2022
Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging
Shin M, Park H, Young J, Kang I. Implication of IL-7 receptor alpha chain expression by CD8+ T cells and its signature in defining biomarkers in aging. Immunity & Ageing 2022, 19: 66. PMID: 36544153, PMCID: PMC9768896, DOI: 10.1186/s12979-022-00324-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsT cellsImmune agingHost defenseIL-7 receptor alpha chainFrequencies of naïveT cell subsetsAlpha chain expressionAssociation of CD8Age-associated conditionsReceptor alpha chainMemory CD8Treatment of illnessCell subsetsInflammatory disordersIL-7RαCD8High riskImmune functionTherapeutic interventionsImmune systemPotential biomarkersGene signatureChain expressionOlder adultsBiomarkers
2020
Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis
Shin M, Kim D, Park H, Dong X, Koumpouras F, Kang I. Defining heterogeneity and biological signature in human effector memory CD8+ T cells expressing different levels of IL-7 receptor alpha by high-dimensional analysis. The Journal Of Immunology 2020, 204: 154.19-154.19. DOI: 10.4049/jimmunol.204.supp.154.19.Peer-Reviewed Original ResearchHuman effector memory CD8EM CD8Effector memory CD8T cellsIL-7RαMemory CD8Cell subsetsIL-7 receptor alphaIL-7 receptor alpha chainT cell subsetsCo-stimulatory moleculesT cell heterogeneityHigh-dimensional single-cell analysisReceptor alpha chainLupus patientsImmune landscapeCell surface moleculesHeterogeneous cell subsetsT-betCD8Effector functionsDifferential expressionReceptor alphaSingle-cell RNA-seq analysisPathologic conditions
2013
An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans (P4293)
Lee N, Kang K, Shin M, Mohanty S, Belshe R, Montgomery R, Shaw A, Kang I. An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans (P4293). The Journal Of Immunology 2013, 190: 123.10-123.10. DOI: 10.4049/jimmunol.190.supp.123.10.Peer-Reviewed Original ResearchT cell immunityMemory T cellsIgG responsesHI antibody titersT cellsAntibody titersMemory CD8Cell immunityHemagglutinin inhibition antibody titersDistinct T cell subsetsCytokine-producing capacityEffector memory CD8Frequency of CD4Inactivated influenza vaccineCentral memory cellsT cell subsetsSpecific IgG responseSerum IgG responsesPotent survivalIL-17Influenza vaccineSignificant morbidityCell subsetsElderly peopleProliferative capacityDefining cellular characteristics of human IL-7Rαlow memory CD8+ T cells using a genome-wide DNA methylation analysis (P1432)
Yoo S, You S, Shin M, Lee N, Kang K, Hwang D, Kang I. Defining cellular characteristics of human IL-7Rαlow memory CD8+ T cells using a genome-wide DNA methylation analysis (P1432). The Journal Of Immunology 2013, 190: 117.16-117.16. DOI: 10.4049/jimmunol.190.supp.117.16.Peer-Reviewed Original ResearchDNA methylationGenome-wide DNA methylation analysisHeritable epigenetic informationPredominant epigenetic mechanismsAbstract DNA methylationDNA methylation analysisEpigenetic informationEpigenetic mechanismsGene promoterMethylation profilingGene expressionTCR triggeringMethylationMethylation analysisGenesHuman agingMemory CD8Cellular characteristicsT cellsCell subsetsIL-7Rα expressionImportant mechanismCellsPotential roleIL-7Rα
2012
The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16)
Lee N, Lee W, Shin M, Kang Y, Jeon S, Kang I. The Relationship of Cytomegalovirus (CMV) Infection with circulatory IFN-α levels and IL-7 receptor α expression on CD8+ T cells in Human Aging (105.16). The Journal Of Immunology 2012, 188: 105.16-105.16. DOI: 10.4049/jimmunol.188.supp.105.16.Peer-Reviewed Original ResearchEM CD8IFN-α levelsT cellsCMV infectionCytomegalovirus infectionIL-7 Receptor α ExpressionHuman effector memory CD8IL-7 receptor alphaCMV immune statusEffector memory CD8Elderly peopleT cell subsetsReceptor α expressionT cell homeostasisAge-associated expansionHigh-affinity receptorCytokine levelsMemory CD8Naïve CD8Cell subsetsImmune statusPlasma levelsCD8IL-7Α expression
2011
Studying the mechanisms for increased IL-7Rαlow Memory CD8+T cells in the elderly (150.11)
Shin M, Lee W, Lee J, Kim S, Lee N, Kang I. Studying the mechanisms for increased IL-7Rαlow Memory CD8+T cells in the elderly (150.11). The Journal Of Immunology 2011, 186: 150.11-150.11. DOI: 10.4049/jimmunol.186.supp.150.11.Peer-Reviewed Original ResearchMemory CD8T cellsAge-associated expansionYoung donorsCMV infectionIL-15Elderly donorsIL-15-mediated proliferationT cell receptor repertoireTCR-mediated proliferationIL-15 expressionCell receptor repertoireCell subsetsCD8Better survivalReceptor repertoireCMVElderly peoplePotential roleSignificant differencesIndependent mechanismsInfectionProliferationSurvivalCellsExpansion of IL-7Ralow memory CD8 T cells in human lupus (101.19)
Lee N, Shah K, Shin M, Kim S, Craft J, Kang I. Expansion of IL-7Ralow memory CD8 T cells in human lupus (101.19). The Journal Of Immunology 2011, 186: 101.19-101.19. DOI: 10.4049/jimmunol.186.supp.101.19.Peer-Reviewed Original ResearchSystemic lupus erythematosusDevelopment of SLESLE Disease Activity IndexMemory CD8SLE patientsT cellsCell subsetsHealthy controlsImmunopathogenesis of SLEAbstract Systemic lupus erythematosusHomeostatic cytokine IL-15IL-7 receptor alphaMemory CD8 T cellsCytotoxic molecules perforinHomeostasis of CD8Disease activity indexRole of CD8Cytokine IL-15CD8 T cellsImmune complex depositionProduction of autoantibodiesInflammatory autoimmune disorderT cell receptorDisease activityLupus erythematosus