Tyrone Cannon
Clark L. Hull Professor of Psychology and Professor of PsychiatryCards
Appointments
Department of Psychology
Primary
Psychiatry
Secondary
Contact Info
About
Titles
Clark L. Hull Professor of Psychology and Professor of Psychiatry
Appointments
Department of Psychology
ProfessorPrimaryPsychiatry
ProfessorSecondary
Other Departments & Organizations
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Tyrone Cannon's published research.
Publications Timeline
A big-picture view of Tyrone Cannon's research output by year.
Scott Woods, MD
Thomas McGlashan, MD
Vinod H. Srihari, MD
Albert Powers, MD, PhD
Brenda Cabrera-Mendoza, MD/PhD
Christopher Pittenger, MD, PhD
43Publications
45Citations
Publications
2024
Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis.
Hamilton H, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Tsuang M, Walker E, Woods S, Cannon T, Mathalon D. Mismatch Negativity as an Index of Auditory Short-Term Plasticity: Associations with Cortisol, Inflammation, and Gray Matter Volume in Youth at Clinical High Risk for Psychosis. Clinical EEG And Neuroscience 2024, 15500594241294035. PMID: 39552576, DOI: 10.1177/15500594241294035.Peer-Reviewed Original ResearchConceptsNMDAR-dependent plasticityClinical high riskGray matter volumeMismatch negativityMagnetic resonance imagingGray matter lossShort-term plasticityMMN amplitudeMatter volumeN-methyl-D-aspartateHigh riskCHR-PPro-inflammatory cytokine levelsPathogenesis of schizophreniaModel of schizophreniaBiomarkers of schizophreniaMismatch negativity amplitudeCHR-P individualsNorth American Prodrome Longitudinal StudyEvent-related potentialsAberrant neurodevelopmental processesInfluence of psychosisSubcortical gray matter volumesTotal gray matter volumeNMDAR hypofunctionConvergent Validity of Experimental Cognitive Tests in a Large Community Sample.
Dean A, Pochon J, Bilder R, Sabb F, Congdon E, Ghahremani D, Karlsgodt K, van Erp T, Schwarzlose R, Cannon T, Freimer N, London E. Convergent Validity of Experimental Cognitive Tests in a Large Community Sample. Assessment 2024, 10731911241283410. PMID: 39523501, DOI: 10.1177/10731911241283410.Peer-Reviewed Original ResearchConceptsExperimental cognitive testsConvergent validityInhibitory controlFactor analysisCognitive testsBalloon Analogue Risk TaskTests of working memoryMultigroup confirmatory factor analysisDelay-discounting taskReversal learning taskStop-signal taskExperimental cognitive measuresTraditional neuropsychological testsAttention Network TestThree-factor structureConfirmatory factor analysisExploratory factor analysisDiscounting taskRemember-knowRisk TaskTask switchingCognitive measuresNeuropsychological testsCognitive domainsPsychiatric diagnosisAttention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis
Braun A, Liu L, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Addington J. Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis. Schizophrenia Bulletin Open 2024, sgae028. DOI: 10.1093/schizbullopen/sgae028.Peer-Reviewed Original ResearchConceptsClinical high riskCo-morbid ADHDClinical high risk of psychosisPredictors of transition to psychosisNorth American Prodrome Longitudinal StudySubstance useClinical high-risk individualsClinical high-risk participantsClinical high-risk youthHigh risk of psychosisAttention deficit hyperactivity disorderNegative psychotic symptomsTransition to psychosisCo-morbid disordersNon-ADHD groupRisk of psychosisDeficit hyperactivity disorderCo-morbidityIncreased substance useAssociated with numerous adverse outcomesPsychotic symptomsNumerous adverse outcomesPremorbid functioningSocial cognitionADHD groupProtective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores
Cadenhead K, Addington J, Bearden C, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Protective Factors Predict Resilient Outcomes in Clinical High-Risk Youth with the Highest Individualized Psychosis Risk Scores. Schizophrenia Bulletin 2024, sbae182. PMID: 39488001, DOI: 10.1093/schbul/sbae182.Peer-Reviewed Original ResearchConceptsClinical high riskClinical high-risk participantsClinical high-risk researchPremorbid functioningResilient outcomesProtective factorsClinical high-risk youthClinical high-risk populationsReduced startle reactivityPrediction of psychosisAssociated with greater resilienceHigh-risk youthStudy of protective factorsStartle reactivityPsychotic conversionBrain areasPsychosisChildhood environmentBrain developmentGreater resilienceExploratory analysisLife experiencesPreventive interventionsSocial engagementHispanic heritageNeighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
Ku B, Yuan Q, Haardörfer R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Druss B, Walker E, Anglin D. Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons. Psychiatry Research 2024, 342: 116222. PMID: 39378539, DOI: 10.1016/j.psychres.2024.116222.Peer-Reviewed Original ResearchAltmetricConceptsHealthy comparisonPositive symptomsCHR-PPeer victimizationNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsAttenuated positive symptomsPositive psychotic symptomsClinical high riskFewer life eventsAssociated with schizophreniaEthnoracial diversityPsychotic symptomsHigh riskPrevent psychosisDepressive symptomsStructural equation modelingLife eventsProdromal symptomsPsychosisDiscriminatory experiencesEthnoracial minoritiesSocial determinantsNeighborhood povertyEthnoracial groupsImpact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis
Giampetruzzi E, Walker E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, LoPilato A. Impact of adverse childhood experiences on risk for internalizing psychiatric disorders in youth at clinical high-risk for psychosis. Psychiatry Research 2024, 342: 116214. PMID: 39368239, DOI: 10.1016/j.psychres.2024.116214.Peer-Reviewed Original ResearchCitationsAltmetricConceptsAdverse childhood experiencesClinical high riskEffects of protective factorsInternalizing disordersDepressive disorderCHR-PEmotional neglectSelf-harm/suicideProtective factorsChildhood experiencesHigher levels of adverse childhood experiencesHistory of depressive disorderSexual abuseLevels of adverse childhood experiencesInternalizing psychiatric disordersChildhood sexual abusePresence of protective factorsImpact of adverse childhood experiencesAnxiety disordersAdministered measuresPsychiatric diagnosisPsychiatric disordersPsychiatric outcomesChild adversitySubstance useBeyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis
Deng W, Chong B, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Beyond the Descriptive: A Comprehensive, Multi-domain Validation of Symptom Trajectories for Individuals at Clinical High Risk for Psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39260565, DOI: 10.1016/j.bpsc.2024.08.020.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PTrajectory groupsMaintenance of symptomsOnset of psychosisNon-convertersHealthy controlsDiagnostic constructSymptom trajectoriesPsychosisAffective comorbiditiesAssess symptomsHeightened riskFunctional impairmentSymptomsEtiological risk factorsFunctional outcomesImminent onsetLevels of intensityRemissionRisk factorsIndividualsPhase 3DistressImpairmentPolygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder
Song J, Pasman J, Johansson V, Kuja-Halkola R, Harder A, Karlsson R, Lu Y, Kowalec K, Pedersen N, Cannon T, Hultman C, Sullivan P. Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder. JAMA Psychiatry 2024, 81 PMID: 39196586, PMCID: PMC11359115, DOI: 10.1001/jamapsychiatry.2024.2406.Peer-Reviewed Original ResearchAltmetricConceptsPolygenic risk scoresGenome-wide association studiesSwedish Twin RegistryBipolar disorderCase-control studyTwin concordanceTwin heritabilityLevels of polygenic risk scoreTwin RegistrySwedish national register dataCompare polygenic risk scoresRisk scoreNational register dataHeritable psychiatric disorderAffected co-twinsPairs of twinsPsychosis phenotypeIllness vulnerabilityClinical interviewPsychiatric disordersGenetic liabilityMain OutcomesStructural equation modelingPsychosisSchizophreniaUnique functional neuroimaging signatures of genetic versus clinical high risk for psychosis
Schleifer C, Chang S, Amir C, O'Hora K, Fung H, Kang J, Kushan-Wells L, Daly E, Di Fabio F, Frascarelli M, Gudbrandsen M, Kates W, Murphy D, Addington J, Anticevic A, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Uddin L, Kumar K, Hoftman G, Bearden C. Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis. Biological Psychiatry 2024 PMID: 39181389, DOI: 10.1016/j.biopsych.2024.08.010.Peer-Reviewed Original ResearchConceptsBrain signal variabilityClinical high riskCHR individualsTD controlsSubthreshold psychosis symptomsResting-state functional MRIFunctional brain alterationsAssociated with psychosisFunctional brain measuresGroup difference mapCopy number variantsCase-control differencesPsychosis symptomsNeural substratesBrain alterationsBrain measuresLocal connectivityFunctional MRIFunctional connectivityCortical regionsNeuroimaging signaturesNeurodevelopmental disordersPsychosisHigh riskBrain mappingSleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis
Cohen S, Goldsmith D, Ning C, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Woods S, Walker E, Miller B. Sleep disturbance, suicidal ideation and psychosis-risk symptoms in individuals at clinical high risk for psychosis. Psychiatry Research 2024, 341: 116147. PMID: 39197223, DOI: 10.1016/j.psychres.2024.116147.Peer-Reviewed Original ResearchAltmetricConceptsPsychosis-risk symptomsClinical high riskSuicidal ideationCHR-P individualsCHR-PSleep disturbanceTerminal insomniaNorth American Prodrome Longitudinal StudyAssociated with conversion to psychosisSleep problemsConversion to psychosisTreatment of sleep disturbancesAssociated with SIIndices of sleep disturbanceMultiple indicesPsychosisIdeationLongitudinal intervention studyInsomniaLongitudinal studySchizophreniaSymptomsSleepSymptom scoresInvestigate relationships
News
News
- September 16, 2020
Yale Researchers to Lead $52M Investigation Into Cause, Effect of Schizophrenia in Some High-risk Adolescents
- July 05, 2020
Brain Imaging Reveals Patterns That Foreshadow Schizophrenia’s Onset
- February 19, 2019
Cannon appointed Chair of Department of Psychology at Yale University
- July 01, 2016
Yale study: Calculator can predict psychosis risk