John Carlson, PhD
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Contact Info
Molecular, Cellular, and Developmental Biology
Dept. MCDB, Yale University, PO Box 208103
New Haven, Ct 06520-8103
United States
About
Titles
Eugene Higgins Professor of Molecular, Cellular, and Developmental Biology
Appointments
Molecular, Cellular, and Developmental Biology
ProfessorPrimary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Interdepartmental Neuroscience Program
- Kavli Institute for Neuroscience
- Molecular Cell Biology, Genetics and Development
- Molecular, Cellular, and Developmental Biology
- Neuroscience Track
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- PhD
- Stanford (1982)
- AB
- Harvard (1977)
Research
Overview
Medical Subject Headings (MeSH)
Drosophila; Mosquito Vectors; Smell; Taste
Research at a Glance
Yale Co-Authors
Frequent collaborators of John Carlson's published research.
Publications Timeline
A big-picture view of John Carlson's research output by year.
Research Interests
Research topics John Carlson is interested in exploring.
Gaëlle J. S. Talross, PhD
Hany Dweck
Lisa Baik, PhD
Shimaa Ebrahim
Yichen Luo
Brian Weiss, PhD
44Publications
10,784Citations
Publications
2024
Exitron splicing of odor receptor genes in Drosophila
Shang X, Talross G, Carlson J. Exitron splicing of odor receptor genes in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2320277121. PMID: 38507450, PMCID: PMC10990081, DOI: 10.1073/pnas.2320277121.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsExitron splicingOdorant receptor genesCases of alternative splicingCanonical open reading framesExpression of odorant receptor genesFunction of olfactory systemReceptor geneProtein-coding exonsOpen reading frameAlternative splicing eventsOlfactory receptor neuronsAlternative polyadenylationReading frameExon-intronEncode proteinsSplicing eventsAlternative splicingNon-coding RNAsStable proteinsPheromone receptorsReceptor neuronsOptogenetic activationPheromone stimulationSplicingNeuronal activity
2023
Diverse mechanisms of taste coding in Drosophila
Dweck H, Carlson J. Diverse mechanisms of taste coding in Drosophila. Science Advances 2023, 9: eadj7032. PMID: 37976361, PMCID: PMC10656072, DOI: 10.1126/sciadv.adj7032.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsA volatile sex attractant of tsetse flies
Ebrahim S, Dweck H, Weiss B, Carlson J. A volatile sex attractant of tsetse flies. Science 2023, 379: eade1877. PMID: 36795837, PMCID: PMC10204727, DOI: 10.1126/science.ade1877.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila
Xiao S, Baik LS, Shang X, Carlson JR. Meeting a threat of the Anthropocene: Taste avoidance of metal ions by Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2204238119. PMID: 35700364, PMCID: PMC9231609, DOI: 10.1073/pnas.2204238119.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenerations of exposureDipteran speciesAnthropogenic stressorsGR familyEnvironmental changesToxic chemical compoundsBitter-sensing neuronsTaste organsTaste receptorsAvoidance of feedingSugar-sensing neuronsElevated concentrationsZinc ionsDrosophilaChemical compoundsInsectsHuman activitiesBehavioral responsesReceptorsOrganismsFliesSpeciesNeuronsRapid rateDifferent subsetsIr56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila
Dweck HKM, Talross GJS, Luo Y, Ebrahim SAM, Carlson JR. Ir56b is an atypical ionotropic receptor that underlies appetitive salt response in Drosophila. Current Biology 2022, 32: 1776-1787.e4. PMID: 35294865, PMCID: PMC9050924, DOI: 10.1016/j.cub.2022.02.063.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSalt tasteBitter-sensing neuronsStop codonLoss of functionNumber of speciesIonotropic receptorsIonotropic receptor familyN-terminal regionReceptor familyNeuronsDrosophila speciesPremature stop codonTaste modalitiesAncient functionGR familySalt responseSense codonsMolecular basisAtypical memberSalt detectionModalitiesCodonSensory modalitiesDrosophilaBehavioral responses
2021
Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila
Ebrahim SAM, Talross GJS, Carlson JR. Sight of parasitoid wasps accelerates sexual behavior and upregulates a micropeptide gene in Drosophila. Nature Communications 2021, 12: 2453. PMID: 33907186, PMCID: PMC8079388, DOI: 10.1038/s41467-021-22712-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAdaptation, PhysiologicalAnimalsAnimals, Genetically ModifiedBeta-Carotene 15,15'-MonooxygenaseCarnivoryDrosophilaDrosophila melanogasterDrosophila ProteinsDrosophila simulansFemaleFertilityGene Expression RegulationMaleNeuronsPattern Recognition, VisualReceptors, Ionotropic GlutamateReceptors, OdorantSexual Behavior, AnimalWaspsConceptsWasp speciesParasitoid waspsParasitoid wasp speciesInsect speciesAdult DrosophilaInsect worldMating behaviorMutational analysisGene expressionFemale fliesWaspsGenesDrosophilaSpeciesFliesDramatic upregulationDefensive responsesWidespread deathVisual circuitsInsectsMicropeptidesBehavioral responsesNervous systemHundreds of thousandsUnexpected responsesEvolutionary shifts in taste coding in the fruit pest Drosophila suzukii
Dweck HK, Talross GJ, Wang W, Carlson JR. Evolutionary shifts in taste coding in the fruit pest Drosophila suzukii. ELife 2021, 10: e64317. PMID: 33616529, PMCID: PMC7899650, DOI: 10.7554/elife.64317.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFruit pest Drosophila suzukiiRipe fruitPest Drosophila suzukiiEvolutionary shiftsBitter compoundsLays eggsAgricultural pestsDrosophila suzukiiBitter taste perceptionDrosophilaTaste sensillaSpeciesPhysiological responsesReduced expressionEggsTaste organsSensillaOverripe fruitsFruitTranscriptomeTaste codingSuzukiiMutantsLabellumPests
2020
The mosquito taste system and disease control
Baik LS, Carlson JR. The mosquito taste system and disease control. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 32848-32856. PMID: 33372129, PMCID: PMC7776869, DOI: 10.1073/pnas.2013076117.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsVectors of diseaseNew mechanistic insightsMosquito olfactionGeographical rangeVector speciesMechanistic insightsSpeciesMosquito controlAfflict hundredsDiverse groupCurrent knowledgeWealth of opportunitiesMosquitoesClimate changeTaste systemInsectsEnormous rangeHabitatsUnderstanding of tasteOrganismsEggsNew strategyOlfactionTechnological advancesUnderstanding
2019
Molecular Logic and Evolution of Bitter Taste in Drosophila
Dweck HKM, Carlson JR. Molecular Logic and Evolution of Bitter Taste in Drosophila. Current Biology 2019, 30: 17-30.e3. PMID: 31839451, PMCID: PMC6946858, DOI: 10.1016/j.cub.2019.11.005.Peer-Reviewed Original ResearchCitationsAltmetricOdor coding in the antenna of the tsetse fly Glossina morsitans
Soni N, Chahda JS, Carlson JR. Odor coding in the antenna of the tsetse fly Glossina morsitans. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 14300-14308. PMID: 31221757, PMCID: PMC6628836, DOI: 10.1073/pnas.1907075116.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTsetse fly Glossina morsitansClasses of sensillaFruit flyPhysiological analysisAlarm pheromoneDifferent response dynamicsOlfactory sensillaFly antennaOlfactory cuesCellular basisWide diversityTsetse fliesSensillaFliesDifferent functionsDifferent odor stimuliGlossina morsitansPheromoneTsetseFunctional organizationHostDrosophilaMorphological typesOdorantsStriking difference
Academic Achievements and Community Involvement
honor Postdoctoral Mentoring Prize, Yale University
Yale University AwardDetails06/02/2023United Stateshonor Byrnes-Sewall Teaching Prize, Yale College
Yale University AwardDetails05/03/2023honor Kornberg-Berg Lifetime Achievement Award in Biomedical Sciences, Stanford Univ.
National AwardDetails10/12/2018honor Max Mozell Award for Outstanding Achievement in the Chemical Senses
National AwardDetails10/12/2018United Stateshonor Member, National Academy of Sciences
UnknownDetails12/31/2012United States
Links & Media
News
- February 19, 2023Source: YaleNews
Newly Identified Tsetse Fly Pheromone May Help Curb Disease Spread
- February 15, 2023Source: Yale News
Newly identified tsetse fly pheromone may help curb disease spread
- May 01, 2017
Sugar-craving crushed — in flies, at least
- April 09, 2013
Research in the News: Flies reveal that a sense of smell, like a melody, depends upon timing
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Contacts
Mailing Address
Molecular, Cellular, and Developmental Biology
Dept. MCDB, Yale University, PO Box 208103
New Haven, Ct 06520-8103
United States