2010
WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A
BOOTH CJ, BROOKS MB, ROCKWELL S, MURPHY JW, RINDER HM, ZELTERMAN D, PAIDAS MJ, COMPTON SR, MARKS PW. WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Journal Of Thrombosis And Haemostasis 2010, 8: 2472-2477. PMID: 20626616, DOI: 10.1111/j.1538-7836.2010.03978.x.Peer-Reviewed Original ResearchConceptsAutosomal locationX chromosomeGenetic basisFactor VIIITertiary structureChromosome 18Point mutationsA1 domainFactor activityGenetic defectsHuman recombinant factor VIIIPartial thromboplastin timeSpecific coagulation factorsNew animal modelNormal prothrombin timeFactor VIII gene mutationsRecombinant factor VIIIMutationsPeripartum deathsGene mutationsCoagulation abnormalitiesSpontaneous bruisingProthrombin timeFemale ratsNovel therapiesAplidin as a potential adjunct to radiation therapy: In vitro studies
Rockwell S, Liu Y. Aplidin as a potential adjunct to radiation therapy: In vitro studies. International Journal Of Radiation Biology 2010, 86: 63-70. PMID: 20070217, PMCID: PMC2837581, DOI: 10.3109/09553000903264531.Peer-Reviewed Original ResearchConceptsH drug treatmentDrug treatmentPhase II clinical trialEMT6 mouse mammary tumor cellsGy of radiationMouse mammary tumor cellsMammary tumor cellsBystander effectSupraadditive cytotoxicityTherapeutic regimensHematologic malignanciesClinical trialsRadiation therapyModerate hypoxiaActive metaboliteSevere hypoxiaTumor cellsUntreated cellsTreatmentCytotoxicityHypoxiaAplidinKV X-raysCellsMonolayer cultures
2009
Hypoxia and radiation therapy: past history, ongoing research, and future promise.
Rockwell S, Dobrucki IT, Kim EY, Marrison ST, Vu VT. Hypoxia and radiation therapy: past history, ongoing research, and future promise. 2009, 9: 442-58. PMID: 19519402, PMCID: PMC2752413, DOI: 10.2174/156652409788167087.Peer-Reviewed Original ResearchConceptsClinical trialsSolid tumorsLarge bulky tumorsMicroscopic tumor involvementSmall primary tumorsSelection of patientsOutcome of treatmentNovel therapeutic approachesNew therapeutic targetsEffects of hypoxiaHypoxic tumor cellsTumor oxygen levelsSurgical marginsTumor involvementBulky tumorsTreatment regimensPrimary tumorVascular bedClinical studiesExtensive necrosisRadiation therapyTherapeutic approachesNew agentsTherapeutic targetTherapeutic resistanceThe FDP Faculty Burden Survey.
Rockwell S. The FDP Faculty Burden Survey. Research Management Review 2009, 16: 29-44. PMID: 20563268, PMCID: PMC2887040.Peer-Reviewed Original Research
2008
Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry
Paz MM, Ladwa S, Champeil E, Liu Y, Rockwell S, Boamah EK, Bargonetti J, Callahan J, Roach J, Tomasz M. Mapping DNA Adducts of Mitomycin C and Decarbamoyl Mitomycin C in Cell Lines Using Liquid Chromatography/Electrospray Tandem Mass Spectrometry. Chemical Research In Toxicology 2008, 21: 2370-2378. PMID: 19053323, PMCID: PMC2630229, DOI: 10.1021/tx8002615.Peer-Reviewed Original ResearchConceptsBreast cancer cellsMitomycin CCancer cellsMCF-7 human breast cancer cellsEMT6 cellsEMT6 mouse mammary tumor cellsHuman breast cancer cellsMCF-7 breast cancer cellsMouse mammary tumor cellsMammary tumor cellsMCF-7 cellsHuman fibroblastsMitomycin C treatmentTumor cellsReductive metabolitesDecarbamoyl mitomycin CNormal human fibroblasts
2006
The Interactions of Polarographic Measurements of Oxygen Tension and Histological Grade in Human Glioma
Lally BE, Rockwell S, Fischer DB, Collingridge DR, Piepmeier JM, Knisely JP. The Interactions of Polarographic Measurements of Oxygen Tension and Histological Grade in Human Glioma. The Cancer Journal 2006, 12: 461-466. PMID: 17207315, DOI: 10.1097/00130404-200611000-00005.Peer-Reviewed Original ResearchConceptsHistological gradeHigh-grade gliomasLow-grade gliomasTumor oxygen tensionUnivariate analysisOxygen tensionGrade gliomasSignificant independent prognostic indicatorExtent of surgeryType of anesthesiaIndependent prognostic indicatorEppendorf pO2 histographTissue oxygen tensionNormal brain tissueImplications of hypoxiaOverall survivalProspective trialPatient ageEntire cohortPrognostic indicatorPatient genderPoor survivalMedian pO2PatientsPO2 histograph
2004
The interactions of polarographic measurements of oxygen tension and histological grade in human glioma and surrounding peritumoral brain tissue
Lally B, Rockwell S, Fischer D, Collingridge D, Piepmeier J, Knisely J. The interactions of polarographic measurements of oxygen tension and histological grade in human glioma and surrounding peritumoral brain tissue. International Journal Of Radiation Oncology • Biology • Physics 2004, 60: s194. DOI: 10.1016/j.ijrobp.2004.06.133.Peer-Reviewed Original ResearchRobert F. Kallman, 19222003
Brown M, Rockwell S. Robert F. Kallman, 19222003. Radiation Research 2004, 161: 120-122. DOI: 10.1667/rr3111.Peer-Reviewed Original Research
2001
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase.
Palom Y, Belcourt M, Tang L, Mehta S, Sartorelli A, Pritsos C, Pritsos K, Rockwell S, Tomasz M. Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase. Biochemical Pharmacology 2001, 61: 1517-1529. PMID: 11377381, DOI: 10.1016/s0006-2952(01)00609-8.Peer-Reviewed Original Research
1999
The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation.
Rosen E, Fan S, Rockwell S, Goldberg I. The molecular and cellular basis of radiosensitivity: implications for understanding how normal tissues and tumors respond to therapeutic radiation. Cancer Investigation 1999, 17: 56-72. PMID: 10999050, DOI: 10.3109/07357909909011718.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAnimalsApoptosisAtaxia Telangiectasia Mutated ProteinsBRCA1 ProteinCell CycleCell Cycle ProteinsCell Transformation, NeoplasticCellsCHO CellsCricetinaeCytokinesDNADNA DamageDNA RepairDNA-Binding ProteinsGenesGenes, BRCA1Genes, p53Growth SubstancesHumansNeoplasmsNeoplasms, Radiation-InducedOncogene ProteinsOncogenesProtein Serine-Threonine KinasesRadiation ToleranceRadiotherapySignal TransductionTime FactorsTumor Suppressor Protein p53Tumor Suppressor ProteinsConceptsGrowth factor signal transductionDNA damage responseCell cycle progressionCellular functionsDamage responseSignal transductionOverexpress proteinsCandidate genesCycle progressionMolecular mechanismsGenetic instabilityFunction mutationsCell typesCellular radiosensitivityCellular basisCellular mechanismsNormal tissuesGenesMutationsRadiosensitivityRecent studiesSevere normal tissue damageMild effectIndividual tumorsTransduction
1995
Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines.
Rockwell S, Kim S. Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1995, 7: 39-47. PMID: 7549043.Peer-Reviewed Original Research
1991
Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur)
Rockwell S, Grindey G. Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur). Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1991, 3: 103-108. PMID: 2025495, DOI: 10.3727/095535491820873434.Peer-Reviewed Original ResearchConceptsEMT6 mouse mammary tumor cellsMouse mammary tumor cellsMammary tumor cellsAcute hypoxiaSolid tumorsSulofenurTumor cellsCytotoxic effectsCulture mediumVitro studyPlateau-phase culturesDiarylsulfonylureasCytotoxicityDrugsFurther examinationProliferative stateMonolayer culturesQuiescent cellsTreatmentCritical determinantCellsRadiotherapy
1987
Effects of the mode of administration of mitomycin on tumor and marrow response and on the therapeutic ratio.
Rockwell S, Nierenburg M, Irvin C. Effects of the mode of administration of mitomycin on tumor and marrow response and on the therapeutic ratio. Journal Of The National Cancer Institute 1987, 71: 927-34. PMID: 3652056.Peer-Reviewed Original ResearchConceptsDoses of mitomycinTherapeutic ratioSingle injectionDaily injectionsAntineoplastic effectsSurvival curvesEMT6 mouse mammary tumorsHost toxicityBALB/c miceLarge single doseTumor growth assaysEffect of mitomycinLess host toxicityMouse mammary tumorsResponse of tumorsBone marrow stem cellsMode of administrationMarrow stem cellsSublethal lesionsMarrow responseDaily fractionsSingle doseTumor responseC miceClinical impression
1984
Enhancement of artificial lung metastases by misonidazole
Rockwell S, Nierenburg M, Irvin C. Enhancement of artificial lung metastases by misonidazole. International Journal Of Radiation Oncology • Biology • Physics 1984, 10: 1395-1398. PMID: 6469763, DOI: 10.1016/0360-3016(84)90356-0.Peer-Reviewed Original ResearchConceptsArtificial lung metastasesLung metastasesHypoxic cell radiosensitizer misonidazoleEMT6 mouse mammary carcinoma cellsLung tumor formationMouse mammary carcinoma cellsEffect of treatmentMammary carcinoma cellsLung tumorsIntravenous injectionPhysiologic effectsLarge dosesRadiosensitizer misonidazoleSmall dosesSingle treatmentCarcinoma cellsMisonidazoleTumor formationMetastasisTreatmentDosesTumors
Others
- Rockwell S. Tumor cell survival. In Tumor Models in Cancer Research, 2nd Ed. (B. Teicher, Ed.), 2010.Peer-Reviewed Original Research