2024
von Meyenburg complexes are more frequently associated with cholangiocarcinoma
Jain D, Khandakar B, Ni P, Kenney B, Qin L, Deshpande V, Fiel M. von Meyenburg complexes are more frequently associated with cholangiocarcinoma. Journal Of Clinical Pathology 2024, 78: 300-306. PMID: 38729770, DOI: 10.1136/jcp-2024-209572.Peer-Reviewed Original ResearchVon Meyenburg complexesHilar CCHepatic resectionCC casesChronic viral hepatitis BAssociated liver disordersMeyenburg complexesProgress to cholangiocarcinomaDysplasia/carcinoma in situMetastatic colon carcinomaViral hepatitis BCases of CCBile duct adenomaPolycystic kidney diseaseAssociated with cholangiocarcinomaBenign lesionsCryptogenic cirrhosisHepatitis BBiliary diseaseColon carcinomaMiscellaneous disordersKidney diseaseLiver diseaseCholangiocarcinomaLiver disorders
2019
Etiology of cirrhosis in the young
Olave MC, Gurung A, Mistry PK, Kakar S, Yeh M, Xu M, Wu TT, Torbenson M, Jain D. Etiology of cirrhosis in the young. Human Pathology 2019, 96: 96-103. PMID: 31698008, DOI: 10.1016/j.humpath.2019.09.015.Peer-Reviewed Original ResearchConceptsEtiology of cirrhosisCommon causeCryptogenic cirrhosisViral hepatitidesAge groupsMulti-institutional retrospective studyYears age group childrenIncidence of cirrhosisCause of cirrhosisFatty liver diseaseDiagnosis of cirrhosisAge group childrenCongenital cholestatic diseasesClinical chartsYounger patientsLiver diseasePathology databaseRetrospective studyCholestatic diseasePathology reportsCirrhosisMetabolic disordersPatientsScant dataYoung adultsCryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine
Nalbantoglu I, Jain D. Cryptogenic cirrhosis: Old and new perspectives in the era of molecular and genomic medicine. Seminars In Diagnostic Pathology 2019, 36: 389-394. PMID: 31395291, DOI: 10.1053/j.semdp.2019.07.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCryptogenic cirrhosisCC casesLiver diseaseUnknown etiologyMain histologic findingsPossible genetic counselingChronic liver diseaseWhole-exome sequencingCirrhosis casesPediatric patientsTransplant eligibilityHistologic findingsHistologic patternPotential etiologiesHistologic examinationHistologic characterizationGenetic testingEtiologyPatientsExome sequencingDiagnostic abilityGenetic counselingGenetic alterationsDiagnosisNew disorder
2008
Liver Involvement in Systemic Lupus Erythematosus: Case Review of 40 Patients
Chowdhary VR, Crowson CS, Poterucha JJ, Moder KG. Liver Involvement in Systemic Lupus Erythematosus: Case Review of 40 Patients. The Journal Of Rheumatology 2008, 35: 2159-2164. PMID: 18793002, DOI: 10.3899/jrheum.080336.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEndstage liver diseaseLiver diseasePortal hypertensionLiver involvementViral hepatitisLupus erythematosusLiver disease-free survivalNonalcoholic fatty liver diseaseCoexistent liver diseaseSubclinical liver involvementDevelopment of cirrhosisLiver enzyme abnormalitiesAlanine aminotransferase levelsDisease-free survivalRetrospective chart reviewCohort of patientsFatty liver diseasePrimary biliary cirrhosisAlkaline phosphatase levelsClinical diagnostic groupsAutoimmune hepatitisCryptogenic cirrhosisHepatitis CAminotransferase levelsA decision analysis study of the value of a liver biopsy in nonalcoholic steatohepatitis
Gaidos JK, Hillner BE, Sanyal AJ. A decision analysis study of the value of a liver biopsy in nonalcoholic steatohepatitis. Liver International 2008, 28: 650-658. PMID: 18331241, DOI: 10.1111/j.1478-3231.2008.01693.x.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseLiver biopsyLiver diseasePrevalence of NAFLDEarly liver biopsyPrevalent clinical syndromeTransplant-eligible patientsAdvanced liver diseaseInitial liver biopsyFatty liver diseaseSeverity of diseaseCryptogenic cirrhosisEligible patientsEarly biopsyLiver histologyDecision analysis studiesNonalcoholic steatohepatitisSurgical interventionClinical syndromeEarly treatmentStudy groupLB groupMortality rateBiopsy categoriesLower mortality
2006
Familial Aggregation of Insulin Resistance in First-Degree Relatives of Patients With Nonalcoholic Fatty Liver Disease
Abdelmalek M, Liu C, Shuster J, Nelson D, Asal N. Familial Aggregation of Insulin Resistance in First-Degree Relatives of Patients With Nonalcoholic Fatty Liver Disease. Clinical Gastroenterology And Hepatology 2006, 4: 1162-1169. PMID: 16901766, DOI: 10.1016/j.cgh.2006.06.001.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseFirst-degree relativesFatty liver diseaseCryptogenic cirrhosisDiabetes mellitusLiver diseaseGenetic predispositionRisk of DMFamilial clusteringFirst-degree family membersBody mass indexInsulin resistance syndromeSignificant survival differenceExpression of IRWarrants further investigationNAFLD patientsMass indexResistance syndromeInsulin resistanceMedical historySurvival differencesHealthy controlsCardiac diseaseRenal stonesFamilial aggregation studies
2005
40 THE NATURAL HISTORY OF CRYPTOGENIC CIRRHOSIS FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION: A HISTORICAL COHORT STUDY
Abdelmalek M, Mudaliar K, Liu C, Reed A, Nelson D, Asal N, Stacpoole P. 40 THE NATURAL HISTORY OF CRYPTOGENIC CIRRHOSIS FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION: A HISTORICAL COHORT STUDY. Journal Of Investigative Medicine 2005, 53: s393. DOI: 10.2310/6650.2005.00205.39.Peer-Reviewed Original ResearchNonalcoholic fatty liver diseaseLiver transplantationCryptogenic cirrhosisSteatosis gradeClinical dataMean age 53Repeat liver transplantationYr post-LTFatty liver diseaseInsulin resistance syndromeCardiovascular disease deathsPost-LTPre-LTMELD scoreGlycemic controlHDL cholesterolLiver biopsyInflammatory activityLDL cholesterolLiver diseaseDisease deathsResistance syndromeSingle pathologistClinicopathologic correlationRisk factors
2002
Thrombendvenectomy for Organized Portal Vein Thrombosis at the Time of Liver Transplantation
Molmenti EP, Roodhouse TW, Molmenti H, Jaiswal K, Jung G, Marubashi S, Sanchez EQ, Gogel B, Levy MF, Goldstein RM, Fasola CG, Elliott EE, Bursac N, Mulligan D, Gonwa TA, Klintmalm GB. Thrombendvenectomy for Organized Portal Vein Thrombosis at the Time of Liver Transplantation. Annals Of Surgery 2002, 235: 292-296. PMID: 11807371, PMCID: PMC1422428, DOI: 10.1097/00000658-200202000-00019.Peer-Reviewed Original ResearchConceptsPortal vein thrombosisGraft survival ratesTime of transplantationLiver transplantationVein thrombosisMale patientsFemale patientsLiver diseasePortal veinControl groupSurvival rateEnd-stage liver diseaseOrthotopic liver transplantOrthotopic liver transplantationFirst postoperative dayIntensive care unitLength of stayCryptogenic cirrhosisDaily aspirinPVT groupPVT patientsTacrolimus immunosuppressionLiver transplantTransplant recipientsPostoperative day
1981
Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study
Haines N, Baker A, Boyer J, Glagov S, Schneir H, Jaspan J, Ferguson D. Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study. Hepatology 1981, 1: 161-167. PMID: 7286895, DOI: 10.1002/hep.1840010212.Peer-Reviewed Original ResearchConceptsJejunoileal bypassInactive cirrhosisWeight lossHepatic injuryLiver biopsyPericentral fibrosisClinical liver failureOral nutritional supplementationAlcoholic liver diseaseSerum aspartate aminotransferaseGreater weight lossRapid weight lossCryptogenic cirrhosisRefractory obesityAsymptomatic patientsOlder patientsLiver failureLiver injuryLiver diseaseParenteral alimentationFatty infiltrationHistologic evidenceProspective studyPrognostic indicatorClinical evaluation
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