Wei Mi

Wei Mi is an Associate Professor of Pharmacology at Yale School of Medicine with secondary appointments in the Departments of Molecular Biophysics & Biochemistry and Microbial Pathogenesis. The Mi Laboratory seeks to understand how Gram-negative bacteria build, sense, and remodel their cell envelope, and to translate these discoveries into next-generation antibiotics. Our research is driven by biological questions rather than any single technique. We integrate structural biology, bacterial genetics, quantitative biochemistry, molecular simulations, chemical biology, and AI-assisted drug development, using the tools best suited to answer important biological questions. Our research spans fundamental biology, interdisciplinary science, and antibiotic discovery. By uncovering the molecular principles that govern bacterial cell-envelope homeostasis, we aim not only to reveal new biological mechanisms but also to develop innovative therapeutic strategies against multidrug-resistant pathogens. Training the next generation of scientists is one of my highest priorities. I strive to create a collaborative and supportive environment where trainees develop scientific independence, critical thinking, and the confidence to pursue ambitious questions. Please visit the Mi Laboratory website to learn more.