2021
Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas
Benhamida J, Vyas M, Tanaka A, Wang L, Bahrami A, Ozcan K, Basturk O, Villafania L, Mata D, El Jabbour T, Selenica P, Roehrl M, Weigelt B, Reis-Filho J, Scaltriti M, Klimstra D. Pancreatoblastomas and mixed and pure acinar cell carcinomas share epigenetic signatures distinct from other neoplasms of the pancreas. Modern Pathology 2021, 35: 956-961. PMID: 34969956, PMCID: PMC10319432, DOI: 10.1038/s41379-021-00989-2.Peer-Reviewed Original ResearchConceptsGenome-wide array platformsAcinar cell carcinomaGenomic methylation signaturesPancreatic neuroendocrine tumorsSolid pseudopapillary neoplasmCell carcinomaNeuroendocrine tumorsMethylation profilesDuctal adenocarcinomaEpigenetic relationshipsMethylation signaturesEpigenetic signaturesEpigenetic levelAcinar differentiationCellular differentiationDistinct clustersPseudopapillary neoplasmArray platformCellular lineagesPancreatic ductal adenocarcinomaPancreatic tissue samplesNeuroendocrine lineNormal pancreatic tissuesDifferentiationAdenocarcinoma clusters
2014
Pathology and genetics of pancreatic neoplasms with acinar differentiation
Wood L, Klimstra D. Pathology and genetics of pancreatic neoplasms with acinar differentiation. Seminars In Diagnostic Pathology 2014, 31: 491-497. PMID: 25441307, PMCID: PMC4316670, DOI: 10.1053/j.semdp.2014.08.003.Peer-Reviewed Original ResearchConceptsPancreatic neoplasmsAcinar differentiationAcinar cell carcinomaConventional ductal adenocarcinomaFamily of neoplasmsTherapeutically targetable mutationsAcinar growth patternGranular eosinophilic cytoplasmMolecular dataAcinar neoplasmsGenomic instabilityRare mutationsGenetic alterationsCell carcinomaTargeted mutationEosinophilic cytoplasmPoor prognosisDuctal adenocarcinomaHistological featuresMutationsNeoplastic cellularityNeoplasmsLineage markersUniform nucleiPathological featuresWhole‐exome sequencing of pancreatic neoplasms with acinar differentiation
Jiao Y, Yonescu R, Offerhaus G, Klimstra D, Maitra A, Eshleman J, Herman J, Poh W, Pelosof L, Wolfgang C, Vogelstein B, Kinzler K, Hruban R, Papadopoulos N, Wood L. Whole‐exome sequencing of pancreatic neoplasms with acinar differentiation. The Journal Of Pathology 2014, 232: 428-435. PMID: 24293293, PMCID: PMC4048021, DOI: 10.1002/path.4310.Peer-Reviewed Original ResearchMeSH KeywordsAcinar CellsBiomarkers, TumorCarcinoma, Acinar CellCell DifferentiationChromosomes, HumanDNA Mutational AnalysisDNA, NeoplasmExomeFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedMutationPancreatic NeoplasmsPhenotypeConceptsFluorescence in situ hybridizationChromosomal levelPancreatic carcinomaAcinar differentiationSomatic mutationsGenetic alterationsWhole-exome sequencing analysisFamilial pancreatic ductal adenocarcinomaWhole-exome sequencingPancreatic neoplasmsSurgically resected pancreatic carcinomaIndividual base pairsResectable pancreatic carcinomaSequence analysisAcinar cell carcinomaTargetable genetic alterationsBase pairsPancreatic ductal adenocarcinomaConstitutional alterationsGenesCell carcinomaMutationsPoor prognosisDuctal adenocarcinomaPALB2
2012
The Prevalence of Pancreatic Acinar Differentiation in Gastric Adenocarcinoma
Lee H, Tang L, Veras E, Klimstra D. The Prevalence of Pancreatic Acinar Differentiation in Gastric Adenocarcinoma. The American Journal Of Surgical Pathology 2012, 36: 402-408. PMID: 22082608, DOI: 10.1097/pas.0b013e318238369e.Peer-Reviewed Original ResearchConceptsGastric adenocarcinomaPancreatic acinar differentiationAcinar differentiationImmunohistochemical stainingCases of gastric adenocarcinomaConventional gastric adenocarcinomaPancreatic acinar metaplasiaTissue microarray sectionsHeterotopic pancreatic tissueWhole tissue sectionsFocal mucin productionHistologically unusual casesPancreatic exocrine enzymesEquivocal stainingNeuroendocrine stainingMicroarray sectionsTissue microarrayImmunohistochemical featuresAcinar metaplasiaUnusual casePositive stainingGastric carcinomaAdenocarcinomaGastric cancerChronic gastritisAcinar cell carcinoma of the pancreas and related neoplasms: a review
Basturk O, Klimstra D. Acinar cell carcinoma of the pancreas and related neoplasms: a review. Diagnostic Histopathology 2012, 18: 8-16. DOI: 10.1016/j.mpdhp.2011.10.011.Peer-Reviewed Original ResearchAcinar cell carcinomaCell carcinomaDuctal adenocarcinomaStroma-poor tumorsTime of diagnosisRare tumorLocalized diseaseAggressive tumorsAllelic lossPancreatic neoplasmsDuctal elementsScattered individual cellsMolecular alterationsChromosome 11pAcinar differentiationKRAS oncogeneNeuroendocrine elementsSheet-like arrangementPancreatic enzymesTumorExocrine pancreasAcinar structuresCarcinomaAdenocarcinomaMetastasis
2005
Composite Glandular and Endocrine Tumors of the Stomach With Pancreatic Acinar Differentiation
Jain D, Eslami-Varzaneh F, Takano AM, Ayer U, Umashankar R, Muller R, Klimstra DS. Composite Glandular and Endocrine Tumors of the Stomach With Pancreatic Acinar Differentiation. The American Journal Of Surgical Pathology 2005, 29: 1524-1529. PMID: 16224221, DOI: 10.1097/01.pas.0000169498.89035.f9.Peer-Reviewed Original ResearchConceptsPancreatic acinar differentiationGlandular componentAbdominal painCytokeratin 20Endocrine tumorsCytokeratin 7Acinar differentiationEndocrine componentElevated serum lipase levelsPerigastric lymph nodesSerum lipase levelsExocrine pancreatic enzymesIntestinal goblet cellsColumnar epithelial cellsGastrointestinal hemorrhageLymph nodesAcute pancreatitisClinicopathologic findingsGastric foveolarLipase levelsPrimary tumorGastric neoplasmsComposite tumorImmunohistochemical stainsPancreatic polypeptide
2001
Acinar Cell Carcinoma of the Pancreas: A Case Associated With the Lipase Hypersecretion Syndrome
Klimstra D, Adsay N. Acinar Cell Carcinoma of the Pancreas: A Case Associated With the Lipase Hypersecretion Syndrome. Advances In Anatomic Pathology 2001, 6: 121-126. DOI: 10.1097/00132583-200105000-00008.Peer-Reviewed Original ResearchAcinar cell carcinomaCell carcinomaHypersecretion syndromePrimary tumorTumor cellsAbsence of hepatic metastasesDegree of nuclear pleomorphismSubcutaneous fat necrosisHypercellular patternSurgical resectionHepatic metastasesAggressive tumorsNuclear pleomorphismFat necrosisDuctal adenocarcinomaHistological featuresTumorAcinar differentiationCarcinomaAcinar architectureSyndromePancreasEnzyme productionZymogen granulesCells
2000
Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: Study of five cases, one arising in a mediastinal teratoma
Cingolani N, Shaco-Levy R, Farruggio A, Klimstra D, Rosai J. Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: Study of five cases, one arising in a mediastinal teratoma. Human Pathology 2000, 31: 938-944. PMID: 10987254, DOI: 10.1053/hupa.2000.9075.Peer-Reviewed Original ResearchConceptsAlpha-fetoprotein productionAlpha-fetoproteinMediastinal teratomaPancreatic tumorsCases of pancreatic neoplasmsProduction of alpha-fetoproteinAcinar cell carcinomaAcinar cell differentiationCell carcinomaSerum elevationImmunohistochemical featuresPancreatic neoplasmsOrthotopic pancreasPancreatic componentAcinar differentiationTumorBetter-documented casesTeratomaCell differentiationYoung adults
1995
Pancreatoblastoma A Clinicopathologic Study and Review of the Literature
Klimstra D, Wenig B, Adair C, Heffess C. Pancreatoblastoma A Clinicopathologic Study and Review of the Literature. The American Journal Of Surgical Pathology 1995, 19: 1371-1389. PMID: 7503360, DOI: 10.1097/00000478-199512000-00005.Peer-Reviewed Original ResearchConceptsDied of tumorGood response to chemotherapyRare pancreatic tumorResponse to chemotherapyIncidental abdominal massCases of pancreatoblastomaPlump spindle cellsAbdominal massPancreatic tumorsObstructive jaundicePediatric patientsSquamoid corpusclesPediatric groupDuctal differentiationSpindle cellsAdult patientsSquamous appearanceIntracellular mucinCarcinoembryonic antigenDuctular formationAcinar differentiationTumorFemale casesPancreatoblastomaEpithelial cells
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