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Keyla Sá, PhD

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Postdoctoral Associate

About

Titles

Postdoctoral Associate

Biography

Cellular and Molecular Immunologist, with focus on basic immunology, Host-pathogens interactions, innate immune sensing and strong background in molecular biology.

Over the past 10 years, I have been focusing my research on answering fundamental question on the host-pathogens interaction, focusing mostly on the innate immune response to different pathogens, including parasites and virus.

During my master's degree at the Universidade do Pará I had the opportunity to work with molecular epidemiology of infectious diseases as well as on Immunogenetics, including the investigation of the presence of SNPs in cytokines genes and their association with susceptibility/resistance to infections and currently.

On my Ph.D. at the University of São Paulo with Dario Zamboni, I was investigating the role o intracellular Nod-like Receptors and pyroptosis (an inflammatory cell death) on the response against Leishmania and SARS-CoV-2 infection.

Currently, on my postdoc at Yale University with Akiko Iwasaki I am working with long COVID.

For a complete list of publications: https://scholar.google.com/cit...

Education & Training

PhD
Universidade de São Paulo, Cellular and molecular biology (2022)
MSc
Universidade Federal do Pará, Biology of Infectious and Parasitic Agents (2018)
BSc
Universidade Federal do Pará, Biomedicine (2016)

Research

Research at a Glance

Publications Timeline

A big-picture view of Keyla Sá's research output by year.
6Publications

Publications

2023

  • CASP4/11 contributes to NLRP3 activation and COVID-19 exacerbation.
    Rodrigues TS, Caetano CCS, de Sá KSG, Almeida L, Becerra A, Gonçalves AV, de Sousa Lopes L, Oliveira S, Mascarenhas DPA, Batah SS, Silva BM, Gomes GF, Castro R, Martins RB, Avila J, Frantz FG, Cunha TM, Arruda E, Cunha FQ, Nakaya H, Cunha LD, Fabro AT, Louzada-Junior P, de Oliveira RDR, Zamboni DS. CASP4/11 contributes to NLRP3 activation and COVID-19 exacerbation. J Infect Dis 2023 PMID: 36763010, DOI: 10.1093/infdis/jiad037.
    Peer-Reviewed Original Research

2022

  • Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection.
    de Almeida L, da Silva ALN, Rodrigues TS, Oliveira S, Ishimoto AY, Seribelli AA, Becerra A, Andrade WA, Ataide MA, Caetano CCS, de Sá KSG, Pelisson N, Martins RB, de Paula Souza J, Arruda E, Batah SS, Castro R, Frantz FG, Cunha FQ, Cunha TM, Fabro AT, Cunha LD, Louzada-Junior P, de Oliveira RDR, Zamboni DS. Identification of immunomodulatory drugs that inhibit multiple inflammasomes and impair SARS-CoV-2 infection. Sci Adv 2022, 8: eabo5400. PMID: 36103544, DOI: 10.1126/sciadv.abo5400.
    Peer-Reviewed Original Research

2021

  • Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients.
    Rodrigues TS, de Sá KSG, Ishimoto AY, Becerra A, Oliveira S, Almeida L, Gonçalves AV, Perucello DB, Andrade WA, Castro R, Veras FP, Toller-Kawahisa JE, Nascimento DC, de Lima MHF, Silva CMS, Caetite DB, Martins RB, Castro IA, Pontelli MC, de Barros FC, do Amaral NB, Giannini MC, Bonjorno LP, Lopes MIF, Santana RC, Vilar FC, Auxiliadora-Martins M, Luppino-Assad R, de Almeida SCL, de Oliveira FR, Batah SS, Siyuan L, Benatti MN, Cunha TM, Alves-Filho JC, Cunha FQ, Cunha LD, Frantz FG, Kohlsdorf T, Fabro AT, Arruda E, de Oliveira RDR, Louzada-Junior P, Zamboni DS. Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients. J Exp Med 2021, 218 PMID: 33231615, DOI: 10.1084/jem.20201707.
    Peer-Reviewed Original Research

2019

2016

Academic Achievements and Community Involvement

  • honor

    Best Abstract Award - Honorable Mention

    International AwardInternational Experimental Biology & Medicine Conference
  • honor

    Honorable Mention in the Newton Freire-Maia award in the area of Human and Medical Genetics, and Pharmacogenetics

    International AwardBrazilian Society of Genetics
  • honor

    Young Talent Award in Life Sciences

    International AwardBrazilian Society of Biochemistry and Molecular Biology (SBBq) and Cytiva
  • honor

    AAI-IUIS Travel Award; AAI Introductory Course of Immunology

    National AwardThe American Association of Immunologists
  • honor

    Highlight of the Scientific and Technological Initiation UFPA 2015

    International AwardUniversidade Federal do Pará
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