2014
A Form of the Metabolic Syndrome Associated with Mutations in DYRK1B
Keramati AR, Fathzadeh M, Go GW, Singh R, Choi M, Faramarzi S, Mane S, Kasaei M, Sarajzadeh-Fard K, Hwa J, Kidd KK, Babaee Bigi MA, Malekzadeh R, Hosseinian A, Babaei M, Lifton RP, Mani A. A Form of the Metabolic Syndrome Associated with Mutations in DYRK1B. New England Journal Of Medicine 2014, 370: 1909-1919. PMID: 24827035, PMCID: PMC4069260, DOI: 10.1056/nejmoa1301824.Peer-Reviewed Original ResearchConceptsKinase-like domainMapping susceptibility genesHistidine 90Disease-causing genesFunctional characterizationDisease genesDYRK1BKey gluconeogenic enzymesGenetic analysisCardiovascular risk traitsWhole-exome sequencingDistinct familiesLinkage analysisSecond mutationPosition 102Susceptibility genesFamily membersLarge familyGenesCausative mutationsUnaffected family membersMutationsFunction activityAffected family membersGluconeogenic enzymes
2011
Selecting SNPs to Identify Ancestry
Sampson JN, Kidd KK, Kidd JR, Zhao H. Selecting SNPs to Identify Ancestry. Annals Of Human Genetics 2011, 75: 539-553. PMID: 21668909, PMCID: PMC3141729, DOI: 10.1111/j.1469-1809.2011.00656.x.Peer-Reviewed Original Research
2004
Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region
Paschou P, Feng Y, Pakstis A, Speed W, DeMille M, Kidd J, Jaghori B, Kurlan R, Pauls D, Sandor P, Barr C, Kidd K. Indications of Linkage and Association of Gilles de la Tourette Syndrome in Two Independent Family Samples: 17q25 Is a Putative Susceptibility Region. American Journal Of Human Genetics 2004, 75: 545-560. PMID: 15303240, PMCID: PMC1182043, DOI: 10.1086/424389.Peer-Reviewed Original ResearchMeSH KeywordsC-Reactive ProteinChromosome MappingChromosomes, Human, Pair 17Gene FrequencyGenetic LinkageGenetic Predisposition to DiseaseGenotypeHaplotypesHumansLinkage DisequilibriumLod ScoreMicrosatellite RepeatsMicrotubule-Associated ProteinsNerve Tissue ProteinsPedigreePolymorphism, Single NucleotideTourette SyndromeWhite PeopleConceptsSingle nucleotide polymorphismsLinkage disequilibriumSusceptibility regionsThree-site haplotypesPutative susceptibility regionsBackground linkage disequilibriumSignificant association resultsIndication of linkageNonparametric LOD scoreGenomic regionsThree-marker haplotypeComplex genetic backgroundAdditional microsatellite markersFine mappingGenetic basisHigher LD valuesMicrosatellite markersExpression profilesAssociation resultsTransmission/disequilibrium testChromosome 17Genetic componentGenetic backgroundGenesLOD score
1999
On a Randomization Procedure in Linkage Analysis
Zhao H, Merikangas K, Kidd K. On a Randomization Procedure in Linkage Analysis. American Journal Of Human Genetics 1999, 65: 1449-1456. PMID: 10521312, PMCID: PMC1288298, DOI: 10.1086/302607.Peer-Reviewed Original ResearchConceptsEfficient simulation procedureObserved test statisticSimulation-based methodTheoretical resultsTest statisticNovel simulation methodSimulation methodReal dataSimulation procedureUninformative markersTheoretical workStatistical testsPedigree structureGenomewide significance levelRandomization procedureDiabetes dataStatisticsGlobal variation in the frequencies of functionally different catechol-O-methyltransferase alleles
Palmatier M, Kang A, Kidd K. Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biological Psychiatry 1999, 46: 557-567. PMID: 10459407, DOI: 10.1016/s0006-3223(99)00098-0.Peer-Reviewed Original ResearchConceptsRestriction site polymorphismsSingle nucleotide polymorphismsAllele frequenciesDifferent population frequenciesControl allele frequenciesEnzyme activity levelsAncestral alleleCandidate genesPopulation-based association studyAssociation studiesSite polymorphismFirst global surveyNucleotide polymorphismsAllelesEnzyme activityPopulation frequencyPolymorphismDifferent populationsCOMT enzyme activityActivity alleleLow-activity alleleGenesProteinGlobal variationPopulationA paradigm for finding genes for a complex human trait: Polycystic ovary syndrome and follistatin
Odunsi K, Kidd K. A paradigm for finding genes for a complex human trait: Polycystic ovary syndrome and follistatin. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8315-8317. PMID: 10411866, PMCID: PMC33617, DOI: 10.1073/pnas.96.15.8315.Peer-Reviewed Original ResearchGenome scan for linkage to Gilles de la Tourette syndrome
Barr C, Wigg K, Pakstis A, Kurlan R, Pauls D, Kidd K, Tsui L, Sandor P. Genome scan for linkage to Gilles de la Tourette syndrome. American Journal Of Medical Genetics 1999, 88: 437-445. PMID: 10402514, DOI: 10.1002/(sici)1096-8628(19990820)88:4<437::aid-ajmg24>3.0.co;2-e.Peer-Reviewed Original ResearchA more powerful method to evaluate p‐values in GENEHUNTER
Zhao H, Sheffield L, Pakstis A, Knauert M, Kidd K. A more powerful method to evaluate p‐values in GENEHUNTER. Genetic Epidemiology 1999, 17: s415-s420. PMID: 10597472, DOI: 10.1002/gepi.1370170770.Peer-Reviewed Original Research
1998
OA1 Mutations and Deletions in X-Linked Ocular Albinism
Schnur R, Gao M, Wick P, Keller M, Benke P, Edwards M, Grix A, Hockey A, Jung J, Kidd K, Kistenmacher M, Levin A, Lewis R, Musarella M, Nowakowski R, Orlow S, Pagon R, Pillers D, Punnett H, Quinn G, Tezcan K, Wagstaff J, Weleber R. OA1 Mutations and Deletions in X-Linked Ocular Albinism. American Journal Of Human Genetics 1998, 62: 800-809. PMID: 9529334, PMCID: PMC1377018, DOI: 10.1086/301776.Peer-Reviewed Original Research
1997
Editorial: Can we find genes for schizophrenia?
Kidd K. Editorial: Can we find genes for schizophrenia? American Journal Of Medical Genetics 1997, 74: 104-111. PMID: 9034016, DOI: 10.1002/(sici)1096-8628(19970221)74:1<104::aid-ajmg21>3.0.co;2-u.Peer-Reviewed Original ResearchDetection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes
Iyengar S, Calafell F, Kidd K. Detection of major genes underlying several quantitative traits associated with a common disease using different ascertainment schemes. Genetic Epidemiology 1997, 14: 809-814. PMID: 9433582, DOI: 10.1002/(sici)1098-2272(1997)14:6<809::aid-gepi41>3.0.co;2-r.Peer-Reviewed Original Research
1996
Molecular Haplotyping of Genetic Markers 10 kb Apart by Allele-Specific Long-Range PCR
Michalatos-Beloin S, Tishkoff S, Bentley K, Kidd K, Ruano G. Molecular Haplotyping of Genetic Markers 10 kb Apart by Allele-Specific Long-Range PCR. Nucleic Acids Research 1996, 24: 4841-4843. PMID: 8972876, PMCID: PMC146303, DOI: 10.1093/nar/24.23.4841.Peer-Reviewed Original ResearchConceptsMolecular haplotypingClassical Mendelian analysisMapping disease genesCD4 locusMolecular haplotypesDisease genesLong-range PCRGenomic samplesFounder effectPolymorphic markersMendelian analysisUnrelated individualsHaplotypingAlu deletionKbRange PCRHaplotypesDiversity researchPopulation samplingPCRChromosomesGenesRepeatsLociDeletionPhenoDB: An Integrated Client/Server Database for Linkage and Population Genetics
Cheung K, Nadkarni P, Silverstein S, Kidd J, Pakstis A, Miller P, Kidd K. PhenoDB: An Integrated Client/Server Database for Linkage and Population Genetics. Journal Of Biomedical Informatics 1996, 29: 327-337. PMID: 8812078, DOI: 10.1006/cbmr.1996.0024.Peer-Reviewed Original ResearchMeSH KeywordsAllelesComputer Communication NetworksComputer GraphicsComputer SystemsData Interpretation, StatisticalDatabase Management SystemsGene FrequencyGenetic LinkageGenetic MarkersGenetics, PopulationHumansInformation Storage and RetrievalInformation SystemsPedigreePhenotypeUser-Computer InterfaceConceptsClient/server databaseClient/server architectureData management tasksData analysis tasksUse graphical interfaceServer architectureDatabase applicationsComplex adServer databaseInteractive validationAnalysis tasksGraphical interfaceFile formatManagement tasksLarge datasetsPhenoDBMultipoint linkageGeneric formatHardy-Weinberg ratiosData entryEfficient managementProject managementGenetic marker dataPopulation geneticsTask
1995
The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome
Gelernter J, Vandenbergh D, Kruger S, Pauls D, Kurlan R, Pakstis A, Kidd K, Uhl G. The Dopamine Transporter Protein Gene (SLC6A3): Primary Linkage Mapping and Linkage Studies in Tourette Syndrome. Genomics 1995, 30: 459-463. PMID: 8825631, DOI: 10.1006/geno.1995.1265.Peer-Reviewed Original ResearchConceptsTourette syndromeDopamine transporterAttention deficit disorderDopaminergic neuronsPresynaptic reuptakeSpecific localizationPsychiatric illnessPsychostimulant drugsChromosome 5pCocaine-induced paranoiaSyndromeDeficit disorderSLC6A3ScoresMajor siteLinkage studiesNegative lod scoresMarkersTransporter protein geneAn international two–stage genome–wide search for schizophrenia susceptibility genes
Moises H, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F, Arolt V, Blackwood D, Liu X, Sjögren B, Aschauer H, Hwu H, Jang K, Livesley W, Kennedy J, Zoega T, Ivarsson O, Bui M, Yu M, Havsteen B, Commenges D, Weissenbach J, Schwinger E, Gottesman I, Pakstis A, Wetterberg L, Kidd K, Helgason T. An international two–stage genome–wide search for schizophrenia susceptibility genes. Nature Genetics 1995, 11: 321-324. PMID: 7581457, DOI: 10.1038/ng1195-321.Peer-Reviewed Original ResearchConceptsGenome-wide searchChromosome 6pIDDM susceptibility genesModel-free linkage analysisSchizophrenia susceptibility genesFine mappingOligogenic transmissionAssociation studiesLinkage analysisGeographical isolatesLinkage findingsSusceptibility genesGenesLocus heterogeneityLarge pedigreeComplex disorderSecond International Collaborative StudyComplex modesHLA regionMultifactorial diseaseLinkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population
Baldwin C, Weiss S, Farrer L, De Stefano A, Adair R, Franklyn B, Kidd K, Korostishevsky M, Bonné-Tamir B. Linkage of congenital, recessive deafness (DFNB4) to chromosome 7q31 and evidence for genetic heterogeneity in the Middle Eastern Druze population. Human Molecular Genetics 1995, 4: 1637-1642. PMID: 8541853, DOI: 10.1093/hmg/4.9.1637.Peer-Reviewed Original ResearchConceptsHuman chromosome 7q31Genetic linkage analysisNon-syndromic deafnessChromosomal locationGene locationNon-syndromic formsRecessive non-syndromic deafnessLinkage analysisChromosome 7q31Nonallelic mutationsGenetic isolateLarge familyLOD scoreGenetic heterogeneityGenetic causeRecessive deafnessGenesRecognizable phenotypeFirst evidenceDruze familyFamilyAffected individualsSpecific patternsMutationsPhenotypeThe CEPH Consortium Linkage Map of Human Chromosome 11
Litt M, Kramer P, Kort E, Fain P, Cox S, Root D, White R, Weissenbach J, Donis-Keller H, Gatti R, Weber J, Nakamura Y, Julier C, Hayashi K, Spurr N, Dean M, Mandel J, Kidd K, Kruse T, Retief A, Bale A, Meo T, Vergnaud G, Warren S, Willard H. The CEPH Consortium Linkage Map of Human Chromosome 11. Genomics 1995, 27: 101-112. PMID: 7665156, DOI: 10.1006/geno.1995.1011.Peer-Reviewed Original ResearchThe CEPH consortium linkage map of human chromosome 16
Kozman H, Keith T, Donis-keller H, White R, Weissenbach J, Dean M, Vergnaud G, Kidd K, Gusella J, Royle N, Sutherland G, Mulley J. The CEPH consortium linkage map of human chromosome 16. Genomics 1995, 25: 44-58. PMID: 7774955, DOI: 10.1016/0888-7543(95)80108-x.Peer-Reviewed Original ResearchConceptsHuman chromosome 16Genetic mapLinkage mapMap lengthSomatic cell hybrid panelFemale map lengthsChromosome 16Male map lengthFramework genetic mapCell hybrid panelMean genetic distanceSex-averaged mapRestriction enzyme combinationsGenetic distanceAverage heterozygosityEntire chromosomesHybrid panelPhysical mapCEPH consortium linkage mapFamily DNACEPH family DNAsPrimer pairsMarker genotypesLociEnzyme combinations
1994
Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred
Barr C, Kennedy J, Pakstis A, Wetterberg L, Sjögren B, Bierut L, Wadelius C, Wahlström J, Martinsson T, Giuffra L, Gelernter J, Hallmayer J, Moises H, Kurth J, Cavalli‐Sforza L, Kidd K. Progress in a genome scan for linkage in schizophrenia in a large Swedish kindred. American Journal Of Medical Genetics 1994, 54: 51-58. PMID: 7909991, DOI: 10.1002/ajmg.1320540110.Peer-Reviewed Original ResearchLinkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region
Barr C, Kennedy J, Pakstis A, Castiglione C, Kidd J, Wetterberg L, Kidd K. Linkage Study of a Susceptibility Locus for Schizophrenia in the Pseudoautosomal Region. Schizophrenia Bulletin 1994, 20: 277-286. PMID: 8085132, DOI: 10.1093/schbul/20.2.277.Peer-Reviewed Original Research