Yun-Hee Youm
Associate Research Scientist in PathologyCards
About
Research
Publications
2025
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging.
Mishra M, Kim HH, Youm YH, Gonzalez-Hurtado E, Zaitsev K, Dlugos T, Shchukina I, Gliniak C, Ravussin E, Mohanty S, Shaw AC, Scherer PE, Artyomov MN, Dixit VD. Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging. BioRxiv 2025 PMID: 40799539, DOI: 10.1101/2025.08.04.668533.Publications for non-academic audiencesFGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression
Gliniak C, Gordillo R, Youm Y, Lin Q, Crewe C, Zhang Z, Field B, Fujikawa T, Virostek M, Zhao S, Zhu Y, Rosen C, Horvath T, Dixit V, Scherer P. FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression. Cell Metabolism 2025, 37: 1547-1567.e6. PMID: 40527315, PMCID: PMC12221793, DOI: 10.1016/j.cmet.2025.05.011.Peer-Reviewed Original ResearchInflammatory immune cellsVisceral adipose tissueDiet-induced obesityAged transgenic miceHigh-fat dietAbsence of adiponectinTreat metabolic syndromeFibroblast growth factor 21Immune cellsLipotoxic ceramidesMetabolic syndromeReduced liver steatosisTransgenic miceMetabolic profileMetabolic benefitsInsulin sensitivityLiver steatosisIn adulthoodAdipose tissueMiceFat tissueImprove metabolismGrowth suppressionMetabolic issuesAge-related diseasesCysteine depletion triggers adipose tissue thermogenesis and weight loss
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey P, Smith S, Ravussin E, Stadler K, Chen B, Artyomov M, Hyder F, Horvath T, Schneeberger M, Sugiura Y, Dixit V. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism 2025, 7: 1204-1222. PMID: 40461845, PMCID: PMC12198010, DOI: 10.1038/s42255-025-01297-8.Peer-Reviewed Original ResearchConceptsWeight lossWhite adipose tissueAdipose browningCaloric restrictionAdipose tissueDietary amino acidsCysteine depletionSulphur amino acids cysteineIncreased energy expenditureAdipose tissue thermogenesisIncreased fat utilizationMetabolic inflammationNoradrenaline signalingOrganismal metabolismAdipose thermogenesisObese miceBrowning of adipocytesIncreased heat productionBrownRemoval of cysteineCore body temperatureAmino acidsEnergy expenditureAmino acid cysteineFat utilizationHormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome.
Guan C, Ryu S, Dong M, Youm YH, Mohanty S, Maeda R, Orliaguet L, Kim HH, Dlugos T, Smith SR, Ravussin E, Onyuru J, Wang A, Shaw AC, Hoffman HM, Kluger Y, Sugiura Y, Dixit VD. Hormetic elevation of taurine restrains inflammaging by deactivating the NLRP3 inflammasome. BioRxiv 2025 PMID: 40501605, DOI: 10.1101/2025.05.27.656381.Publications for non-academic audiencesEnhanced paracrine action of FGF21 in stromal cells delays thymic aging
Youm Y, Gliniak C, Zhang Y, Dlugos T, Scherer P, Dixit V. Enhanced paracrine action of FGF21 in stromal cells delays thymic aging. Nature Aging 2025, 5: 576-587. PMID: 39972172, PMCID: PMC12003152, DOI: 10.1038/s43587-025-00813-5.Peer-Reviewed Original ResearchThymic epithelial cellsThymic agingNaive CD8 T cellsCD8 T cellsAge-related thymic involutionT cell diversityThymic functionImmune dysfunctionThymic stromaT cellsThymic lymphopoiesisThymic involutionActions of FGF21Immune agingAged miceStromal cellsEpithelial cellsAged animalsCo-receptorHepatic overexpressionElevation of FGF21FGF21AgeCellsAdipocytes
2010
Obesity increases the production of pro-inflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin-resistance (87.32)
Youm Y, Yang H, Badanmagsar B, Gimble J, Greenway F, Mynatt R. Obesity increases the production of pro-inflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin-resistance (87.32). The Journal Of Immunology 2010, 184: 87.32-87.32. DOI: 10.4049/jimmunol.184.supp.87.32.Peer-Reviewed Original ResearchT cellsVisceral fatTCR repertoireTCR diversityAdipose depotsAdipose tissueAdipose tissue T cellsSpecific adipose depotsTCR Vβ repertoireUnique TCR repertoireEffector memory cellsObesity-Associated InflammationPro-inflammatory mediatorsActivated T cell populationsPro-inflammatory cytokinesTissue T cellsT cell populationsTCR repertoire diversityProinflammatory microenvironmentSystemic inflammationObesity altersObese miceT lymphocytesObesityRepertoire diversity
2008
Proteomic analysis of androgen-independent growth in low and high passage human LNCaP prostatic adenocarcinoma cells
Youm YH, Kim S, Bahk YY, Yoo TK. Proteomic analysis of androgen-independent growth in low and high passage human LNCaP prostatic adenocarcinoma cells. BMB Reports 2008, 41: 722-727. PMID: 18959819, DOI: 10.5483/bmbrep.2008.41.10.722.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAndrogensCell ExtractsCell Line, TumorCell ProliferationClone CellsDoxazosinElectrophoresis, Gel, Two-DimensionalGene Expression Regulation, NeoplasticGene SilencingHumansMaleNeoplasm ProteinsProstatic NeoplasmsProteomeProteomicsReceptors, AndrogenRNA, MessengerRNA, Small InterferingConceptsAndrogen-independent growthAndrogen-independent phenotypeProstatic adenocarcinoma cellsAndrogen receptorLNCaP cellsLow passage numberReceptor productionAdenocarcinoma cellsCell clonesProtein expressionExpression levelsPassage numberPresent studyCellsProteomic characteristicsProteomic analysisAndrogensExpressionProgression
2007
Doxazosin-induced clusterin expression and apoptosis in prostate cancer cells
Youm YH, Yang H, Yoon YD, Kim DY, Lee C, Yoo TK. Doxazosin-induced clusterin expression and apoptosis in prostate cancer cells. Urologic Oncology Seminars And Original Investigations 2007, 25: 483-488. PMID: 18047956, DOI: 10.1016/j.urolonc.2007.02.010.Peer-Reviewed Original ResearchConceptsProstate cancer cellsAndrogen-independent human prostate cancer cellsCancer cellsHuman prostate cancer cellsTranscriptase-polymerase chain reactionNick-end labeling assayMicroM doxazosinDegree of apoptosisDNA fragmentationDoxazosin treatmentClusterin mRNA expressionPolymerase chain reactionDoxazosin-induced apoptosisClusterin expressionMRNA expressionPC3 cellsPresence of clusterinClusterin mRNAChain reactionClusterinApoptotic cellsLabeling assaysDoxazosinApoptosisMP-17.13: Silencing of clusterin gene with siRNA accelerates doxazosin induced apoptosis in PC-3 human prostate cancer cell lines
Cha G, Yoo T, Youm Y, Jo M, Lee C. MP-17.13: Silencing of clusterin gene with siRNA accelerates doxazosin induced apoptosis in PC-3 human prostate cancer cell lines. Urology 2007, 70: 133-134. DOI: 10.1016/j.urology.2007.06.500.Peer-Reviewed Original Research
2006
MP-08.15 Prolonged culture of LNCaP prostate cancer cells leads to androgen independence and resistance to doxazosin induced apoptosis with clusterin up-regulation
Yoo T, Youm Y, Park H, Kang J, Park J, Kim T. MP-08.15 Prolonged culture of LNCaP prostate cancer cells leads to androgen independence and resistance to doxazosin induced apoptosis with clusterin up-regulation. Urology 2006, 68: 100-101. DOI: 10.1016/j.urology.2006.08.322.Peer-Reviewed Original Research