Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis
Sun M, Phan J, Kieswetter N, Huang H, Yu K, Smith M, Liu Y, Wang C, Gupta S, Obermoser G, Maecker H, Krishnan A, Suresh S, Gupta N, Rieck M, Acs P, Ghanizada M, Chiou S, Khatri P, Boom W, Hawn T, Stein C, Mayanja-Kizza H, Davis M, Seshadri C. Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis. Nature Immunology 2024, 25: 1411-1421. PMID: 38997431, PMCID: PMC11291275, DOI: 10.1038/s41590-024-01897-8.Peer-Reviewed Original ResearchConceptsMtb-specific T cellsT cellsPriming of adaptive immune responsesMtb infectionCD4+ T cellsProgression to active tuberculosisIndividuals exposed to Mycobacterium tuberculosisT-cell biomarkersMtb-specific antigensLatent MTB infectionAdaptive immune responsesBacterial controlAssociated with lackActive tuberculosisClinical phenotypeMtb exposureImmune responseClinical testingSouth African adolescentsTh17Mycobacterium tuberculosisInfectionNegative resultsNonhuman primatesImmune priming