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Leukocyte Development & Differentiation

Areas of major interest include the receptors and signals that control leukocyte lineage commitment, cell maturation, cell proliferation, homing, and cell death; the establishment of the proper environments for leukocyte development; mechanisms that regulate the state of chromatin during leukocyte development and differentiation; and the mechanisms by which antibody and T cell receptor genes are assembled and diversified. After maturation, immune cells recognizing foreign antigens are activated and initiate programs of cellular differentiate into effector cells that perform critical effector functions to protect the host. After successful resolution of the response, a small fraction of T and B lymphocytes develop into long-lived memory cells that protect against reinfection.