Yannick Jacob, PhD
Associate Professor Tenure of Molecular, Cellular and Developmental BiologyCards
About
Research
Publications
2026
TONSOKU prevents the formation of large tandem duplications and restrains ATR–WEE1 checkpoint activation
Thomson G, Poulet A, Huang Y, Liao H, LeBlanc C, Jacob Y. TONSOKU prevents the formation of large tandem duplications and restrains ATR–WEE1 checkpoint activation. Nature Communications 2026, 17: 2874. PMID: 41896247, PMCID: PMC13031928, DOI: 10.1038/s41467-026-70906-1.Peer-Reviewed Original Research
2025
Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair
Li Q, Zhao C, Guo Y, Bai Y, Liu J, Jin X, Yuan Y, Jacob Y, Dong J. Direct recruitment of TONSOKU by the N-terminal tails of histone variants H2A.X and H2A.W coordinates DNA repair. Science Advances 2025, 11: eady2104. PMID: 41406205, PMCID: PMC12710692, DOI: 10.1126/sciadv.ady2104.Peer-Reviewed Original ResearchEnzymatic depletion of transposable elements in sequencing libraries and its application for genotyping multiplexed CRISPR‐edited plants
Thomson G, Mermaz B, Sagawa C, Lin C, Tachev M, Joly V, Irish V, Jacob Y. Enzymatic depletion of transposable elements in sequencing libraries and its application for genotyping multiplexed CRISPR‐edited plants. The Plant Journal 2025, 124: e70501. PMID: 41045024, DOI: 10.1111/tpj.70501.Peer-Reviewed Original ResearchH3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability
Yuan W, Huang Y, LeBlanc C, Poulet A, De Luna Vitorino F, Valsakumar D, Dean R, Garcia B, van Wolfswinkel J, Voigt P, Jacob Y. H3.1K27M-induced misregulation of the TONSOKU-H3.1 pathway causes genomic instability. Nature Communications 2025, 16: 3547. PMID: 40229276, PMCID: PMC11997104, DOI: 10.1038/s41467-025-58892-2.Peer-Reviewed Original Research
2024
An efficient multiplex approach to CRISPR/Cas9 gene editing in citrus
Sagawa C, Thomson G, Mermaz B, Vernon C, Liu S, Jacob Y, Irish V. An efficient multiplex approach to CRISPR/Cas9 gene editing in citrus. Plant Methods 2024, 20: 148. PMID: 39342225, PMCID: PMC11438372, DOI: 10.1186/s13007-024-01274-4.Peer-Reviewed Original Research
2023
H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome
Wang Z, Castillo-González C, Zhao C, Tong C, Li C, Zhong S, Liu Z, Xie K, Zhu J, Wu Z, Peng X, Jacob Y, Michaels S, Jacobsen S, Zhang X. H3.1K27me1 loss confers Arabidopsis resistance to Geminivirus by sequestering DNA repair proteins onto host genome. Nature Communications 2023, 14: 7484. PMID: 37980416, PMCID: PMC10657422, DOI: 10.1038/s41467-023-43311-1.Peer-Reviewed Original Research
2022
The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication
Davarinejad H, Huang YC, Mermaz B, LeBlanc C, Poulet A, Thomson G, Joly V, Muñoz M, Arvanitis-Vigneault A, Valsakumar D, Villarino G, Ross A, Rotstein BH, Alarcon EI, Brunzelle JS, Voigt P, Dong J, Couture JF, Jacob Y. The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication. Science 2022, 375: 1281-1286. PMID: 35298257, PMCID: PMC9153895, DOI: 10.1126/science.abm5320.Peer-Reviewed Original Research
2021
H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation
Dong J, LeBlanc C, Poulet A, Mermaz B, Villarino G, Webb KM, Joly V, Mendez J, Voigt P, Jacob Y. H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation. The Plant Cell 2021, 33: 961-979. PMID: 33793815, PMCID: PMC8226292, DOI: 10.1093/plcell/koaa027.Peer-Reviewed Original Research
2017
Increased efficiency of targeted mutagenesis by CRISPR/Cas9 in plants using heat stress
LeBlanc C, Zhang F, Mendez J, Lozano Y, Chatpar K, Irish V, Jacob Y. Increased efficiency of targeted mutagenesis by CRISPR/Cas9 in plants using heat stress. The Plant Journal 2017, 93: 377-386. PMID: 29161464, DOI: 10.1111/tpj.13782.Peer-Reviewed Original Research
2014
Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication
Jacob Y, Bergamin E, Donoghue MT, Mongeon V, LeBlanc C, Voigt P, Underwood CJ, Brunzelle JS, Michaels SD, Reinberg D, Couture JF, Martienssen RA. Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication. Science 2014, 343: 1249-1253. PMID: 24626927, PMCID: PMC4049228, DOI: 10.1126/science.1248357.Peer-Reviewed Original ResearchAmino Acid SequenceArabidopsisArabidopsis ProteinsCatalytic DomainConserved SequenceCrystallography, X-RayDNA ReplicationEpigenesis, GeneticGene Expression Regulation, PlantHeterochromatinHistonesMethylationMethyltransferasesMitosisMolecular Sequence DataProtein Processing, Post-TranslationalThreonine
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Osborn Memorial Lab
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165 Prospect Street, Rm 354
New Haven, CT 06511