2015
Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease
Sun H, Palcza J, Rosenberg R, Kryger M, Siringhaus T, Rowe J, Lines C, Wagner JA, Troyer MD. Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respiratory Medicine 2015, 109: 416-426. PMID: 25661282, DOI: 10.1016/j.rmed.2014.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAzepinesCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedOrexin Receptor AntagonistsPulmonary Disease, Chronic ObstructiveRespirationSeverity of Illness IndexSleepSleep Aids, PharmaceuticalSpirometryTreatment OutcomeTriazolesUnited StatesConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep breathing disordersOrexin receptor antagonistPulmonary diseaseBreathing disordersReceptor antagonistModerate chronic obstructive pulmonary diseaseDay 4Effects of suvorexantModerate airflow limitationRespiratory depressant effectsApnea-hypopnea indexMaximum daily doseClinical research unitTotal sleep timeTreatment of insomniaMean AHICOPD patientsAirflow limitationHypopnea indexDaily doseMean SpO2Spirometry criteriaHypnotic medications
2013
The use of combined thermal/pressure polyvinylidene fluoride film airflow sensor in polysomnography
Kryger M, Eiken T, Qin L. The use of combined thermal/pressure polyvinylidene fluoride film airflow sensor in polysomnography. Sleep And Breathing 2013, 17: 1267-1273. PMID: 23716021, DOI: 10.1007/s11325-013-0832-5.Peer-Reviewed Original Research
2005
Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease
Singh H, Pollock R, Uhanova J, Kryger M, Hawkins K, Minuk GY. Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease. Digestive Diseases And Sciences 2005, 50: 2338-2343. PMID: 16416185, DOI: 10.1007/s10620-005-3058-y.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseSymptoms of OSANonalcoholic fatty liverObstructive sleep apneaFatty liver diseaseNAFLD patientsNASH patientsNonalcoholic steatohepatitisRisk factorsLiver diseaseSleep apneaInsulin resistancePrevalence of OSASleep apnea questionnaireIndependent risk factorPrevalence of diabetesBody mass indexPeripheral insulin resistanceLiver biopsyFatty liverMass indexTriglyceride levelsQuestionnaire criteriaPrevalence ratesPatients
1996
Effect of severe gastroesophageal reflux on sleep stage in patients with aperistaltic esophagus
Shoenut J, Yamashiro Y, Orr W, Kerr P, Micflikier A, Kryger M. Effect of severe gastroesophageal reflux on sleep stage in patients with aperistaltic esophagus. Digestive Diseases And Sciences 1996, 41: 372-376. PMID: 8601385, DOI: 10.1007/bf02093831.Peer-Reviewed Original Research
1995
Sleep complaints are common in a dialysis unit
Walker S, Fine A, Kryger M. Sleep complaints are common in a dialysis unit. American Journal Of Kidney Diseases 1995, 26: 751-756. PMID: 7485127, DOI: 10.1016/0272-6386(95)90438-7.Peer-Reviewed Original ResearchConceptsRestless legs syndromeSleep-wake complaintsSpecific sleep disordersCreatinine levelsDialysis patientsLegs syndromeSleep apneaUremic patientsFrequent awakeningsImpaired qualitySleep complaintsSleep QuestionnaireHemodialysis unitDaytime sleepinessDisturbed sleepMale genderDialysis unitsCaffeine intakeClinical significanceSleep disordersSleep problemsFrequent complaintPatientsSpecific complaintsActual prevalence
1994
The Effect of Nasal CPAP on Nocturnal Reflux in Patients With Aperistaltic Esophagus
Shoenut J, Kerr P, Micflikier A, Yamashiro Y, Kryger M. The Effect of Nasal CPAP on Nocturnal Reflux in Patients With Aperistaltic Esophagus. CHEST Journal 1994, 106: 738-741. PMID: 8082351, DOI: 10.1378/chest.106.3.738.Peer-Reviewed Original ResearchConceptsNocturnal refluxNasal CPAPAperistaltic esophagusLES pressureReflux eventsNasal continuous positive airway pressureContinuous positive airway pressureLower esophageal sphincter pressurePositive airway pressureEsophageal sphincter pressureGroup of patientsScleroderma esophagusScleroderma groupAirway pressureSphincter pressureSleep apneaPercentage of timeCPAPPatientsSecond nightRefluxEsophagusFirst nightAchalasiaGroup
1987
The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease
Easton P, West P, Meatherall R, Brewster J, Lertzman M, Kryger M. The Effect of Excessive Ethanol Ingestion on Sleep in Severe Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 224-233. PMID: 3629084, DOI: 10.1093/sleep/10.3.224.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseSevere chronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep timePulmonary diseaseHeart rateEmphysematous chronic obstructive pulmonary diseaseExcessive ethanol ingestionSignificant O2 desaturationArterial oxygen saturationIngestion of alcoholDose of ethanolSleep stagesExcessive alcohol ingestionTotal sleep timeMean heart ratePremature ventricular contractionsCOPD altersAlcohol ingestionO2 desaturationEthanol ingestionOxygen saturationVentricular contractionsREM timeSerum ethanol