2000
Rabies virus entry at the neuromuscular junction in nerve–muscle cocultures
Lewis P, Fu Y, Lentz T. Rabies virus entry at the neuromuscular junction in nerve–muscle cocultures. Muscle & Nerve 2000, 23: 720-730. PMID: 10797395, DOI: 10.1002/(sici)1097-4598(200005)23:5<720::aid-mus9>3.0.co;2-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBungarotoxinsCells, CulturedChick EmbryoCoculture TechniquesMuscle, SkeletalNeuromuscular JunctionNeuronsRabies virusSpinal CordSynapsinsConceptsNerve cell bodiesRabies virus entryNerve-muscle coculturesNerve terminalsNerve fibersNeuromuscular junctionRabies virusCell bodiesVirus entryMotor nerve terminalsNerve-muscle contactsNicotinic acetylcholine receptorsVirus adsorption periodAcetylcholine receptorsLucifer YellowSynapsin ISynaptic vesiclesRetrograde transportVirusProgressive increaseEarly eventsCocultureSurface of cellsMyotube surfaceNeurons
1988
Neurotoxin-Binding Site on The Acetylcholine Receptor
Lentz T, Wilson P. Neurotoxin-Binding Site on The Acetylcholine Receptor. International Review Of Neurobiology 1988, 29: 117-160. PMID: 3042662, DOI: 10.1016/s0074-7742(08)60085-9.Peer-Reviewed Original ResearchConceptsAcetylcholine-binding siteBinding of acetylcholineToxin-binding sitesPrimary amino acid sequenceAmino acid sequenceAcetylcholine receptorsCation-selective channelsAcid sequenceGenetic engineeringEssential functionsChemical signalsConformational changesNicotinic acetylcholine receptorsUse of toxinsMotor nerve terminalsMuscle cellsAChRCuraremimetic neurotoxinsBindingNeurotransmitter acetylcholineNeuromuscular junctionNicotinic AChRsReceptorsNerve terminalsHigh affinity
1983
The acetylcholine receptor as a cellular receptor for rabies virus.
Lentz T, Burrage T, Smith A, Tignor G. The acetylcholine receptor as a cellular receptor for rabies virus. The Yale Journal Of Biology And Medicine 1983, 56: 315-22. PMID: 6367238, PMCID: PMC2589619.Peer-Reviewed Original ResearchMeSH KeywordsAdhesivenessAnimalsHumansNervous SystemNeuromuscular JunctionRabiesRabies virusReceptors, CholinergicReceptors, VirusConceptsAcetylcholine receptorsHost cell receptorsRabies virusSpecific host cell receptorsCell receptorTissue tropismMotor nerve endingsRabies virus pathogenesisMyasthenia gravisAutoimmune diseasesCultured muscle cellsNerve endingsTranssynaptic transferViral antigensViral immunizationVirus pathogenesisDisease processNeurotransmitter receptorsViral infectionIntact hostCellular tropismNeuromuscular junctionInfected animalsMuscle cellsVirus attachment
1982
Is the Acetylcholine Receptor a Rabies Virus Receptor?
Lentz T, Burrage T, Smith A, Crick J, Tignor G. Is the Acetylcholine Receptor a Rabies Virus Receptor? Science 1982, 215: 182-184. PMID: 7053569, DOI: 10.1126/science.7053569.Peer-Reviewed Original ResearchSynaptic vesicle recycling at the neuromuscular junction in the presence of a presynaptic membrane marker
Lentz T, Chester J. Synaptic vesicle recycling at the neuromuscular junction in the presence of a presynaptic membrane marker. Neuroscience 1982, 7: 9-20. PMID: 6176905, DOI: 10.1016/0306-4522(82)90148-8.Peer-Reviewed Original ResearchConceptsSynaptic vesicle recyclingSynaptic vesiclesVesicle recyclingNew synaptic vesiclesAxolemmal infoldingsPresynaptic axonal membraneMechanism of recyclingSynaptic vesicle releaseNeuromuscular junctionBlack widow spider venomMembranous cisternaeVesicle membraneCoated vesiclesVesicle releaseSpider venomAxonal membraneMembrane markersVesiclesMembraneExternal potassium ionsCisternaeInfoldingsRecyclingMarkersBungarotoxin
1977
Development of the myotomal neuromuscular junction in Xenopus laevis: An electrophysiological and fine-structural study
Kullberg R, Lentz T, Cohen M. Development of the myotomal neuromuscular junction in Xenopus laevis: An electrophysiological and fine-structural study. Developmental Biology 1977, 60: 101-129. PMID: 902924, DOI: 10.1016/0012-1606(77)90113-0.Peer-Reviewed Original ResearchConceptsMiniature end-plate potentialsEnd-plate potentialsMuscle cellsIndividual muscle cellsNerve processesNerve endingsSpinal cordNeuromuscular junctionSchwann cell processesIntracellular recordingsStage 24Electrical stimulationStage 24 embryosStage 21External recordingCordTetrodotoxinLater stagesGap junctionsFunctional contactsFine structural studyStage 48CellsJunctional specializationsCell processesCytochemical localization of acetylcholine receptors at the neuromuscular junction by means of horseradish peroxidase-labelled α-bungarotoxin
Lentz T, Mazurkiewicz J, Rosenthal J. Cytochemical localization of acetylcholine receptors at the neuromuscular junction by means of horseradish peroxidase-labelled α-bungarotoxin. Brain Research 1977, 132: 423-442. PMID: 912399, DOI: 10.1016/0006-8993(77)90192-5.Peer-Reviewed Original ResearchConceptsMotor endplatesNerve terminalsACh receptorsJunctional foldsAcetylcholine receptorsNeuromuscular junctionPreincubation of tissuesIncubation of tissuePresynaptic activityAlpha-BTXHorseradish peroxidaseSynaptic cleftΑ-bungarotoxinNon-junctional regionsExtrajunctional regionsReceptorsMuscle fibersMuscle surfaceEndplateApical portionObvious accumulationTissueAxolemmaSlight activityCytochemical localization
1976
Cytochemical localization of cyclic 3′,5′-nucleotide phosphodiesterase activity in the neuromuscular junction and skeletal muscle of the newt
Pardos G, Lentz T. Cytochemical localization of cyclic 3′,5′-nucleotide phosphodiesterase activity in the neuromuscular junction and skeletal muscle of the newt. Brain Research 1976, 107: 355-364. PMID: 178408, DOI: 10.1016/0006-8993(76)90232-8.Peer-Reviewed Original Research
1974
NEUROTROPHIC REGULATION AT THE NEUROMUSCULAR JUNCTION*
Lentz T. NEUROTROPHIC REGULATION AT THE NEUROMUSCULAR JUNCTION*. Annals Of The New York Academy Of Sciences 1974, 228: 323-337. PMID: 4366904, DOI: 10.1111/j.1749-6632.1974.tb20521.x.Peer-Reviewed Original Research
1972
Effect of colchicine on the fine structure of the neuromuscular junction
Hsu L, Lentz T. Effect of colchicine on the fine structure of the neuromuscular junction. Cell And Tissue Research 1972, 135: 439-448. PMID: 4346118, DOI: 10.1007/bf00583428.Peer-Reviewed Original ResearchConceptsNeuromuscular junctionDrug-treated animalsInjection of colchicineMuscle surfaceNeurotrophic substancesEffect of colchicineNerve terminalsPostsynaptic foldsSynaptic vesiclesSpecialized morphological featuresNervePresent findingsColchicineDisappearance of microtubulesAdult newtsForearmConcomitant lossDEVELOPMENT OF THE NEUROMUSCULAR JUNCTION
Lentz T. DEVELOPMENT OF THE NEUROMUSCULAR JUNCTION. Journal Of Cell Biology 1972, 55: 93-103. PMID: 4653422, PMCID: PMC2108754, DOI: 10.1083/jcb.55.1.93.Peer-Reviewed Original ResearchConceptsMotor end platesJunctional foldsNerve explantsCholinesterase activitySensory gangliaNeuromuscular junctionIntense cholinesterase activityResult of denervationSchwann cell cytoplasmAbsence of innervationMuscle surfaceEnd platesDegenerative changesSchwann cellsSynaptic cleftSynaptic vesiclesOrgan cultureTerminal axoplasmMuscleGangliaVivoAxoplasmCell cytoplasmDenervationResidual bodiesA Role of Cyclic AMP in a Neurotrophic Process
LENTZ T. A Role of Cyclic AMP in a Neurotrophic Process. Nature 1972, 238: 154-155. PMID: 4340794, DOI: 10.1038/newbio238154a0.Peer-Reviewed Original Research
1971
Nerve Trophic Function: In vitro Assay of Effects of Nerve Tissue on Muscle Cholinesterase Activity
Lentz T. Nerve Trophic Function: In vitro Assay of Effects of Nerve Tissue on Muscle Cholinesterase Activity. Science 1971, 171: 187-189. PMID: 5538829, DOI: 10.1126/science.171.3967.187.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCholinesterasesCulture TechniquesForelimbGangliaHistocytochemistryMusclesNeuromuscular JunctionOrgan Culture TechniquesSpectrophotometryUrodelaConceptsNerve homogenatesCholinesterase activityAssays of effectsMuscle cholinesterase activityNeurotrophic processesSensory gangliaSpinal cordUntreated musclesDiffusible chemical substanceTrophic effectsNerve tissueGangliaOrgan cultureTissue explantsMuscleMuscle cholinesterasesConvenient bioassayHomogenatesSame periodGreater activityNerveCordSpleenKidneyMillipore filters
1969
DEVELOPMENT OF THE NEUROMUSCULAR JUNCTION
Lentz T. DEVELOPMENT OF THE NEUROMUSCULAR JUNCTION. Journal Of Cell Biology 1969, 42: 431-443. PMID: 5792331, PMCID: PMC2107686, DOI: 10.1083/jcb.42.2.431.Peer-Reviewed Original Research