Neill Epperson, MD
Director, Yale Program For Women’s Reproductive Behavioral Health (WRBH)About
Research
Publications
2024
Extortion experiences of recent adult immigrants from Latin America: self-reported prevalence, associated costs, and current mental health
Vargas L, Epperson C, Richmond T, Sharif S, Berkowitz L, Giano Z, Hargarten S, Ungar M, Weigend-Vargas E, Sakai J. Extortion experiences of recent adult immigrants from Latin America: self-reported prevalence, associated costs, and current mental health. Injury Epidemiology 2024, 11: 43. PMID: 39238066, PMCID: PMC11376018, DOI: 10.1186/s40621-024-00524-2.Peer-Reviewed Original ResearchMaternal adverse childhood experiences and infant visual-limbic white matter development
Demers C, Hankin B, Haase M, Todd E, Hoffman M, Epperson C, Styner M, Davis E. Maternal adverse childhood experiences and infant visual-limbic white matter development. Journal Of Affective Disorders 2024 PMID: 39191307, DOI: 10.1016/j.jad.2024.08.146.Peer-Reviewed Original ResearchMaternal adverse childhood experiencesAdverse childhood experiencesInferior longitudinal fasciculusFractional anisotropyLongitudinal fasciculusChildhood experiencesLeft inferior longitudinal fasciculusStructural magnetic resonance imagingPredictors of mental healthVisual processing networksNo group differencesExploratory analysisChildhood questionnaireEarly life adversity exposuresWhite matter microstructureMother-infant dyadsFollow-up analysisCognitive circuitsPreliminary supportNeural circuit developmentInfant brain developmentMagnetic resonance imagingGroup differencesSensory processingIntergenerational riskTrends in Individual Career Development Awards from National Institutes of Health to Physicians in Departments of Psychiatry (2013–2022)
Sakai J, Epperson C, Panchal Z, Ali D, Singhal S, Mikulich-Gilbertson S. Trends in Individual Career Development Awards from National Institutes of Health to Physicians in Departments of Psychiatry (2013–2022). Academic Psychiatry 2024, 1-5. PMID: 39174721, DOI: 10.1007/s40596-024-02027-0.Peer-Reviewed Original ResearchDepartment of PsychiatryCareer development awardsDevelopment AwardNon-physician facultyNational InstituteNational Institutes of HealthNational Institutes of Health (NIHInstitutes of HealthPhysiciansPsychiatry facultyObjectiveThe authorsPsychiatryConclusionsThe numberDepartmentLinear regressionFacultyNationalMethodsDataHealthEstimated slopePsychiatristsLack of growthTreating new-onset cognitive complaints after risk-reducing salpingo-oophorectomy: A randomized controlled crossover trial of lisdexamfetamine
Metcalf C, Page C, Stocker B, Johnson R, Duffy K, Sammel M, Loughead J, Epperson C. Treating new-onset cognitive complaints after risk-reducing salpingo-oophorectomy: A randomized controlled crossover trial of lisdexamfetamine. Gynecologic Oncology 2024, 190: 62-69. PMID: 39146756, DOI: 10.1016/j.ygyno.2024.07.689.Peer-Reviewed Original ResearchRisk-reducing salpingo-oophorectomySelf-report measures of executive functionBrown Attention Deficit Disorder ScaleMeasures of executive functionMeasures of cognitive functionWorking memory performanceExecutive function difficultiesMeasures of attentionSelf-report measuresTrial completion ratesGenetically at-riskRandomized controlled crossover trialAttention/working memoryExecutive functionWorking memoryDisorder ScaleMemory performanceSustained attentionCognitive complaintsCognitive tasksLisdexamfetamineCognitive functionActive medicationTotal scoreFunctional difficultiesLuteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation
Barone J, Ho A, Osborne L, Eisenlohr-Moul T, Morrow A, Payne J, Epperson C, Hantsoo L. Luteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation. Psychoneuroendocrinology 2024, 169: 107145. PMID: 39096755, DOI: 10.1016/j.psyneuen.2024.107145.Peer-Reviewed Original ResearchPremenstrual dysphoric disorderSertraline treatmentMultilevel linear modelsDysphoric disorderHypothalamic pituitary gonadalHypothalamic pituitary adrenal (HPA) axisEffects of sertraline treatmentHypothalamic pituitary adrenal (HPA) axis activityPMDD patientsPMDD statusOpen-label sertralineMildly stressful tasksPremenstrual dysphoric disorder groupDaily symptom ratingsSevere affective symptomsEffect of groupPremenstrual symptom severityMenstrual cycle phaseAssociated with higher levelsALLO levelsInflammatory markersMenstrual cycleAffective symptomsAffective disordersClinical interviewTraumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America
Vargas L, Sammel M, Richmond T, Ulrich C, Giano Z, Berkowitz L, Epperson C. Traumatic experiences and place of occurrence: An analysis of sex differences among a sample of recently arrived immigrant adults from Latin America. PLOS ONE 2024, 19: e0302363. PMID: 38875238, PMCID: PMC11178180, DOI: 10.1371/journal.pone.0302363.Peer-Reviewed Original ResearchConceptsHome countryLatin AmericaU.S. southern borderLatin American migrantsU.S.-Mexico borderCountry of originAmerican migrantsIncreased violenceMigration journeySexual assaultImmigrant adultsEconomic instabilitySexual traumaMigrantsGender differencesExposed to traumatic eventsSouthern borderCountriesAnalysis of sex differencesTraumatic experiencesTrauma exposureLatinTraumatic exposureCombat exposureHomeBeyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder
Page C, Epperson C, Novick A, Duffy K, Thompson S. Beyond the serotonin deficit hypothesis: communicating a neuroplasticity framework of major depressive disorder. Molecular Psychiatry 2024, 1-12. PMID: 38816586, DOI: 10.1038/s41380-024-02625-2.Peer-Reviewed Original ResearchDepressive disorderTreatment of MDDEmotional brain circuitsMental health crisisMonoaminergic antidepressantsSerotonergic antidepressantsEmotional processingDeficit hypothesisBrain circuitsMDDBehavioral functionsHypothesis explanationAntidepressantsInsufficient supportive evidenceSerotoninNeuromodulation techniquesPreclinical researchNegative biasDisordersPersistent negative biasSupportive evidenceCliniciansPsychotherapyEffective treatmentPsychedelicsSex differences in stress-induced cortisol response among infants of mothers exposed to childhood adversity
Duffy K, Sammel M, Johnson R, Morrison K, Bale T, Epperson C. Sex differences in stress-induced cortisol response among infants of mothers exposed to childhood adversity. Biological Psychiatry 2024 PMID: 38821195, DOI: 10.1016/j.biopsych.2024.05.015.Peer-Reviewed Original ResearchAdverse childhood experiencesMother-infant dyadsCortisol responseSex differencesAssociated with lower cortisol responsesHypothalamic-pituitary-adrenal (HPA) axisStress-induced cortisol responseExposure to childhood abuseSix-month-old infantsAdverse Childhood Experiences QuestionnaireInfants of mothersLow cortisol responseMeasured salivary cortisolSignificant sex differencesImpact of adverse childhood experiencesInfant cortisolChildhood abuseLaboratory stressorHPA axisChildhood adversityMental illnessChildhood experiencesSalivary cortisolAbuseStressorsHarnessing technology to improve sleep in frontline healthcare workers: A pilot study of electronic noise-masking earbuds on subjective and objective sleep measures
Haller H, Moore S, Green K, Johnson R, Sammel M, Epperson C, Novick A. Harnessing technology to improve sleep in frontline healthcare workers: A pilot study of electronic noise-masking earbuds on subjective and objective sleep measures. Science Progress 2024, 107: 00368504241242276. PMID: 38614463, PMCID: PMC11016237, DOI: 10.1177/00368504241242276.Peer-Reviewed Original ResearchConceptsInsomnia Severity IndexHealthcare workersIntervention periodObjective sleep measuresSleep onset latencyBaseline assessmentCompared to baseline assessmentsSleep qualitySleep measuresReported sleep difficultiesPre-post designFrontline healthcare workersPilot studyInsomnia Severity Index scoreSelf-report assessmentsBaseline to interventionNonpharmacological interventionsLinear mixed modelsObjective sleep parametersImprove sleepObjective sleep onset latencySleep difficultiesInterventionSubjective sleep perceptionCompared to baselineApplication of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T
Jacobs P, Jee J, Fang L, Devlin E, Iannelli C, Thakuri D, Loughead J, Epperson C, Wilson N, Roalf D, Reddy R, Nanga R. Application of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T. PLOS ONE 2024, 19: e0297310. PMID: 38363747, PMCID: PMC10871471, DOI: 10.1371/journal.pone.0297310.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexNon-smokersCingulate gyrusAnterior cingulate cortexContext of addictionTreating nicotine addictionApplication of glutamatePopulation of smokersWilcoxon rank sum testGluCEST imagingTraumatic brain injuryT1-weighted imagesInvestigated glutamateSignificant healthcare issueCingulate cortexGray matter regionsRank sum testNicotine useNicotine addictionNicotine dependenceBrain regionsChemical exchange saturation transferNegative age dependenceHealthy participantsUltra-high field MRI
News
News
- May 18, 2018
Epperson named Chair of Psychiatry at CU School of Medicine
- October 01, 2006
Grants and contracts awarded to Yale School of Medicine
- June 01, 2006
Grants and contracts awarded to Yale School of Medicine, November/December 2005
- July 01, 2005
Grants and contracts awarded to Yale School of Medicine