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Titles
Assistant Professor
Appointments
Comparative Medicine
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Associate
- University of Pittsburgh School of Medicine (2024)
- Postdoctoral Associate
- The Johns Hopkins University (2021)
- PhD
- New York University School of Medicine, Biochemistry & Molecular Pharmacology (2017)
- BS
- University of Maryland, Baltimore County, Biochemistry & Molecular Biology (2011)
Research
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Overview
Medical Research Interests
Adipose Tissue; Drosophila melanogaster; Endocrinology; Fertility; Gametogenesis; Gonadal Hormones; Reproduction; Sex Differentiation
Public Health Interests
Aging; Metabolism
ORCIDs
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Grmai Lab
Research at a Glance
Publications Timeline
A big-picture view of Lydia Grmai's research output by year.
Research Interests
Research topics Lydia Grmai is interested in exploring.
12Publications
216Citations
Drosophila melanogaster
Sex Differentiation
Publications
2025
Emerging roles for integrated stress response signaling in homeostasis
Nandakumar S, Grmai L, Vasudevan D. Emerging roles for integrated stress response signaling in homeostasis. The FEBS Journal 2025, 292: 4418-4445. PMID: 40657906, PMCID: PMC12276862, DOI: 10.1111/febs.70166.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntegrated stress responseIntegrated stress response signalingLoss-of-function mutantsYeast to humansSignaling ComponentsStress response signalingSingle-celled organismsStress adaptation mechanismsMulticellular organismsProtein misfoldingCellular processesModel organismsNutrient deprivationEvolutionary complexityCellular functionsStress responseSignaling mechanismsCell-intrinsicHomeostatic functionsHomeostatic roleHomeostasisOxidative stressInfectious agentsYeastPhylum
2024
Integrated stress response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation
Grmai L, Michaca M, Lackner E, Narayanan N, Vasudevan D. Integrated stress response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation. Cell Reports 2024, 43: 113863. PMID: 38457339, PMCID: PMC11077669, DOI: 10.1016/j.celrep.2024.113863.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntegrated stress response signalingIntegrated stress responseMetabolic sensorFat bodyNutrient-sensing roleDepletion of ATF4Amino acid deprivationStress response signalingEgg-laying behaviorDrosophila melanogasterReproductive outputTranscription factorsATF4Stress responseSignaling mechanismsLipoprotein productionNutrient statusLipoprotein synthesisOogenesisLipase activityRe-feedingOocyte maturationMelanogasterCNMamideFat tissue
2023
A ‘citizen science’ approach to transforming scientific research and education
Grmai L. A ‘citizen science’ approach to transforming scientific research and education. Developmental Biology 2023, 501: a9-a10. PMID: 37343747, DOI: 10.1016/j.ydbio.2023.06.009.Peer-Reviewed Original ResearchFrom motor neurons to Malta – A graduate student profile
Grmai L. From motor neurons to Malta – A graduate student profile. Developmental Biology 2023, 496: 97. PMID: 36774278, DOI: 10.1016/j.ydbio.2023.02.003.Peer-Reviewed Original ResearchAltmetric
2022
The Regulation of Germline Sex Determination in Drosophila by Sex lethal
Grmai L, Pozmanter C, Van Doren M. The Regulation of Germline Sex Determination in Drosophila by Sex lethal. Sexual Development 2022, 16: 323-328. PMID: 35259743, PMCID: PMC10540089, DOI: 10.1159/000521235.Peer-Reviewed Original ResearchCitationsAltmetricConceptsGermline sex determinationSex determinationGerm cellsInheritance of sex chromosomesProduction of healthy gametesConsequences of sex determinationSexual developmentFemale germ cellsGeneration of spermDisorders of sexual developmentSomatic gonadSex chromosomesFemale oocytesHealthy gametesSxlDrosophilaSomatic cellsGermlineSexual dimorphismCell typesEnvironmental factorsGonadsCellsBehavioral differencesSpermatids
2021
Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin
Herrera S, de la Maza D, Grmai L, Margolis S, Plessel R, Burel M, O’Connor M, Amoyel M, Bach E. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin. Developmental Cell 2021, 56: 2284-2294.e6. PMID: 34363758, PMCID: PMC8387025, DOI: 10.1016/j.devcel.2021.07.010.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHub cellsSomatic cyst stem cellsCyst stem cellsGermline stem cellsCell quiescenceTestis nicheDrosophila testisStem cellsTranscription factorsStem cell nicheProliferative stem cellsStem cell poolActivin ligandsReceptor signalingActivin receptor signalingStem cell dysfunctionNicheActivin antagonist follistatinNiche cellsCell nicheActivin inhibitor follistatinInhibitor follistatinTestisCell poolCellsTranscriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveals putative downstream effectors of the transcription factor Chinmo
Grmai L, Harsh S, Lu S, Korman A, Deb I, Bach E. Transcriptomic analysis of feminizing somatic stem cells in the Drosophila testis reveals putative downstream effectors of the transcription factor Chinmo. G3: Genes, Genomes, Genetics 2021, 11: jkab067. PMID: 33751104, PMCID: PMC8759813, DOI: 10.1093/g3journal/jkab067.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLoss of chinmoSomatic gonadal cellsSomatic support cellsTranscription factor ChinmoSomatic cellsPotential target genesTranscriptome analysisGonadal cellsAdult Drosophila testisDrosophila melanogaster testisSex-specific gametesNext-generation sequencingSupporting cellsDrosophila testisMale germlineChinmoExpressed genesGerm cellsDownregulated genesFemale gonadsSexual dimorphismTestisMale sexual identitySomatic stem cellsTranscription
2018
Chinmo prevents transformer alternative splicing to maintain male sex identity
Grmai L, Hudry B, Miguel-Aliaga I, Bach E. Chinmo prevents transformer alternative splicing to maintain male sex identity. PLOS Genetics 2018, 14: e1007203. PMID: 29389999, PMCID: PMC5811060, DOI: 10.1371/journal.pgen.1007203.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAlternative SplicingAnimalsAnimals, Genetically ModifiedCell DifferentiationDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianFemaleGene Expression Regulation, DevelopmentalMaleNerve Tissue ProteinsNuclear ProteinsOvaryRNA-Binding ProteinsSex Determination ProcessesSex DifferentiationTestisConceptsFemale isoformSex transformationLoss of chinmoSexually dimorphic animalsSex determination hierarchySomatic support cellsSexually dimorphic tissuesFemale-specific expressionPost-transcriptional regulationSomatic stem cellsSex identitySex-lethalTra mRNASomatic gonadGermline differentiationSex maintenanceTranscriptional regulationAlternative splicingDetermination hierarchyTranscriptional controlChinmoStem cellsFl(2)dMale infertilityGamete production
2013
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway
Zoranovic T, Grmai L, Bach E. Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway. JAK-STAT 2013, 2: e25408. PMID: 24069565, PMCID: PMC3772117, DOI: 10.4161/jkst.25408.Peer-Reviewed Original ResearchCitationsConceptsJAK-STAT pathwayJAK-STATCell competitionRegulator of tissue sizeJAK-STAT pathway activationRegulation of proliferationImaginal discsSTAT genesDrosophila melanogasterGenetic dissectionGenetic toolsDiverse signalsDiploid cellsCellular growthGrowth assayControl proliferationGrowth controlIdeal organismDrosophilaPathway activationClonal growth assayPathwayTissue sizeCellsEarly stages of transformation
2011
An unassigned DAHP synthase activity found only in pathogenic Escherichia coli strains
Yep A, Grmai L, Emanuele A, Woodard R. An unassigned DAHP synthase activity found only in pathogenic Escherichia coli strains. The FASEB Journal 2011, 25: 967.8-967.8. DOI: 10.1096/fasebj.25.1_supplement.967.8.Peer-Reviewed Original ResearchConceptsE. coli CFT073Enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthasePathogenic Escherichia coli strainsExtraintestinal pathogenic E. coli strainsPathogenic E. coli strainsSynthesis of aromatic amino acidsUncomplicated urinary tract infectionsShikimate biosynthetic pathwayActive site topologyBLAST searchShikimate pathwayMinimal mediumKnockout strainBiosynthetic pathwayInhibitor binding siteEscherichia coliAroGAromatic amino acidsSite topologyAroFAmino acidsDAHPBinding sitesCFT073Genes
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