2012
The use of rhDNAse in severely ill, non-intubated adult asthmatics refractory to bronchodilators: A pilot study
Silverman RA, Foley F, Dalipi R, Kline M, Lesser M. The use of rhDNAse in severely ill, non-intubated adult asthmatics refractory to bronchodilators: A pilot study. Respiratory Medicine 2012, 106: 1096-1102. PMID: 22580235, DOI: 10.1016/j.rmed.2012.04.002.Peer-Reviewed Original ResearchConceptsAcute asthmaSevere acute asthmaSevere asthma episodesUse of rhDNasePrimary study endpointNon-fatal casesPost-randomization time pointsViscoelasticity of sputumBronchodilator therapyIpratropium treatmentPlacebo patientsSymptomatic asthmaticsFatal asthmaAdult asthmaticsClinical improvementMucous pluggingIll adultsStudy endpointStandardized careAsthma episodesEmergency departmentClinical trialsTherapeutic roleMucolytic agentTreatment groups
1987
A reappraisal of the United Kingdom epidemic of fatal asthma. Can general mortality data implicate a therapeutic agent?
Esdaile J, Feinstein A, Horwitz R. A reappraisal of the United Kingdom epidemic of fatal asthma. Can general mortality data implicate a therapeutic agent? JAMA Internal Medicine 1987, 147: 543-9. PMID: 3827432, DOI: 10.1001/archinte.147.3.543.Peer-Reviewed Original ResearchConceptsAsthma deathsMortality dataEpidemic of asthma deathsInternational mortality dataScientific evidenceNonprescription salesYoung personAffecting young personsAsthmaUnited KingdomFatal asthmaEcological studiesNonprescriptionOriginal associationNew ZealandDeathEpidemicAerosolized bronchodilatorsBronchodilatorUnitsAssociationWales
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