2024
Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment
McCurdy L, DeVito E, Loya J, Nich C, Zhai Z, Kiluk B, Potenza M. Structural brain changes associated with cocaine use and digital cognitive behavioral therapy in cocaine use disorder treatment. Drug And Alcohol Dependence Reports 2024, 11: 100246. PMID: 38966567, PMCID: PMC11222934, DOI: 10.1016/j.dadr.2024.100246.Peer-Reviewed Original ResearchCocaine use disorderCognitive behavioral therapyCocaine useBehavioral therapyBrain changesBrain structuresWhole-brain voxel-based morphometry analysisCocaine use disorder treatmentLevel of cocaine useWeeks of outpatient treatmentVoxel-based morphometry analysisDigital cognitive behavioral therapyT1-weighted magnetic resonance imaging scansRight caudate bodyAssociated with cocaine useMethadone-maintained individualsGray matter volumeStructural brain changesFunction of engagementCaudate bodyRight caudateCUD treatmentMatter volumeUse disorderBilateral cerebellum
2023
The Effect of Cognitive Behavioral Therapy on Impulsivity in Addictive Disorders: a Narrative Review
Loya J, Benitez B, Kiluk B. The Effect of Cognitive Behavioral Therapy on Impulsivity in Addictive Disorders: a Narrative Review. Current Addiction Reports 2023, 10: 485-493. PMID: 38269068, PMCID: PMC10805411, DOI: 10.1007/s40429-023-00491-6.Peer-Reviewed Original ResearchCognitive behavioral therapyBehavioral therapySubstance useAddictive disordersFuture clinical trialsPoor treatment outcomesEvidence-based treatmentsMeasures of impulsivityCycle of addictionCBT effectsRisk factorsClinical trialsTreatment outcomesRecent FindingsThereNarrative reviewCharacteristics of addictionLimited evidenceRange of addictionsAssessment of impulsivityTherapyAddictionTrialsDisordersImpulsivityAddictive behaviorsEfficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate?
Magill M, Kiluk B, Ray L. Efficacy of Cognitive Behavioral Therapy for Alcohol and Other Drug Use Disorders: Is a One-Size-Fits-All Approach Appropriate? Substance Abuse And Rehabilitation 2023, 14: 1-11. PMID: 36844999, PMCID: PMC9948631, DOI: 10.2147/sar.s362864.Peer-Reviewed Original ResearchUsual care control conditionCare control conditionDrug use disordersUse disordersEvidence-based treatmentsCognitive behavioral therapyMechanism of actionCBT effectsControl conditionDemonstrated efficacyCBT efficacyForm of CBTBehavioral therapyTherapy efficacyAdult alcoholAOD useMotivational interviewingNarrative overviewContingency managementEfficacyIntervention outcomesTraditional CBTCBTPreliminary evidenceEffect sizePromoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
Edelman E, Rojas-Perez O, Nich C, Corvino J, Frankforter T, Gordon D, Jordan A, Paris, Jr M, Weimer M, Yates B, Williams E, Kiluk B. Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population. Addiction Science & Clinical Practice 2023, 18: 55. PMID: 37726823, PMCID: PMC10510167, DOI: 10.1186/s13722-023-00407-9.Peer-Reviewed Original ResearchConceptsPost-hospital dischargeCognitive behavioral therapySelf-reported alcohol useBrief Negotiation InterviewUse disordersAlcohol use outcomesComputer-based trainingDays post-hospital dischargeAlcohol use disorderBehavioral therapyInitiation of medicationHealth care utilizationHealth promotion advocatesTreatment engagementUse outcomesAlcohol useSecondary outcomesHospitalized patientsPrimary outcomeCare utilizationClinical trialsAcademic hospitalExploratory outcomesAUDProcess evaluation
2022
Computer-based training for cognitive behavioral therapy for Spanish-speaking substance users: adaptation and satisfaction
Silva M, Añez L, Carroll K, Jaramillo Y, Kiluk B, Frankforter T, Ball S, Gordon M, Paris M. Computer-based training for cognitive behavioral therapy for Spanish-speaking substance users: adaptation and satisfaction. Journal Of Ethnicity In Substance Abuse 2022, 23: 251-271. PMID: 35714996, PMCID: PMC10350903, DOI: 10.1080/15332640.2022.2086194.Peer-Reviewed Original ResearchComputer-based trainingCognitive-behavioral skills trainingCognitive behavioral therapy programSubstance useBehavioral therapy programCognitive behavioral therapyBehavioral health interventionsBehavioral therapySkills trainingMonolingual SpanishSubstance usersLife experiencesTherapy programProgram contentCultural adaptationSpanishTrainingSatisfactionHealth interventionsAdultsCBT4CBTHigh levelsParticipantsAdaptationIntervention
2021
A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy
Kacmarek CN, Yates BT, Nich C, Kiluk BD. A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy. Alcohol Clinical And Experimental Research 2021, 45: 1109-1121. PMID: 33730384, PMCID: PMC8131237, DOI: 10.1111/acer.14601.Peer-Reviewed Original ResearchConceptsAlcohol use disorderIncremental cost-effective ratioCognitive behavioral therapyStandard outpatient treatmentPilot economic evaluationOutpatient treatmentTreatment costsUse disordersDrinking daysBehavioral therapyComputerized cognitive behavioral therapyEvidence-based treatmentsOutpatient treatment facilitiesTotal treatment costsCost of treatmentCost-effective ratioComputer-delivered interventionNet benefit analysisHealthcare utilizationCost-effective additionClinical trialsTreatment protocolCriminal justice involvementTraditional therapiesTreatment termination
2020
Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders
Ray LA, Meredith LR, Kiluk BD, Walthers J, Carroll KM, Magill M. Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders. JAMA Network Open 2020, 3: e208279. PMID: 32558914, PMCID: PMC7305524, DOI: 10.1001/jamanetworkopen.2020.8279.Peer-Reviewed Original ResearchConceptsSubstance use disordersAdult alcohol use disordersCognitive behavioral therapyUsual careRandomized clinical trialsUse disordersBehavioral therapySpecific therapyClinical trialsAddition of CBTSuperiority of CBTTreatment of SUDsUsual clinical managementForms of pharmacotherapyFirst-line interventionEvidence-based therapiesClinical trial samplesEvidence-based modalitiesAlcohol use disorderEnglish-language articlesPublic health concernFull-text articlesEffect sizeCochrane RegisterRandom effects estimatesThe search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review
Magill M, Tonigan JS, Kiluk B, Ray L, Walthers J, Carroll K. The search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review. Behaviour Research And Therapy 2020, 131: 103648. PMID: 32474226, PMCID: PMC7329023, DOI: 10.1016/j.brat.2020.103648.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug use disordersUse disordersSystematic reviewBehavioral therapyRandomized clinical trialsStudy inclusion criteriaPatient behavior changeCBT-based treatmentClinical trialsInclusion criteriaStatistical mediatorMediator candidatesIntervention ingredientsProject MATCHCBT mechanismsTherapyBehavior change frameworkMediatorsBehavior changeDisordersAddiction researchReportReviewReview sample
2019
Computerized Cognitive Behavioral Therapy for Substance Use Disorders: A Summary of the Evidence and Potential Mechanisms of Behavior Change
Kiluk BD. Computerized Cognitive Behavioral Therapy for Substance Use Disorders: A Summary of the Evidence and Potential Mechanisms of Behavior Change. Perspectives On Behavior Science 2019, 42: 465-478. PMID: 31976445, PMCID: PMC6768920, DOI: 10.1007/s40614-019-00205-2.Peer-Reviewed Original ResearchCognitive behavioral therapySubstance use disordersTraditional cognitive behavioral therapyComputerized cognitive behavioral therapyBehavior changeSubstance useBehavioral coping skillsComputer-delivered interventionComputerized CBT programUse disordersMinimal clinical monitoringCBT programCoping skillsBehavioral therapyCBT mechanismsRates of alcoholConsiderable empirical evidenceBehavioral skillsBehavioral interventionsTheory-driven assumptionsDifferent treatment settingsNew skillsStrong supportEvaluation of individualsTreatment termination
2018
Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisorders
2017
Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial
DeVito EE, Kiluk BD, Nich C, Mouratidis M, Carroll KM. Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial. Drug And Alcohol Dependence 2017, 183: 162-168. PMID: 29258028, PMCID: PMC5803332, DOI: 10.1016/j.drugalcdep.2017.10.022.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug-related stimuliAttentional biasDrug-related cuesCognitive controlStroop effectStroop taskBehavioral therapyTreatment componentsComputer-based cognitive behavioral therapyComputerized cognitive behavioral therapyPoor cognitive controlCognitive control processesExecutive cognitive controlSubstance use severityCocaine use outcomesCocaine use disorderResponse inhibitionUse severityUse outcomesControl processGreater engagementTreatment retentionCBT4CBTCocaine dependenceEffect of computerized cognitive behavioral therapy on acquisition of coping skills among cocaine-dependent individuals enrolled in methadone maintenance
Kiluk BD, DeVito EE, Buck MB, Hunkele K, Nich C, Carroll KM. Effect of computerized cognitive behavioral therapy on acquisition of coping skills among cocaine-dependent individuals enrolled in methadone maintenance. Journal Of Substance Use And Addiction Treatment 2017, 82: 87-92. PMID: 29021121, PMCID: PMC5687291, DOI: 10.1016/j.jsat.2017.09.011.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCocaine-dependent individualsHigh-risk situationsBehavioral therapyVerbal responsesComputerized cognitive behavioral therapyAbstinence outcomesComputerized CBT programParticipants' verbal responsesRole-play assessmentComputer-based trainingCertain high-risk situationsStandard methadone treatmentSubstance use disordersConsistent statistical supportCBT programMethadone treatmentMethadone maintenanceDependent individualsPlay assessmentPrior findingsClinical trialsTreatment periodUse disordersSubstance users
2016
Randomized Trial of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorders: Efficacy as a Virtual Stand‐Alone and Treatment Add‐On Compared with Standard Outpatient Treatment
Kiluk BD, Devore KA, Buck MB, Nich C, Frankforter TL, LaPaglia DM, Yates BT, Gordon MA, Carroll KM. Randomized Trial of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorders: Efficacy as a Virtual Stand‐Alone and Treatment Add‐On Compared with Standard Outpatient Treatment. Alcohol Clinical And Experimental Research 2016, 40: 1991-2000. PMID: 27488212, PMCID: PMC5008977, DOI: 10.1111/acer.13162.Peer-Reviewed Original ResearchConceptsAlcohol use disorderCognitive behavioral therapyComputerized cognitive behavioral therapyAlcohol useUse disordersClinical monitoringBehavioral therapyCurrent alcohol use disorderStandard outpatient treatmentEvidence-based treatmentsWeb-based CBT programPercentage of daysRandomized trialsPreliminary efficacyStandard treatmentOutpatient treatmentTreatment completionTreatment periodOutpatient facilitiesParticipants' alcohol useClinical practiceCBT4CBTCBT programTreatment-seeking individualsClinical samples
2015
The acquisition of coping skills from computerized cognitive behavioral therapy for substance use disorders: It's all where you start
Kiluk B, DeVito E, Buck M, Nich C, Carroll K. The acquisition of coping skills from computerized cognitive behavioral therapy for substance use disorders: It's all where you start. Drug And Alcohol Dependence 2015, 156: e110. DOI: 10.1016/j.drugalcdep.2015.07.305.Commentaries, Editorials and LettersActive Ingredients of Treatment and Client Mechanisms of Change in Behavioral Treatments for Alcohol Use Disorders: Progress 10 Years Later
Magill M, Kiluk BD, McCrady BS, Tonigan JS, Longabaugh R. Active Ingredients of Treatment and Client Mechanisms of Change in Behavioral Treatments for Alcohol Use Disorders: Progress 10 Years Later. Alcohol Clinical And Experimental Research 2015, 39: 1852-1862. PMID: 26344200, PMCID: PMC4592447, DOI: 10.1111/acer.12848.Peer-Reviewed Original ResearchConceptsAlcohol use disorderBehavioral treatmentUse disordersCognitive behavioral therapyActive treatment ingredientsEvidence-based treatmentsTreatment ingredientsBehavioral therapyMotivational interviewingIntervention workFourth treatment modalityBehavioral interventionsDrug use disordersAlcohol behaviorCurrent theoriesCurrent reviewBehavior changeRobust research agendaEvaluation of progressDisordersResearch agendaTreatment modalitiesConceptual frameworkResearchActive ingredients
2014
Only connect: The working alliance in computer-based cognitive behavioral therapy
Kiluk BD, Serafini K, Frankforter T, Nich C, Carroll KM. Only connect: The working alliance in computer-based cognitive behavioral therapy. Behaviour Research And Therapy 2014, 63: 139-146. PMID: 25461789, PMCID: PMC4408209, DOI: 10.1016/j.brat.2014.10.003.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyTechnology-based interventionsWorking Alliance InventoryBehavioral therapyComputer-based cognitive behavioral therapyCocaine-dependent individualsCocaine use outcomesEfficacy of computerDays abstinentFace psychotherapyUse outcomesSimilar psychometric characteristicsPsychometric characteristicsSubscale scoresAlliance InventoryTherapistsPreliminary findingsTotal scoreInterventionTreatment outcomesCBTScoresAbstinentPsychotherapyLittle evidence
2013
Illegal Drug Use
Kiluk B, Carroll K. Illegal Drug Use. 2013, 1339-1358. DOI: 10.1002/9781118528563.wbcbt56.ChaptersCognitive behavioral therapyBehavioral therapyIllegal drug useDrug useNew treatment developmentComputer-delivered versionCognitive functioningMotivational enhancementSubstance use disordersPerson's thoughtsTherapist trainingSkills trainingCognitive functionOperant conditioningTreatment developmentContingency managementBehavior theoryPractice assignmentsSubstance useUse disordersDefining featureTreatment approachesThoughtTrainingFunctioning
2011
A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field
Kiluk BD, Sugarman DE, Nich C, Gibbons CJ, Martino S, Rounsaville BJ, Carroll KM. A Methodological Analysis of Randomized Clinical Trials of Computer-Assisted Therapies for Psychiatric Disorders: Toward Improved Standards for an Emerging Field. American Journal Of Psychiatry 2011, 168: 790-799. PMID: 21536689, PMCID: PMC3607199, DOI: 10.1176/appi.ajp.2011.10101443.Peer-Reviewed Original ResearchConceptsComputer-assisted therapyRandomized clinical trialsPsychiatric disordersClinical trialsMethodological qualityEvidence-based behavioral therapiesMethodological Quality IndexPotential adverse eventsEvidence-based therapiesAxis I DisordersAdult psychiatric disordersMethodological quality scoreEvidence-based interventionsAdverse eventsTreat principleRandomized trialsI disordersStudy qualityTreatment exposureTherapyBehavioral therapyCost-effective strategyDisordersTrialsCurrent standard
2010
Relationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders
Kiluk BD, Nich C, Carroll KM. Relationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders. Drug And Alcohol Dependence 2010, 114: 169-176. PMID: 21050679, PMCID: PMC3046302, DOI: 10.1016/j.drugalcdep.2010.09.019.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyCognitive functioningCoping skillsBehavioral therapySubstance useCoping skills trainingMeasures of IQSubstance-dependent individualsSignificant indirect effectSubstance use outcomesChronic substance useNeuropsychological measuresNeuropsychological factorsSubstance use disordersComputerized versionHigher IQSkills trainingCognitive functionLower IQLittle previous researchIQDependent individualsPoor functioningUse outcomesCognitive impairmentQuality versus quantity: acquisition of coping skills following computerized cognitive–behavioral therapy for substance use disorders
Kiluk BD, Nich C, Babuscio T, Carroll KM. Quality versus quantity: acquisition of coping skills following computerized cognitive–behavioral therapy for substance use disorders. Addiction 2010, 105: 2120-2127. PMID: 20854334, PMCID: PMC2975828, DOI: 10.1111/j.1360-0443.2010.03076.x.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyComputerized CBT programEffects of CBTComputerized cognitive behavioral therapySubstance use disordersEffect of treatmentSubstance use outcomesRole-play taskTreatment completionHigh riskPrimary drugUse disordersAverage ageCommunity settingsBehavioral therapyPatient treatmentSubstance dependenceAlcohol useCBT programSubstance useUse outcomesComputerized versionParticipants' durationSignificant increaseTreatment