Serena Susan Spudich, MD, MA

2024

• PP7.7 – 00092 Single-Nucleus Multiomic Sequencing Uncovers Differential Chromatin Accessibility and Gene Regulation in Cerebrospinal Fluid Cells of PWH

  Lu C, Orlinick B, Das B, Filippidis P, Mehta S, Spudich S, Pang A, Kluger Y, Corley M, Farhadian S. PP7.7 – 00092 Single-Nucleus Multiomic Sequencing Uncovers Differential Chromatin Accessibility and Gene Regulation in Cerebrospinal Fluid Cells of PWH. Journal Of Virus Eradication 2024, 10: 87-88. DOI: 10.1016/j.jve.2024.100530.

  Peer-Reviewed Original Research

  Concepts

• PP7.9 – 00031 Memory B Cells in the CSF of People with HIV Exhibit Changes in Interferon Signaling and Antigen Presentation Capacity

  Filippidis P, Corley M, Spudich S, Wang M, Kleinstein S, Farhadian S. PP7.9 – 00031 Memory B Cells in the CSF of People with HIV Exhibit Changes in Interferon Signaling and Antigen Presentation Capacity. Journal Of Virus Eradication 2024, 10: 89-90. DOI: 10.1016/j.jve.2024.100532.

  Peer-Reviewed Original Research

  Concepts

• PP4.10 – 00082 Simultaneous measurement of HIV proviral DNA and cell associated RNA in CSF cells of PWH using single-cell Multiomics

  Orlinick B, Mehta S, Lu C, Pang A, Das B, Spudich S, Kluger Y, Corley M, Farhadian S. PP4.10 – 00082 Simultaneous measurement of HIV proviral DNA and cell associated RNA in CSF cells of PWH using single-cell Multiomics. Journal Of Virus Eradication 2024, 10: 69-70. DOI: 10.1016/j.jve.2024.100497.

  Peer-Reviewed Original Research

  Concepts

• PP7.2 – 00169 Longitudinal Persistence of HIV DNA in CSF Over 4 Years Despite Up to 20 Years of ART

  Cyktor J, Aga E, Naqvi A, Hoeth D, Bosch R, Macatangay B, Eron J, Koletar S, Benson C, Mcmahon D, Mellors J, Spudich S, Gandhi R, Team F. PP7.2 – 00169 Longitudinal Persistence of HIV DNA in CSF Over 4 Years Despite Up to 20 Years of ART. Journal Of Virus Eradication 2024, 10: 84-85. DOI: 10.1016/j.jve.2024.100525.

  Peer-Reviewed Original Research

• Neurosymptomatic HIV-1 CSF escape is associated with replication in CNS T cells and inflammation

  Kincer L, Dravid A, Trunfio M, Calcagno A, Zhou S, Vercesi R, Spudich S, Gisslen M, Price R, Cinque P, Joseph S. Neurosymptomatic HIV-1 CSF escape is associated with replication in CNS T cells and inflammation. Journal Of Clinical Investigation 2024, 134: e176358. PMID: 39352388, PMCID: PMC11444166, DOI: 10.1172/jci176358.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts

• Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection

  Hu Z, Cinque P, Dravid A, Hagberg L, Yilmaz A, Zetterberg H, Fuchs D, Gostner J, Blennow K, Spudich S, Kincer L, Zhou S, Joseph S, Swanstrom R, Price R, Gisslén M. Changes in cerebrospinal fluid proteins across the spectrum of untreated and treated chronic HIV-1 infection. PLOS Pathogens 2024, 20: e1012470. PMID: 39316609, PMCID: PMC11469498, DOI: 10.1371/journal.ppat.1012470.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts

• Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV

  Patel P, Prince D, Bolenzius J, Ch’en P, Chiarella J, Kolind S, Vavasour I, Pedersen T, Levendovszky S, Spudich S, Marra C, Paul R. Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV. AIDS 2024, 38: 1932-1939. PMID: 39110577, PMCID: PMC11524773, DOI: 10.1097/qad.0000000000003989.

  Peer-Reviewed Original Research

  Concepts

• Central Nervous System Effects of Early HIV Infection and Consequences of Antiretroviral Therapy Initiation during Acute HIV

  Chan P, Spudich S. Central Nervous System Effects of Early HIV Infection and Consequences of Antiretroviral Therapy Initiation during Acute HIV. Viruses 2024, 16: 1082. PMID: 39066244, PMCID: PMC11281648, DOI: 10.3390/v16071082.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

  Citations

  MeSH Keywords and Concepts

• Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency

  Pluvinage J, Ngo T, Fouassier C, McDonagh M, Holmes B, Bartley C, Kondapavulur S, Hurabielle C, Bodansky A, Pai V, Hinman S, Aslanpour A, Alvarenga B, Zorn K, Zamecnik C, McCann A, Asencor A, Huynh T, Browne W, Tubati A, Haney M, Douglas V, Louine M, Cree B, Hauser S, Seeley W, Baranzini S, Wells J, Spudich S, Farhadian S, Ramachandran P, Gillum L, Hales C, Zikherman J, Anderson M, Yazdany J, Smith B, Nath A, Suh G, Flanagan E, Green A, Green R, Gelfand J, DeRisi J, Pleasure S, Wilson M. Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency. Science Translational Medicine 2024, 16: eadl3758. PMID: 38924428, PMCID: PMC11520464, DOI: 10.1126/scitranslmed.adl3758.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts

• The single-cell opioid responses in the context of HIV (SCORCH) consortium

  Ament S, Campbell R, Lobo M, Receveur J, Agrawal K, Borjabad A, Byrareddy S, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton K, Giglio M, Giorgi F, Gok B, Guda C, Hadas E, Herb B, Hu W, Huttner A, Ishmam M, Jacobs M, Kelschenbach J, Kim D, Lee C, Liu S, Liu X, Madras B, Mahurkar A, Mash D, Mukamel E, Niu M, O’Connor R, Pagan C, Pang A, Pillai P, Repunte-Canonigo V, Ruzicka W, Stanley J, Tickle T, Tsai S, Wang A, Wills L, Wilson A, Wright S, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng C, Corley M, Fox H, Gerstein M, Gummuluru S, Heiman M, Ho Y, Kellis M, Kenny P, Kluger Y, Milner T, Moore D, Morgello S, Ndhlovu L, Rana T, Sanna P, Satterlee J, Sestan N, Spector S, Spudich S, Tilgner H, Volsky D, White O, Williams D, Zeng H. The single-cell opioid responses in the context of HIV (SCORCH) consortium. Molecular Psychiatry 2024, 29: 3950-3961. PMID: 38879719, PMCID: PMC11609103, DOI: 10.1038/s41380-024-02620-7.

  Peer-Reviewed Original Research

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