Anna Christina Nobre
Wu Tsai Professor of PsychologyCards
About
Research
Publications
2025
Divergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing
Trubshaw M, Kohl O, Gohil C, van Es M, Quinn A, Yoganathan K, Edmond E, Proudfoot M, Zokaei N, Raymont V, Pitt J, Thayanandan T, Thompson A, Talbot K, Hu M, Perquin M, Kocagoncu E, Rowe J, Woolrich M, Nobre A, Turner M. Divergence of cortical neurophysiology across different neurodegenerative disorders compared to healthy ageing. Progress In Neurobiology 2025, 257: 102865. PMID: 41349953, DOI: 10.1016/j.pneurobio.2025.102865.Peer-Reviewed Original ResearchPower spectrum slopeSpectrum slopeBrain network communicationBeta powerMagnetic fieldHealthy agingEmergence of symptomsSlowing of oscillatory activityPatterns of activityCortical neuronal activityGamma connectivityAging trajectoriesNeuronal activityOscillatory activityNeurodegenerative disordersMagnetoencephalographyCortical neurophysiologyHealthy controlsStages of neurodegenerationMEG recordingsPresymptomatic stageParkinson's diseaseAlzheimer's diseaseDisordersSource of biomarkersImplicit learning across varying temporal scales in individuals with and without mood instability
Atkinson L, Zokaei N, Panchal P, Nelissen N, Saunders K, Rushworth M, Darby D, Geddes J, Harmer C, Harrison P, Nobre A. Implicit learning across varying temporal scales in individuals with and without mood instability. Journal Of Affective Disorders 2025, 395: 120728. PMID: 41260366, DOI: 10.1016/j.jad.2025.120728.Peer-Reviewed Original ResearchConceptsMood Disorder QuestionnaireMood instabilityImplicit learningBipolar disorderContextual cuesExperimental sessionsMood disorder questionnaire scoresContextual cueing taskAssociated with greater instabilityLearning of regularitiesGroups of participantsCueing taskMood ratingsLearning slopePsychiatric disordersBetween-subjects experimental studyStimulus regularitiesMDQ scoreMoodCognitive impairmentCognitionCuesParticipantsDisordersAlternate daysAlzheimer's disease and its progression reduce pyramidal cell gain and connectivity
Lanskey J, Jafarian A, Karadag M, Kocagoncu E, Williams R, Yadav P, Quinn A, Pitt J, Thayanandan T, Lowe S, Perkinton M, Timmers M, Raymont V, Singh K, Woolrich M, Nobre A, Henson R, Rowe J. Alzheimer's disease and its progression reduce pyramidal cell gain and connectivity. Alzheimer's & Dementia 2025, 21: e70805. PMID: 41137705, PMCID: PMC12553034, DOI: 10.1002/alz.70805.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseIn vivo assaysTest-retest reliabilitySensitive to Alzheimer's diseaseHuman diseasesAD mechanismsNeurophysiological deficitsCell gainDisease mechanismsLoss of neuronsMismatch negativity amplitudeCell functionExperimental medicine studiesDynamic causal modelingMismatch negativity paradigmPyramidal cellsEmpirical Bayes analysisMismatch negativity responseEvoked responsesIntervention studiesAlzheimerSymptomatic ADPotential biomarkersCognitive declineHealthy adultsDisambiguating dimensions of external and internal brain processes
van Ede F, Gresch D, Nobre A. Disambiguating dimensions of external and internal brain processes. Trends In Neurosciences 2025 PMID: 41111012, DOI: 10.1016/j.tins.2025.10.001.Peer-Reviewed Original ResearchDivergent Brain Network Activity in Asymptomatic C9orf72 and SOD1 Variant Carriers Compared With Established Amyotrophic Lateral Sclerosis
Trubshaw M, Gohil C, Edmond E, Proudfoot M, Yoganathan K, Wuu J, Northall A, Kohl O, Stagg C, Nobre A, Talbot K, Thompson A, Benatar M, Woolrich M, Turner M. Divergent Brain Network Activity in Asymptomatic C9orf72 and SOD1 Variant Carriers Compared With Established Amyotrophic Lateral Sclerosis. Human Brain Mapping 2025, 46: e70345. PMID: 41042072, PMCID: PMC12492477, DOI: 10.1002/hbm.70345.Peer-Reviewed Original ResearchConceptsAmyotrophic lateral sclerosisAt-risk populationsGenetically at-risk groupSymptomatic amyotrophic lateral sclerosisAsymptomatic gene carriersSOD1-amyotrophic lateral sclerosisResting-state MEG recordingsPreventive therapeutic interventionsLateral sclerosisC9orf72 amyotrophic lateral sclerosisPathogenic variantsTherapy efficacyVariant carriersHealthy controlsChronic adaptive changesFrontal oscillatory activityHigh riskAt-risk groupsGene carriersOscillatory activityTherapeutic interventionsCortical pathologyBeta frequency powerNeurodevelopmental factorsC9orf72 carriersConfidence and Insight into Working Memory Are Shaped by Attention and Recent Performance
Chekroud S, Nobre A, Kolling N. Confidence and Insight into Working Memory Are Shaped by Attention and Recent Performance. Journal Of Cognitive Neuroscience 2025, 37: 1685-1702. PMID: 40136267, PMCID: PMC7617916, DOI: 10.1162/jocn_a_02326.Peer-Reviewed Original ResearchInternally directed attentionWorking memoryConfidence judgmentsIntrospective judgmentsMemory performanceAccuracy of confidence judgmentsMemory contentWorking-memory maintenanceWorking memory contentsObjective memory performanceWorking-memory contentsRetrospective cuesProbe itemMemory qualityMemory errorsAlpha desynchronizationIntrospective insightsMemoryJudgmentItemsParticipantsRetrocueCuesAttentionSequential processReduced beta bursting underpins loss of corticomuscular coherence in amyotrophic lateral sclerosis
Yoganathan K, Trubshaw M, Kohl O, Gohil C, Echeverria-Altuna I, Dharmadasa T, Northall A, Zokaei N, Lester D, Garcia G, Collins A, Amein B, Nobre A, Talbot K, Thompson A, Woolrich M, Turner M. Reduced beta bursting underpins loss of corticomuscular coherence in amyotrophic lateral sclerosis. Brain Communications 2025, 7: fcaf339. PMID: 41063967, PMCID: PMC12501500, DOI: 10.1093/braincomms/fcaf339.Peer-Reviewed Original ResearchSurface electromyographyGrip strengthCorticomuscular coherenceBipolar surface electromyographySecondary outcome measuresHand grip taskFlexor forearm musclesMotor system dysfunctionMuscle activityAmyotrophic lateral sclerosisOutcome measuresForearm musclesGrip taskEMG signalsProdromal markersBiomarkers of disease activityMotor cortexAsymptomatic individualsHealthy age-matched controlsParticipantsCortical motor regionsElectromyographyAmyotrophic lateral sclerosis patientsMuscle contractionNon-invasive measurementHow the brain shifts between external and internal attention
Nobre A, Gresch D. How the brain shifts between external and internal attention. Neuron 2025, 113: 2382-2398. PMID: 40675155, DOI: 10.1016/j.neuron.2025.06.013.Peer-Reviewed Original ResearchThe Influence of Local and Global Temporal Regularities on Visual Detection
Gao L, Nobre A. The Influence of Local and Global Temporal Regularities on Visual Detection. Journal Of Vision 2025, 25: 2392. DOI: 10.1167/jov.25.9.2392.Peer-Reviewed Original ResearchImmediate reselection of visual and motor memories after external interference
Gresch D, Behnke L, Nobre A, Boettcher S. Immediate reselection of visual and motor memories after external interference. Journal Of Vision 2025, 25: 2398. DOI: 10.1167/jov.25.9.2398.Peer-Reviewed Original Research
News
Get In Touch
Contacts
Email