2021
Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden
Wei L, Christensen SR, Fitzgerald ME, Graham J, Hutson ND, Zhang C, Huang Z, Hu Q, Zhan F, Xie J, Zhang J, Liu S, Remenyik E, Gellen E, Colegio OR, Bax M, Xu J, Lin H, Huss WJ, Foster BA, Paragh G. Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden. Science Advances 2021, 7: eabd7703. PMID: 33523857, PMCID: PMC7775785, DOI: 10.1126/sciadv.abd7703.Peer-Reviewed Original ResearchConceptsSkin cancer riskCancer burdenCancer riskCutaneous squamous cell carcinomaNormal human skin samplesClonal mutationsCarcinogenic effectsSun-exposure statusSquamous cell carcinomaSkin cancer burdenCell carcinomaClonal cell growthNormal skinHuman skin samplesUV exposureUltradeep sequencingUV-induced mutationsSkin samplesCell growthSkinBurdenRiskMutationsExposureUV damage
2020
Getting Under the Skin: Targeting Cutaneous Autoimmune Disease.
Vesely MD. Getting Under the Skin: Targeting Cutaneous Autoimmune Disease. The Yale Journal Of Biology And Medicine 2020, 93: 197-206. PMID: 32226348, PMCID: PMC7087062.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCutaneous autoimmune diseasesAutoimmune diseasesCutaneous autoimmunityImmune systemEffector armT cellsTherapeutic strategiesChimeric autoantibody receptor T cellsRegulatory armLow-dose interleukin-2Regulatory T cellsExcessive immune activationReceptor T cellsGreater treatment efficacyBroad immunosuppressantsCytokine blockadeTolerogenic vaccinesCostimulatory blockadeDisease remissionImmune activationInflammatory pathwaysImmune homeostasisInterleukin-2Treatment efficacyNormal skin
2015
Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection
Esaki H, Ewald DA, Ungar B, Rozenblit M, Zheng X, Xu H, Estrada YD, Peng X, Mitsui H, Litman T, Suárez-Fariñas M, Krueger JG, Guttman-Yassky E. Identification of novel immune and barrier genes in atopic dermatitis by means of laser capture microdissection. Journal Of Allergy And Clinical Immunology 2015, 135: 153-163. PMID: 25567045, PMCID: PMC4452382, DOI: 10.1016/j.jaci.2014.10.037.Peer-Reviewed Original ResearchConceptsNonlesional AD skinLaser capture microdissectionAD transcriptomeNormal skinAD skinNonlesional skinNovel ImmuneCapture microdissectionAtopic dermatitis lesionsBarrier genesPossible cellular sourcesAtopic dermatitisHealthy volunteersEpidermal alterationsBarrier phenotypeCellular sourceImmune moleculesCellular subsetsDermatitis lesionsImmuneDermal compartmentSkinGenomic profilesPatientsMolecular signatures
2010
Viability and Burden of Leishmania in Extralesional Sites during Human Dermal Leishmaniasis
Romero I, Téllez J, Suárez Y, Cardona M, Figueroa R, Zelazny A, Saravia N. Viability and Burden of Leishmania in Extralesional Sites during Human Dermal Leishmaniasis. PLOS Neglected Tropical Diseases 2010, 4: e819. PMID: 20856851, PMCID: PMC2939031, DOI: 10.1371/journal.pntd.0000819.Peer-Reviewed Original ResearchConceptsLeishmaniasis patientsExtralesional sitesNormal skinTonsil swabsViable parasitesDissemination of LeishmaniaMucocutaneous leishmaniasis patientsMonocyte samplesPositive samplesLuciferase activityParasite viabilitySkin aspiratesActive diseaseDermal leishmaniasisHuman leishmaniasisBlood monocytesEpidemiologic investigationsPatientsLeishmania DNAParasite burdenHuman infectionsIntracellular amastigotesLesionsSwabsEpidemiological significance
2009
Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid.
Galan A, Hui P, McNiff JM. Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid. International Journal Of Clinical And Experimental Pathology 2009, 2: 456-62. PMID: 19294004, PMCID: PMC2655157.Peer-Reviewed Original ResearchHuman herpesvirus 8Presence of HHV8Cases of PVBullous pemphigoidPemphigus vulgarisCases of pemphigusHerpesvirus 8Cases of BPAutoimmune vesiculobullous disordersBasement membrane antigensPolymerase chain reaction techniqueAutoimmune attackChain reaction techniqueHHV8 DNAVesiculobullous diseaseVesiculobullous disordersImmunohistochemical expressionVesicobullous disordersSerologic dataImmunohistochemical localizationMembrane antigenPemphigoidNormal skinPemphigusConfirmatory PCR
2008
Substantial Alterations of the Cutaneous Bacterial Biota in Psoriatic Lesions
Gao Z, Tseng C, Strober B, Pei Z, Blaser M. Substantial Alterations of the Cutaneous Bacterial Biota in Psoriatic Lesions. PLOS ONE 2008, 3: e2719. PMID: 18648509, PMCID: PMC2447873, DOI: 10.1371/journal.pone.0002719.Peer-Reviewed Original ResearchConceptsPsoriatic lesionsHealthy personsIdiopathic inflammatory disorderNormal skin samplesBroad-range PCRPsoriatic patientsInflammatory disordersUninvolved skinPsoriatic skinCutaneous samplesNormal skinPatientsLesion samplesNormal personsSubstantial alterationsLesionsPropionibacterium speciesSkin samplesPsoriasisSkinSpecies-level operational taxonomic unitsRDNA PCRAlterationsExtracted DNARange PCRSuppressor role of activating transcription factor 2 (ATF2) in skin cancer
Bhoumik A, Fichtman B, DeRossi C, Breitwieser W, Kluger HM, Davis S, Subtil A, Meltzer P, Krajewski S, Jones N, Ronai Z. Suppressor role of activating transcription factor 2 (ATF2) in skin cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 1674-1679. PMID: 18227516, PMCID: PMC2234203, DOI: 10.1073/pnas.0706057105.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneActivating Transcription Factor 2AnimalsApoptosisbeta CateninCarcinogensCell ProliferationCyclin D1DNAEpidermisKeratinocytesMiceMice, KnockoutPapillomaPresenilin-1Proto-Oncogene Proteins c-mybReceptor, Notch1Skin NeoplasmsTetradecanoylphorbol AcetateTissue Array AnalysisTumor Suppressor ProteinsConceptsSkin tumor formationTranscription factor 2Two-stage skin carcinogenesis protocolTumor formationBasal cell carcinomaSkin carcinogenesis protocolFactor 2K14-Cre miceCell carcinomaCarcinogenesis protocolMouse modelBeta-catenin expressionPapilloma developmentSkin cancerExhibit reduced expressionAnchorage-independent growthNormal skinNotch1 expressionCyclin D1MiceReduced expressionSuppressor roleSuppressor activitySelective expressionBasal layer
2006
Evidence for Leishmania (Viannia) Parasites in the Skin and Blood of Patients Before and After Treatment
Vergel C, Palacios R, Cadena H, Posso CJ, Valderrama L, Perez M, Walker J, Travi BL, Saravia NG. Evidence for Leishmania (Viannia) Parasites in the Skin and Blood of Patients Before and After Treatment. The Journal Of Infectious Diseases 2006, 194: 503-511. PMID: 16845635, DOI: 10.1086/505583.Peer-Reviewed Original ResearchConceptsPeripheral blood monocytesAmerican cutaneous leishmaniasisCutaneous leishmaniasisLeishmania parasitesUnaffected skinAnthroponotic transmissionAcquisition of infectionBlood of patientsSource of infectionSand fliesAdult patientsLesion scarTreatment failureAntimonial drugsPatientsNormal skinLeishmaniasisMonocytesZoonotic diseaseLesion bordersSkinTreatmentMolecular detection methodsPositive resultsInfection
2003
Nephrogenic fibrosing dermopathy: the first 6 years
Cowper SE. Nephrogenic fibrosing dermopathy: the first 6 years. Current Opinion In Rheumatology 2003, 15: 785-790. PMID: 14569211, DOI: 10.1097/00002281-200311000-00017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNephrogenic fibrosing dermopathyRecent case reportsCase reportCutaneous fibrosing disorderYellow scleral plaquesDistinct clinical patternsDual immunohistochemical stainingAntiphospholipid antibodiesRenal insufficiencyClinical patternDual immunolabelingFibrosing disorderSystemic disordersClinical spectrumScleral plaquesDisease onsetEpidemiologic dataSpindle cellsImmunohistochemical stainingDisease triggersSkin conditionsDisease pathogenesisNormal skinRegistry projectDiagnostic tests
1999
Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors
Asgari M, Haggerty J, McNiff J, Milstone L, Schwartz P. Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors. Journal Of Cutaneous Pathology 1999, 26: 287-294. PMID: 10472757, DOI: 10.1111/j.1600-0560.1999.tb01846.x.Peer-Reviewed Original ResearchConceptsPlatelet-derived endothelial cell growth factorThymidine phosphorylase/platelet-derived endothelial cell growth factorPD-ECGF expressionEndothelial cell growth factorCutaneous tumorsPD-ECGFCell carcinomaCell growth factorGrowth factorSquamous cell carcinomaMerkel cell carcinomaBasal cell carcinomaVariety of tumorsCell of originNuclei of keratinocytesFollicular infundibulumTumor degreeDifferentiation of keratinocytesEccrine poromaImmunohistochemical analysisPositive stainingIntradermal nevusNormal skinTumorsIntense staining
1998
Skin precancer.
Brash DE, Pontén J. Skin precancer. Cancer Surveys 1998, 32: 69-113. PMID: 10489624.ChaptersConceptsTP53 mutationsClonal expansionCell carcinomaHair follicle originHigh-risk papillomasRegression of dysplasiaTP53 mutant clonesSquamous cell carcinomaBasal cell carcinomaRegression of melanomaCell of originPrecancerous eventsBCC tumorsMelanoma cell linesGenetics of melanomaPrecancerous lesionsRelative riskFamilial predispositionSuch lesionsImmunosuppressant drugsDysplastic naeviNormal skinPrecancerChemotherapeutic agentsMelanoma
1997
A Model of Corrective Gene Transfer in X-Linked Ichthyosis
Freiberg R, Choate K, Deng H, Alperin E, Shapiro L, Khavari P. A Model of Corrective Gene Transfer in X-Linked Ichthyosis. Human Molecular Genetics 1997, 6: 927-933. PMID: 9175741, DOI: 10.1093/hmg/6.6.927.Peer-Reviewed Original ResearchConceptsSTS protein expressionCorrective gene deliveryDefective skin barrier functionSkin barrier functionSTS expressionCorrective gene transferBarrier function parametersCutaneous gene deliveryGenetic skin disordersImmunodeficient miceHistologic appearanceSame patientNormal controlsHyperkeratotic epidermisSkin disordersLoss of functionNormal skinPatientsBarrier functionXLI patientsProtein expressionPrimary keratinocytesPatient skin tissueCutaneous gene therapyHuman epidermis
1996
Corrective gene transfer in the human skin disorder lamellar ichthyosis
Choate K, Medalie D, Morgan J, Khavari P. Corrective gene transfer in the human skin disorder lamellar ichthyosis. Nature Medicine 1996, 2: 1263-1267. PMID: 8898758, DOI: 10.1038/nm1196-1263.Peer-Reviewed Original ResearchConceptsLamellar ichthyosisImmunodeficient mouse xenograft modelPrimary pathophysiologic defectMouse xenograft modelAbnormal epidermal differentiationCorrective gene transferCutaneous gene deliveryPathophysiologic defectsLI patientsEpidermal differentiationFunctional abnormalitiesPotential future approachesImmunodeficient miceXenograft modelSkin diseasesCutaneous barrierDifferentiation marker filaggrinFunction measuresNormal skinEpidermal barrierPatient's skinPrimary keratinocytesPatientsSkinHuman skinSunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.
Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. Journal Of Investigative Dermatology Symposium Proceedings 1996, 1: 136-42. PMID: 9627707.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSquamous cell carcinomaCell carcinomaActinic keratosisBasal cell carcinomaHuman skin cancerP53 tumor suppressor geneP53-mutated cellsSunburn cellsApoptotic keratinocytesSkin cancerP53 mutationsNormal skinTumor initiatorTumor promotionFunction of p53Cellular proofreadingTumor suppressor geneCarcinomaMouse skinClonal expansionP53 geneCarcinogenic DNA lesionsP53 allelePrecancerous cellsSunlight exposure
1994
Immunofluorescent analysis of the basement membrane zone in lichen planus suggests destruction of the lamina lucida in bullous lesions
Smoller B, Glusac E. Immunofluorescent analysis of the basement membrane zone in lichen planus suggests destruction of the lamina lucida in bullous lesions. Journal Of Cutaneous Pathology 1994, 21: 123-128. PMID: 8040461, DOI: 10.1111/j.1600-0560.1994.tb00246.x.Peer-Reviewed Original ResearchConceptsBasement membrane zoneLichen planusMembrane zoneLymphocytic infiltrateBullous lesionsBullous pemphigoid antigenIntense lymphocytic infiltrateLamina lucida regionPemphigoid antigenNormal staining patternInflammatory dermatosesDermal-epidermal junctionFocal decreasePlanusType IV collagenNormal skinLesionsStaining patternEpidermal junctionImmunofluorescent analysisType VIIInfiltratesIV collagenLamina lucidaAntigen
1993
Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture.
Petzelbauer P, Bender JR, Wilson J, Pober JS. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. The Journal Of Immunology 1993, 151: 5062-72. PMID: 7691964, DOI: 10.4049/jimmunol.151.9.5062.Peer-Reviewed Original ResearchConceptsVCAM-1 expressionDermal microvascular endothelial cellsSuperficial vascular plexusAdhesion molecule-1 expressionDeep vascular plexusMolecule-1 expressionIL-1IL-4Molecule expressionVascular bedAntigen expressionCD36 expressionEndothelial leukocyte adhesion molecule-1 expressionELAM-1Normal skinEndothelial cell antigen expressionCytokine responsivenessVascular cell adhesion molecule-1 expressionVascular plexusCapillary loopsCell adhesion molecule-1 expressionParticular vascular bedEndothelial leukocyte adhesion moleculeAdhesion molecule expressionSites of inflammation
1991
The Use of Immunohistologic Analysis in Differentiating Cutaneous T-cell Lymphoma From Psoriasis and Dermatitis
Verga M, Braverman I. The Use of Immunohistologic Analysis in Differentiating Cutaneous T-cell Lymphoma From Psoriasis and Dermatitis. JAMA Dermatology 1991, 127: 1503-1510. PMID: 1929457, DOI: 10.1001/archderm.1991.01680090067006.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaCTCL lesionsImmunohistologic analysisEarly-stage cutaneous T-cell lymphomaBenign inflammatory diseaseImmunohistologic patternsDR antibodiesHLA-DRBiopsy specimensInflammatory diseasesPsoriatic lesionsImmunoperoxidase techniquePsoriatic skinDermatitic lesionsExtensive stainingPsoriasisNormal skinDermatitisLesionsPatientsMonoclonal antibodiesEpidermal areaLymphomaAntibodies
1989
Angiogenic properties of normal and psoriatic skin associate with epidermis, not dermis.
Malhotra R, Stenn K, Fernandez L, Braverman I. Angiogenic properties of normal and psoriatic skin associate with epidermis, not dermis. Laboratory Investigation 1989, 61: 162-5. PMID: 2474089.Peer-Reviewed Original ResearchConceptsPsoriatic patientsPsoriatic plaque skinInflammatory cellsVascular proliferationPsoriatic lesionsPsoriatic skinNormal subjectsSkin diseasesDay 2Nonpsoriatic skinNormal skinPatient's skinAngiogenic activityAngiogenic stimuliVessel growthAngiogenic propertiesDermisNew vesselsAngiogenic assaysSkinPsoriasisVessel formationPatientsEpidermal growthLesions
1988
Local effects of UV radiation on immunization with contact sensitizers. I. Down-regulation of contact hypersensitivity by application of TNCB to UV-irradiated skin.
Cruz P, Nixon-Fulton J, Tigelaar R, Bergstresser P. Local effects of UV radiation on immunization with contact sensitizers. I. Down-regulation of contact hypersensitivity by application of TNCB to UV-irradiated skin. Photodermatology Photoimmunology & Photomedicine 1988, 5: 126-32. PMID: 3174491.Peer-Reviewed Original ResearchConceptsContact hypersensitivityNon-irradiated skinNormal skinApplication of trinitrochlorobenzeneEar-swelling responseUVB-treated miceUV-irradiated skinDaily dosesSuccessful immunizationContact sensitizersC3H miceSite of irradiationFinal exposureTrinitrochlorobenzeneLow dosesAbdominal skinImmunogenic propertiesMiceHypersensitivityImmunizationMouse skinSensitization reactionsDosesSuccessive daysSkin
1987
Electron microscopic and immunolabeling studies of the lesional and normal skin of patients with mycosis fungoides treated by total body electron beam irradiation
Braverman I, Klein S, Grant A. Electron microscopic and immunolabeling studies of the lesional and normal skin of patients with mycosis fungoides treated by total body electron beam irradiation. Journal Of The American Academy Of Dermatology 1987, 16: 61-74. PMID: 3100584, DOI: 10.1016/s0190-9622(87)70005-x.Peer-Reviewed Original ResearchConceptsEpidermal Langerhans cellsElectron beam therapyLangerhans cellsMycosis fungoidesIndeterminate cellsNormal skinDisease courseLesional skinBeam therapySkin lesionsNonspecific skin lesionsPatient's disease courseIa-positive cellsEpidermal cell suspensionsEpidermal thymocyteClinical remissionBiopsy specimensPretreatment levelsIa antigensFungoidesTherapyLesionsSkinPatientsCells
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