Yang Zhou, PhD, MPH
Associate Research ScientistCards
About
Research
Publications
2024
Further Optimizing Care of Patients With Operable Hormone Receptor-Sensitive Breast Cancer.
Thomas A, Mayer EL, DeMichele A, Harbeck N, Curigliano G, Ignatiadis M, Adam V, Zhou Y, Brown TP, Gilham L, Chua BH, Kalinsky K, Wolff AC, O'Reilly S. Further Optimizing Care of Patients With Operable Hormone Receptor-Sensitive Breast Cancer. J Clin Oncol 2024, JCO2401080. PMID: 39383501, DOI: 10.1200/JCO.24.01080.Peer-Reviewed Original Research
2023
Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomen
2021
Randomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC)
Cartmel B, Hughes M, Ercolano EA, Gottlieb L, Li F, Zhou Y, Harrigan M, Ligibel JA, von Gruenigen VE, Gogoi R, Schwartz PE, Risch HA, Lu L, Irwin ML. Randomized trial of exercise on depressive symptomatology and brain derived neurotrophic factor (BDNF) in ovarian cancer survivors: The Women's Activity and Lifestyle Study in Connecticut (WALC). Gynecologic Oncology 2021, 161: 587-594. PMID: 33773809, PMCID: PMC8085084, DOI: 10.1016/j.ygyno.2021.02.036.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsCES-D scoresCancer survivorsOvarian cancerDepressive symptomatologyAC armStage III/IV ovarian cancerBaseline CES-D scoreTrial of exerciseEpidemiologic Studies Depression ScaleOvarian cancer patientsEffects of exerciseSix-month changesPrevalent mental disordersLower depressive symptomsExercise armSerum BrainNeurotrophin factorRandomized trialsNeurotrophic factorCancer patientsLifestyle StudyDepression ScalePhysical activityDepressive symptoms
2018
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Sanft T, Usiskin I, Harrigan M, Cartmel B, Lu L, Li FY, Zhou Y, Chagpar A, Ferrucci LM, Pusztai L, Irwin ML. Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Research And Treatment 2018, 172: 105-112. PMID: 30062572, DOI: 10.1007/s10549-018-4895-7.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsWeight loss interventionUsual care groupBody mass indexBreast cancer riskCancer survivorsUsual careLoss interventionBreast cancerStage 0Quantitative polymerase chain reactionCare groupTelomere lengthCancer riskStage II/III breast cancerObese breast cancer survivorsWeight lossI breast cancerNon-Hispanic whitesPurposeSome studiesMass indexIntervention groupPhysical activityBlood samplesConclusionOur findingsLymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity
Iyer NS, Cartmel B, Friedman L, Li F, Zhou Y, Ercolano E, Harrigan M, Gottlieb L, McCorkle R, Schwartz PE, Irwin ML. Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity. Cancer 2018, 124: 1929-1937. PMID: 29437202, DOI: 10.1002/cncr.31239.Peer-Reviewed Original ResearchConceptsLower limb lymphedemaOvarian cancer survivorsCancer survivorsSelf-report questionnairesSide effectsSpecialist evaluationCancer treatmentDiagnostic methodsRandomized exercise interventionTrial of exerciseBody mass indexPhysical activity recommendationsEffects of exerciseOvarian cancer treatmentGynecologic cancer treatmentLymphedema prevalenceLymphedema specialistExercise groupExercise interventionDifferent diagnostic methodsMass indexBaseline prevalenceActivity recommendationsOvarian cancerLimb lymphedema
2017
Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC)
Zhou Y, Cartmel B, Gottlieb L, Ercolano EA, Li F, Harrigan M, McCorkle R, Ligibel JA, von Gruenigen VE, Gogoi R, Schwartz PE, Risch HA, Irwin ML. Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC). Journal Of The National Cancer Institute 2017, 109: djx072. PMID: 30053074, PMCID: PMC6515522, DOI: 10.1093/jnci/djx072.Peer-Reviewed Original ResearchConceptsCancer-related fatigueOvarian cancer survivorsOvarian cancerCancer survivorsExercise interventionPhysical HRQoLCommunity-based exercise programSix-month RCTHealth-related qualityPrimary care providersTreatment side effectsGroup differencesSix-month assessmentQuality of lifeExercise armOverall survivalHigher HRQoLExercise programMental HRQOLRandomized trialsLifestyle StudyControl armFatigue scoresHRQoLPhysical activity
2016
Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors
Thomas G, Cartmel B, Harrigan M, Fiellin M, Capozza S, Zhou Y, Ercolano E, Gross C, Hershman D, Ligibel J, Schmitz K, Li F, Sanft T, Irwin M. Randomized Trial Of Exercise On Body Composition In Breast Cancer Survivors Taking Aromatase Inhibitors. Medicine & Science In Sports & Exercise 2016, 48: 334. DOI: 10.1249/01.mss.0000486010.57056.60.Peer-Reviewed Original ResearchHealth-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I
Zhou Y, Irwin ML, Ferrucci LM, McCorkle R, Ercolano EA, Li F, Stein K, Cartmel B. Health-related quality of life in ovarian cancer survivors: Results from the American Cancer Society's Study of Cancer Survivors — I. Gynecologic Oncology 2016, 141: 543-549. PMID: 27072805, PMCID: PMC4913461, DOI: 10.1016/j.ygyno.2016.04.006.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsGreater symptom burdenAmerican Cancer Society's StudyHealth-related qualityCancer survivorsSymptom burdenDisease recurrencePhysical functioningTwo yearsOne-yearPredictors of HRQOLNumber of comorbiditiesHigher disease stagePhysical HRQoL scoresPoor mental functioningSubset of participantsMental health issuesMental functioningMore comorbiditiesHRQoL scoresClinical factorsLower HRQoLDisease stageHRQoL dataSecondary data analysisScientific Advances in Lung Cancer 2015
Tsao AS, Scagliotti GV, Bunn PA, Carbone DP, Warren GW, Bai C, de Koning HJ, Yousaf-Khan AU, McWilliams A, Tsao MS, Adusumilli PS, Rami-Porta R, Asamura H, Van Schil PE, Darling GE, Ramalingam SS, Gomez DR, Rosenzweig KE, Zimmermann S, Peters S, Ou S, Reungwetwattana T, Jänne PA, Mok TS, Wakelee HA, Pirker R, Mazières J, Brahmer JR, Zhou Y, Herbst RS, Papadimitrakopoulou VA, Redman MW, Wynes MW, Gandara DR, Kelly RJ, Hirsch FR, Pass HI. Scientific Advances in Lung Cancer 2015. Journal Of Thoracic Oncology 2016, 11: 613-638. PMID: 27013409, DOI: 10.1016/j.jtho.2016.03.012.Peer-Reviewed Original ResearchConceptsLung cancerMajor global health problemSpecific oncogenic driversLung cancer therapyGlobal health problemLung cancer researchOncogene-driven tumorsQuality of lifeImportant therapeutic breakthroughsAdvanced diseaseImmunotherapy fieldPrecision cancer medicineNew patientsNew agentsTherapeutic breakthroughHealth problemsOncogenic driversCancerTherapyCancer medicinePast yearSignificant scientific advancementsCancer 2015Cancer therapyRegulatory approvalExercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study
Arem H, Sorkin M, Cartmel B, Fiellin M, Capozza S, Harrigan M, Ercolano E, Zhou Y, Sanft T, Gross C, Schmitz K, Neogi T, Hershman D, Ligibel J, Irwin ML. Exercise adherence in a randomized trial of exercise on aromatase inhibitor arthralgias in breast cancer survivors: the Hormones and Physical Exercise (HOPE) study. Journal Of Cancer Survivorship 2016, 10: 654-662. PMID: 26782031, PMCID: PMC5418660, DOI: 10.1007/s11764-015-0511-6.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsCancer survivorsExercise adherenceAerobic exerciseCancer SurvivorsBreast cancer survivorsPostmenopausal breast cancer survivorsModerate-intensity aerobic exerciseAerobic exercise levelBetter exercise adherenceConclusionsBreast cancer survivorsLong exercise programSupervised exercise sessionsTrial of exerciseExercise training sessionsMin/weekPhysical exercise studiesPredictors of adherenceMaximal oxygen consumptionMonths postrandomizationJoint painExercise programExercise studiesCardiorespiratory fitnessExercise sessionsArthralgia
Clinical Trials
Current Trials
Determining Mechanisms of Sensitivity and Resistance to Anti-Cancer Therapy for Advanced Lung Cancer
HIC ID1603017333RoleSub InvestigatorPrimary Completion Date06/20/2026Recruiting Participants