- October 19, 2020
Bell and Colón-Ramos Are Named to National Academy of Medicine
- August 29, 2020Source: BioRxiv
New lab's preprint in BioRxiv!
- August 12, 2020Source: Biophysical Journal
SoRi's paper, "Phosphofructokinase Relocalizes into Subcellular Compartments with Liquid-like Properties In Vivo", has been published in Biophysical Journal!
- August 10, 2020
The lab welcomes Research Associate Ben Clark.
- August 10, 2020
Sisi re-names gene W09C5.7 as SAC-2 and provides the first characterization of its alleles on WormBase.
Welcome to the Colón-Ramos Lab
Overview
A fundamental question in neuroscience is how synapses are assembled in living animals to produce behaviors and store memories. Our lab is focused on this question and uses the nematode C. elegans to examine the cell biological mechanisms by which synapses are precisely assembled during development, maintained during growth and modified during learning to store memories.
video: Cell biology of the synapse and behavior in C. elegans
Cell biology of the synapse and behavior in C. elegans
https://www.ibiology.org/neuroscience/neuronal-synapse/
Projects
We can scrutinize the interplay between the cell biology of the synapse and behavior at three levels:
video: Mechanisms of neuronal synapse assembly and function
Mechanisms of neuronal synapse assembly and function
https://www.ibiology.org/neuroscience/neuronal-synapse/#part-2
video: Actuating memory: how C. elegans remembers
Actuating memory: how C. elegans remembers
https://www.ibiology.org/neuroscience/neuronal-synapse/#part-3
Recent Publications
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A muscle-epidermis-glia signaling axis sustains synaptic specificity during allometric growth in Caenorhabditis elegans.
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The Journey of the Synaptic Autophagosome: A Cell Biological Perspective.
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A specific ATG-4 isoform is required for autophagic maturation and clearance in C. elegans neurons.
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Transforming the development and dissemination of cutting-edge microscopy and computation.
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Isotropic Light-Sheet Microscopy and Automated Cell Lineage Analyses to Catalogue Caenorhabditis elegans Embryogenesis with Subcellular Resolution.
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Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2.