2023
Evolving Therapeutic Roles of Nasogastric Tubes: Current Concepts in Clinical Practice
Vadivelu N, Kodumudi G, Leffert L, Pierson D, Rein L, Silverman M, Cornett E, Kaye A. Evolving Therapeutic Roles of Nasogastric Tubes: Current Concepts in Clinical Practice. Advances In Therapy 2023, 40: 828-843. PMID: 36637690, PMCID: PMC9838367, DOI: 10.1007/s12325-022-02406-9.Peer-Reviewed Original ResearchConceptsNasogastric tubeShort-term parenteral nutritionTerm parenteral nutritionManagement of complicationsAdministration of medicationsMultiple medical specialtiesTechnique of insertionResuscitative toolBowel obstructionParenteral nutritionChronic careTherapeutic roleClinical practiceComplicationsSurgical specialtiesCurrent conceptsMedical specialtiesRecent updatesCorrect positioningSpecialtiesContraindicationsMedicationsObstructionStomachAdministration
2021
Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor
Pang K, Ghim M, Liu C, Tay H, Fhu C, Chia R, Qiu B, Sarathchandra P, Chester A, Yacoub M, Wilkinson F, Weston R, Warboys C, Hou H, Weinberg P, Wang X. Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor. Frontiers In Cell And Developmental Biology 2021, 9: 706143. PMID: 34291056, PMCID: PMC8288075, DOI: 10.3389/fcell.2021.706143.Peer-Reviewed Original ResearchTumor necrosis factor receptor 1Critical limb ischemiaSera of patientsEndothelial activationEndothelial cellsLRG1 expressionElevated serum concentrationsPotential therapeutic roleLeucine-Rich αTumor necrosis factorTNF-α receptorWild-type miceEndothelial cell activationNecrosis factor receptor 1Role of LRG1NF-κB activationNF-κB signalingFactor receptor 1STNFR1 concentrationCLI patientsLimb ischemiaSerum concentrationsHealthy controlsInflammatory diseasesTherapeutic roleVitamin E Improves Neurite Complexity by Enhancing Mitochondrial Function
Park H, Crowe-White K, Davis A, Bannerman S, Burnett G, Scott M, Broman K, Lackey K, Licznerski P, Jonas E. Vitamin E Improves Neurite Complexity by Enhancing Mitochondrial Function. Current Developments In Nutrition 2021, 5: 5140915. PMCID: PMC8181647, DOI: 10.1093/cdn/nzab049_028.Peer-Reviewed Original ResearchPost-translational cleavagePrimary hippocampal neuronsBcl-xLMitochondrial functionHippocampal neuronsNeurite complexityNeurite outgrowthOxidative stressProtein levelsPotential therapeutic roleProtein Bcl-xLVitamin E familyATP/ADP ratioNormal physiological developmentNovel functionBrain injuryTherapeutic roleReal-time PCRSholl analysisNew synapsesNeurobasal mediumATP productionNeurite injuryControl groupVitamin E
2020
Endoscopic ultrasound (EUS) and the management of pancreatic cancer
Yousaf MN, Chaudhary FS, Ehsan A, Suarez AL, Muniraj T, Jamidar P, Aslanian HR, Farrell JJ. Endoscopic ultrasound (EUS) and the management of pancreatic cancer. BMJ Open Gastroenterology 2020, 7: e000408. PMID: 32414753, PMCID: PMC7232396, DOI: 10.1136/bmjgast-2020-000408.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Pancreatic DuctalCholangiopancreatography, Endoscopic RetrogradeEarly DiagnosisEndosonographyFemaleGastroenterologyHumansInterdisciplinary CommunicationMaleMedical OncologyPancreatic NeoplasmsPatient Care ManagementPrevalenceRadiologyRandomized Controlled Trials as TopicSensitivity and SpecificityStentsSurgical OncologyConceptsManagement of patientsPancreatic cancerEndoscopic ultrasoundIdentification of patientsCancer-related mortalityPancreatic ductal adenocarcinomaSurgical candidatesMedical oncologyPancreatic malignancyDuctal adenocarcinomaRadiological imagingTherapeutic roleSurgical oncologyDiagnostic evaluationEarly diagnosisMultidisciplinary involvementInterventional endoscopyCancerPatientsWestern countriesOncologyManagementAdenocarcinomaMalignancyEndoscopyImpaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine
Mishra PK, Adusumilli M, Deolal P, Mason GF, Kumar A, Patel AB. Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine. Neurochemistry International 2020, 137: 104750. PMID: 32360130, DOI: 10.1016/j.neuint.2020.104750.Peer-Reviewed Original ResearchConceptsChronic unpredictable mild stressCUMS micePrefrontal cortexChronic unpredictable mild stress (CUMS) modelNeurotransmitter cyclingThree-compartment metabolic modelUnpredictable mild stressCause of disabilityNMDA receptor antagonistPotential therapeutic roleMajor depressive disorderAstrocytic TCA cycleNeural metabolic activityMetabolic activityGABAergic neuronsInhibitory neurotransmissionReceptor antagonistSwim testSucrose preferenceC57BL6 miceDepressive disorderTherapeutic roleChronic depressionGlutamatergic pathwaysMetabolic deficitsThe Long‐Term Effects of Acupuncture on Hippocampal Functional Connectivity in aMCI with Hippocampal Atrophy: A Randomized Longitudinal fMRI Study
Li H, Wang Z, Yu H, Pang R, Ni H, Li C, Li K. The Long‐Term Effects of Acupuncture on Hippocampal Functional Connectivity in aMCI with Hippocampal Atrophy: A Randomized Longitudinal fMRI Study. Neural Plasticity 2020, 2020: 1-9. DOI: 10.1155/2020/6389368.Peer-Reviewed Original ResearchHippocampal functional connectivityAmnestic mild cognitive impairmentAcupuncture treatmentAcupuncture groupLong-term effectsFunctional magnetic resonance imagingFunctional connectivityControl groupAMCI patientsWhole-brain FC analysisResting-state functional magnetic resonance imagingResting-state fMRI scanningLongitudinal fMRI studyMagnetic resonance imagingHealthy control participantsMild cognitive impairmentMiddle temporal gyrusAcupuncture patientsHippocampal atrophyTherapeutic roleRight hippocampusBilateral caudateFC strengthAcupunctureCognitive decline
2019
Hidradenitis suppurativa Current and emerging treatments
Goldburg S, Strober B, Payette M. Hidradenitis suppurativa Current and emerging treatments. Journal Of The American Academy Of Dermatology 2019, 82: 1061-1082. PMID: 31604100, DOI: 10.1016/j.jaad.2019.08.089.Peer-Reviewed Original ResearchConceptsHidradenitis suppurativaPathogenesis of HSNumerous clinical trialsPotential therapeutic roleMedical education seriesAnticytokine therapyTreatment optionsHS pathogenesisClinical trialsTherapeutic roleNovel therapiesNew therapiesTherapyPathogenesisEducation seriesRecent studiesTreatmentSuppurativaSurgeryCytokinesEtiologyTrials
2018
QOLP-04. THE EVOLVING ROLE OF COMPLEMENTARY CANNABIS THERAPY IN GLIOBLASTOMA TREATMENT
Blondin N. QOLP-04. THE EVOLVING ROLE OF COMPLEMENTARY CANNABIS THERAPY IN GLIOBLASTOMA TREATMENT. Neuro-Oncology 2018, 20: vi214-vi215. PMCID: PMC6217477, DOI: 10.1093/neuonc/noy148.890.Peer-Reviewed Original ResearchOverall survivalCannabis therapyTherapeutic cannabisPalliative useMedian ageCare treatmentGBM patientsSignificant adverse eventsTime period 2Time period 1Diagnosis dateAdverse eventsPatient ageSurvival benefitTumor characteristicsTherapeutic roleTreatment strategiesPatientsAnimal modelsHuman patientsGlioblastoma treatmentTherapeutic treatmentCannabis useTherapyGlioblastomaCoagulopathies and inflammatory diseases: ‘…glimpse of a Snark’
del Carmen S, Hapak SM, Ghosh S, Rothlin CV. Coagulopathies and inflammatory diseases: ‘…glimpse of a Snark’. Current Opinion In Immunology 2018, 55: 44-53. PMID: 30268838, PMCID: PMC6366937, DOI: 10.1016/j.coi.2018.09.005.BooksConceptsAnti-pathogen defenseUnderlying molecular basisInflammatory diseasesMolecular basisSelective pressureHost defense mechanismsSubset of patientsDefense mechanismsVertebratesRegulation of inflammationHuman populationThrombophilic stateTherapeutic roleDefenseDiseaseInvertebratesCoagulopathyInflammationPhysical injuryMutationsRegulationPathogensCascadeApixabanThrombophilia
2017
PALL-07. COMPLEMENTARY CANNABIS THERAPY FOR MALIGNANT GLIOMA: INITIAL EXPERIENCE
Blondin N. PALL-07. COMPLEMENTARY CANNABIS THERAPY FOR MALIGNANT GLIOMA: INITIAL EXPERIENCE. Neuro-Oncology 2017, 19: vi169-vi169. PMCID: PMC5692009, DOI: 10.1093/neuonc/nox168.688.Peer-Reviewed Original ResearchMalignant glioma patientsCannabis treatmentGlioma patientsCannabis therapyInitial experienceTherapeutic useBeneficial palliative effectBrain tumor symptomsCertain medical conditionsLow usePalliative useStandard therapyTumor symptomsOral sprayTherapeutic roleMalignant gliomasPalliative effectMild fatigueAnaplastic astrocytomaMedical conditionsAstrocytoma casesGlioblastoma patientsPatientsSide effectsAnimal models
2016
Safety and Outcome of Microincision Vitreous Surgery in Uveitis
Bansal R, Gupta A, Gupta V, Mulkutkar S, Dogra M, Katoch D, Dogra M, Sharma K, Singh M, Sharma A, Kamal S, Sharma S. Safety and Outcome of Microincision Vitreous Surgery in Uveitis. Ocular Immunology And Inflammation 2016, 25: 775-784. PMID: 27191861, DOI: 10.3109/09273948.2016.1165259.Peer-Reviewed Original ResearchConceptsBest-corrected visual acuityMicroincision vitreous surgeryVitreous haze gradeHaze gradeVitreous surgeryMean follow-upWorsening of inflammationEpiretinal membraneVitreous hemorrhageRetinal detachmentIntraocular pressureVisual acuityPostoperative complicationsPostoperative evaluationMean ageFollow-upUveitisTherapeutic roleSurgeryComplicationsMonthsOutcomesGradeHypotonyAcuity
2015
Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050
Naganawa M, Dickinson GL, Zheng MQ, Henry S, Vandenhende F, Witcher J, Bell R, Nabulsi N, Lin SF, Ropchan J, Neumeister A, Ranganathan M, Tauscher J, Huang Y, Carson RE. Receptor Occupancy of the κ-Opioid Antagonist LY2456302 Measured with Positron Emission Tomography and the Novel Radiotracer 11C-LY2795050. Journal Of Pharmacology And Experimental Therapeutics 2015, 356: 260-266. PMID: 26628406, PMCID: PMC4727157, DOI: 10.1124/jpet.115.229278.Peer-Reviewed Original ResearchConceptsHours postdosePositron emission tomographyReceptor occupancyEmission tomographySerious adverse eventsSingle oral dosesImportant therapeutic roleΚ-opioid receptorsSubstance abuse disordersFurther clinical testingHealthy human subjectsMultilinear analysis-1 (MA1) methodAntagonist radiotracersAdverse eventsOral dosesBrain penetrationTherapeutic rolePlasma concentrationsAbuse disordersEthanol consumptionLY2456302Clinical testingNovel radiotracersAlcohol dependenceDistribution volume
2014
Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling
Zhao Y, Liu B, Tian Q, Wei J, Richbourgh B, Liu C. Progranulin protects against osteoarthritis through interacting with TNF-α and β-Catenin signalling. Annals Of The Rheumatic Diseases 2014, 74: 2244-2253. PMID: 25169730, PMCID: PMC4408266, DOI: 10.1136/annrheumdis-2014-205779.Peer-Reviewed Original ResearchConceptsPGRN-deficient miceProgression of OAOA modelTumor necrosis factor αMechanism of progranulinRecombinant PGRN proteinArthritis mouse modelOA-like phenotypeRole of progranulinNecrosis factor αPathogenesis of OAJoint degenerative diseaseTNF receptor 2Degradation of cartilageExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Β-catenin signalingInflammatory actionsOA progressionAnabolic biomarkersAnabolic effectsOA developmentSafranin O stainingTherapeutic roleMouse model
2013
Therapeutic Role of Bmi-1 Inhibitors in Eliminating Prostate Tumor Stem Cells
Kim I, Bertino J, Sabaawy H. Therapeutic Role of Bmi-1 Inhibitors in Eliminating Prostate Tumor Stem Cells. 2013 DOI: 10.21236/ada598365.Peer-Reviewed Original ResearchProstate tumor-initiating cellsTumor-initiating cellsBmi-1Stem cellsTreatment of zebrafishCancer cell senescenceMouse xenograftsZebrafish xenograft modelCell cycle arrestG1 cell cycle arrestCellular senescenceTranslational inhibitorBmi-1 expressionTumor stem cellsCell senescenceCycle arrestCurrent therapiesTherapeutic roleProstate cancerInvasion abilityTherapeutic strategiesXenograft modelCD44hi cellsTumor growthMetastatic potentialClaudins, dietary milk proteins, and intestinal barrier regulation
Kotler BM, Kerstetter JE, Insogna KL. Claudins, dietary milk proteins, and intestinal barrier regulation. Nutrition Reviews 2013, 71: 60-65. PMID: 23282252, DOI: 10.1111/j.1753-4887.2012.00549.x.BooksConceptsDietary milk proteinsIntestinal barrier regulationClaudin expressionIntestinal barrier dysfunctionIntestinal barrier functionLimited clinical studiesClaudin-4 expressionGrowth factor βMechanism of actionBarrier dysfunctionIntestinal barrierTherapeutic roleClinical studiesBarrier functionDietary proteinFactor βTight junctionsBarrier regulationClaudin proteinsRecent studiesProtein componentsExpressionMilk protein componentsMilk proteinsProtein
2012
The use of rhDNAse in severely ill, non-intubated adult asthmatics refractory to bronchodilators: A pilot study
Silverman RA, Foley F, Dalipi R, Kline M, Lesser M. The use of rhDNAse in severely ill, non-intubated adult asthmatics refractory to bronchodilators: A pilot study. Respiratory Medicine 2012, 106: 1096-1102. PMID: 22580235, DOI: 10.1016/j.rmed.2012.04.002.Peer-Reviewed Original ResearchConceptsAcute asthmaSevere acute asthmaSevere asthma episodesUse of rhDNasePrimary study endpointNon-fatal casesPost-randomization time pointsViscoelasticity of sputumBronchodilator therapyIpratropium treatmentPlacebo patientsSymptomatic asthmaticsFatal asthmaAdult asthmaticsClinical improvementMucous pluggingIll adultsStudy endpointStandardized careAsthma episodesEmergency departmentClinical trialsTherapeutic roleMucolytic agentTreatment groups
2010
Cyclosporin A therapy for Henoch–Schönlein nephritis with nephrotic-range proteinuria
Park J, Won S, Shin J, Yim H, Pai K. Cyclosporin A therapy for Henoch–Schönlein nephritis with nephrotic-range proteinuria. Pediatric Nephrology 2010, 26: 411-417. PMID: 21184240, DOI: 10.1007/s00467-010-1723-7.Peer-Reviewed Original ResearchConceptsHenoch-Schonlein nephritisNephrotic-range proteinuriaDiagnosis of Henoch-Schonlein purpuraHenoch-Schonlein purpuraCyA treatmentCyA dependenceDuration of CyA treatmentMean follow-up timeEnd-stage renal diseaseCyclosporin A therapyFollow-up durationFollow-up timeRenal functionA therapyMean durationRenal diseaseProteinuriaPoor complianceCyclosporin ATherapeutic rolePatientsCyACyA.CyclosporineNephritisAldosterone and inflammation
Gilbert KC, Brown NJ. Aldosterone and inflammation. Current Opinion In Endocrinology Diabetes And Obesity 2010, 17: 199-204. PMID: 20422780, PMCID: PMC4079531, DOI: 10.1097/med.0b013e3283391989.Peer-Reviewed Original ResearchConceptsMineralocorticoid receptorAngiotensin subtype 1 receptorAldosterone-induced inflammationMineralocorticoid receptor activationVascular collagen depositionMineralocorticoid receptor antagonistsSubtype 1 receptorInflammatory cell infiltrationVascular smooth muscle cellsAldosterone synthase inhibitorsNuclear factor-kappaBSmooth muscle cellsCell-specific effectsInflammatory phenotypeReceptor antagonistTissue inflammationCell infiltrationTherapeutic roleCollagen depositionSynthase inhibitorAldosteroneFactor-kappaBInflammationReceptor activationMuscle cells
2009
StAR Overexpression Decreases Serum and Tissue Lipids in Apolipoprotein E‐deficient Mice
Ning Y, Xu L, Ren S, Pandak WM, Chen S, Yin L. StAR Overexpression Decreases Serum and Tissue Lipids in Apolipoprotein E‐deficient Mice. Lipids 2009, 44: 511-519. PMID: 19373502, PMCID: PMC2911774, DOI: 10.1007/s11745-009-3299-1.Peer-Reviewed Original ResearchConceptsDeficient miceApolipoprotein ESerum HDL cholesterolSerum total cholesterolTreatment of dyslipidemiaPossible therapeutic roleSudan IV stainingMonths of ageNeutral lipid stainingSteroidogenic acute regulatory proteinDecreases SerumHDL cholesterolTotal cholesterolTriglyceride levelsAcute regulatory proteinTherapeutic roleStAR protein expressionCholesterol metabolismAnimal modelsAortic wallTissue lipidsLipid accumulationMiceRecombinant cytomegalovirusesLipid homeostasis
2008
Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation
Hao Z, Huang Y, Cleman J, Jovin IS, Vale WW, Bale TL, Giordano FJ. Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 3939-3944. PMID: 18308934, PMCID: PMC2268793, DOI: 10.1073/pnas.0712366105.Peer-Reviewed Original ResearchConceptsInhibits tumor growthTumor growthTumor vascularizationActivation of CRFR2Potential therapeutic roleTumor growth inhibitionTumor-suppressing effectsCRFR2 activationMeasurable tumorsTumor cell cyclingCell tumorsTherapeutic roleClinical malignancyUrocortin 2Peripheral tissuesCRFR2Ucn2Genetic deletionTissue vascularityDirect inhibitionVessel diameterCell proliferationVessel numberVascularizationTumors
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