Gianfilippo Coppola
Research Scientist in PathologyCards
About
Research
Publications
2026
Phenotypic changes in cortical astrocytes translatome across the estrous cycle
Rurak G, Groulx C, McFee A, Aguilar-Valles A, Charih F, Green J, Woodside B, Coppola G, Salmaso N. Phenotypic changes in cortical astrocytes translatome across the estrous cycle. Glial Health Research 2026, 3: 100013. DOI: 10.1016/j.ghres.2026.100013.Peer-Reviewed Original ResearchEstrous cycleNeuronal network functionCirculating LevelsGonadal hormonesCirculating levels of estrogenGonadal hormone receptorsRibosome affinity purificationAdult female miceLevels of estrogenBlood-brain barrierProtein expression changesAffinity purificationGene OntologyExpressed genesGene translationTranslatomeFemale miceRNA sequencingMale miceGene expressionHigher-order behaviorFemale rodentsHormone receptorsExpression changesPhenotypic changesDeletion of miR-130b/301b cluster promotes macrophage efferocytosis and resolution of adipose tissue inflammation
Yang L, Abuduyimiti T, Xi Y, Coppola G, Liu C, Jiang S. Deletion of miR-130b/301b cluster promotes macrophage efferocytosis and resolution of adipose tissue inflammation. IScience 2026, 29: 115307. DOI: 10.1016/j.isci.2026.115307.Peer-Reviewed Original ResearchRegulation of mitochondrial metabolismApoptotic cellsAdipose tissue inflammationAdipose tissue macrophagesClearance of apoptotic cellsMacrophage efferocytosisApoptotic cell uptakeMiR-130bApoptotic cell clearance in vivoHigh-fat diet-fed miceBone marrowTissue inflammationEfferocytosis in vitroGlobal deletionResolution of adipose tissue inflammationMitochondrial metabolismMitochondrial respirationBone marrow of miceGene expressionMacrophages of individualsTissue homeostasisDeletionDiet-fed miceMarrow of miceBone marrow-derived macrophagesEx vivo expansion of melanoma tumor infiltrating lymphocytes leads to a dominant exhausted T cell population with lack of memory markers.
Coppola G, Kerr S, Cha P, Bersenev A, Olino K, Kluger H, Sznol M, Weiss S, Bosenberg M, Kleinstein S, Krause D, Hurwitz M, Katz S. Ex vivo expansion of melanoma tumor infiltrating lymphocytes leads to a dominant exhausted T cell population with lack of memory markers. Cancer Immunology Research 2026, of1-of14. PMID: 41686210, PMCID: PMC13032746, DOI: 10.1158/2326-6066.cir-25-0798.Peer-Reviewed Original ResearchTumor-infiltrating lymphocytesMemory cell phenotypeEx vivo expansionInfiltrating lymphocytesEx vivoPatient tumorsT cellsEfficacy of tumor-infiltrating lymphocytesSubpopulations of tumor-infiltrating lymphocytesMelanoma tumor-infiltrating lymphocytesTIL expansionCD8 T cellsCell phenotypeT cell populationsReceptor PD1Individual clonotypesDN cellsEx vivo growthPost-expansionTCR sequencesClinical trialsFDA approvalStem-likeCell differentiation stateTherapeutic effect
2017
Comparative transcriptome and gene regulation in human iPSC-derived organoids and donor-identical brain tissue
Scuderi S, Amiri A, Coppola G, Wu F, Franjic D, Sestan N, Gerstein M, Weissman S, Abyzov A, Vaccarino F. Comparative transcriptome and gene regulation in human iPSC-derived organoids and donor-identical brain tissue. Italian Journal Of Anatomy And Embryology 2017, 196-196. DOI: 10.36253/ijae-2084.Peer-Reviewed Original ResearchStage-specific patternsChIP-seqEpigenomic featuresH3K4me3 peaksOrganoid transcriptomeGene expressionChIP-seq experimentsStage-specific patterns of gene expressionPatterns of gene expressionHuman fetal brain samplesPathophysiology of neuropsychiatric disordersBrain development in vitroAdult brain samplesHuman fetal developmentRNA-seqComparative transcriptomicsGene regulationMature cortical neuronsChromatin immunoprecipitationIn vitro developmentExpressed genesPluripotent stem cellsDevelopment in vitroFetal brain samplesFetal human brainDifferentiation of Human iPSCs Into Telencephalic Neurons Using 3D Organoids and Monolayer Culture
Altobelli G, Scuderi S, Coppola G, Park J, Cimini V, Vaccarino F. Differentiation of Human iPSCs Into Telencephalic Neurons Using 3D Organoids and Monolayer Culture. Italian Journal Of Anatomy And Embryology 2017, 10-10. DOI: 10.36253/ijae-1708.Peer-Reviewed Original ResearchNeural progenitor cellsCortical neuron subtypesDifferentiation of human iPSCsHuman neural stem cellsCell surface moleculesNeural stem cellsNeuronal cell typesCell-to-cell interactionsNeuronal differentiation efficiencyEarly brain developmentNeuronal progenitorsNeuronal subtypesProgenitor cellsHuman iPSCsStem cellsTelencephalic neuronsProtein expressionSurface moleculesRegion-SpecificCell interactionsWestern blottingBrain developmentHiPSCsSpecification of neuronal cell typesNeuronal differentiation