2023
COVID‐19 mRNA vaccine, but not a viral vector‐based vaccine, promotes neutralizing anti‐type I interferon autoantibody production in a small group of healthy individuals
Xu W, Wen X, Cong X, Jiang W. COVID‐19 mRNA vaccine, but not a viral vector‐based vaccine, promotes neutralizing anti‐type I interferon autoantibody production in a small group of healthy individuals. Journal Of Medical Virology 2023, 95: e29137. PMID: 37792386, PMCID: PMC10603818, DOI: 10.1002/jmv.29137.Peer-Reviewed Original ResearchMeSH KeywordsAutoantibodiesCOVID-19COVID-19 VaccinesHumansImmunoglobulin GInterferon Type ILeukocytes, MononuclearSARS-CoV-2Viral VaccinesConceptsViral vector-based vaccinesCOVID-19 mRNA vaccinesVector-based vaccinesGroup of healthy individualsMRNA vaccinesHealthy individualsPlasma levelsAnti-type I IFN autoantibodiesI interferonLevels of IgG autoantibodiesEvaluate plasma levelsHuman self-antigensPost-COVID-19 vaccinationCOVID-19 vaccineImpaired immune defenseInduce adverse eventsBaseline in vitroIncreased antibody levelsSARS-CoV-2 infectionSARS-CoV-2 antigensType I IFNType I interferonAutoantibody productionSelf-antigensInduce autoimmunity
2022
COVID-19 mRNA vaccine BNT162b2 induces autoantibodies against type I interferons in a healthy woman
Ning W, Xu W, Cong X, Fan H, Gilkeson G, Wu X, Hughes H, Jiang W. COVID-19 mRNA vaccine BNT162b2 induces autoantibodies against type I interferons in a healthy woman. Journal Of Autoimmunity 2022, 132: 102896. PMID: 36029717, PMCID: PMC9385769, DOI: 10.1016/j.jaut.2022.102896.Peer-Reviewed Original ResearchConceptsType I interferonHealthy womenI interferonAutoantibody productionPre-vaccinationAssociated with COVID-19 disease severityBetamethasone dipropionate ointmentMRNA vaccine BNT162b2Human PBMCs in vitroPBMCs in vitroDose of vaccineImmune response to infectious diseasesCOVID-19 disease severityType I IFNResponse to type I IFNsAutoimmune featuresNeutralizing autoantibodiesVaccine BNT162b2Case reportChronic disease pathogenesisInduce autoantibodiesClinical manifestationsAutoimmune responsePlasma levelsResponse to infectious diseases