Keyla Sá, PhD
Postdoctoral AssociateAbout
Titles
Postdoctoral Associate
Biography
I am a Pew Latin American Fellow and postdoctoral researcher in the Department of Immunobiology at Yale School of Medicine under the guidance of Dr. Akiko Iwasaki. My work investigates how pathogenic autoantibodies emerge after infections and contribute to chronic diseases such as Long COVID and ME/CFS. I integrate large-scale proteomics, immunology, and translational approaches to uncover mechanisms of neuro-immune interactions and identify therapeutic targets. My long-term goal is to establish an independent research program focused on autoantibody-mediated neurological chronic diseases and precision medicine.
For a complete list of publications: https://scholar.google.com/cit...
Last Updated on September 25, 2025.
Education & Training
- PhD
- Universidade de São Paulo, Cellular and molecular biology (2022)
- MSc
- Universidade Federal do Pará, Biology of Infectious and Parasitic Agents (2018)
- BSc
- Universidade Federal do Pará, Biomedicine (2016)
Research
Publications
2024
Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19.
de Sá KSG, Amaral LA, Rodrigues TS, Caetano CCS, Becerra A, Batah SS, Lopes FT, de Oliveira IM, Lopes LS, Almeida L, Mota CM, Oliveira S, Wada DT, Koenigkam-Santos M, Martins RB, Rosales RRC, Arruda E, Fabro AT, Zamboni DS. Pulmonary inflammation and viral replication define distinct clinical outcomes in fatal cases of COVID-19. PLoS Pathog 2024, 20: e1012222. PMID: 38838044, DOI: 10.1371/journal.ppat.1012222.Peer-Reviewed Original Research
2023
Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection.
de Sá KSG, Amaral LA, Rodrigues TS, Ishimoto AY, de Andrade WAC, de Almeida L, Freitas-Castro F, Batah SS, Oliveira SC, Pastorello MT, Fabro AT, Zamboni DS. Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection. Nat Commun 2023, 14: 1049. PMID: 36828815, DOI: 10.1038/s41467-023-36626-6.Peer-Reviewed Original ResearchCASP4/11 contributes to NLRP3 activation and COVID-19 exacerbation.
Rodrigues TS, Caetano CCS, de Sá KSG, Almeida L, Becerra A, Gonçalves AV, de Sousa Lopes L, Oliveira S, Mascarenhas DPA, Batah SS, Silva BM, Gomes GF, Castro R, Martins RB, Avila J, Frantz FG, Cunha TM, Arruda E, Cunha FQ, Nakaya H, Cunha LD, Fabro AT, Louzada-Junior P, de Oliveira RDR, Zamboni DS. CASP4/11 contributes to NLRP3 activation and COVID-19 exacerbation. J Infect Dis 2023 PMID: 36763010, DOI: 10.1093/infdis/jiad037.Peer-Reviewed Original Research
2022
Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
de Almeida L, da Silva ALN, Rodrigues TS, Oliveira S, Ishimoto AY, Seribelli AA, Becerra A, Andrade WA, Ataide MA, Caetano CCS, de Sá KSG, Pelisson N, Martins RB, de Paula Souza J, Arruda E, Batah SS, Castro R, Frantz FG, Cunha FQ, Cunha TM, Fabro AT, Cunha LD, Louzada-Junior P, de Oliveira RDR, Zamboni DS. Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection. Sci Adv 2022, 8: eabo5400. PMID: 36103544, DOI: 10.1126/sciadv.abo5400.Peer-Reviewed Original Research
2021
Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients. J Exp Med 2021, 218 PMID: 33231615, DOI: 10.1084/jem.20201707.Peer-Reviewed Original Research
2019
Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication.
de Carvalho RVH, Silva ALN, Santos LL, Andrade WA, de Sá KSG, Zamboni DS. Macrophage priming is dispensable for NLRP3 inflammasome activation and restriction of Leishmania amazonensis replication. J Leukoc Biol 2019, 106: 631-640. PMID: 31063608, DOI: 10.1002/JLB.MA1118-471R.Peer-Reviewed Original Research
2016
IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy.
de Sá KS, Santana BB, de Souza Ferreira TC, Sousa RC, Caldas CA, Azevedo VN, Feitosa RN, Machado LF, de Oliveira Guimarães Ishak M, Ishak R, Vallinoto AC. IL28B gene polymorphisms and Th1/Th2 cytokine levels might be associated with HTLV-associated arthropathy. Cytokine 2016, 77: 79-87. PMID: 26546777, DOI: 10.1016/j.cyto.2015.11.004.Peer-Reviewed Original Research
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300 Cedar Street
New Haven, CT 06519