Sarah Emerson, PhD
Associate Research ScientistCards
About
Research
Publications
2025
Exploring neurodevelopment via spatiotemporal collation of anatomical networks with NeuroSC
Koonce N, Emerson S, Bhaskar D, Kuchroo M, Moyle M, Arroyo-Morales P, Vázquez-Martínez N, Emerson J, Krishnaswamy S, Mohler W, Colón-Ramos D. Exploring neurodevelopment via spatiotemporal collation of anatomical networks with NeuroSC. ELife 2025, 13: rp103977. PMID: 41118245, PMCID: PMC12539806, DOI: 10.7554/elife.103977.Peer-Reviewed Original ResearchExploring neurodevelopment via spatiotemporal collation of anatomical networks with NeuroSC
Koonce N, Emerson S, Bhaskar D, Kuchroo M, Moyle M, Arroyo-Morales P, Vázquez-Martínez N, Emerson J, Krishnaswamy S, Mohler W, Colón-Ramos D. Exploring neurodevelopment via spatiotemporal collation of anatomical networks with NeuroSC. ELife 2025, 13 DOI: 10.7554/elife.103977.3.Peer-Reviewed Original ResearchGlycogen supports glycolytic plasticity in neurons
Singh M, Wolfe A, Vishwanath A, Tsives A, Gonzalez I, Emerson S, Goodman R, Colón-Ramos D. Glycogen supports glycolytic plasticity in neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2509003122. PMID: 40638090, PMCID: PMC12280961, DOI: 10.1073/pnas.2509003122.Peer-Reviewed Original ResearchConceptsCaenorhabditis elegansConditions of mitochondrial dysfunctionCells of living animalsSynaptic vesicle recyclingTransient hypoxiaSingle cellsVesicle recyclingRNAi screenAssociated with defectsMitochondrial functionResponse to activationGlycolytic stateMitochondrial dysfunctionEnergy metabolism in vivoMetabolism in vivoSynaptic functionNeuronsIn vivoHypoxiaEnergy reservesGlycogen phosphorylaseGlycogenOrthologsCaenorhabditisMutants
2021
Differential adhesion regulates neurite placement via a retrograde zippering mechanism
Sengupta T, Koonce NL, Vázquez-Martínez N, Moyle MW, Duncan LH, Emerson SE, Han X, Shao L, Wu Y, Santella A, Fan L, Bao Z, Mohler W, Shroff H, Colón-Ramos DA. Differential adhesion regulates neurite placement via a retrograde zippering mechanism. ELife 2021, 10: e71171. PMID: 34783657, PMCID: PMC8843091, DOI: 10.7554/elife.71171.Peer-Reviewed Original ResearchConceptsDifferential adhesionDifferential adhesion mechanismsSYG-1SYG-2Developmental programEmbryonic developmentNeurite tipsZippering mechanismBiophysical principlesNeurite shaftSynaptic specificityBrain neuropilSingle neuriteLayers occursAlternate mechanismAdhesion mechanismExpressionNeuritesZipperingAdhesionMechanismOutgrowth
2020
Shootin‐1 is required for nervous system development in zebrafish
Emerson S, Stergas H, Bupp‐Chickering S, Ebert A. Shootin‐1 is required for nervous system development in zebrafish. Developmental Dynamics 2020, 249: 1285-1295. PMID: 32406957, DOI: 10.1002/dvdy.194.Peer-Reviewed Original ResearchConceptsNervous system developmentLoss of repressionShootin-1Peripheral nervous systemRepulsive axon guidance cuesDownstream signaling mechanismsPhenotypic consequencesNervous systemAxon guidance cuesNeuronal polarityPatterning defectsMicroarray screeningRetinal pigment epitheliumCell migrationGuidance cuesSignaling mechanismsFunctional roleImpaired migrationPLXNA2RepressionPigment epitheliumOptic vesiclePathfinding errorsZebrafishRegulation
2018
Developmental expression patterns of protein kinase A catalytic subunits in zebrafish
Emerson S, Grebber B, McNellis M, Orr A, Deming P, Ebert A. Developmental expression patterns of protein kinase A catalytic subunits in zebrafish. Gene Expression Patterns 2018, 31: 1-6. PMID: 30468770, DOI: 10.1016/j.gep.2018.11.001.Peer-Reviewed Original ResearchConceptsProtein kinase ACatalytic subunitProtein kinase A catalytic subunitExpression profilesRegulate key developmental processesCAMP-dependent protein kinasePKA catalytic subunitTemporal expression profilesDevelopmental expression patternsTetrameric holoenzymeRegulatory subunitDevelopmental time pointsCAMP bindingProtein kinaseZebrafish developmentExpression patternsSignaling pathwayDevelopmental processesFunctional studiesSubunitKinase AZebrafishPost-fertilizationExpressionHoloenzymeInvestigating Sema6A‐PlxnA Signaling Mechanisms in Development: Identification of Key PlxnA Phosphorylation Sites and the Discovery of a Novel Naturally‐Released Sema
St. Clair R, Emerson S, D'Elia K, Weir M, Schmoker A, Williams K, Goldstein M, Stant E, Ebert A, Ballif B. Investigating Sema6A‐PlxnA Signaling Mechanisms in Development: Identification of Key PlxnA Phosphorylation Sites and the Discovery of a Novel Naturally‐Released Sema. The FASEB Journal 2018, 32: 791.14-791.14. DOI: 10.1096/fasebj.2018.32.1_supplement.791.14.Peer-Reviewed Original ResearchPhosphorylation sitesTyrosine phosphorylationEye developmentTyrosine phosphorylation sitesSite to phenylalanineReceptor-proximal eventsRegulate cellular processesEye developmental defectsImmune systemNervous systemCytoskeletal dynamicsReverse signalingGenetic networksTransmembrane natureMass spectrometry-based approachHighly-conservedObserved phenotypesCellular processesZebrafish eye developmentTyrosine sitesSignal transductionTransmembrane proteinsPoint mutationsVertebrate eye developmentKnock-down
2017
Fyn‐dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development
St. Clair R, Emerson S, D'Elia K, Weir M, Schmoker A, Ebert A, Ballif B. Fyn‐dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development. The FEBS Journal 2017, 285: 72-86. PMID: 29091353, PMCID: PMC5760361, DOI: 10.1111/febs.14313.Peer-Reviewed Original ResearchConceptsTyrosine phosphorylationPhosphorylation sitesSignal transductionSrc family kinase FynTyrosine phosphorylation sitesSite to phenylalanineNonreceptor tyrosine kinaseEye developmental defectsCytoskeletal dynamicsMass spectrometry-based approachKinase FynCellular processesPoint mutationsSignaling eventsSignaling roleZebrafish eye developmentEye developmentTyrosine kinaseDevelopmental defectsPLXNA2Signaling mechanismsPhosphorylationZebrafish embryosTyrosineMutationsNeuronal expression patterns of the PlexinA family during zebrafish development
Emerson S, Light S, Ebert A. Neuronal expression patterns of the PlexinA family during zebrafish development. Gene Expression Patterns 2017, 27: 56-66. PMID: 29107805, DOI: 10.1016/j.gep.2017.10.007.Peer-Reviewed Original ResearchConceptsSignaling moleculesZebrafish developmentExpression patternsSecreted signaling moleculesRegulate many aspectsTransmembrane protein receptorIntracellular signaling cascadesNeuronal expression patternProtein receptorExpression of receptor subtypesSignaling cascadesAxon guidancePlxnsExtracellular bindingFamily membersExpression profilesDevelopmental processesNeuronal positioningAppropriate signalsSpatial expressionZebrafishReceptor subtypesPost-fertilizationExpressionNeuronal tissueIdentification of target genes downstream of semaphorin6A/PlexinA2 signaling in zebrafish
Emerson S, St. Clair R, Waldron A, Bruno S, Duong A, Driscoll H, Ballif B, McFarlane S, Ebert A. Identification of target genes downstream of semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics 2017, 246: 539-549. PMID: 28440030, PMCID: PMC6322676, DOI: 10.1002/dvdy.24512.Peer-Reviewed Original ResearchConceptsSignaling pathwayTarget genesMicroarray analysisIdentification of target genesRegulate proliferationRetinal precursor cellsGuidance signaling pathwayGene expression changesTranscriptional regulationEarly eye developmentGenesDisrupted proliferationExpression changesEye developmentNeuronal developmentNeuronal positioningUp-regulatedZebrafish embryosMorphantsPLXNA2Downstream effectsRASL11BPathwayZebrafish eyeSema6A
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100 College Street, Fl 10, Rm 1053
New Haven, CT 06510