2025
AAnet resolves a continuum of spatially-localized cell states to unveil intratumoral heterogeneity.
Venkat A, Youlten S, San Juan B, Purcell C, Gupta S, Amodio M, Neumann D, Lock J, Westacott A, McCool C, Burkhardt D, Benz A, Mollbrink A, Lundeberg J, van Dijk D, Holst J, Goldstein L, Kummerfeld S, Krishnaswamy S, Chaffer C. AAnet resolves a continuum of spatially-localized cell states to unveil intratumoral heterogeneity. Cancer Discovery 2025 PMID: 40552975, DOI: 10.1158/2159-8290.cd-24-0684.Peer-Reviewed Original ResearchGenomic and proteomic predictors of sites of metastases in renal cell carcinoma.
Steiner C, Saad E, Machaalani M, Saliby R, Eid M, Semaan K, Yekeduz E, Ascione L, Horst J, Lee J, Phillips N, Trowbridge R, Lee G, Harel M, Dicker A, McGregor B, Braun D, McKay R, Choueiri T, Xu W. Genomic and proteomic predictors of sites of metastases in renal cell carcinoma. Journal Of Clinical Oncology 2025, 43: 4538-4538. DOI: 10.1200/jco.2025.43.16_suppl.4538.Peer-Reviewed Original ResearchSite of metastasisRenal cell carcinomaDana-Farber Cancer InstituteMetastatic sitesLymph node metastasisLymph nodesCell carcinomaNode metastasisProteomic predictorsInstitutional cohort of patientsSites of RCC metastasisMetastatic renal cell carcinomaAssociated with bone metastasisAssociated with liver metastasisTwo-sided Fisher's exact testAssociated with lymph node metastasisCancer-specific outcomesPairwise comparison of patientsMetastasis to lungMultivariate modelTumor genomic alterationsCohort of patientsIndependent external cohortComparison of patientsAssociated with lungPrediction of Lymph Node Metastasis in Non–Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data
Lee V, Moore N, Doyle J, Hicks D, Oh P, Bodofsky S, Hossain S, Patel A, Aneja S, Homer R, Park H. Prediction of Lymph Node Metastasis in Non–Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data. JCO Clinical Cancer Informatics 2025, 9: e2400303. PMID: 40446175, DOI: 10.1200/cci-24-00303.Peer-Reviewed Original ResearchThis study investigates machine learning models using tumor genetic data to predict lymph node metastasis in lung cancer, showing improved accuracy over traditional methods and more potential for personalized treatment.
2024
A Comparison of Machine Learning Models to Predict Lymph Node Metastasis with Primary Tumor Transcriptome in Non-Small Cell Lung Cancer
Lee V, Park H, Aneja S, Patel A. A Comparison of Machine Learning Models to Predict Lymph Node Metastasis with Primary Tumor Transcriptome in Non-Small Cell Lung Cancer. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: e638. DOI: 10.1016/j.ijrobp.2024.07.1402.Peer-Reviewed Original ResearchNon-small cell lung cancerLymph nodal metastasisCell lung cancerMedian AUCNodal metastasisPrimary tumorEndobronchial ultrasoundNon-small cell lung cancer stagingLung cancerDiagnostic uncertaintyPrediction of nodal metastasisPET-avid lesionsTreatment strategy formulationPrimary lung adenocarcinomaEBUS-guided biopsiesLymph node metastasisPrimary tumor tissuesReceiver operating characteristic curveTumor transcriptomic dataPET-CTNode metastasisNeedle aspirationCT scanNon-smallClinical decision-makingLymph node metastasis prediction with non-small cell lung cancer histopathology imaging.
Lee V, King A, Sritharan D, Moore N, Chadha S, Maresca R, Hager T, Aneja S. Lymph node metastasis prediction with non-small cell lung cancer histopathology imaging. Journal Of Clinical Oncology 2024, 42: 8063-8063. DOI: 10.1200/jco.2024.42.16_suppl.8063.Peer-Reviewed Original ResearchNon-small cell lung cancerLymph nodal metastasisNational Lung Screening TrialLymph node metastasisNodal metastasisNode metastasisEndobronchial ultrasound-guided transbronchial needle aspirationUltrasound-guided transbronchial needle aspirationTreatment strategy formulationTransbronchial needle aspirationCell lung cancerDistant metastasis statusLymph node metastasis predictionPrimary tumor dataHematoxylin and eosin (H&EInvasive diagnostic techniquesInfluence clinical decisionsN0 diseaseN3 diseaseEosin (H&EPrimary resectionDistant metastasisPET-CTNeedle aspirationCT scanArtificial Intelligence Helps Pathologists Increase Diagnostic Accuracy and Efficiency in the Detection of Breast Cancer Lymph Node Metastases
Retamero J, Gulturk E, Bozkurt A, Liu S, Gorgan M, Moral L, Horton M, Parke A, Malfroid K, Sue J, Rothrock B, Oakley G, DeMuth G, Millar E, Fuchs T, Klimstra D. Artificial Intelligence Helps Pathologists Increase Diagnostic Accuracy and Efficiency in the Detection of Breast Cancer Lymph Node Metastases. The American Journal Of Surgical Pathology 2024, 48: 846-854. PMID: 38809272, PMCID: PMC11191045, DOI: 10.1097/pas.0000000000002248.Peer-Reviewed Original ResearchConceptsLymph node metastasisNode metastasisDetection of lymph node metastasesBreast cancer lymph node metastasisMetastasis detection rateWhole slide imagesBreast cancer stageArtificial intelligenceIncrease diagnostic accuracyReading pathologistsCancer stageDiagnostic accuracyMetastasisCancer metastasisAverage reading timeBreastPathologistsDetection rateAI algorithmsImmune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer
Michikawa C, Gleber-Netto F, Pickering C, Rao X, Wang J, Sikora A, Myers J, Frederick M. Immune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer. Oral Oncology 2024, 153: 106729. PMID: 38663156, DOI: 10.1016/j.oraloncology.2024.106729.Peer-Reviewed Original ResearchConceptsOral cavity squamous cell carcinomaAssociated with clinical outcomesExtranodal extensionLymph node metastasisImmune infiltrationImmune infiltration statusOverall survivalPrimary tumorNode metastasisOral cancerInfiltration statusClinical outcomes of OSCC patientsExtension of lymph node metastasesAssociated with clinical outcomes of patientsAssociated with OS rateLocally advanced oral cancerClinical outcomes of patientsOutcome of OSCC patientsAssociated with poor overall survivalImmune infiltration of tumorsLow immune infiltrationNode negative tumorsAdvanced oral cancerHuman papillomavirus-negativeInfiltration of tumorsPrognostic significance of tumour budding in noncolorectal gastrointestinal tract and pancreatobiliary tract: a systematic review and meta‐analysis
Park J, Shin J, Lim B. Prognostic significance of tumour budding in noncolorectal gastrointestinal tract and pancreatobiliary tract: a systematic review and meta‐analysis. Histopathology 2024, 84: 1079-1091. PMID: 38362762, DOI: 10.1111/his.15154.Peer-Reviewed Original ResearchConceptsHigh-grade tumor buddingTumor buddingOverall survivalClinicopathological featuresMeta-analysisHazard ratioOdds ratioBiliary tract adenocarcinomaOesophageal squamous cell carcinomaSquamous cell carcinomaLymph node metastasisPancreatobiliary tract cancerStandard criteriaAdverse clinicopathological featuresPooled odds ratioPancreatic ductal adenocarcinomaConfidence intervalsNewcastle-Ottawa ScaleLymphovascular invasionDistant metastasisPrognostic factorsPrognostic rolePrognostic significanceCell carcinomaNode metastasis
2023
Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review
Bernasconi M, Bilic A, Kauke-Navarro M, Safi A. Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review. Frontiers In Oral Health 2023, 4: 1229931. PMID: 37654649, PMCID: PMC10467257, DOI: 10.3389/froh.2023.1229931.Peer-Reviewed Original ResearchOral squamous cell carcinomaNodal tumor volumeSquamous cell carcinomaPrognostic factorsPrognostic significanceCell carcinomaTumor volumeSystematic reviewAccurate nodal stagingLymph node metastasisNodal disease burdenNovel prognostic factorPoor survival outcomesPoor survival rateTraditional staging methodsNode metastasisSurvival outcomesNodal stagingDisease burdenInclusion criteriaPrognostic assessmentOSCC managementElectronic databasesSurvival rateMajority of studiesTP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study
Wadia R, McHenry A, Abi-Raad R, Hui P. TP53 Mutation-driven Stratified Mucin-producing Carcinoma Coexisting With Squamous Cell Carcinoma of the Vulva: A Case Study. International Journal Of Gynecological Pathology 2023, 42: 555-560. PMID: 37255422, DOI: 10.1097/pgp.0000000000000961.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaInvasive squamous cell carcinomaVulvar intraepithelial neoplasiaCell carcinomaIntraepithelial neoplasiaLichen sclerosusAssociated with high-risk human papillomavirus infectionHigh-risk human papillomavirus infectionDifferentiated vulvar intraepithelial neoplasiaPresence of lymphovascular invasionInguinal lymph node metastasisHuman papillomavirus infectionVulvar lichen sclerosusMucin-producing carcinomaLymph node metastasisIntraepithelial lesionsLymphovascular invasionTP53 mutationsNode metastasisPapillomavirus infectionNeoplastic componentsCarcinomaUnique caseTP53Sclerosus
2022
Larynx Cancer
Fan D, Kang J, Yu Y, Cahlon O, Riaz N, Lee N. Larynx Cancer. Practical Guides In Radiation Oncology 2022, 45-60. DOI: 10.1007/978-3-030-99590-4_4.Peer-Reviewed Original ResearchPostoperative radiotherapyLarynx cancerEarly stage squamous cell carcinomaOrgan preservation therapyEarly-stage diseaseLymph node metastasisAdvanced larynx cancerSquamous cell carcinomaStandard of careHigh-risk casesPre-treatment evaluationCommon clinical scenariosThin-cut CTPET/CTDefinitive chemoradiotherapyAdvanced diseaseLocoregional recurrencePreservation therapyGlottic larynxNode metastasisSubglottic extensionCell carcinomaLaryngeal cancerPhysical examOrgan preservationIncreased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated With Lymphovascular Invasion and Lymph Node Metastasis
Dolezal D, Zhang X, Harigopal M. Increased Expression of LEF1 and β-Catenin in Invasive Micropapillary Carcinoma of the Breast is Associated With Lymphovascular Invasion and Lymph Node Metastasis. Applied Immunohistochemistry & Molecular Morphology 2022, 30: 557-565. PMID: 35960138, DOI: 10.1097/pai.0000000000001052.Peer-Reviewed Original ResearchConceptsInvasive micropapillary breast carcinomaLymph node metastasisLymphoid enhancer-binding factor 1Lymphovascular invasionNode metastasisNodal metastasisPrimary tumorΒ-cateninBreast tumorsRare breast cancer subtypeSmall tumor cell clustersLEF1 expressionMicropapillary breast carcinomaAggressive breast tumorsBasal-like carcinomasInvasive micropapillary carcinomaΒ-catenin expression levelsBreast cancer subtypesΒ-catenin expressionTumor cell clustersEnhancer-binding factor 1Disease relapseMicropapillary carcinomaBreast carcinomaHigh incidenceThe Role of Surgery in Managing Primary and Metastatic Colorectal Cancer
Straker R, Witmer H, Deschner B, Shibata D, Turaga K, Mahmoud N. The Role of Surgery in Managing Primary and Metastatic Colorectal Cancer. 2022, 407-419. DOI: 10.1007/978-3-030-93084-4_38.Peer-Reviewed Original ResearchMetastatic colorectal cancerColorectal cancerPrognostic implicationsLymph nodesDetection of regional lymph node metastasesArea of active ongoing researchManagement of metastatic colorectal cancerRegional lymph node metastasisManagement of peritoneal metastasesAnalysis of tumor specimensHepatic CRC metastasesHyperthermic intraperitoneal chemotherapyHarvested lymph nodesLymph node evaluationLymph node metastasisEra of precision medicineCytoreductive surgeryIntraperitoneal chemotherapyPeritoneal metastasisSurgical resectionAdjuvant therapyTumor specimensSurvival benefitNode metastasisSurgical management
2021
Pathologic Examination of Pancreatic Specimens Resected for Treated Pancreatic Ductal Adenocarcinoma
Wang H, Chetty R, Hosseini M, Allende D, Esposito I, Matsuda Y, Deshpande V, Shi J, Dhall D, Jang K, Kim G, Luchini C, Graham R, Reid M, Basturk O, Hruban R, Krasinskas A, Klimstra D, Adsay V, Society F. Pathologic Examination of Pancreatic Specimens Resected for Treated Pancreatic Ductal Adenocarcinoma. The American Journal Of Surgical Pathology 2021, 46: 754-764. PMID: 34889852, PMCID: PMC9106848, DOI: 10.1097/pas.0000000000001853.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaTreating pancreatic ductal adenocarcinomaCollege of American PathologistsPancreatectomy specimensPathological evaluationTumor responseTumor sizePancreatic specimensDuctal adenocarcinomaAccurate tumor size measurementTumor size measurementsLymph node metastasisAmpulla of VaterNeoadjuvant therapyTumor dimensionNode metastasisPeripancreatic tissuePathological examinationImmunohistochemical markersConsensus guidelinesTumor cellsGrossing protocolsInterobserver concordanceOptimal patient careCancer protocolsA machine‐learning modified CART algorithm informs Merkel cell carcinoma prognosis
Cheraghlou S, Sadda P, Agogo GO, Girardi M. A machine‐learning modified CART algorithm informs Merkel cell carcinoma prognosis. Australasian Journal Of Dermatology 2021, 62: 323-330. PMID: 34028790, DOI: 10.1111/ajd.13624.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseMerkel cell carcinomaPositive lymph node countLymph node countPositive nodesDistant metastasisValidation cohortRare neuroendocrine skin cancerRetrospective cohort studyEnd Results registryLymph node biopsyLymph node metastasisThree-year survivalNeuroendocrine skin cancerNovel prognostic factorHigh mortality rateNode countAJCC groupsMCC stagingSEER cohortCohort studyMCC patientsNode biopsyPrognostic factorsNode metastasisExtent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage.
Paulson N, Vollmer RT, Humphrey PA, Sprenkle PC, Onofrey J, Huber S, Amirkhiz K, Levi AW. Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage. Archives Of Pathology & Laboratory Medicine 2021, 146: 201-204. PMID: 34015819, DOI: 10.5858/arpa.2020-0568-oa.Peer-Reviewed Original ResearchConceptsMpMRI-targeted biopsiesHigh-grade prostatic adenocarcinomaMultiparametric magnetic resonance imagingHG PCaRadical prostatectomyHigh-grade groupMagnetic resonance imagingPathologic stageRP outcomesProstatic adenocarcinomaGrade Group 2 diseaseResonance imagingGrade groupProstate-confined diseaseSeminal vesicle involvementLymph node metastasisHigher pathologic stageAdditional predictive valueLogistic regression modelsLinear millimeterNode metastasisRetrospective reviewAdverse outcomesTargeted biopsiesProstate biopsyAdjuvant Chemotherapy for T4 Non-Small Cell Lung Cancer with Additional Ipsilateral Lung Nodules
Li AX, Flores K, Canavan ME, Boffa DJ, Blasberg JD. Adjuvant Chemotherapy for T4 Non-Small Cell Lung Cancer with Additional Ipsilateral Lung Nodules. The Annals Of Thoracic Surgery 2021, 113: 421-428. PMID: 33684345, DOI: 10.1016/j.athoracsur.2021.02.042.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerDifferent ipsilateral lobeCell lung cancerAdditional tumor nodulesT4 non-small cell lung cancerAdjuvant chemotherapyIpsilateral lobeT4 diseaseTumor nodulesLung cancerT4 tumorsOverall survivalSurgical resectionIIIA non-small cell lung cancerAdjuvant multiagent chemotherapyResectable stage IINational Cancer DatabaseFurther prospective studiesLymph node metastasisMultiagent chemotherapyNode metastasisPrimary outcomeProspective studyPatient populationCancer Database
2020
Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination
Sundar R, Liu D, Hutchins G, Slaney H, Silva A, Oosting J, Hayden J, Hewitt L, Ng C, Mangalvedhekar A, Ng S, Tan I, Tan P, Grabsch H. Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination. Gut 2020, 70: 1823-1832. PMID: 33229445, PMCID: PMC8458060, DOI: 10.1136/gutjnl-2020-320805.Peer-Reviewed Original ResearchConceptsPrimary gastric cancerLymph node metastasisPrimary tumorGastric cancerIntratumour heterogeneityNode metastasisMatched lymph node metastasesRegional lymph node metastasisMultiplex ligation-dependent probe amplificationLigation-dependent probe amplificationPatient-matchedProgressive genomic changesDNA copy number profilesEndoscopic mucosal biopsiesCopy number profilesTherapeutically relevant genesLocoregional metastasesTumor disseminationResected samplesTargeted therapyHistomorphological phenotypesProbe amplificationBiomarker testingClinical trialsNanoString resultsCXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer
Nagaya N, Lee G, Horie S, Kim I. CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer. Frontiers In Molecular Biosciences 2020, 7: 579874. PMID: 33195424, PMCID: PMC7593595, DOI: 10.3389/fmolb.2020.579874.Peer-Reviewed Original ResearchLymph node metastasisPrimary prostate cancerChemokines/receptorsMetastatic prostate cancerNode metastasisProstate cancerReceptor expressionMetastatic sitesChemokine/receptor axisMultivariate logistic regression analysisLog-rank test resultsLogistic regression analysisCancer Genome AtlasBone metastasesIndependent predictorsLymph nodesPostoperative recurrenceDistant metastasisCXCL10 expressionMRNA expression dataReceptor axisMetastasisTeam databaseLow expressionCancer progressionMeta-analysis of the clinicopathological significance of miRNA-145 in breast cancer
Lv P, Zhang Z, Hou L, Zhang Y, Lu L, Wang C, Shi F. Meta-analysis of the clinicopathological significance of miRNA-145 in breast cancer. Bioscience Reports 2020, 40: bsr20193974. PMID: 32869851, PMCID: PMC7502658, DOI: 10.1042/bsr20193974.Peer-Reviewed Original ResearchConceptsMiR-145 expressionBreast cancer patientsBreast cancerStandardized mean differenceBreast cancer tissuesAdjacent normal tissuesMiR-145Cancer patientsTumor suppressor miRNACancer tissuesLow expressionNormal tissuesLymph node metastasisUnfavorable prognostic factorLargest tumor diameterSuppressor miRNALower miR-145Normal breast tissueWeb of ScienceNode metastasisPrognostic factorsHealthy womenTumor diameterClinicopathological significanceEligible studies
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