2024
A human autoimmune organoid model reveals IL-7 function in coeliac disease
Santos A, van Unen V, Lin Z, Chirieleison S, Ha N, Batish A, Chan J, Cedano J, Zhang E, Mu Q, Guh-Siesel A, Tomaske M, Colburg D, Varma S, Choi S, Christophersen A, Baghdasaryan A, Yost K, Karlsson K, Ha A, Li J, Dai H, Sellers Z, Chang H, Dunn J, Zhang B, Mellins E, Sollid L, Fernandez-Becker N, Davis M, Kuo C. A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 2024, 632: 401-410. PMID: 39048815, DOI: 10.1038/s41586-024-07716-2.Peer-Reviewed Original ResearchMeSH KeywordsAutoantibodiesAutoimmunityB-LymphocytesBiopsyCeliac DiseaseDuodenumEpitopesGlutensGTP-Binding ProteinsHLA-DQ AntigensHumansInterleukin-7Intestinal MucosaKiller Cells, NaturalModels, BiologicalMyeloid CellsOrganoidsProtein Glutamine gamma Glutamyltransferase 2Receptors, Antigen, B-CellReceptors, Antigen, T-CellT-LymphocytesConceptsInterleukin-7Major histocompatibility complexT cellsEpithelial destructionNatural killer (NK) cellsCoeliac diseaseTissue-resident immune cellsB cell receptor repertoiresOrganoid modelsModels of autoimmunityAir-liquid interfaceGluten-free dietActive CeDRemission diseaseIn vitro modelImmune microenvironmentEndoscopic biopsyMyeloid subsetsAutoantibody productionMyeloid cellsPatient biopsiesHLA-DQ8Immune cellsAnti-transglutaminasePlasma cells
2023
IRX5 promotes DNA damage repair and activation of hair follicle stem cells
Chen J, Wiedemann J, Nguyen L, Lin Z, Tahir M, Hui C, Plikus M, Andersen B. IRX5 promotes DNA damage repair and activation of hair follicle stem cells. Stem Cell Reports 2023, 18: 1227-1243. PMID: 37084727, PMCID: PMC10202659, DOI: 10.1016/j.stemcr.2023.03.013.Peer-Reviewed Original ResearchConceptsDNA damage repairDamage repairStem cellsDNA damageDNA damage repair genesCell cycle progressionHair follicle stem cellsEpidermal stem cellsFollicle stem cellsIrx genesChromatin regionsHFSC proliferationHFSC activationInterfollicular epidermal stem cellsDownstream targetsCycle progressionIRX5Molecular mechanismsRepair genesFGF18 expressionAnagen onsetBRCA1 expressionQuiescent phenotypeGenesPromoter
2020
Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
Lin Z, Jin S, Chen J, Li Z, Lin Z, Tang L, Nie Q, Andersen B. Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states. Nature Communications 2020, 11: 5434. PMID: 33116143, PMCID: PMC7595230, DOI: 10.1038/s41467-020-19234-6.Peer-Reviewed Original ResearchConceptsCell statesRNA velocity analysisSingle-cell RNA-seqTerminal differentiation genesStem cell stateInterfollicular epidermisStem cellsInterfollicular epidermal differentiationStem cell expansionDifferentiation genesRNA-seqCommitment pointTerminal differentiationGRHL3Epidermal differentiationCell expansionDifferentiationCellsTransition cellsWntGenesHomeostasis