Differential adhesion regulates neurite placement via a retrograde zippering mechanism
Sengupta T, Koonce NL, Vázquez-MartÃnez N, Moyle MW, Duncan LH, Emerson SE, Han X, Shao L, Wu Y, Santella A, Fan L, Bao Z, Mohler W, Shroff H, Colón-Ramos DA. Differential adhesion regulates neurite placement via a retrograde zippering mechanism. ELife 2021, 10: e71171. PMID: 34783657, PMCID: PMC8843091, DOI: 10.7554/elife.71171.Peer-Reviewed Original ResearchConceptsDifferential adhesionDifferential adhesion mechanismsSYG-1SYG-2Developmental programEmbryonic developmentNeurite tipsZippering mechanismBiophysical principlesNeurite shaftSynaptic specificityBrain neuropilSingle neuriteLayers occursAlternate mechanismAdhesion mechanismExpressionNeuritesZipperingAdhesionMechanismOutgrowthStructural and developmental principles of neuropil assembly in C. elegans
Moyle MW, Barnes KM, Kuchroo M, Gonopolskiy A, Duncan LH, Sengupta T, Shao L, Guo M, Santella A, Christensen R, Kumar A, Wu Y, Moon KR, Wolf G, Krishnaswamy S, Bao Z, Shroff H, Mohler WA, Colón-Ramos DA. Structural and developmental principles of neuropil assembly in C. elegans. Nature 2021, 591: 99-104. PMID: 33627875, PMCID: PMC8385650, DOI: 10.1038/s41586-020-03169-5.Peer-Reviewed Original ResearchConceptsSpecific sensory organsNerve ringCaenorhabditis elegansC. elegansMuscle quadrantsNeuropil organizationDevelopmental principlesTissue organizationSensory organsBehavioral circuitsElegansPioneer neuronsCell positionDevelopmental sequenceStratified architectureTemporal progressionPrecise circuitsPacked neuronsUnique morphologyNeuronsSequenceOutgrowthAssemblyHierarchical developmentNeuropil