1995
Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry.
Raz N, Torres I, Briggs S, Spencer W, Thornton A, Loken W, Gunning F, McQuain J, Driesen N, Acker J. Selective neuroanatomic abnormalities in Down's syndrome and their cognitive correlates: evidence from MRI morphometry. Neurology 1995, 45: 356-66. PMID: 7854539, DOI: 10.1212/wnl.45.2.356.Peer-Reviewed Original ResearchConceptsDS subjectsDown syndromeNeuroanatomic abnormalitiesParahippocampal gyrusWhite matterBrain regionsSex-matched healthy volunteersDisease hypothesisAnterior cingulate gyrusParietal white matterPrefrontal white matterPremature agingDorsolateral prefrontal cortexCerebral damageThyroid dysfunctionAge-related declineSeizure disorderSignificant group differencesBasal gangliaBrain abnormalitiesCardiovascular diseaseMammillary bodiesCerebellar hemispherePostcentral gyrusCingulate gyrus
1994
Individual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults With IDDM
Gonder-Frederick L, Cox D, Driesen N, Ryan C, Clarke W. Individual Differences in Neurobehavioral Disruption During Mild and Moderate Hypoglycemia in Adults With IDDM. Diabetes 1994, 43: 1407-1412. PMID: 7958491, DOI: 10.2337/diab.43.12.1407.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusModerate hypoglycemiaDegree of impairmentHistory of unconsciousnessNeurobehavioral deteriorationDiabetes mellitusGlycemic thresholdsTest four timesMild hypoglycemiaDay protocolNeurobehavioral disruptionNeurobehavioral effectsGlycemic recoveryHypoglycemiaMore deteriorationRepeat testingCrossover designControl dayDeterioration scoresConsecutive daysExperimental daysImpairment