During development, neurons contact many potential synaptic partners, yet connect only to a selected subset. What are the the cellular and molecular mechanisms that instruct this precise...
A fundamental question in neuroscience is how synapses are assembled in living animals to produce behaviors and store memories. Our lab is focused on this question and uses the nematode C. elegans to examine the cell biological mechanisms by which synapses are precisely assembled during development, maintained during growth and modified during learning to store memories.
Cell biology of the synapse and behavior in C. elegans
We can scrutinize the interplay between the cell biology of the synapse and behavior at three levels:
After synapses are specified, their relative positions and functional properties must be maintained to ensure proper circuit function. What are the mechanisms that maintain synaptic...
Mechanisms of neuronal synapse assembly and function
Actuating memory: how C. elegans remembers