Robert Ostroff, MD
Medical Director Mood Disorders Unit Yale Psychiatric hospitalCards
About
Research
Publications
2024
Blood pressure changes during ketamine infusion for the treatment of depression
Ansari M, Pittman B, Tylee D, Ostroff R, Wilkinson S, Nikayin S. Blood pressure changes during ketamine infusion for the treatment of depression. General Hospital Psychiatry 2024, 90: 62-67. PMID: 38991311, DOI: 10.1016/j.genhosppsych.2024.07.001.Peer-Reviewed Original ResearchKetamine infusionBlood pressure changesBlood pressureRetrospective chart review of patientsChart review of patientsMedical history of hypertensionRetrospective chart reviewHistory of hypertensionSignificant blood pressureDiastolic blood pressureTreatment of depressionSevere hypertensionPatient demographicsHypertensive patientsInfusion sessionsMedical historyHypertensive eventsInfusionPatientsKetamineBP surgeCardiovascular monitoringBloodHypertensionPressure changesKetamine vs Electroconvulsive Therapy for Treatment-Resistant Depression
Jha M, Wilkinson S, Krishnan K, Collins K, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Costi S, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wolski K, Wang D, Hu B, Mathew S, Anand A. Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression. JAMA Network Open 2024, 7: e2417786. PMID: 38916891, PMCID: PMC11200139, DOI: 10.1001/jamanetworkopen.2024.17786.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionQIDS-SR16 scoresElectroconvulsive therapy groupElectroconvulsive therapyQIDS-SR16Measure of premorbid intelligencePosttraumatic stress disorder diagnosisTrial of electroconvulsive therapyNonpsychotic depressive episodeImpaired memory recallAssociated with differential improvementStress disorder diagnosisIntravenous ketamineEnd-of-treatment visitInfusion of ketamineMADRS scorePremorbid intelligenceResistant depressionDepressive episodeMeasures mixed-effects modelsFalse discovery rate adjustmentDisorder diagnosisMemory recallSevere depressionDifferential improvement
2023
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression
Anand A, Mathew S, Sanacora G, Murrough J, Goes F, Altinay M, Aloysi A, Asghar-Ali A, Barnett B, Chang L, Collins K, Costi S, Iqbal S, Jha M, Krishnan K, Malone D, Nikayin S, Nissen S, Ostroff R, Reti I, Wilkinson S, Wolski K, Hu B. Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. New England Journal Of Medicine 2023, 388: 2315-2325. PMID: 37224232, DOI: 10.1056/nejmoa2302399.Peer-Reviewed Original ResearchConceptsTreatment-resistant major depressionPatient-reported qualityElectroconvulsive therapyMajor depressionECT groupKetamine groupTreatment phaseMusculoskeletal adverse effectsSubanesthetic intravenous ketamineWeeks of treatmentInitial treatment phaseIntravenous ketamineSecondary outcomesPrimary outcomeNoninferiority marginTrial groupECT clinicsNoninferiority trialPatientsComparative effectivenessKetamineClinical sitesAdverse effectsDepressionThree times
2019
Interventional psychiatry, a new competency for 21st century psychiatry residents
Ostroff R, Kitay B, Wilkinson S, Taylor J. Interventional psychiatry, a new competency for 21st century psychiatry residents. Brain Stimulation 2019, 12: 475. DOI: 10.1016/j.brs.2018.12.547.Peer-Reviewed Original ResearchClinical factors contributing to morbidity, mortality, and cost in patients requiring ECT for the management of catatonia
Kitay B, Ostroff R. Clinical factors contributing to morbidity, mortality, and cost in patients requiring ECT for the management of catatonia. Brain Stimulation 2019, 12: 462. DOI: 10.1016/j.brs.2018.12.503.Peer-Reviewed Original ResearchAdjustment of pulse wave parameters to optimize effective ect treatment
Ostroff R, Kitay B. Adjustment of pulse wave parameters to optimize effective ect treatment. Brain Stimulation 2019, 12: 385. DOI: 10.1016/j.brs.2018.12.229.Peer-Reviewed Case Reports and Technical Notes
2018
The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion
Kitay B, Katz R, Wilkinson S, Ostroff R. The Successful Use of Electroconvulsive Therapy in a Patient With Cerebral Aneurysms and a Pituitary Lesion. Journal Of Ect 2018, 1. DOI: 10.1097/00124509-900000000-99225.Peer-Reviewed Original ResearchErratum to: Ketamine: A Promising Rapid-Acting Antidepressant
Wilkinson S, Ostroff R, Katz R, Krystal J. Erratum to: Ketamine: A Promising Rapid-Acting Antidepressant. 2018, e1-e1. DOI: 10.1007/978-981-10-6577-4_24.Commentaries, Editorials and LettersS106. Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital
Wilkinson S, Webler R, Katz R, Toprak M, Ostroff R, Sanacora G. S106. Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital. Biological Psychiatry 2018, 83: s388. DOI: 10.1016/j.biopsych.2018.02.997.Peer-Reviewed Original ResearchThe Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders
Ostroff R, Katz R. The Use of Electroconvulsive Therapy in Late-Life Psychiatric Disorders. Current Treatment Options In Psychiatry 2018, 5: 228-241. DOI: 10.1007/s40501-018-0144-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsUse of ECTElectroconvulsive therapyTreatment of depressionMovement disordersDepressed Elderly (PRIDE) studySevere psychiatric illnessLife-saving treatmentWarrants further investigationProlonging RemissionPharmacologic treatmentGeriatric patientsElderly StudyClinical algorithmDementia syndromesPsychiatric illnessEffective treatmentParkinson's diseaseElderly populationPsychiatric disordersAge groupsTherapyRemissionTreatmentBehavioral dysregulationDisorders
Clinical Care
Overview
Robert Ostroff, MD, is a psychiatrist who focuses on treating mood disorders, particularly severe depression and bipolar disorder. He serves as the medical director of the Mood Disorders Unit and the co-medical director of the Interventional Psychiatry Service at Yale Psychiatric Hospital. He states, “I am drawn to psychiatry in order to help people with severe mental illness live the best possible lives with minimal impact from the symptoms of their illness.”
Dr. Ostroff provides a range of treatments for his patients, including electroconvulsive therapy (ECT), which involves sending electrical currents through the brain to treat severe depression and other psychiatric conditions. ECT is often used when other treatments have failed and is an especially useful option for patients with treatment-resistant depression, severe depression accompanied by delusions, or those who need rapid symptom relief.
Dr. Ostroff emphasizes that modern ECT is much safer and more controlled than its earlier versions, which were often depicted negatively in the media. The procedure involves inducing a brief seizure under general anesthesia, with thorough monitoring of cardiac and respiratory functions. Advances in ECT technology have significantly improved its safety and reduced cognitive side effects.
As a clinical professor of psychiatry at Yale School of Medicine, Dr. Ostroff's research focuses on improving the efficacy and safety of ECT and exploring other interventional treatments such as ketamine and transcranial magnetic stimulation (TMS). His studies aim to optimize treatment protocols to minimize side effects, particularly cognitive issues, while maximizing therapeutic benefits for patients with severe psychiatric conditions.
Dr. Ostroff received his medical training from George Washington University School of Medicine and completed his residency in psychiatry at the Yale University School of medicine. He trained as a psychoanalyst and is interested in the complementary relationship of psychotherapy and traditional biological treatments.
Clinical Specialties
Fact Sheets
Electroconvulsive Therapy (ECT)
Learn More on Yale Medicine
Board Certifications
Psychiatry
- Certification Organization
- AB of Psychiatry & Neurology
- Original Certification Date
- 1982
Yale Medicine News
News
News
- October 24, 2024Source: Yale Medicine
Electroconvulsive Therapy (ECT) Has Changed: What You Should Know
- March 20, 2023
Six Psychiatry Faculty Recognized by Class of 2023
- January 02, 2022Source: Journal of the Neurological Sciences
Nikayin, Ostroff: Advanced Training in Interventional Psychiatry
- July 31, 2018Source: Biological Psychiatry
Acute and longer-term outcomes using ketamine as a clinical treatment at the Yale Psychiatric Hospital
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