2024
Editorial: Engineered medicines to mitigate resistance to cancer immunotherapy
Ranjan K, Dube P, Mishra S. Editorial: Engineered medicines to mitigate resistance to cancer immunotherapy. Frontiers In Medicine 2024, 11: 1452812. PMID: 39165370, PMCID: PMC11333442, DOI: 10.3389/fmed.2024.1452812.Peer-Reviewed Original ResearchEffect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma.
Shewarega A, Santana J, Nam D, Berz A, Tefera J, Kahl V, Mishra S, Coman D, Duncan J, Roberts S, Wetter A, Madoff D, Chapiro J. Effect of Incomplete Cryoablation and Matrix Metalloproteinase Inhibition on Intratumoral CD8+ T-Cell Infiltration in Murine Hepatocellular Carcinoma. Radiology 2024, 310: e232365. PMID: 38349244, PMCID: PMC10902598, DOI: 10.1148/radiol.232365.Peer-Reviewed Original ResearchConceptsT cell infiltrationCD8<sup>+</sup> T cellsMatrix metalloproteinase inhibitionT cellsHepatocellular carcinomaMatrix metalloproteinase inhibitorsMatrix metalloproteinasesResidual tumorCXCR3<sup>+</sup> CD8<sup>+</sup> T cellsCytotoxic CD8<sup>+</sup> T cell infiltrationIntratumoral CD8+ T cell infiltrationCD8+ T cell infiltrationCD8<sup>+</sup> T cell infiltrationMouse model of hepatocellular carcinomaEarly-stage hepatocellular carcinomaImage-guided tumor ablationUnpaired Student's <i>t</i> testModel of hepatocellular carcinomaFirst-line therapyMurine hepatocellular carcinomaT cell subsetsTumor-associated macrophagesMurine HCC modelLocal immune responseFemale BALB/c miceTransmembrane pH gradient imaging in rodent glioma models
Mishra S, Santana J, Mihailovic J, Hyder F, Coman D. Transmembrane pH gradient imaging in rodent glioma models. NMR In Biomedicine 2024, 37: e5102. PMID: 38263680, PMCID: PMC10987279, DOI: 10.1002/nbm.5102.Peer-Reviewed Original ResearchNormal tissuesRodent glioma modelsGL261 gliomasU87 gliomasTumor microenvironmentPotential therapeutic targetGlioma modelTumor survivalExtracellular acidosisTumorMetabolic reprogrammingRegulate drug deliveryIntracellular pHRat brainExtracellular pHTherapeutic targetGliomaMouse brainDrug deliveryIntracellular milieuTransmembrane pH gradientBrainSubmillimeter resolutionTissueCells
2023
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic wasteImaging the transmembrane pH gradient in gliomas
Mishra S, Mihailović J, Hyder F, Coman D. Imaging the transmembrane pH gradient in gliomas. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/3928.Peer-Reviewed Original ResearchAssess tumor aggressivenessMonitoring treatment efficacyTransmembrane pH gradientTumor responseTumor microenvironmentTumor aggressivenessRG2 tumorsLocal drug deliveryExtracellular acidosisTherapeutic outcomesTumorTreatment efficacyNormal tissuesBrain tumorsIntracellular pHExtracellular pHFunction biomarkersPositive therapeutic outcomesDrug deliveryIntracellular milieuBrainAcidosisGlioma
2022
Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiographyMethylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST
Zakaria ABM, Huang Y, Coman D, Mishra SK, Mihailovic JM, Maritim S, Rojas‐Quijano F, Jurek P, Kiefer GE, Hyder F. Methylated tetra‐amide derivatives of paramagnetic complexes for magnetic resonance biosensing with both BIRDS and CEST. NMR In Biomedicine 2022, 35: e4687. PMID: 34970801, DOI: 10.1002/nbm.4687.Peer-Reviewed Original ResearchComparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors
Khan MH, Mishra SK, Zakaria ABM, Mihailović J, Coman D, Hyder F. Comparison of Lanthanide Macrocyclic Complexes as 23Na NMR Sensors. Analytical Chemistry 2022, 94: 2536-2545. PMID: 35073049, DOI: 10.1021/acs.analchem.1c04432.Peer-Reviewed Original ResearchConceptsLanthanide macrocyclic complexesParamagnetic lanthanide ionsMagnetic resonance agentsLanthanide complexesMacrocyclic complexesMacrocyclic designDownfield shiftLanthanide ionsNa NMRBulk magnetic susceptibility effectsUnpaired electronChelating agentBiomedical applicationsNegative chargeNMR sensorSodium ionsTriazacyclononaneIonsComplexesBiological importanceMacrocyclicTmDOTPNaCationsGd
2021
High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents
Mihailovic JM, Huang Y, Walsh JJ, Khan MH, Mishra SK, Samuels S, Hyder F, Coman D. High‐resolution pH imaging using ratiometric chemical exchange saturation transfer combined with biosensor imaging of redundant deviation in shifts featuring paramagnetic DOTA‐tetraglycinate agents. NMR In Biomedicine 2021, 35: e4658. PMID: 34837412, DOI: 10.1002/nbm.4658.Peer-Reviewed Original ResearchImaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression
Walsh JJ, Parent M, Akif A, Adam LC, Maritim S, Mishra SK, Khan MH, Coman D, Hyder F. Imaging Hallmarks of the Tumor Microenvironment in Glioblastoma Progression. Frontiers In Oncology 2021, 11: 692650. PMID: 34513675, PMCID: PMC8426346, DOI: 10.3389/fonc.2021.692650.Peer-Reviewed Original ResearchPublisher Correction: Imaging the transmembrane and transendothelial sodium gradients in gliomas
Khan MH, Walsh JJ, Mihailović JM, Mishra SK, Coman D, Hyder F. Publisher Correction: Imaging the transmembrane and transendothelial sodium gradients in gliomas. Scientific Reports 2021, 11: 12463. PMID: 34103626, PMCID: PMC8187420, DOI: 10.1038/s41598-021-91581-w.Peer-Reviewed Original ResearchImaging the transmembrane and transendothelial sodium gradients in gliomas
Khan MH, Walsh JJ, Mihailović JM, Mishra SK, Coman D, Hyder F. Imaging the transmembrane and transendothelial sodium gradients in gliomas. Scientific Reports 2021, 11: 6710. PMID: 33758290, PMCID: PMC7987982, DOI: 10.1038/s41598-021-85925-9.Peer-Reviewed Original Research
2017
Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release
Mishra S, Kannan S. Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release. ACS Biomaterials Science & Engineering 2017, 3: 3607-3619. PMID: 33445395, DOI: 10.1021/acsbiomaterials.7b00498.Peer-Reviewed Original ResearchBimetallic nanoparticlesMicrowave-assisted polyol synthesisPH-sensitive hydrazone linkageDrug releaseResponsive drug releaseNegligible drug releaseOne-pot synthesisBimetallic silverCancer theranosisContrast abilityCapping agentPolyol synthesisAverage sizeHydrazone linkagePotential anticancer drugsAcidic mediumContrast performanceOptical imagingParamagnetic behaviorPhysiological pHMolar ratioChitosanAnticancer drugsAgDOXA Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy
Mishra SK, Kannan S. A Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy. Inorganic Chemistry 2017, 56: 12054-12066. PMID: 28933536, DOI: 10.1021/acs.inorgchem.7b02103.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAntineoplastic AgentsChitosanContrast MediaDrug CarriersDrug LiberationGreen Chemistry TechnologyHeatingHeLa CellsHumansMagnetic Resonance ImagingMetal NanoparticlesMultimodal ImagingNeodymiumOptical ImagingPaclitaxelParticle SizeSilverTheranostic NanomedicineTomography, X-Ray ComputedConceptsChemo-photothermal therapyPhotothermal effectMicrowave-assisted polyol synthesisCombined chemo-photothermal therapyMRI/CT imagingEfficient photothermal effectHigh loading efficiencyLoading of paclitaxelTheranostic nanoparticlesBimetallic nanoparticlesMetallic nanostructuresGood monodispersityPolyol synthesisNIR laserLoading efficiencyAverage sizeNanoparticlesGood biocompatibilityMultimodal imagingInfrared regionExcellent candidateNIR imagingChitosan functionalizationSynergistic effectDrug moleculesStructural elucidation and iron oxidation states in situ formed β‐Ca3(PO4)2/α‐Fe2O3 composites
Kumar P, Mishra S, Kannan S. Structural elucidation and iron oxidation states in situ formed β‐Ca3(PO4)2/α‐Fe2O3 composites. Journal Of The American Ceramic Society 2017, 100: 3746-3756. DOI: 10.1111/jace.14889.Peer-Reviewed Original ResearchΑ-Fe 2 O 3Oxidation statePowder X-ray diffractionX-ray photoelectron spectroscopyOccupancy of ironIron oxidation stateΑ-Fe2O3 compositesX-ray diffractionO 3Compositional ratioSoft ferromagnetic behaviorFT-IRPhotoelectron spectroscopyStructural elucidationDetailed structural analysisCa/P ratioAnalytical techniquesAmbient conditionsCalcium phosphate systemFe 3Ferromagnetic behaviorPhosphate systemStructural analysisStructural Perceptions and Mechanical Evaluation of β‑Ca3(PO4)2/c‑CeO2 Composites with Preferential Occupancy of Ce3+ and Ce4+
Kumar P, Mishra S, Kannan S. Structural Perceptions and Mechanical Evaluation of β‑Ca3(PO4)2/c‑CeO2 Composites with Preferential Occupancy of Ce3+ and Ce4+. Inorganic Chemistry 2017, 56: 3600-3611. PMID: 28234010, DOI: 10.1021/acs.inorgchem.7b00045.Peer-Reviewed Original Research
2016
Microwave Synthesis of Chitosan Capped Silver–Dysprosium Bimetallic Nanoparticles: A Potential Nanotheranosis Device
Mishra SK, Kannan S. Microwave Synthesis of Chitosan Capped Silver–Dysprosium Bimetallic Nanoparticles: A Potential Nanotheranosis Device. Langmuir 2016, 32: 13687-13696. PMID: 27981845, DOI: 10.1021/acs.langmuir.6b03438.Peer-Reviewed Original ResearchBimetallic nanoparticlesX-ray photoelectron spectroscopyAnnular dark-field scanning transmission electron microscopyHigh-angle annular dark-field scanning transmission electron microscopyDark-field scanning transmission electron microscopyScanning transmission electron microscopyInfrared (NIR-II) biological windowGreen chemistry routeTransmission electron microscopyX-ray attenuation effectTheranostic devicesMicrowave synthesisBiological windowChemistry routeNanoparticlesIndividual imagingPhotoelectron spectroscopyGood biocompatibilityHigh relaxivityMetallic stateDy-componentsParamagnetic featuresElectron microscopyCharacterization resultsBiological targetsCopper incorporated microporous chitosan-polyethylene glycol hydrogels loaded with naproxen for effective drug release and anti-infection wound dressing
Mishra S, Mary D, Kannan S. Copper incorporated microporous chitosan-polyethylene glycol hydrogels loaded with naproxen for effective drug release and anti-infection wound dressing. International Journal Of Biological Macromolecules 2016, 95: 928-937. PMID: 27984151, DOI: 10.1016/j.ijbiomac.2016.10.080.Peer-Reviewed Original ResearchConceptsMoisture permeabilityEnhanced mechanical stabilityStability of filmsDrug releaseCell adhesion testsIncorporated hydrogelsMechanical propertiesEfficiency of CuMicroporous surfaceAbsorption capabilityAdhesion testHydrogel filmsMechanical stabilityChitosan filmsFilmsAntibacterial testsDegradation studiesHydrated conditionsRelease of CuWound dressingsGlycol hydrogelsEffective drug releaseHydrogelsCopper ionsCuIn Situ Impregnation of Silver Nanoclusters in Microporous Chitosan-PEG Membranes as an Antibacterial and Drug Delivery Percutaneous Device
Mishra SK, Raveendran S, Ferreira JM, Kannan S. In Situ Impregnation of Silver Nanoclusters in Microporous Chitosan-PEG Membranes as an Antibacterial and Drug Delivery Percutaneous Device. Langmuir 2016, 32: 10305-10316. PMID: 27685160, DOI: 10.1021/acs.langmuir.6b02844.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAnimalsAnti-Bacterial AgentsBiofilmsCattleCell Line, TumorChickensChitosanDrug CarriersDrug LiberationElastic ModulusEscherichia coliHumansHydrogen PeroxideMembranes, ArtificialMetal NanoparticlesMuramidaseNaproxenParticle SizePolyethylene GlycolsSilverStaphylococcus aureusSurface PropertiesConceptsMultifunctional devicesSilver nanoclustersSitu synthesis methodEfficient antibacterial activityDrug deliverySitu impregnationSynthesis methodCharacterization techniquesDrug releaseSustainable releaseLocal drug deliveryFormation of fluorescentMechanical stabilityBiofilm inhibitionAgNCsMicroporous membranesDevicesPresence of lysozymeAntibacterial activityNanoclustersMultiple arraysPercutaneous devicesBiocompatibilityAnti-inflammatory drug naproxenBiofilm formationMechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, and sustained drug delivery
Mishra SK, Teotia AK, Kumar A, Kannan S. Mechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, and sustained drug delivery. Nanomedicine Nanotechnology Biology And Medicine 2016, 13: 23-35. PMID: 27558354, DOI: 10.1016/j.nano.2016.08.010.Peer-Reviewed Original ResearchConceptsDrug releaseSustained drug releaseAnti-inflammatory drug naproxenLong-term antibacterial activitySustainable drug releaseIntrinsic antibacterial propertiesTitanium metalSuitable coating materialCS matrixPolymeric shellSynthesized nanohybridsSilver nanoparticlesDrug deliveryDrug naproxenChitosan matrixNanocomposite coatingsAntibacterial propertiesExcellent inhibitionInorganic fillersCoating materialsAntibacterial activityNanohybridsTi metalAgNPsCoatings