2019
High ambient temperature dampens adaptive immune responses to influenza A virus infection
Moriyama M, Ichinohe T. High ambient temperature dampens adaptive immune responses to influenza A virus infection. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 3118-3125. PMID: 30718396, PMCID: PMC6386664, DOI: 10.1073/pnas.1815029116.Peer-Reviewed Original ResearchConceptsAdaptive immune responsesHeat-exposed miceVirus-specific adaptive immune responsesInfluenza virus infectionImmune responseVirus infectionVirus-specific CD8 T cellsRespiratory influenza virus infectionDietary short chain fatty acidCD8 T cellsDendritic cell migrationExposure of miceAdministration of glucoseThrombocytopenia syndrome phlebovirusCommensal microbiota compositionInflammasome-dependent cytokine secretionShort-chain fatty acidsAntibody responseCytokine secretionLung tissueSevere feverT cellsViral infectionInduction of autophagyMicrobiota composition
2017
Induction of lung CD8+ T cell responses by consecutive inoculations of a poly(I:C) influenza vaccine
Moriyama M, Takeyama H, Hasegawa H, Ichinohe T. Induction of lung CD8+ T cell responses by consecutive inoculations of a poly(I:C) influenza vaccine. Vaccine 2017, 35: 6620-6626. PMID: 29079103, DOI: 10.1016/j.vaccine.2017.10.038.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAdministration, IntranasalAnimalsAntibodies, ViralCD8-Positive T-LymphocytesCross ProtectionImmunoglobulin AInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesLungMiceMice, Inbred BALB COrthomyxoviridae InfectionsPoly I-CT-Lymphocytes, CytotoxicVaccinationVaccines, InactivatedConceptsMediastinal lymph nodesStrong CTL responsesCTL responsesIntranasal vaccinationInfluenza vaccineVirus vaccineInfluenza virus-specific CD8Cytotoxic T lymphocyte responsesInfluenza virusHeterologous influenza virusesVirus-specific CD8T lymphocyte responsesT cell responsesInfluenza virus infectionInfluenza virus vaccineWhole virus vaccineLung CD8Respiratory DCsVaccine elicitsLymph nodesLymphocyte responsesIntranasal administrationConsecutive vaccinationsT cellsVirus infection