stahl M, Kim T, Kewan T, Stempel J, Zeidan A, Bewersdorf J. Contemporary understanding of myeloid-derived suppressor cells in the acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) tumor microenvironment. Expert Review Of Anticancer Therapy 2025, 25: 435-456. PMID: 40122075, DOI: 10.1080/14737140.2025.2483855.Peer-Reviewed Original ResearchMyeloid-derived suppressor cellsAcute myeloid leukemiaMyelodysplastic syndromeSuppressor cellsTumor microenvironmentMyeloid leukemiaEffects of myeloid-derived suppressor cellsTargets myeloid-derived suppressor cellsLeukemic stem cell survivalRisk of leukemia relapseMDSC-targeted therapiesMDSC-mediated immunosuppressionBone marrow nicheStem cell survivalCytokine-mediated pathwaysLeukemia relapseMyeloid diseasesImprove patient outcomesMarrow nichePost-transplantationPreclinical modelsImmunosuppressive propertiesImmunosuppressive componentsFunctional reprogrammingImmune evasionLong-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease
Marmion D, Deng P, Hiller B, Lewis R, Harms L, Cameron D, Nolta J, Kordower J, Fink K, Wakeman D. Long-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease. Biology 2025, 14: 217. PMID: 40001985, PMCID: PMC11852092, DOI: 10.3390/biology14020217.Peer-Reviewed Original ResearchCentral nervous systemStriatum of Sprague-Dawley ratsForebrain GABAergic neuronsLong-term engraftmentHuman induced pluripotent stem cellsHuman neuronsSprague-Dawley ratsWild-type controlsPluripotent stem cellsPrefrontal cortexMature neuronal phenotypeRNU ratsHost striatumDisease in vivoGABAergic neuronsPost-transplantationImmunodeficient ratsIn vivo disease modelsIGABAHuntington's diseaseCynomolgus monkeysNeuronal phenotypeHD miceCNS environmentNeuronal survival
2024
Incidence of bacterial blood stream infections in patients with acute GVHD
Wallis W, Gulbis A, Wang T, Lee C, Sharma A, Williams K, Nishihori T, Prestidge T, Gowda L, Byrne M, Krem M, MacMillan M, Kitko C, Pidala J, Spellman S, Lee S, Alousi A. Incidence of bacterial blood stream infections in patients with acute GVHD. Bone Marrow Transplantation 2024, 60: 52-57. PMID: 39420192, PMCID: PMC11724748, DOI: 10.1038/s41409-024-02426-9.Peer-Reviewed Original ResearchBacterial bloodstream infectionsHematopoietic stem cell transplantationAcute GVHDNon-relapse mortalityGrade II-IV acute GVHDAllogeneic hematopoietic stem cell transplantationGrade III/IV acute GVHDBacterial blood stream infectionsAssociated with worse survivalStem cell transplantationBlood stream infectionsHigh-risk populationGVHD treatmentNeutrophil engraftmentBloodstream infectionsWorse survivalCell transplantationGI involvementOrgan involvementPost-transplantationPost-engraftmentRisk populationHigh riskPatientsGVHDMixed-field ABO front typing as an early sign of disease recurrence in ABO-matched stem cell transplantation
Yurtsever N, Lee E, Pinatti L, Shah B, Tormey C, Siddon A. Mixed-field ABO front typing as an early sign of disease recurrence in ABO-matched stem cell transplantation. Immunohematology 2024, 40: 89-92. PMID: 39373301, PMCID: PMC11700658, DOI: 10.2478/immunohematology-2024-013.Peer-Reviewed Original ResearchConceptsStem cell transplantationCell transplantationDisease recurrenceMyeloid neoplasmsChimerism testingAllogeneic stem cell transplantationSigns of disease recurrenceIndicator of disease recurrenceDonor-recipient pairsABO antigen expressionGraft statusAntigen expressionFemale patientsPost-transplantationAllograft statusTransplantationABO typeRecurrenceClinical settingEarly signsNeoplasmsChimerismEarly indicatorABOEngraftmentAttachment Styles and Quality of Life among Liver Transplant Recipients
Coskun A, Tosun S, Luo J, Zhang Y, Emre S, Zimbrean P. Attachment Styles and Quality of Life among Liver Transplant Recipients. Health Behavior And Policy Review 2024, 11: 1672-1686. DOI: 10.14485/hbpr.11.4.4.Peer-Reviewed Original ResearchQuality of lifeAttachment styleLiver transplant recipientsTransplant recipientsPatient-physician relationshipPresence of depressionCross-sectional studyPatients' attachment styleAssessed attachment styleChronic illnessQOL scoresQoLChronic painPsychological factorsRelationship styleAnxietyDepressionPost-transplantationLiver transplantationTransplant candidatesTransplantationAssociationRecipientsLiverStyleThe nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study
Heigl T, Kaes J, Aelbrecht C, Serré J, Yamada Y, Geudens V, Van Herck A, Vanstapel A, Sacreas A, Ordies S, Frick A, Gimenez B, Van Slambrouck J, Beeckmans H, Oztürk N, Orlitova M, Vaneylen A, Claes S, Schols D, Velde G, Schupp J, Kaminski N, Boesch M, Korf H, van der Merwe S, Dupont L, Vanoirbeek J, Godinas L, Van Raemdonck D, Janssens W, Gayan-Ramirez G, Ceulemans L, McDonough J, Verbeken E, Vos R, Vanaudenaerde B. The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study. Frontiers In Immunology 2024, 15: 1369536. PMID: 38736881, PMCID: PMC11084670, DOI: 10.3389/fimmu.2024.1369536.Peer-Reviewed Original ResearchConceptsChronic lung allograft dysfunctionChronic rejectionLung transplantationSingle cell RNASingle cell RNA profilingOrthotopic left lung transplantationComplications post-transplantationLung allograft dysfunctionMouse lung transplantationLeft lung transplantationLung transplantation studiesAllograft dysfunctionPleural infiltrationPost-transplantationBronchiolitis obliteransInnate inflammationChronic complicationsPrimary onsetEndothelial destructionTransplantationDay 7Immunological perspectiveArterial responseTransplantation studiesLungAtypical pneumonia testing in transplant recipients
Feller F, Trubin P, Malinis M, Vogel J, Merwede J, Peaper D, Azar M. Atypical pneumonia testing in transplant recipients. Transplant Infectious Disease 2024, 26: e14256. PMID: 38430482, DOI: 10.1111/tid.14256.Peer-Reviewed Original ResearchHematopoietic stem cell transplantationTransplant recipientsPathogens of pneumoniaAtypical pneumoniaAugmented immunosuppressionAtypical pathogensTest positivity rateChimeric antigen receptor T cellsHematopoietic stem cell transplant recipientsDiagnosis of atypical pneumoniaPositive rateCases of mycoplasma infectionStem cell transplantationSolid organ transplantationRetrospective cohort studyMycoplasma infectionImmunocompromised patientsCell transplantationAnalysis of diagnostic testsDiagnostic yieldTransplant cohortPost-transplantationT cellsCohort studyRates of testing
2022
Addressing Diaphragm Dysfunction in Lung Transplant Recipients: The Expanding Role of Diaphragm Pacing
Onders R, Elgudin Y, Abu-Omar Y, Pelletier M, Chavin K, Schilz R. Addressing Diaphragm Dysfunction in Lung Transplant Recipients: The Expanding Role of Diaphragm Pacing. The Journal Of Heart And Lung Transplantation 2022, 41: s431-s432. DOI: 10.1016/j.healun.2022.01.1089.Peer-Reviewed Original ResearchVentilator induced diaphragm dysfunctionPhrenic nerve injuryLung transplant recipientsMonths post-transplantDiaphragm dysfunctionDiaphragm pacingLung transplantationMechanical ventilationNerve injuryDiaphragm electromyographyTransplant recipientsPost-transplantPost-operativelyNerve recoveryPhrenic nerve recoveryYear post-transplantationTime of transplantationSustained hip fracturesCOVID-19 sepsisDiaphragm recoveryDiaphragmatic dysfunctionRemoval of electrodesRespiratory failurePost-transplantationUneventful recovery
2014
PRE-TRANSPLANT CHEMOTHERAPY DOES NOT AFFECT POST TRANSPLANT OUTCOME IN PATIENTS UNDERGOING OHT FOR AL CARDIOMYOPATHY
Sarswat N, Niehaus E, Tabtabai S, Stone J, Gilstrap L, Maurer M, Witteles R, Estep J, Baran D, Zucker M, Seldin D, Semigran M. PRE-TRANSPLANT CHEMOTHERAPY DOES NOT AFFECT POST TRANSPLANT OUTCOME IN PATIENTS UNDERGOING OHT FOR AL CARDIOMYOPATHY. Journal Of The American College Of Cardiology 2014, 63: a884. DOI: 10.1016/s0735-1097(14)60884-6.Peer-Reviewed Original Research
2012
Delayed graft function requiring more than one‐time dialysis treatment is associated with inferior clinical outcomes
Jayaram D, Kommareddi M, Sung R, Luan F. Delayed graft function requiring more than one‐time dialysis treatment is associated with inferior clinical outcomes. Clinical Transplantation 2012, 26: e536-e543. PMID: 23061763, DOI: 10.1111/ctr.12029.Peer-Reviewed Original ResearchConceptsDelayed graft functionIncidence of acute rejectionDelayed graft function patientsKidney transplant patientsClinical outcomesDialysis treatmentAcute rejectionTransplant patientsGraft functionComplication of deceased donor kidney transplantationDeceased donor kidney transplant patientsProlonged delayed graft functionAssociated with inferior clinical outcomesHigher incidence of acute rejectionSingle-center retrospective analysisAdult kidney transplant patientsEarly renal functionStudies of therapeutic approachesInferior clinical outcomesDeceased donor kidney transplantationDonor kidney transplantationKidney survivalDialysis requirementRenal functionPost-transplantation
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