Induction of lung CD8+ T cell responses by consecutive inoculations of a poly(I:C) influenza vaccine
Moriyama M, Takeyama H, Hasegawa H, Ichinohe T. Induction of lung CD8+ T cell responses by consecutive inoculations of a poly(I:C) influenza vaccine. Vaccine 2017, 35: 6620-6626. PMID: 29079103, DOI: 10.1016/j.vaccine.2017.10.038.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, IntranasalAnimalsAntibodies, ViralCD8-Positive T-LymphocytesCross ProtectionImmunoglobulin AInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesLungMiceMice, Inbred BALB COrthomyxoviridae InfectionsPoly I-CT-Lymphocytes, CytotoxicVaccinationVaccines, InactivatedConceptsMediastinal lymph nodesStrong CTL responsesCTL responsesIntranasal vaccinationInfluenza vaccineVirus vaccineInfluenza virus-specific CD8Cytotoxic T lymphocyte responsesInfluenza virusHeterologous influenza virusesVirus-specific CD8T lymphocyte responsesT cell responsesInfluenza virus infectionInfluenza virus vaccineWhole virus vaccineLung CD8Respiratory DCsVaccine elicitsLymph nodesLymphocyte responsesIntranasal administrationConsecutive vaccinationsT cellsVirus infectionConsecutive inoculations of influenza virus vaccine and poly(I:C) protects mice against homologous and heterologous virus challenge
Moriyama M, Chino S, Ichinohe T. Consecutive inoculations of influenza virus vaccine and poly(I:C) protects mice against homologous and heterologous virus challenge. Vaccine 2017, 35: 1001-1007. PMID: 28111142, DOI: 10.1016/j.vaccine.2017.01.025.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, IntranasalAnimalsAntibodies, ViralCross ProtectionFemaleFormaldehydeImmunity, MucosalImmunization ScheduleImmunoglobulin AImmunoglobulin GInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza VaccinesMiceMice, Inbred BALB COrthomyxoviridae InfectionsPoly I-CSurvival AnalysisVaccines, InactivatedConceptsInfluenza virus vaccinePrimary immune responseVirus vaccineIntranasal vaccinationVirus challengeImmune responseInactivated influenza virus vaccineInfluenza virusHeterologous influenza virus challengeVirus-specific IgAInfluenza virus challengeHeterologous virus challengeNatural infectionSerum IgG responsesConsecutive inoculationsSingle intranasal vaccinationCross-protective activityNasal IgANasal washesIgG responsesMucosal immunitySystemic immunityVaccinationNaïve animalsVaccine