Anna Christina Nobre
Wu Tsai Professor of PsychologyCards
About
Research
Publications
2025
Neurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography
Jafarian A, Assem M, Kocagoncu E, Lanskey J, Fye H, Williams R, Quinn A, Pitt J, Raymont V, Lowe S, Singh K, Woolrich M, Nobre A, Henson R, Friston K, Rowe J. Neurophysiological Progression in Alzheimer's Disease: Insights From Dynamic Causal Modelling of Longitudinal Magnetoencephalography. Human Brain Mapping 2025, 46: e70234. PMID: 40396657, PMCID: PMC12093352, DOI: 10.1002/hbm.70234.Peer-Reviewed Original ResearchConceptsDynamic causal modelingAssociated with neurophysiological changesCognitive declineMedial prefrontal cortexAlzheimer's diseaseCausal modelEffects of Alzheimer's diseaseHuman neuroimaging dataExperimental medicine studiesRegion-specificLongitudinal changesApplication of dynamic causal modelingResting-state magnetoencephalographyMild cognitive impairmentPrefrontal cortexAmyloid-positive mild cognitive impairmentMode networkNMDA neurotransmissionTwenty-nine peopleNMDA type glutamate receptorsNeuroimaging dataCortical regionsEffective connectivityNeuropsychiatric diseasesNeuronal vulnerabilityAge-invariant benefits of spatiotemporal predictions amidst distraction during dynamic visual search
Shalev N, Boettcher S, Nobre A. Age-invariant benefits of spatiotemporal predictions amidst distraction during dynamic visual search. Scientific Reports 2025, 15: 17078. PMID: 40379870, PMCID: PMC12084335, DOI: 10.1038/s41598-025-01796-4.Peer-Reviewed Original ResearchConceptsSensitivity to distractionGoal-driven attentionGuidance of attentionVisual search taskOlder adultsAge-related differencesEffects of predictabilityDynamic visual searchAttentional controlHigh distractionAttentional guidanceGoal-directedVisual searchSearch taskDistractorsStudy attentionDistractionPoor performanceSpatiotemporal regularityDistracting elementsAdultsAttentionDeficitsFocusing attention in working and long-term memory through dissociable mechanisms
Gong D, Draschkow D, Nobre A. Focusing attention in working and long-term memory through dissociable mechanisms. Nature Communications 2025, 16: 4126. PMID: 40319062, PMCID: PMC12049562, DOI: 10.1038/s41467-025-59359-0.Peer-Reviewed Original ResearchConceptsLong-term memoryWorking memoryPerceptual tasksLTM representationsSpatial working memoryMemory typesSensory information processingAttentional orientingAttentional prioritizationMemory itemsHealthy young adultsGaze biasAttentional cuesVisual discriminationVisual stimuliItem matchingEye trackingInformation processingBenefit performanceYoung adultsMemoryGaze shiftsNon-spatialTaskItemsConfidence and Insight into Working Memories Are Shaped by Attention and Recent Performance.
Chekroud S, Nobre A, Kolling N. Confidence and Insight into Working Memories Are Shaped by Attention and Recent Performance. Journal Of Cognitive Neuroscience 2025, 1-18. PMID: 40136267, DOI: 10.1162/jocn_a_02326.Peer-Reviewed Original ResearchInternally directed attentionWorking memoryConfidence judgmentsIntrospective judgmentsMemory performanceAccuracy of confidence judgmentsMemory contentWorking-memory maintenanceWorking memory contentsObjective memory performanceWorking-memory contentsRetrospective cuesProbe itemMemory qualityMemory errorsAlpha desynchronizationIntrospective insightsMemoryJudgmentItemsParticipantsRetrocueCuesAttentionSequential processNeural Dynamics of Reselecting Visual and Motor Contents in Working Memory after External Interference
Gresch D, Behnke L, van Ede F, Nobre A, Boettcher S. Neural Dynamics of Reselecting Visual and Motor Contents in Working Memory after External Interference. Journal Of Neuroscience 2025, 45: e2347242025. PMID: 40097181, PMCID: PMC12044030, DOI: 10.1523/jneurosci.2347-24.2025.Peer-Reviewed Original ResearchWorking memoryMotor contentMemory itemsInterrupting taskInternal representationNeural dynamicsPerceptual discrimination taskWorking-memory taskMemory-guided behaviorBeta (13-30 HzRetro-cueResponse handRetention intervalDiscrimination taskMemory attributesMotor representationsMotor attributesPerceptual eventsCognitive systemPosterior alphaMulti-tasking situationsInternal focusItem locationsMemoryResponse demandsReducing inequalities through greater diversity in clinical trials – As important for medical devices as for drugs and therapeutics
Roope L, Walsh J, Welland M, Samuel G, Johansen-Berg H, Nobre A, Clare S, Higham H, Campbell J, Denison T, Miller K, Fazel S, Costa M, Farmer A, Knight M, Taylor R, Henderson L, Vaid A, Geddes J, Kiparoglou V, McShane H, Clarke P. Reducing inequalities through greater diversity in clinical trials – As important for medical devices as for drugs and therapeutics. Contemporary Clinical Trials Communications 2025, 45: 101467. PMID: 40235622, PMCID: PMC11999327, DOI: 10.1016/j.conctc.2025.101467.Peer-Reviewed Original ResearchRandomised controlled trialsTrial recruitmentImprove trial recruitmentInvolvement of community partnersIncreasing health inequalitiesActual recruitment processCohort of participantsHigh quality evidenceGold standard evidenceHealth inequalitiesCommunity partnersImprove recruitmentRecruitment processQuality evidenceEvidence baseNon-monetary incentivesStandard evidenceReduce inequalitiesFinancial incentivesControlled trialsFunding streamsPublic healthClinical researchReal-world populationTrialsLong-term memory facilitates spontaneous memory usage through multiple pathways
Kumle L, Kovoor J, Watt R, Boettcher S, Nobre A, Draschkow D. Long-term memory facilitates spontaneous memory usage through multiple pathways. Current Biology 2025, 35: 1171-1179.e5. PMID: 40023149, DOI: 10.1016/j.cub.2025.01.045.Peer-Reviewed Original ResearchConceptsLong-term memoryWorking memorySensory samplingSensory informationMemory taskMemory encodingStimulus arrangementMemory informationExplicit reportsAdaptive behaviorSensory processingMemory contentEye movementsMemoryTaskParticipantsRealistic objectsIncreased relianceEngagementBehaviorImpressive flexibilityNatural behaviorEncodingNeural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment
Scholl J, Panchal P, Nelissen N, Atkinson L, Kolling N, Saunders K, Geddes J, Rushworth M, Nobre A, Harrison P, Harmer C. Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment. Molecular Psychiatry 2025, 30: 2955-2965. PMID: 39880901, PMCID: PMC12185344, DOI: 10.1038/s41380-025-02900-w.Peer-Reviewed Original ResearchBipolar disorderDecision-making taskReward-guided decision-making taskFunctional magnetic resonance imagingWeeks of lithiumSymptoms of maniaDorsolateral prefrontal cortexMood Disorder QuestionnaireRisk-takingReward outcomesReward processingPrefrontal cortexMood ratingsNeural signaturesNeural mechanismsRisk-related behaviorsLithium treatmentMoodDiagnosed BDBD studiesFunction of riskDisordersOutcome historyMagnetic resonance imagingMDQSensorimnemonic decisions: choosing memories versus sensory information
Kumle L, Nobre A, Draschkow D. Sensorimnemonic decisions: choosing memories versus sensory information. Trends In Cognitive Sciences 2025, 29: 311-313. PMID: 39855974, DOI: 10.1016/j.tics.2024.12.010.Peer-Reviewed Original Research
2024
Spatiotemporal predictions guide attention throughout the adult lifespan
Shalev N, Boettcher S, Nobre A. Spatiotemporal predictions guide attention throughout the adult lifespan. Npj Science Of Learning 2024, 9: 70. PMID: 39572597, PMCID: PMC11582576, DOI: 10.1038/s41539-024-00281-3.Peer-Reviewed Original Research
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